Thalamic activation and cortical deactivation during typical absence status monitored using [18F]FDG-PET: a case report(269 visite) Bilo L, Meo R, de Leva MF, Vicidomini C, Salvatore M, Pappata S
Parole chiave: Absence Status Epilepticus, Default State, Fdg-Pet Study, Fluorodeoxyglucose F 18, Adult, Article, Brain Metabolism, Case Report, Frontal Cortex, Glucose Metabolism, Human, Nuclear Magnetic Resonance Imaging, Priority Journal, Stress, Thalamus, Tonic Clonic Seizure, Cerebral Cortex, Image Interpretation, Computer-Assisted, Middle Aged, Positron-Emission Tomography, Radiopharmaceuticals,
Affiliazioni:
*** IBB - CNR *** Epilepsy Center, Department of Neurological Sciences, Federico II University, Naples, Italy. ledabilo@fastwebnet.it Neurology Outpatients Service, Azienda Sanitaria Locale Napoli 1, Naples, Italy Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, Naples, Italy
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We describe the ictal [(18)F]FDG-PET study of a case of absence status showing bilateral thalamic hypermetabolism and frontal cortex hypometabolism. This is the first ictal assessment of absence status by [(18)F]FDG-PET reporting this particular cortical and subcortical involvement. Our findings support the theory of corticothalamic circuitry involvement in the pathophysiology of absence seizures and stress the similarities of the clinical and metabolic pattern observed during absences with the pattern of task-induced interruption of the default state of brain function. (c) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(139 visite) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 DettagliEsporta in BibTeXEsporta in EndNote
209 Records (195 escludendo Abstract e Conferenze). Impact factor totale: 638.806 (597.717 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 698.283 (651.232 escludendo Abstract e Conferenze).
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