Thalamic activation and cortical deactivation during typical absence status monitored using [18F]FDG-PET: a case report(226 visite) Bilo L, Meo R, de Leva MF, Vicidomini C, Salvatore M, Pappata S
Parole chiave: Absence Status Epilepticus, Default State, Fdg-Pet Study, Fluorodeoxyglucose F 18, Adult, Article, Brain Metabolism, Case Report, Frontal Cortex, Glucose Metabolism, Human, Nuclear Magnetic Resonance Imaging, Priority Journal, Stress, Thalamus, Tonic Clonic Seizure, Cerebral Cortex, Image Interpretation, Computer-Assisted, Middle Aged, Positron-Emission Tomography, Radiopharmaceuticals,
Affiliazioni:
*** IBB - CNR *** Epilepsy Center, Department of Neurological Sciences, Federico II University, Naples, Italy. ledabilo@fastwebnet.it Neurology Outpatients Service, Azienda Sanitaria Locale Napoli 1, Naples, Italy Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, Naples, Italy
Riferimenti:
Aghakhani, Y., Bagshaw, A.P., Bénar, C.G., Hawco, C., Andermann, F., Dubeau, F., fMRI activation during spike and wave discharges in idiopathic generalized epilepsy (2004) Brain, 127, pp. 1127-114
Blumenfeld, H., From molecules to networks: cortical/subcortical interactions in the pathophysiology of idiopathic generalized epilepsy (2003) Epilepsia, 44, pp. 7-15
Duncan, J.S., Brain imaging in idiopathic generalized epilepsies (2005) Epilepsia, 46, pp. 108-111
Engel Jr., J., Lubens, P., Kuhl, D.E., Phelps, M.E., Local cerebral metabolic rate for glucose during petit mal absences (1985) Ann Neurol, 17, pp. 121-128
Gotman, J., Grova, C., Bagshaw, A., Kobayashi, E., Aghakani, Y., Dubeau, F., Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain (2005) Proc Natl Acad Sci USA, 102, pp. 15236-15240
Panayiotopoulos, C.P., (2005) Absence Status Epilepticus, , http://www.ilae-epilepsy/Visitors/Centre/ctf/absence_status.cfm, http://www.ilae-epilepsy/Visitors/Centre/ctf/absence_status.cfm
Prevett, M.C., Duncan, J.S., Jones, T., Fish, D.R., Brooks, D.J., Demonstration of thalamic activation during typical absence seizures using H 2(15)O and PET (1995) Neurology, 45, pp. 1396-1402
Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function (2001) Proc Natl Acad Sci USA, 98, pp. 676-682
Salek-Haddadi, A., Lemieux, L., Merschhemke, M., Friston, K.J., Duncan, J.S., Fish, D.R., Functional magnetic resonance imaging of human absence seizures (2003) Ann Neurol, 53, pp. 663-667
Shorvon, S., Walker, M., Status epilepticus in idiopathic generalized epilepsy (2005) Epilepsia, 46, pp. 73-79
Theodore, W.H., Brooks, R., Margolin, R., Patronas, N., Sato, S., Porter, R.J., Positron emission tomography in generalized seizures (1985) Neurology, 35, pp. 684-690
Thomas, P., Valton, P., Genton, P., Absence and myoclonic status epilepticus precipitated by antiepileptic drugs in idiopathic generalized epilepsy (2006) Brain, 129, pp. 1281-1292
We describe the ictal [(18)F]FDG-PET study of a case of absence status showing bilateral thalamic hypermetabolism and frontal cortex hypometabolism. This is the first ictal assessment of absence status by [(18)F]FDG-PET reporting this particular cortical and subcortical involvement. Our findings support the theory of corticothalamic circuitry involvement in the pathophysiology of absence seizures and stress the similarities of the clinical and metabolic pattern observed during absences with the pattern of task-induced interruption of the default state of brain function. (c) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(112 visite) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 DettagliEsporta in BibTeXEsporta in EndNote
209 Records (195 escludendo Abstract e Conferenze). Impact factor totale: 638.806 (597.717 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 693.986 (646.935 escludendo Abstract e Conferenze).
ibb.cnr.it