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Chemical Modifications Of Peptide Sequences Via S-Alkylation Reaction (100 visite)

Calce E, Leone M, Monfregola L, De Luca S

Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2013; 15(20): 5354-5357.

Tipo di articolo: Journal Article,

Impact factor: 6.324

Impact factor a 5 anni: 5.72


Parole chiave: Cysteine, Peptide, Thiol Derivative, Alkylation, Amino Acid Sequence, Article, Chemical Structure, Chemistry, Synthesis, Molecular Structure, Sulfhydryl Compounds,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886242435&partnerID=40&md5=c74d7953648f57ec9bd7a8273d90bd28

A chemoselective, convenient, and mild synthetic strategy to modify peptides on a cysteine sulfhydryl group is described. It simply requires activated molecular sieves to selectively promote S-alkylation in the presence of peptide nucleophilic functionalities. The procedure is easy to perform, fast, and provides high yields even in the case of poor electrophilic groups. Moreover, the method allows an efficient one-pot poly alkylation, proving that the sulfhydryl reactivity does not rely on its specific position within the peptide sequence. 2013 American Chemical Society
*** IBB - CNR ***

Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy

Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, United States
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13 Records (13 escludendo Abstract e Conferenze).
Impact factor totale: 61.537 (61.537 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 53.533 (53.533 escludendo Abstract e Conferenze).







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