Parole chiave: Biomarkers, Dopamine Transporter, Parkinson, S Disease, Spect, Urate, Uric Acid, Ioflupane I 123, Adult, Article, Caudate Nucleus, Controlled Study, Corpus Striatum, Disease Duration, Female, Hoehn And Yahr Scale, Human, Major Clinical Study, Middle Aged, Parkinson Disease, Putamen, Single Photon Emission Computer Tomography, Unified Parkinson Disease Rating Scale, Uric Acid Blood Level, 2-Carbomethoxy-8-(3-Fluoropropyl)-3-(4-Iodophenyl)tropane, Biological Marker, Radiopharmaceutical Agent, Tropane Derivative, Diagnostic Use, Early Diagnosis, Metabolism, Procedures, Scintiscanning, Dopamine Plasma Membrane Transport Proteins, Emission-Computed, Single-Photon,
Affiliazioni:
*** IBB - CNR *** Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II UniversityNaples, Italy Institute of Biostructure and Bioimaging, CNRNaples, Italy Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL), Institute of NeurologyLondon, United Kingdom Dipartimento di Scienze Neurologiche e del Movimento, Universit di Verona, Policlinico Borgo RomaVerona, Italy University of Naples ParthenopeNaples, Italy IDC Hermitage-CapodimonteNaples, Italy Department of Primary Care and Public Health, Imperial CollegeLondon, United Kingdom Department of Public Health, Federico II UniversityNaples, Italy Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, University of SalernoSalerno, Italy
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Schwarzschild, M.A., Schwid, S.R., Marek, K., Serum urate as a predictor of clinical and radiographic progression in Parkinson disease (2008) Arch Neurol, 65, pp. 716-723
Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J., Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinic-pathological study of 100 cases (1992) J Neurol Neurosurg Psychiatry, 55, pp. 181-184
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BACKGROUND: Diagnosing Parkinson's disease (PD) and tracking its progression may require the combination of reliable biomarkers. Among them, both serum uric acid (UA) and dopamine transporter (DaT) binding deserve more investigations.; AIMS OF THE STUDY: We aimed to investigate the relationship between serum UA levels and DaT availability in newly diagnosed, drug-naive PD patients, by means of semiquantitative [(123) I] FP-CIT-SPECT.; METHODS: We recruited 52 newly diagnosed, drug-naive PD patients, and performed serum UA dosage and [(123) I] FP-CIT-SPECT.; RESULTS: Pearson's correlation analysis showed that UA levels were significantly higher in patients with higher averaged, ipsilateral and contralateral DaT binding in caudate, putamen, and striatum.; CONCLUSIONS: We showed, for the first time, by regional semiquantitative analysis of DaT binding in PD patients that UA levels significantly correlates with the severity of dopaminergic impairment in caudate, putamen, and striatum. This study broadens our knowledge on the importance of UA as a biomarker of PD. 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(20 visite) NEW ENGL J MED (ISSN: 0028-4793), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(158 visite) Parkinsonism Relat Disord (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 DettagliEsporta in BibTeXEsporta in EndNote
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201 Records (177 escludendo Abstract e Conferenze). Impact factor totale: 819.441 (734.439 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 845.639 (745.098 escludendo Abstract e Conferenze).
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