Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (188 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.444, Impact factor a 5 anni: 3.447
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84887597737&partnerID=40&md5=d7ad471b9da6009813d5c4f2d150c293
Parole chiave: Amyloid, Carnosinase, Copper, Dipeptide, Superoxide Dismutase Mimics, Trehalose, Amyloid Beta Protein, Chelating Agent, Cupric Ion, Glycoconjugate, Homocarnosine, Article, Chemical Structure, Enzyme Activity, Potentiometric Titration, Protein Aggregation, Proton Nuclear Magnetic Resonance, Synthesis, Amyloid Beta-Peptides, Circular Dichroism, Coordination Complexes, Drug Stability, Electron Spin Resonance Spectroscopy, Magnetic Resonance Spectroscopy, Spectrophotometry, Ultraviolet, Amyloid Beta-Peptides Antagonists, Inhibitors Chemistry Metabolism, Carnosine Analogs, Derivatives Chemistry, Chelating Agents Chemical Synthesis Chemistry Pharmacology, Coordination Complexes Chemistry, Copper Chemistry Metabolism, Glycoconjugates Chemistry, Superoxide Dismutase Metabolism, Trehalose Chemistry,
Affiliazioni:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council (CNR), Viale A. Doria 6, Catania, Italy.
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania, Italy
Riferimenti:
Crush, K.G., (1970) Comp. Biochem. Physiol., 34, pp. 3-3
Jackson, M.C., Lenney, J.F., (1996) Inflamm. Res., 45, pp. 132-135
Bonfanti, L., Peretto, P., De Marchis, S., Fasolo, A., (1999) Prog. Neurobiol., 59, pp. 333-353
Gjessing, L.R., Lunde, H.A., Mørkrid, L., Lenney, J.F., Sjaastad, O., (1990) J. Neural Transm. Suppl., 29, pp. 91-106
Petroff, O.A.C., (2002) Neuroscientist, 8, pp. 562-573
Petroff, O.A.C., Hyder, F., Rothman, D.L., Mattson, R.H., (2001) Neurology, 56, pp. 709-715
Bauer, K., (2005) Neurochem. Res., 30, p. 13391345
Hipkiss, A.R., (2009) Advances in Food and Nutrition Research, pp. 87-154. , S.L. Taylor, Academic Press Burlington
Kohen, R., Misgav, R., Ginsburg, I., (1991) Free Radic. Res. Commun., 12, pp. 179-185
Bellia, F., Vecchio, G., Cuzzocrea, S., Calabrese, V., Rizzarelli, E., (2011) Mol. Aspects Med., 32, pp. 258-266
Di Paola, R., Impellizzeri, D., Salinaro, A.T., Mazzon, E., Bellia, F., Cavallaro, M., Cornelius, C., Cuzzocrea, S., (2011) Biochem. Pharmacol., 82, pp. 1478-1489
Barnham, K.J., Bush, A.I., (2008) Curr. Opin. Chem. Biol., 12, pp. 222-228
Di Donato, M., Hsu, H.F., Narindrasorak, S., Que, L., Sarkar, B., (2000) Biochemistry, 39, pp. 1890-1896
Fu, Q., Dai, H., Hu, W., Fan, Y., Shen, Y., Zhang, W., Chen, Z., (2008) Cell. Mol. Neurobiol., 28, pp. 307-316
Trombley, P.Q., Horning, M.S., Blakemore, L.J., (2000) Biochemistry (Mosc), 65, pp. 807-816
Teufel, M., Saudek, V., Ledig, J.P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., (2003) J. Biol. Chem., 278, pp. 6521-6531
Bellia, F., Calabrese, V., Guarino, F., Cavallaro, M., Cornelius, C., De Pinto, V., Rizzarelli, E., (2009) Antioxid. Redox Signal., 11, pp. 2759-2775
Peters, V., Kebbewar, M., Jansen, E.W., Jakobs, C., Riedl, E., Koeppel, H., Frey, D., Yard, B.A., (2010) Amino Acids, 38, pp. 1607-1615
Bellia, F., Oliveri, V., Rizzarelli, E., Vecchio, G., (2013) Eur. J. Med. Chem., 70, pp. 225-232
Amorini, A.M., Bellia, F., Di Pietro, V., Giardina, B., La Mendola, D., Lazzarino, G., Sortino, S., Vecchio, G., (2007) Eur. J. Med. Chem., 42, pp. 910-920
Lanza, V., Bellia, F., D'Agata, R., Grasso, G., Rizzarelli, E., Vecchio, G., (2011) J. Inorg. Biochem., 105, pp. 181-188
Pilobello, K.T., Mahal, L.K., (2007) Curr. Opin. Chem. Biol., 11, pp. 300-305
Ohtake, S., Wang, Y.J., (2011) J. Pharm. Sci., 100, pp. 2020-2053
Liu, R., Barkhordarian, H., Emadi, S., Chan, B.P., Sierks, M.R., (2005) Neurobiol. Dis., 20, pp. 74-81
Sarkar, S., Davies, J.E., Huang, Z., Tunnacliffe, A., Rubinsztein, D.C., (2007) J. Biol. Chem., 282, pp. 5641-5652
Arora, A., Ha, C., Park, C.B., (2004) FEBS Lett., 564, pp. 121-125
Béranger, F., Crozet, C., Goldsborough, A., Lehmann, S., (2008) Biochem. Biophys. Res. Commun., 374, pp. 44-48
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nukina, N., (2004) Nat. Med., 10, pp. 148-154
Flaschka, H.A., (1959) EDTA Titrations: An Introduction to Theory and Practice, , Pergamon Press New York
Gran, G., (1952) Analyst, 77, pp. 661-671
Gans, P., Sabatini, A., Vacca, A., (1985) J. Chem. Soc. Dalton Trans., pp. 1195-1200
La Mendola, D., Farkas, D., Bellia, F., Magrì, A., Travaglia, A., Hansson, O., Rizzarelli, E., (2012) Inorg. Chem., 51, pp. 128-141
Arena, G., Contino, A., Longo, E., Sciotto, D., Sgarlata, C., Spoto, G., (2003) Tetrahedron Lett., 44, pp. 5415-5418
http://www.hyperquad.co.ukBellia, F., Pietropaolo, A., Grasso, G., Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges (2013) J. Mass Spectrom., 48, pp. 135-140
Liu, Z.X., Robinson, G.B., Gregory, E.M., (1994) Arch. Biochem. Biophys., 315, pp. 74-81
Attanasio, F., De Bona, P., Cataldo, S., Sciacca, M.F.M., Milardi, D., Pignataro, B., Pappalardo, G., (2013) New J. Chem., 37, pp. 1206-1215
Hanessian, S., Lavallée, P., (1973) Carbohydr. Res., 28, pp. 303-311
Cucinotta, V., Giuffrida, A., Grasso, G., Maccarrone, G., Mazzaglia, A., Messina, M., Vecchio, G., (2011) J. Sep. Sci., 34, pp. 70-76
Grasso, G.I., Bellia, F., Arena, G., Vecchio, G., Rizzarelli, E., (2011) Inorg. Chem., 50, pp. 4917-4924
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) Dalton Trans., pp. 4406-4415
Bellia, F., La Mendola, D., Maccarrone, G., Mineo, P., Vitalini, D., Scamporrino, E., Sortino, S., Rizzarelli, E., (2007) Inorg. Chim. Acta, 360, pp. 945-954
Grasso, G.I., Arena, G., Bellia, F., Maccarrone, G., Parrinello, M., Pietropaolo, A., Vecchio, G., Rizzarelli, E., (2011) Chem. Eur. J., 17, pp. 9448-9455
Sovago, I., Farkas, E., Bertalan, C., Lebkiri, A., Kowalik-Jankowska, T., Kozlowski, H., (1993) J. Inorg. Biochem., 51, pp. 715-726
Magrì, A., D'Alessandro, F., Distefano, D.A., Campagna, T., Pappalardo, G., Impellizzeri, G., La Mendola, D., (2012) J. Inorg. Biochem., 113, pp. 15-24
Oliveri, V., Puglisi, A., Viale, M., Aiello, C., Sgarlata, C., Vecchio, G., Clarke, J., Spencer, J., (2013) Chem. Eur. J., 19, pp. 13946-13955
Urquiola, C., Gambino, D., Cabrera, M., Lavaggi, M.L., Cerecetto, H., González, M., De Cerain, A.L., Torre, M.H., (2008) J. Inorg. Biochem., 102, pp. 119-126
Hellstrand, E., Boland, B., Walsh, D.M., Linse, S., (2010) ACS Chem. Neurosci., 1, pp. 13-18
Ehrnhoefer, D.E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S., Wanker, E.E., (2008) Nat. Struct. Mol. Biol., 15, pp. 558-566
Ryan, T.M., Friedhuber, A., Lind, M., Howlett, G.J., Masters, C., Roberts, B.R., (2012) J. Biol. Chem., 287, pp. 16947-16954
Corona, C., Frazzini, V., Silvestri, E., Lattanzio, R., La Sorda, R., Piantelli, M., Canzoniero, L.M., Sensi, S.L., (2011) PLoS One, 6, p. 17971
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Tipo di articolo: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.444, Impact factor a 5 anni: 3.447
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84887597737&partnerID=40&md5=d7ad471b9da6009813d5c4f2d150c293
Parole chiave: Amyloid, Carnosinase, Copper, Dipeptide, Superoxide Dismutase Mimics, Trehalose, Amyloid Beta Protein, Chelating Agent, Cupric Ion, Glycoconjugate, Homocarnosine, Article, Chemical Structure, Enzyme Activity, Potentiometric Titration, Protein Aggregation, Proton Nuclear Magnetic Resonance, Synthesis, Amyloid Beta-Peptides, Circular Dichroism, Coordination Complexes, Drug Stability, Electron Spin Resonance Spectroscopy, Magnetic Resonance Spectroscopy, Spectrophotometry, Ultraviolet, Amyloid Beta-Peptides Antagonists, Inhibitors Chemistry Metabolism, Carnosine Analogs, Derivatives Chemistry, Chelating Agents Chemical Synthesis Chemistry Pharmacology, Coordination Complexes Chemistry, Copper Chemistry Metabolism, Glycoconjugates Chemistry, Superoxide Dismutase Metabolism, Trehalose Chemistry,
Affiliazioni:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council (CNR), Viale A. Doria 6, Catania, Italy.
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania, Italy
Riferimenti:
Crush, K.G., (1970) Comp. Biochem. Physiol., 34, pp. 3-3
Jackson, M.C., Lenney, J.F., (1996) Inflamm. Res., 45, pp. 132-135
Bonfanti, L., Peretto, P., De Marchis, S., Fasolo, A., (1999) Prog. Neurobiol., 59, pp. 333-353
Gjessing, L.R., Lunde, H.A., Mørkrid, L., Lenney, J.F., Sjaastad, O., (1990) J. Neural Transm. Suppl., 29, pp. 91-106
Petroff, O.A.C., (2002) Neuroscientist, 8, pp. 562-573
Petroff, O.A.C., Hyder, F., Rothman, D.L., Mattson, R.H., (2001) Neurology, 56, pp. 709-715
Bauer, K., (2005) Neurochem. Res., 30, p. 13391345
Hipkiss, A.R., (2009) Advances in Food and Nutrition Research, pp. 87-154. , S.L. Taylor, Academic Press Burlington
Kohen, R., Misgav, R., Ginsburg, I., (1991) Free Radic. Res. Commun., 12, pp. 179-185
Bellia, F., Vecchio, G., Cuzzocrea, S., Calabrese, V., Rizzarelli, E., (2011) Mol. Aspects Med., 32, pp. 258-266
Di Paola, R., Impellizzeri, D., Salinaro, A.T., Mazzon, E., Bellia, F., Cavallaro, M., Cornelius, C., Cuzzocrea, S., (2011) Biochem. Pharmacol., 82, pp. 1478-1489
Barnham, K.J., Bush, A.I., (2008) Curr. Opin. Chem. Biol., 12, pp. 222-228
Di Donato, M., Hsu, H.F., Narindrasorak, S., Que, L., Sarkar, B., (2000) Biochemistry, 39, pp. 1890-1896
Fu, Q., Dai, H., Hu, W., Fan, Y., Shen, Y., Zhang, W., Chen, Z., (2008) Cell. Mol. Neurobiol., 28, pp. 307-316
Trombley, P.Q., Horning, M.S., Blakemore, L.J., (2000) Biochemistry (Mosc), 65, pp. 807-816
Teufel, M., Saudek, V., Ledig, J.P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., (2003) J. Biol. Chem., 278, pp. 6521-6531
Bellia, F., Calabrese, V., Guarino, F., Cavallaro, M., Cornelius, C., De Pinto, V., Rizzarelli, E., (2009) Antioxid. Redox Signal., 11, pp. 2759-2775
Peters, V., Kebbewar, M., Jansen, E.W., Jakobs, C., Riedl, E., Koeppel, H., Frey, D., Yard, B.A., (2010) Amino Acids, 38, pp. 1607-1615
Bellia, F., Oliveri, V., Rizzarelli, E., Vecchio, G., (2013) Eur. J. Med. Chem., 70, pp. 225-232
Amorini, A.M., Bellia, F., Di Pietro, V., Giardina, B., La Mendola, D., Lazzarino, G., Sortino, S., Vecchio, G., (2007) Eur. J. Med. Chem., 42, pp. 910-920
Lanza, V., Bellia, F., D'Agata, R., Grasso, G., Rizzarelli, E., Vecchio, G., (2011) J. Inorg. Biochem., 105, pp. 181-188
Pilobello, K.T., Mahal, L.K., (2007) Curr. Opin. Chem. Biol., 11, pp. 300-305
Ohtake, S., Wang, Y.J., (2011) J. Pharm. Sci., 100, pp. 2020-2053
Liu, R., Barkhordarian, H., Emadi, S., Chan, B.P., Sierks, M.R., (2005) Neurobiol. Dis., 20, pp. 74-81
Sarkar, S., Davies, J.E., Huang, Z., Tunnacliffe, A., Rubinsztein, D.C., (2007) J. Biol. Chem., 282, pp. 5641-5652
Arora, A., Ha, C., Park, C.B., (2004) FEBS Lett., 564, pp. 121-125
Béranger, F., Crozet, C., Goldsborough, A., Lehmann, S., (2008) Biochem. Biophys. Res. Commun., 374, pp. 44-48
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nukina, N., (2004) Nat. Med., 10, pp. 148-154
Flaschka, H.A., (1959) EDTA Titrations: An Introduction to Theory and Practice, , Pergamon Press New York
Gran, G., (1952) Analyst, 77, pp. 661-671
Gans, P., Sabatini, A., Vacca, A., (1985) J. Chem. Soc. Dalton Trans., pp. 1195-1200
La Mendola, D., Farkas, D., Bellia, F., Magrì, A., Travaglia, A., Hansson, O., Rizzarelli, E., (2012) Inorg. Chem., 51, pp. 128-141
Arena, G., Contino, A., Longo, E., Sciotto, D., Sgarlata, C., Spoto, G., (2003) Tetrahedron Lett., 44, pp. 5415-5418
http://www.hyperquad.co.ukBellia, F., Pietropaolo, A., Grasso, G., Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges (2013) J. Mass Spectrom., 48, pp. 135-140
Liu, Z.X., Robinson, G.B., Gregory, E.M., (1994) Arch. Biochem. Biophys., 315, pp. 74-81
Attanasio, F., De Bona, P., Cataldo, S., Sciacca, M.F.M., Milardi, D., Pignataro, B., Pappalardo, G., (2013) New J. Chem., 37, pp. 1206-1215
Hanessian, S., Lavallée, P., (1973) Carbohydr. Res., 28, pp. 303-311
Cucinotta, V., Giuffrida, A., Grasso, G., Maccarrone, G., Mazzaglia, A., Messina, M., Vecchio, G., (2011) J. Sep. Sci., 34, pp. 70-76
Grasso, G.I., Bellia, F., Arena, G., Vecchio, G., Rizzarelli, E., (2011) Inorg. Chem., 50, pp. 4917-4924
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., (2003) Dalton Trans., pp. 4406-4415
Bellia, F., La Mendola, D., Maccarrone, G., Mineo, P., Vitalini, D., Scamporrino, E., Sortino, S., Rizzarelli, E., (2007) Inorg. Chim. Acta, 360, pp. 945-954
Grasso, G.I., Arena, G., Bellia, F., Maccarrone, G., Parrinello, M., Pietropaolo, A., Vecchio, G., Rizzarelli, E., (2011) Chem. Eur. J., 17, pp. 9448-9455
Sovago, I., Farkas, E., Bertalan, C., Lebkiri, A., Kowalik-Jankowska, T., Kozlowski, H., (1993) J. Inorg. Biochem., 51, pp. 715-726
Magrì, A., D'Alessandro, F., Distefano, D.A., Campagna, T., Pappalardo, G., Impellizzeri, G., La Mendola, D., (2012) J. Inorg. Biochem., 113, pp. 15-24
Oliveri, V., Puglisi, A., Viale, M., Aiello, C., Sgarlata, C., Vecchio, G., Clarke, J., Spencer, J., (2013) Chem. Eur. J., 19, pp. 13946-13955
Urquiola, C., Gambino, D., Cabrera, M., Lavaggi, M.L., Cerecetto, H., González, M., De Cerain, A.L., Torre, M.H., (2008) J. Inorg. Biochem., 102, pp. 119-126
Hellstrand, E., Boland, B., Walsh, D.M., Linse, S., (2010) ACS Chem. Neurosci., 1, pp. 13-18
Ehrnhoefer, D.E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S., Wanker, E.E., (2008) Nat. Struct. Mol. Biol., 15, pp. 558-566
Ryan, T.M., Friedhuber, A., Lind, M., Howlett, G.J., Masters, C., Roberts, B.R., (2012) J. Biol. Chem., 287, pp. 16947-16954
Corona, C., Frazzini, V., Silvestri, E., Lattanzio, R., La Sorda, R., Piantelli, M., Canzoniero, L.M., Sensi, S.L., (2011) PLoS One, 6, p. 17971
Homocarnosine is an endogenous dipeptide distributed in cerebral regions and cerebrospinal fluid. Homocarnosine may serve as an antioxidant, free radical scavenger, neurotransmitter, buffering system and metal chelating agent, especially for copper(II) and zinc(II). The homeostasis of homocarnosine is regulated by carnosinases; the serum-circulating isoform of these metallodipeptidases partially hydrolyses homocarnosine in the blood. The enzyme activity is also inhibited by homocarnosine itself in a dose-dependent manner. We synthesized a new multifunctional homocarnosine derivative with trehalose, a disaccharide that possesses several beneficial properties, among which the inhibition of protein aggregation (i.e. Aβ amyloid and polyglutamine proteins) involved in widespread neurodegenerative disorders. We studied the copper(II) binding features of the new conjugate by means of potentiometric and spectroscopic techniques (UV-visible and circular dichroism) and the superoxide dismutase-like activity of the copper(II) complexes with homocarnosine and its trehalose conjugate was evaluated. The inhibitory effect of the new homocarnosine derivative on the carnosinase activity and its effects on Aβ aggregation were also investigated. © 2013 Elsevier Inc.
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GrassoG, Magrì A, Bellia F, Pietropaolo A, La Mendola D, Rizzarelli E
* The Copper (ii) And Zinc (ii) Coordination Mode Of Hexxh And Hxxeh Motif In Small Peptides: The Role Of Carboxylate Location And Hydrogen Bonding Network (219 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Jan; 130(1): 92-102.
Impact Factor: 3.444
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Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (176 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014; 19(2): 2299-2329.
Impact Factor: 2.416
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (37 visite)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
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Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (187 visite)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
Impact Factor: 3.432
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Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (243 visite)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (193 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (270 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (269 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (251 visite)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (221 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (254 visite)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (237 visite)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (247 visite)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (224 visite)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Roviello GN, Mottola A, Musumeci D, Bucci EM, Pedone C
* Synthesis and aggregation properties of a novel enzymatically resistant nucleoamino acid (219 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Oct; 43(4): 1465-1470.
Impact Factor: 3.914
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (327 visite)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine derivatives: new multifunctional drug-like molecules (208 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Jul; 43(1): 153-163.
Impact Factor: 3.914
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (233 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
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Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (271 visite)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
Impact Factor: 2.406
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (279 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (180 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (314 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (142 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (216 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (169 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (208 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
* TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (178 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Impact Factor: 2.554
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (235 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (390 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (261 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (234 visite)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (183 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (155 visite)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (203 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (232 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (199 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2010 Sep; 104(8): 885-891.
Impact Factor: 3.317
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Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R
* Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers (164 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2010 Jul 15; 15(7): 4924-4933.
Impact Factor: 1.988
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (256 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (152 visite)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
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Chambery A, Severino V, Di Maro A, D'Aniello A, Ruvo M, Parente A
* Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry (182 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Apr; 38(4): 1031-1041.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (214 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (229 visite)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (216 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (183 visite)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (252 visite)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (243 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (164 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (220 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (317 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (224 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (216 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (177 visite)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (184 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Di Natale G, Damante CA, Nagy Z, Osz K, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) binding to two novel histidine-containing model hexapeptides: evidence for a metal ion driven turn conformation (236 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2008 Nov; 102(11): 2012-2019.
Impact Factor: 3.133
Dettagli Esporta in BibTeX Esporta in EndNote
Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (189 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
Dettagli Esporta in BibTeX Esporta in EndNote
De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (223 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (219 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (151 visite)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (212 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (221 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (182 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
Dettagli Esporta in BibTeX Esporta in EndNote
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (192 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (175 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
Dettagli Esporta in BibTeX Esporta in EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (198 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (180 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Trehalose effects on alpha-crystallin aggregates (235 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x, 0006-291xlinking), 2007 Mar 23; 354(4): 899-905.
Impact Factor: 2.749
Dettagli Esporta in BibTeX Esporta in EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (259 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (212 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
Dettagli Esporta in BibTeX Esporta in EndNote
Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* A new spot test for sulfhydryl-containing compounds (200 visite)
Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
Impact Factor: 2.305
Dettagli Esporta in BibTeX Esporta in EndNote
Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (205 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
Impact Factor: 3.633
Dettagli Esporta in BibTeX Esporta in EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (186 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli Esporta in BibTeX Esporta in EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (148 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic), 2006; 27(4): 606-613.
Impact Factor: 5.599
Dettagli Esporta in BibTeX Esporta in EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (221 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
Dettagli Esporta in BibTeX Esporta in EndNote
La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (253 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
Dettagli Esporta in BibTeX Esporta in EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (412 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
Dettagli Esporta in BibTeX Esporta in EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (245 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli Esporta in BibTeX Esporta in EndNote
De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (177 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
Dettagli Esporta in BibTeX Esporta in EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (164 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
Dettagli Esporta in BibTeX Esporta in EndNote
Improta R, Barone V
* Assesing the reliability of density functional methods in the conformational study of polypeptides: The treatment of intraresidue nonbonding interactions (210 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2004; 25(11): 1333-1341.
Impact Factor: 3.168
Dettagli Esporta in BibTeX Esporta in EndNote
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (238 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
Dettagli Esporta in BibTeX Esporta in EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (251 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
Dettagli Esporta in BibTeX Esporta in EndNote
Langella E, Improta R, Barone V
* Conformational and spectroscopic analysis of the tyrosyl radical dipeptide analogue in the gas phase and in aqueous solution by a density functional/continuum solvent model (166 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Sep 25; 124(38): 11531-11540.
Impact Factor: 6.201
Dettagli Esporta in BibTeX Esporta in EndNote
Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (139 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
Dettagli Esporta in BibTeX Esporta in EndNote
Langella E, Rega N, Improta R, Crescenzi O, Barone V
* Conformational analysis of the tyrosine dipeptide analogue in the gas phase and in aqueous solution by a density functional/continuum solvent model (156 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2002 Apr 30; 23(6): 650-661.
Impact Factor: 2.931
Dettagli Esporta in BibTeX Esporta in EndNote
Benzi C, Improta R, Scalmani G, Barone V
* Quantum mechanical study of the conformational behavior of proline and 4R-hydroxyproline dipeptide analogues in vacuum and in aqueous solution (123 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2002 Feb; 23(3): 341-350.
Impact Factor: 2.931
Dettagli Esporta in BibTeX Esporta in EndNote
Goodman M, Del Valle JR, Amino Y, Benedetti E
* Molecular basis of sweet taste in dipeptide taste ligands (100 visite)
Pure Appl Chem (ISSN: 0033-4545), 2002; 74(7): 1109-1116.
Impact Factor: 1.75
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Lombardi A, Galdiero S, Nastri F, Di Costanzo L, Gohda S, Sano A, Yamada T, Pavone V
The crystal structure of a Dcp-containing peptide (220 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 182-188.
Impact Factor: 2.405
Dettagli Esporta in BibTeX Esporta in EndNote
Lombardi A, De Simone G, Galdiero S, Nastri F, Di Costanzo L, Makihiara K, Yamada T, Pavone V
The crystal structure of Afc-containing peptide (204 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 150-160.
Impact Factor: 2.405
Dettagli Esporta in BibTeX Esporta in EndNote
Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (165 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
Dettagli Esporta in BibTeX Esporta in EndNote
Cucinotta V, Grasso D, Grasso G, Milardi D
Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (199 visite)
Nucleosides Nucleotides (ISSN: 0732-8311), 1997; 16(10-11): 1847-1854.
Impact Factor: 0.905
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (203 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
Di Blasio B, Saviano M, Del Duca V, De Simone G, Rossi F, Pedone C, Benedetti E, Lorenzi GP
CONFORMATIONAL STUDIES OF HETEROCHIRAL PEPTIDES WITH DIASTEREOISOMERIC RESIDUES - CRYSTAL AND MOLECULAR-STRUCTURES OF LINEAR DIPEPTIDES DERIVED FROM LEUCINE, ISOLEUCINE, AND ALLO-ISOLEUCINE (213 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Oct; 36(4): 401-408.
Impact Factor: 2.425
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (200 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (176 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
Determination of superoxide dismutase-like activity of copper(II) complexes. Relevance of the speciation for the correct interpretation of in vitro O2 - scavenger activity (199 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Jun; 50(4): 273-281.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
Pavone V, Di Blasio B, Lombardi A, Maglio O, Isernia C, Pedone C, Benedetti E, Altmann E, Mutter M
Non coded C alpha, alpha-disubstituted amino acids. X-ray diffraction analysis of a dipeptide containing (S)-alpha-methylserine (182 visite)
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print, 0367-8377linking), 1993 Jan; 41(1): 15-20.
Impact Factor: 1.255
Dettagli Esporta in BibTeX Esporta in EndNote
Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (187 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
Dettagli Esporta in BibTeX Esporta in EndNote
Alberghina M, Lupo G, La Spina G, Mangiameli A, Gulisano M, Sciotto D, Rizzarelli E
Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa (185 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1992 Mar; 45(4): 245-259.
Impact Factor: 1.342
Dettagli Esporta in BibTeX Esporta in EndNote
Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Thermodynamic and 1H-NMR Study of Proton Complex Formation of Histidine-Containing Cyclodipeptides in Aqueous Solution (204 visite)
J Chem Soc, 1992; N/D: 371-376.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (174 visite)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
115 Records (111 escludendo Abstract e Conferenze).
Impact factor totale: 381.033 (366.722 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 406.695 (391.735 escludendo Abstract e Conferenze).
Impact factor totale: 381.033 (366.722 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 406.695 (391.735 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 19 March 2015, 14:22:36
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