Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease(181 visite) Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Tipo di articolo: Journal Article, Comparative Study, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, P. H. S.,
Impact factor: 5.973, Impact factor a 5 anni: 8.375
Parole chiave: 2beta Carbomethoxy 3beta (4 Iodophenyl)n (3 Fluoropropyl)nortropane, Dopamine Transporter, Iodine 123, Nortropane Derivative, Parkin, Unclassified Drug, Adult, Article, Clinical Article, Controlled Study, Disease Duration, Dopaminergic Activity, Female, Gene Mutation, Human, Motor Activity, Parkinson Disease, Priority Journal, Rating Scale, Single Photon Emission Computer Tomography, Adolescent, Age Of Onset, Corpus Striatum, Dna Mutational Analysis, Dopamine Plasma Membrane Transport Proteins, Genotype, Iodine Radioisotopes, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Parkinsonian Disorders, Radiopharmaceuticals, Sequence Deletion, Substantia Nigra, Emission-Computed, Single-Photon, Ubiquitin-Protein Ligases, 2beta Carbomethoxy 3beta (4 Iodophenyl) N (3 Fluoropropyl) Nortropane,
Affiliazioni:
*** IBB - CNR *** Biostructure and Bioimaging Inst., National Research Council, Napoli, Italy Department of Neurological Sciences, University Federico II, Napoli, Italy Dept. Biomorphological Funct. Sci., University Federico II, Napoli, Italy Dept. of Molecular Neurogenetics, C. Besta Neurological Institute, Milan, Italy INSERM U289, Dept. Genet., Cytogenet. Embriology, Pitie-Salpetriere Hosp., Paris, France
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Khan, N. L., Brooks, D. J., Pavese, N., Progression of nigrostriatal dysfunction in a parkin kindred: An [18F] dopa PET and clinical study (2002) Brain, 125, pp. 2248-2256
Gibb, W. R., Lees, A. J., The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease (1988) J Neurol Neurosurg Psychiatry, 51, pp. 745-752
Goetz, C. G., Blasucci, L., Stebbins, G. T., Switching dopamine agonists in advanced Parkinson's disease. Is rapid titration preferable to slow? (1999) Neurology, 52, pp. 1227-1229
Oliveira, S. A., Scott, W. K., Martin, E. R., Parkin mutations and susceptibility alleles in late-onset Parkinson's disease (2003) Ann Neurol, 53, pp. 624-629
Van Dyck, C. H., Seibyl, J. P., Malison, R. T., Age-related decline in striatal dopamine transporter binding with iodine-123- -CIT SPECT (1995) J Nucl Med, 36, pp. 1175-1181
Mozley, P. D., Kim, H. J., Gur, R. C., Iodine-123-IPT SPECT imaging of CNS dopamine transporters: Nonlinear effects of normal aging on striatal uptake values (1996) J Nucl Med, 37, pp. 1965-1970
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Ahlskog, J. E., Uitti, R. J., O'Connor, M. K., The effect of dopamine agonist therapy on dopamine transporter imaging in Parkinson's disease (1999) Mov Disord, 14, pp. 940-946
Innis, R. B., Marek, K. L., Sheff, K., Effect of treatment with L-dopa/carbidopa or L-selegiline on striatal dopamine transporter SPECT imaging with [123I] -CIT (1999) Mov Disord, 14, pp. 436-442
Objective: To investigate whether the presence of parkin gene mutations is associated with different nigrostriatal impairment than other early-onset parkinsonism. Methods: Eighteen consecutive early-onset Parkinson disease (PD) patients (nine parkin and nine nonparkin patients) and six controls were studied with [123I]FP-CIT SPECT. Results: Parkin patients had longer disease duration (15 ± 9 vs 6 ± 2 years, p = 0.008) and higher Unified Parkinson's Disease Rating Scale (UPDRS) motor score (35.8 ± 13.7 vs 22.8 ± 7.9, p = 0.025) than nonparkin patients. Caudate and putamen DAT density were reduced by 60% and 79% in parkin and by 43% and 70% in nonparkin patients. Multiple regression analysis showed that the UPDRS and the presence of parkin gene mutations, but not the disease duration, were significantly correlated with the striatal DAT density. Parkin patients showed a more symmetric DAT loss in both caudate and putamen as compared with nonparkin patients. Conclusions: Parkin-related disease may be associated with a higher degree of nigrostriatal impairment, independently of the clinical severity of the disease, and a more symmetric involvement as compared with non-parkin early-onset disease.
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