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Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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Chemical Modifications Of Peptide Sequences Via S-Alkylation Reaction (107 visite)

Calce E, Leone M, Monfregola L, De Luca S

Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2013; 15(20): 5354-5357.

Tipo di articolo: Journal Article, , Impact factor: 6.324, Impact factor a 5 anni: 5.72, Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886242435&partnerID=40&md5=c74d7953648f57ec9bd7a8273d90bd28

Parole chiave: Cysteine, Peptide, Thiol Derivative, Alkylation, Amino Acid Sequence, Article, Chemical Structure, Chemistry, Synthesis, Molecular Structure, Sulfhydryl Compounds,

Affiliazioni: *** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy
Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, United States


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Monfregola, L., De Luca, S., (2011) Amino Acids, 41, pp. 981-990

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Monfregola, L., Leone, M., Calce, E., De Luca, S., (2012) Org. Lett., 14, pp. 1664-1667

Triola, G., Brunsveld, L., Waldmann, H., (2008) J. Org. Chem., 79, pp. 3646-3649. , references therein

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Everaerts, F., Torrianni, M., Hendriks, M., Feijen, J. J., (2007) Biomed. Mater. Res. Part A, 83, pp. 1176-1183



A chemoselective, convenient, and mild synthetic strategy to modify peptides on a cysteine sulfhydryl group is described. It simply requires activated molecular sieves to selectively promote S-alkylation in the presence of peptide nucleophilic functionalities. The procedure is easy to perform, fast, and provides high yields even in the case of poor electrophilic groups. Moreover, the method allows an efficient one-pot poly alkylation, proving that the sulfhydryl reactivity does not rely on its specific position within the peptide sequence. 2013 American Chemical Society
Nessun risultato.

Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
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De Luca S, Digilio G, Verdoliva V, Saviano M, Menchise V, Tovillas P, Jimenez-oses G, Peregrina JM
* A Late-Stage Synthetic Approach to Lanthionine-Containing Peptides via S-Alkylation on Cyclic Sulfamidates Promoted by Molecular Sieves (15 visite)
Org Lett (ISSN: 1523-7052electronic, 1523-7052linking), 2018 Nov 14; N/D: N/D-N/D.
Impact Factor: 6.492
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Calce E, Digilio G, Menchise V, Saviano M, De Luca S
* Chemoselective Glycosylation of Peptides through S-Alkylation Reaction (104 visite) (PDF 59 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Apr 20; 24(23): 6231-6238.
Impact Factor: 5.476
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Calce E, De Luca S
* The Cysteine S-Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences (103 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2016 Aug 19; 22: 1-11.
Impact Factor: 5.317
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Calce E, De Luca S
* Microwave heating in peptide side chain modification via cysteine alkylation (91 visite)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2016 Jun 28; 48: 2267-2271.
Impact Factor: 3.173
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Calce E, Leone M, Mercurio FA, Monfregola L, De Luca S
* Solid-Phase S-Alkylation Promoted by Molecular Sieves (86 visite)
Org Lett (ISSN: 1523-7052electronic, 1523-7052linking, 1523-7060), 2015 Nov 20; 17(22): 5646-5649.
Impact Factor: 6.732
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Squeglia F, Ruggiero A, Romanò MF, Vitagliano L, Berisio R
* Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: Evidence for the l-to-d inversion of configuration of the catalytic cysteine (125 visite)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Sep; 70(9): 2295-2300.
Impact Factor: 14.1
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Caterino M, Merlino A, Balsamo A, Russo Krauss I, Parisi S, Vergara A
* Reaction of Hg2+ Insertion into Cysteine Pairs Within Bovine Insulin Crystals Followed via Raman Spectroscopy (111 visite)
Journal Of Solution Chemistry (ISSN: 0095-9782), 2014 Feb; 43(1): 135-143.
Impact Factor: 1.177
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Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (125 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
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Calce E, Leone M, Monfregola L, De Luca S
* Lipidated Peptides Via Post-Synthetic Thioalkylation Promoted By Molecular Sieves (142 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(8): 1899-1905.
Impact Factor: 3.293
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Monfregola L, Leone M, Calce E,  de Luca S
* Postsynthetic modification of peptides via chemoselective N-alkylation of their side chains (141 visite)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2012 Apr 6; 14(7): 1664-1667.
Impact Factor: 6.142
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Monfregola L, De Luca S
* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (174 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
Impact Factor: 3.248
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Palmieri G, Catara G, Saviano M, Langella E, Gogliettino M, Rossi M
* First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop (104 visite)
J Proteome Res Journal Of Proteome Research (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Impact Factor: 5.132
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Herga S, Brutus A, Vitale RM, Miche H, Perrier J, Puigserver A, Scaloni A, Giardina T
* Site-directed mutagenesis and molecular modelling studies show the role of Asp82 and cysteines in rat acylase 1, a member of the M20 family (90 visite)
Biochem Biophys Res Commun (ISSN: 0006-291xprint, 0006-291xlinking), 2005 May 6; 330(2): 540-546.
Impact Factor: 3
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Campagna T, Grasso G, Rizzarelli E, Vecchio G
L- and D-cysteine derivatives of β-cyclodextrin: Different molecular recognition properties of their copper(II) complexes for amino acids (119 visite)
Inorg Chim Acta (ISSN: 0020-1693), 1998; 275-276: 395-400.
Impact Factor: 1.454
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14 Records (14 escludendo Abstract e Conferenze).
Impact factor totale: 68.029 (68.029 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 60.131 (60.131 escludendo Abstract e Conferenze).







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