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Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease: Relation to coronary anatomy and ventricular function (112 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1993 Oct; 34(10): 1688-1692.
Tipo di articolo: Journal Article,
Impact factor: 3.491
Impact factor a 5 anni: 5.331
Parole chiave: Thallium 201, Adult, Angiocardiography, Article, Clinical Article, Coronary Artery Disease, Coronary Artery Obstruction, Data Analysis, Diagnostic Imaging, Heart Left Ventricle Ejection Fraction, Heart Left Ventricle Wall Motion, Heart Ventricle Function, Human, Priority Journal, Scintigraphy, Statistical Analysis, Tissue Necrosis, Coronary Angiography, Coronary Disease, Middle Age, Stroke Volume, Support, Non-U.S. Gov, Technetium Tc 99m Sestamibi, Thallium Radioisotopes, Ventricular Function,
We studied 25 male patients, with coronary artery disease, mean age 56 +/- 8 yr. All underwent Tl-204 rest-redistribution and resting Tc-99m methoxyisobutyl isonitrile (MIBI) cardiac imaging. Regional Tl-201 and MIBI uptake were quantitatively analyzed. Regional left ventricular wall motion (WM) was visually assessed on MIBI gated images using a three-point scale (0 = normal, 1 = hypokinetic, 2 = a/dyskinetic). Two patterns of reverse redistribution (RR) were identified: RR-A when Tl-201 uptake was normal on rest images and abnormal on redistribution images, and RR-B when Tl-201 uptake was abnormal on rest images and a significant decrease in uptake was observed on redistribution images. Of the total 375 myocardial segments analyzed, 229 were classified as normal (NI), 40 as reversible defect (RD), 74 as irreversible defect (ID); 26 showed RR-A while 6 myocardial segments had RR-B. Myocardial segments with RR-A differed from NI in the degree of coronary artery stenosis (81% +/- 33% versus 57% +/- 39%, respectively, p < 0. 05), in WM score (1. 1 +/-0.7 versus 0.5 +/- 0.6, respectively, p < 0.01), and in MIBI uptake (81% +/- 10% versus 92% +/- 9%, respectively, p < 0.0001). Moreover, the percent of myocardial segments supplied by a totally occluded coronary artery was significantly higher (p < 0.05) in myocardial segments with RR-A (46%) than in NI (22%). Segments with RR-B did not show any significant difference either from RD and ID. These results suggest that myocardial segments with RR-A on resting Tl-201 images have impaired function and are supplied by severely stenosed coronary arteries and should not be considered normal.
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