Keywords Parole chiave: Biomarkers, Dopamine Transporter, Parkinson, S Disease, Spect, Urate, Uric Acid, Ioflupane I 123, Adult, Article, Caudate Nucleus, Controlled Study, Corpus Striatum, Disease Duration, Female, Hoehn And Yahr Scale, Human, Major Clinical Study, Middle Aged, Parkinson Disease, Putamen, Single Photon Emission Computer Tomography, Unified Parkinson Disease Rating Scale, Uric Acid Blood Level, 2-Carbomethoxy-8-(3-Fluoropropyl)-3-(4-Iodophenyl)tropane, Biological Marker, Radiopharmaceutical Agent, Tropane Derivative, Diagnostic Use, Early Diagnosis, Metabolism, Procedures, Scintiscanning, Dopamine Plasma Membrane Transport Proteins, Emission-Computed, Single-Photon,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II UniversityNaples, Italy Institute of Biostructure and Bioimaging, CNRNaples, Italy Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL), Institute of NeurologyLondon, United Kingdom Dipartimento di Scienze Neurologiche e del Movimento, Universit di Verona, Policlinico Borgo RomaVerona, Italy University of Naples ParthenopeNaples, Italy IDC Hermitage-CapodimonteNaples, Italy Department of Primary Care and Public Health, Imperial CollegeLondon, United Kingdom Department of Public Health, Federico II UniversityNaples, Italy Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, University of SalernoSalerno, Italy
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Alonso, A., Rodríguez, L.A., Logroscino, G., Hernán, M.A., Gout and risk of Parkinson disease: a prospective study (2007) Neurology, 69, pp. 1696-1700
Schwarzschild, M.A., Schwid, S.R., Marek, K., Serum urate as a predictor of clinical and radiographic progression in Parkinson disease (2008) Arch Neurol, 65, pp. 716-723
Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J., Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinic-pathological study of 100 cases (1992) J Neurol Neurosurg Psychiatry, 55, pp. 181-184
Fahn, S., Elton, R.L., (1987) Unified Parkinson's disease rating scale. Recent developments in Parkinson's disease, 2, pp. 153-163. , UPDRS Program Members., vol. . Florham Park, NJ: Macmillan Healthcare Information
Uric Acid Relates To Dopamine Transporter Availability In Parkinson'S Disease
BACKGROUND: Diagnosing Parkinson's disease (PD) and tracking its progression may require the combination of reliable biomarkers. Among them, both serum uric acid (UA) and dopamine transporter (DaT) binding deserve more investigations.; AIMS OF THE STUDY: We aimed to investigate the relationship between serum UA levels and DaT availability in newly diagnosed, drug-naive PD patients, by means of semiquantitative [(123) I] FP-CIT-SPECT.; METHODS: We recruited 52 newly diagnosed, drug-naive PD patients, and performed serum UA dosage and [(123) I] FP-CIT-SPECT.; RESULTS: Pearson's correlation analysis showed that UA levels were significantly higher in patients with higher averaged, ipsilateral and contralateral DaT binding in caudate, putamen, and striatum.; CONCLUSIONS: We showed, for the first time, by regional semiquantitative analysis of DaT binding in PD patients that UA levels significantly correlates with the severity of dopaminergic impairment in caudate, putamen, and striatum. This study broadens our knowledge on the importance of UA as a biomarker of PD. 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Uric Acid Relates To Dopamine Transporter Availability In Parkinson'S Disease
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