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Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy (113 visite)

Mancini M, Prinster A, Annuzzi G, Liuzzi R, Giacco R, Medagli C, Cremone M, Clemente G, Maurea S, Riccardi G, Rivellese AA, Salvatore M

Metab Clin Exp (ISSN: 1532-8600, 0026-0495), 2009 Dec; 58(12): 1724-1730.

Tipo di articolo: Journal Article, Comparative Study, , Impact factor: 2.588, Impact factor a 5 anni: 2.659, Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-71849117865&partnerID=40&md5=fe85f35730041b0c011a41ba1826ab2b

Parole chiave: Fat, Adult, Aged, Article, Clinical Article, Controlled Study, Echography, Fatty Liver, Human, Intermethod Comparison, Nuclear Magnetic Resonance Spectroscopy, Pilot Study, Priority Journal, Receiver Operating Characteristic, Sensitivity And Specificity, Adipose Tissue, Female, Image Processing, Computer-Assisted, Kidney, Linear Models, Middle Aged, Pilot Projects, Protons, Roc Curve, Triglycerides, Adipose Tissue Chemistry Ultrasonography, Fatty Liver Ultrasonography, Kidney Chemistry Ultrasonography, Liver Chemistry Ultrasonography, Triglycerides Analysis Metabolism,

Affiliazioni: *** IBB - CNR ***
Biostructure and Bioimaging Institute, National Council of Research (CNR), Naples, Italy. marcello.mancini@libero.it
SDN Foundation, Institute of Diagnostic and Nuclear Development Naples, Italy
Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
Institute of Food Science, National Council of Research, Avellino, Italy
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy

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The aim of this study was to determine the diagnostic performance of ultrasound (US) in the quantitative assessment of steatosis by comparison with proton magnetic resonance spectroscopy ((1)H-MRS) as a reference standard. Three liver echo-intensity indices were derived: US hepatic mean gray level, hepatic-renal echo-intensity ratio (H/R), and hepatic-portal blood echo-intensity ratio. The (1)H-MRS degree of steatosis was determined as percentage fat by wet weight. Regression equations were used to estimate quantitatively hepatic fat content. The hepatic fat content by (1)H-MRS analysis ranged from 0.10% to 28.9% (median value, 4.8%). Ultrasound H/R was correlated with the degree of steatosis on (1)H-MRS (R(2)= 0.92; P < .0001), whereas no correlation with (1)H-MRS was found for hepatic mean gray level and hepatic-portal blood echo-intensity ratio. A receiver operating characteristic curve identified the H/R of 2.2 as the best cutoff point for the prediction of (1)H-MRS of at least 5%, yielding measures of sensitivity and specificity of 100% and 95%, respectively. In this pilot study, US H/R exhibits high sensitivity and specificity for detecting liver fatty changes. Our results indicate that quantitative evaluation of hepatic fat content can be performed using US H/R and could therefore be a valuable analytic tool in clinical investigation.
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Mancini M, Summers P, Faita F, Brunetto MR, Callea F, De Nicola A, Di Lascio N, Farinati F, Gastaldelli A, Gridelli B, Mirabelli P, Neri E, Salvadori PA, Rebelos E, Tiribelli C, Valenti L, Salvatore M, Bonino F
* Digital liver biopsy: Bio-imaging of fatty liver for translational and clinical research (107 visite) (PDF 48 visite)
World Journal Of Hepatology (ISSN: 1948-5182print), 2018 Feb 27; 10(2): 231-245.
Impact Factor: 0.78
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Petta S, Valenti L, Bugianesi E, Targher G, Bellentani S, Bonino F, Fargion S, Vanni E, Ferrannini E, Loguercio C, Lonardo A, Marra F, Mancini M, Miele L, Nobili V, Baroni GS, Alessandro F, Ballestri S, Brunetto MR, Coco B, Grieco A, Kondili L, Nascimbeni F, Prinster A, Romagnoli D, Taddei S, Vella S
* A "systems medicine" approach to the study of non-alcoholic fatty liver disease (122 visite)
Dig Liver Dis (ISSN: 1590-8658, 1878-3562electronic), 2016; 48(3): 333-342.
Impact Factor: 3.061
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Iaccarino C, Tedeschi E, Rapanà A, Massarelli I, Belfiore G, Quarantelli M, Bellotti A
* Is the distance between mammillary bodies predictive of a thickened third ventricle floor? Clinical article (97 visite)
J Neurosurg (ISSN: 0022-3085), 2009; 110(5): 852-857.
Impact Factor: 2.594
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Maurea S, Maurelli L, Lastoria S, Cuocolo A, Brunetti A, Pace L, Caracò C, Klain M, Lupoli G, Salvatore M
Familial pheochromocytoma in Sipple's syndrome. A comparison between scintigraphy with 131I-meta-iodobenzylguanidine, computed tomography and echography (96 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1992; 83(4): 486-490.
Impact Factor: 0.967
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4 Records (4 escludendo Abstract e Conferenze).
Impact factor totale: 7.402 (7.402 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 7.308 (7.308 escludendo Abstract e Conferenze).

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