Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study (421 views visite) (PDF restricted privato 246 views visite)
Neuroradiol J (ISSN: 1971-4009, 1971-4009print, 1971-4009linking), 2013 Aug; 26(4): 373-379.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Clinical Trial, Validation Studies,
Impact factor: 2.16, 5-year impact factor Impact factor a 5 anni: 2.304
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884711917&partnerID=40&md5=61e04db53b2edda52d151d2887c8bf4f
Keywords Parole chiave: Graves, Orbitopathy, Mri Segmentation, Orbital Quadrant Definition, Regional Orbital Fat Quantification, Semiautomatic Numeric Segmentation, Validation, Adipose Tissue, Adult, Article, Clinical Article, Controlled Study, Endocrine Ophthalmopathy, Female, Graves Disease, Human, Measurement, Nuclear Magnetic Resonance Imaging, Validation Study, Exophthalmos, Graves Ophthalmopathy, Middle Aged, Reproducibility Of Results, Adipose Tissue Pathology, Exophthalmos Pathology, Graves Ophthalmopathy Pathology, Magnetic Resonance Imaging Methods Standards, Orbit Pathology,
Affiliations Affiliazioni:
*** IBB - CNR ***
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Department of Advanced Biomedical Sciences, Neuroradiology, Federico II University, Naples, Italy
Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy
Naples, Italy - marco. comerci@ibb. cnr. it.
Consiglio Nazionale delle Ricerche
Universita degli Studi di Napoli Federico II
References Riferimenti:
Tian, S., Nishida, Y., Isberg, B., Lennerstrand, G., MRI measurements of normal extraocular muscles and other orbital structures (2000) Graefe's Archive for Clinical and Experimental Ophthalmology, 238 (5), pp. 393-404. , DOI 10. 1007/s00417005037
Feldon, S. E., Celina, P., Saundra, K., Quantitive computer tomography of Graves' ophthalmopathy (1985) Arch Ophtal, 103, pp. 213-215
Peyster, R. G., Ginsberg, F., Silber, J. H., Adler, L. P., Exophthalmos caused by excessive fat: CT volumetric analysis and differential diagnosis (1986) American Journal of Roentgenology, 146 (3), pp. 459-464
Nishida, Y., Aoki, Y., Hayashi, O., Murata, T., Nishida, E., Kani, K., Volume measurement of horizontal extraocular muscles with magnetic resonance imaging (1996) Japanese Journal of Ophthalmology, 40 (3), pp. 439-446
Majos, A., Grzelak, P., Mynarczyk, W., Assessment of the volume of intra-orbital structures using the numerical segmentation image technique (NSI): The extra ocular muscles (2007) Endokrynol Pol., 58 (2), pp. 110-115
Bartalena, L., Pinchera, A., Marcocci, C., Management of graves' ophthalmopathy: Reality and perspectives (2000) Endocrine Reviews, 21 (2), pp. 168-199. , DOI 10. 1210/er. 21. 2. 168
Weetman, A. P., Cohen, S., Gatter, K. C., Fells, P., Shine, B., Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy (1989) Clinical and Experimental Immunology, 75 (2), pp. 222-227
Grubeck-Loebenstein, B., Trieb, K., Sztankay, A., Holter, W., Anderl, H., Wick, G., Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts (1994) Journal of Clinical Investigation, 93 (6), pp. 2738-2743
Heufelder, A., Herterich, S., Ernst, G., Analysis of retro orbital T cell antigen receptor variable region gene usage in patients with Graves' ophthalmopathy (1995) Eur J Endocrinol., 132, pp. 266-277
Bartley, G. B., Fatourechi, V., Kadrmas, E. F., Jacobsen, S. J., Ilstrup, D. M., Garrity, J. A., Gorman, C. A., Clinical features of Graves' ophthalmopathy in an incidence cohort (1996) American Journal of Ophthalmology, 121 (3), pp. 284-290
Feldon, S. E., Lee, C. P., Muramatsu, S. K., Weiner, J. M., Quantitative computed tomography of Graves' ophthalmopathy. Extraocular muscle and orbital fat in development of optic neuropathy (1985) Archives of Ophthalmology, 103 (2), pp. 213-215
Boboridis, K. G., Gogakos, A., Krassas, G. E., Orbital fat decompression for Graves' orbitopathy: A literature review (2010) Pediatr Endocrinol Rev, 7 (SUPPL. 2), pp. 222-226
Alfano, B., Comerci, M., Larobina, M., An MRI digital brain phantom for validation of segmentation methods (2011) Med Image Anal, 15 (3), pp. 329-339
Alfano, B., Brunetti, A., Covelli, E. M., Quarantelli, M., Panico, M. R., Ciarmiello, A., Salvatore, M., Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach (1997) Magnetic Resonance in Medicine, 37 (1), pp. 84-93. , DOI 10. 1002/mrm. 1910370113
Nishida, Y., Tian, S., Isberg, B., Tallstedt, L., Lennerstrand, G., Significance of orbital fatty tissue for exophthalmos in thyroid-associated ophthalmopathy (2002) Graefe's Archive for Clinical and Experimental Ophthalmology, 240 (7), pp. 515-520
Prummel, M. F., Gerding, M. N., Zonneveld, F. W., Wiersinga, W. M., The usefulness of quantitative orbital magnetic resonance imaging in Graves' ophthalmopathy (2001) Clinical Endocrinology, 54 (2), pp. 205-209. , DOI 10. 1046/j. 1365-2265. 2001. 01220. x
Dolman, P. J., Cahill, K., Czyz, C. N., Reliability of estimating ductions in thyroid eye disease: An International Thyroid Eye Disease Society multicenter study (2012) Ophthalmology, 119 (2), pp. 382-389
Ossoinig, K. C., The role of standardized ophthalmic echography in the management of Graves' ophthalmopathy (1989) Dev Ophthalmol, 20, pp. 28-37
Feldon, S. E., Weiner, J. M., Clinical significance of extraocular muscle volumes in Graves' ophthalmopathy. A quantitative computed tomography study (1982) Archives of Ophthalmology, 100 (8), pp. 1266-1269
Matsuo, H., Motomura, M., Takeo, G., Magnetic resonance imaging in diagnosis and follow-up of minimal thyroid ophthalmopathy (1991) Jpn J Med, 30 (3), pp. 229-232
Bahn, R. S., Clinical review 157 - Pathophysiology of Graves' ophthalmopathy: The cycle of disease (2003) Journal of Clinical Endocrinology and Metabolism, 88 (5), pp. 1939-1946. , DOI 10. 1210/jc. 2002-030010
Ben, S. G. J., Schwarcz, R. M., Mansury, A. M., Wang, L., McCann, J. D., Goldberg, R. A., Minimally invasive orbital decompression: Local anesthesia and hand-carved bone (2005) Archives of Ophthalmology, 123 (12), pp. 1671-1675. , http: //archopht. ama-assn. org/cgi/reprint/123/12/1671, DOI 10. 1001/archopht. 123. 12. 1671
Chang, M., Baek, S., Lee, T. S., Long-term outcomes of unilateral orbital fat decompression for thyroid eye disease (2013) Graefes Arch Clin Exp Ophthalmol, 251 (3), pp. 935-939
Strianese, D., Piscopo, R., Elefante, A., Unilateral proptosis in thyroid eye disease with subsequent contralateral involvement: Retrospective follow-up study (2013) BMC Ophthalmol, 30, pp. 13-21
Feldon, S.E., Celina, P., Saundra, K., Quantitive computer tomography of Graves' ophthalmopathy (1985) Arch Ophtal, 103, pp. 213-215
Peyster, R.G., Ginsberg, F., Silber, J.H., Adler, L.P., Exophthalmos caused by excessive fat: CT volumetric analysis and differential diagnosis (1986) American Journal of Roentgenology, 146 (3), pp. 459-464
Weetman, A.P., Cohen, S., Gatter, K.C., Fells, P., Shine, B., Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy (1989) Clinical and Experimental Immunology, 75 (2), pp. 222-227
Bartley, G.B., Fatourechi, V., Kadrmas, E.F., Jacobsen, S.J., Ilstrup, D.M., Garrity, J.A., Gorman, C.A., Clinical features of Graves' ophthalmopathy in an incidence cohort (1996) American Journal of Ophthalmology, 121 (3), pp. 284-290
Feldon, S.E., Lee, C.P., Muramatsu, S.K., Weiner, J.M., Quantitative computed tomography of Graves' ophthalmopathy. Extraocular muscle and orbital fat in development of optic neuropathy (1985) Archives of Ophthalmology, 103 (2), pp. 213-215
Boboridis, K.G., Gogakos, A., Krassas, G.E., Orbital fat decompression for Graves' orbitopathy: A literature review (2010) Pediatr Endocrinol Rev, 7 (SUPPL. 2), pp. 222-226
Prummel, M.F., Gerding, M.N., Zonneveld, F.W., Wiersinga, W.M., The usefulness of quantitative orbital magnetic resonance imaging in Graves' ophthalmopathy (2001) Clinical Endocrinology, 54 (2), pp. 205-209. , DOI 10.1046/j.1365-2265.2001.01220.x
Dolman, P.J., Cahill, K., Czyz, C.N., Reliability of estimating ductions in thyroid eye disease: An International Thyroid Eye Disease Society multicenter study (2012) Ophthalmology, 119 (2), pp. 382-389
Ossoinig, K.C., The role of standardized ophthalmic echography in the management of Graves' ophthalmopathy (1989) Dev Ophthalmol, 20, pp. 28-37
Feldon, S.E., Weiner, J.M., Clinical significance of extraocular muscle volumes in Graves' ophthalmopathy. A quantitative computed tomography study (1982) Archives of Ophthalmology, 100 (8), pp. 1266-1269
Bahn, R.S., Clinical review 157 - Pathophysiology of Graves' ophthalmopathy: The cycle of disease (2003) Journal of Clinical Endocrinology and Metabolism, 88 (5), pp. 1939-1946. , DOI 10.1210/jc.2002-030010
Ben, S.G.J., Schwarcz, R.M., Mansury, A.M., Wang, L., McCann, J.D., Goldberg, R.A., Minimally invasive orbital decompression: Local anesthesia and hand-carved bone (2005) Archives of Ophthalmology, 123 (12), pp. 1671-1675. , http://archopht.ama-assn.org/cgi/reprint/123/12/1671, DOI 10.1001/archopht.123.12.1671
Neuroradiol J (ISSN: 1971-4009, 1971-4009print, 1971-4009linking), 2013 Aug; 26(4): 373-379.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Clinical Trial, Validation Studies,
Impact factor: 2.16, 5-year impact factor Impact factor a 5 anni: 2.304
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884711917&partnerID=40&md5=61e04db53b2edda52d151d2887c8bf4f
Keywords Parole chiave: Graves, Orbitopathy, Mri Segmentation, Orbital Quadrant Definition, Regional Orbital Fat Quantification, Semiautomatic Numeric Segmentation, Validation, Adipose Tissue, Adult, Article, Clinical Article, Controlled Study, Endocrine Ophthalmopathy, Female, Graves Disease, Human, Measurement, Nuclear Magnetic Resonance Imaging, Validation Study, Exophthalmos, Graves Ophthalmopathy, Middle Aged, Reproducibility Of Results, Adipose Tissue Pathology, Exophthalmos Pathology, Graves Ophthalmopathy Pathology, Magnetic Resonance Imaging Methods Standards, Orbit Pathology,
Affiliations Affiliazioni:
*** IBB - CNR ***
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Department of Advanced Biomedical Sciences, Neuroradiology, Federico II University, Naples, Italy
Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy
Naples, Italy - marco. comerci@ibb. cnr. it.
Consiglio Nazionale delle Ricerche
Universita degli Studi di Napoli Federico II
References Riferimenti:
Tian, S., Nishida, Y., Isberg, B., Lennerstrand, G., MRI measurements of normal extraocular muscles and other orbital structures (2000) Graefe's Archive for Clinical and Experimental Ophthalmology, 238 (5), pp. 393-404. , DOI 10. 1007/s00417005037
Feldon, S. E., Celina, P., Saundra, K., Quantitive computer tomography of Graves' ophthalmopathy (1985) Arch Ophtal, 103, pp. 213-215
Peyster, R. G., Ginsberg, F., Silber, J. H., Adler, L. P., Exophthalmos caused by excessive fat: CT volumetric analysis and differential diagnosis (1986) American Journal of Roentgenology, 146 (3), pp. 459-464
Nishida, Y., Aoki, Y., Hayashi, O., Murata, T., Nishida, E., Kani, K., Volume measurement of horizontal extraocular muscles with magnetic resonance imaging (1996) Japanese Journal of Ophthalmology, 40 (3), pp. 439-446
Majos, A., Grzelak, P., Mynarczyk, W., Assessment of the volume of intra-orbital structures using the numerical segmentation image technique (NSI): The extra ocular muscles (2007) Endokrynol Pol., 58 (2), pp. 110-115
Bartalena, L., Pinchera, A., Marcocci, C., Management of graves' ophthalmopathy: Reality and perspectives (2000) Endocrine Reviews, 21 (2), pp. 168-199. , DOI 10. 1210/er. 21. 2. 168
Weetman, A. P., Cohen, S., Gatter, K. C., Fells, P., Shine, B., Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy (1989) Clinical and Experimental Immunology, 75 (2), pp. 222-227
Grubeck-Loebenstein, B., Trieb, K., Sztankay, A., Holter, W., Anderl, H., Wick, G., Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts (1994) Journal of Clinical Investigation, 93 (6), pp. 2738-2743
Heufelder, A., Herterich, S., Ernst, G., Analysis of retro orbital T cell antigen receptor variable region gene usage in patients with Graves' ophthalmopathy (1995) Eur J Endocrinol., 132, pp. 266-277
Bartley, G. B., Fatourechi, V., Kadrmas, E. F., Jacobsen, S. J., Ilstrup, D. M., Garrity, J. A., Gorman, C. A., Clinical features of Graves' ophthalmopathy in an incidence cohort (1996) American Journal of Ophthalmology, 121 (3), pp. 284-290
Feldon, S. E., Lee, C. P., Muramatsu, S. K., Weiner, J. M., Quantitative computed tomography of Graves' ophthalmopathy. Extraocular muscle and orbital fat in development of optic neuropathy (1985) Archives of Ophthalmology, 103 (2), pp. 213-215
Boboridis, K. G., Gogakos, A., Krassas, G. E., Orbital fat decompression for Graves' orbitopathy: A literature review (2010) Pediatr Endocrinol Rev, 7 (SUPPL. 2), pp. 222-226
Alfano, B., Comerci, M., Larobina, M., An MRI digital brain phantom for validation of segmentation methods (2011) Med Image Anal, 15 (3), pp. 329-339
Alfano, B., Brunetti, A., Covelli, E. M., Quarantelli, M., Panico, M. R., Ciarmiello, A., Salvatore, M., Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach (1997) Magnetic Resonance in Medicine, 37 (1), pp. 84-93. , DOI 10. 1002/mrm. 1910370113
Nishida, Y., Tian, S., Isberg, B., Tallstedt, L., Lennerstrand, G., Significance of orbital fatty tissue for exophthalmos in thyroid-associated ophthalmopathy (2002) Graefe's Archive for Clinical and Experimental Ophthalmology, 240 (7), pp. 515-520
Prummel, M. F., Gerding, M. N., Zonneveld, F. W., Wiersinga, W. M., The usefulness of quantitative orbital magnetic resonance imaging in Graves' ophthalmopathy (2001) Clinical Endocrinology, 54 (2), pp. 205-209. , DOI 10. 1046/j. 1365-2265. 2001. 01220. x
Dolman, P. J., Cahill, K., Czyz, C. N., Reliability of estimating ductions in thyroid eye disease: An International Thyroid Eye Disease Society multicenter study (2012) Ophthalmology, 119 (2), pp. 382-389
Ossoinig, K. C., The role of standardized ophthalmic echography in the management of Graves' ophthalmopathy (1989) Dev Ophthalmol, 20, pp. 28-37
Feldon, S. E., Weiner, J. M., Clinical significance of extraocular muscle volumes in Graves' ophthalmopathy. A quantitative computed tomography study (1982) Archives of Ophthalmology, 100 (8), pp. 1266-1269
Matsuo, H., Motomura, M., Takeo, G., Magnetic resonance imaging in diagnosis and follow-up of minimal thyroid ophthalmopathy (1991) Jpn J Med, 30 (3), pp. 229-232
Bahn, R. S., Clinical review 157 - Pathophysiology of Graves' ophthalmopathy: The cycle of disease (2003) Journal of Clinical Endocrinology and Metabolism, 88 (5), pp. 1939-1946. , DOI 10. 1210/jc. 2002-030010
Ben, S. G. J., Schwarcz, R. M., Mansury, A. M., Wang, L., McCann, J. D., Goldberg, R. A., Minimally invasive orbital decompression: Local anesthesia and hand-carved bone (2005) Archives of Ophthalmology, 123 (12), pp. 1671-1675. , http: //archopht. ama-assn. org/cgi/reprint/123/12/1671, DOI 10. 1001/archopht. 123. 12. 1671
Chang, M., Baek, S., Lee, T. S., Long-term outcomes of unilateral orbital fat decompression for thyroid eye disease (2013) Graefes Arch Clin Exp Ophthalmol, 251 (3), pp. 935-939
Strianese, D., Piscopo, R., Elefante, A., Unilateral proptosis in thyroid eye disease with subsequent contralateral involvement: Retrospective follow-up study (2013) BMC Ophthalmol, 30, pp. 13-21
Feldon, S.E., Celina, P., Saundra, K., Quantitive computer tomography of Graves' ophthalmopathy (1985) Arch Ophtal, 103, pp. 213-215
Peyster, R.G., Ginsberg, F., Silber, J.H., Adler, L.P., Exophthalmos caused by excessive fat: CT volumetric analysis and differential diagnosis (1986) American Journal of Roentgenology, 146 (3), pp. 459-464
Weetman, A.P., Cohen, S., Gatter, K.C., Fells, P., Shine, B., Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy (1989) Clinical and Experimental Immunology, 75 (2), pp. 222-227
Bartley, G.B., Fatourechi, V., Kadrmas, E.F., Jacobsen, S.J., Ilstrup, D.M., Garrity, J.A., Gorman, C.A., Clinical features of Graves' ophthalmopathy in an incidence cohort (1996) American Journal of Ophthalmology, 121 (3), pp. 284-290
Feldon, S.E., Lee, C.P., Muramatsu, S.K., Weiner, J.M., Quantitative computed tomography of Graves' ophthalmopathy. Extraocular muscle and orbital fat in development of optic neuropathy (1985) Archives of Ophthalmology, 103 (2), pp. 213-215
Boboridis, K.G., Gogakos, A., Krassas, G.E., Orbital fat decompression for Graves' orbitopathy: A literature review (2010) Pediatr Endocrinol Rev, 7 (SUPPL. 2), pp. 222-226
Prummel, M.F., Gerding, M.N., Zonneveld, F.W., Wiersinga, W.M., The usefulness of quantitative orbital magnetic resonance imaging in Graves' ophthalmopathy (2001) Clinical Endocrinology, 54 (2), pp. 205-209. , DOI 10.1046/j.1365-2265.2001.01220.x
Dolman, P.J., Cahill, K., Czyz, C.N., Reliability of estimating ductions in thyroid eye disease: An International Thyroid Eye Disease Society multicenter study (2012) Ophthalmology, 119 (2), pp. 382-389
Ossoinig, K.C., The role of standardized ophthalmic echography in the management of Graves' ophthalmopathy (1989) Dev Ophthalmol, 20, pp. 28-37
Feldon, S.E., Weiner, J.M., Clinical significance of extraocular muscle volumes in Graves' ophthalmopathy. A quantitative computed tomography study (1982) Archives of Ophthalmology, 100 (8), pp. 1266-1269
Bahn, R.S., Clinical review 157 - Pathophysiology of Graves' ophthalmopathy: The cycle of disease (2003) Journal of Clinical Endocrinology and Metabolism, 88 (5), pp. 1939-1946. , DOI 10.1210/jc.2002-030010
Ben, S.G.J., Schwarcz, R.M., Mansury, A.M., Wang, L., McCann, J.D., Goldberg, R.A., Minimally invasive orbital decompression: Local anesthesia and hand-carved bone (2005) Archives of Ophthalmology, 123 (12), pp. 1671-1675. , http://archopht.ama-assn.org/cgi/reprint/123/12/1671, DOI 10.1001/archopht.123.12.1671
Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study
This study was designed to validate a novel semi-automated segmentation method to measure regional intra-orbital fat tissue volume in Graves' ophthalmopathy. Twenty-four orbits from 12 patients with Graves' ophthalmopathy, 24 orbits from 12 controls, ten orbits from five MRI study simulations and two orbits from a digital model were used. Following manual region of interest definition of the orbital volumes performed by two operators with different levels of expertise, an automated procedure calculated intra-orbital fat tissue volumes (global and regional, with automated definition of four quadrants). In patients with Graves' disease, clinical activity score and degree of exophthalmos were measured and correlated with intra-orbital fat volumes. Operator performance was evaluated and statistical analysis of the measurements was performed. Accurate intra-orbital fat volume measurements were obtained with coefficients of variation below 5\\%. The mean operator difference in total fat volume measurements was 0.56\\%. Patients had significantly higher intra-orbital fat volumes than controls (p<0.001 using Student's t test). Fat volumes and clinical score were significantly correlated (p<0.001). The semi-automated method described here can provide accurate, reproducible intra-orbital fat measurements with low inter-operator variation and good correlation with clinical data.
This study was designed to validate a novel semi-automated segmentation method to measure regional intra-orbital fat tissue volume in Graves' ophthalmopathy. Twenty-four orbits from 12 patients with Graves' ophthalmopathy, 24 orbits from 12 controls, ten orbits from five MRI study simulations and two orbits from a digital model were used. Following manual region of interest definition of the orbital volumes performed by two operators with different levels of expertise, an automated procedure calculated intra-orbital fat tissue volumes (global and regional, with automated definition of four quadrants). In patients with Graves' disease, clinical activity score and degree of exophthalmos were measured and correlated with intra-orbital fat volumes. Operator performance was evaluated and statistical analysis of the measurements was performed. Accurate intra-orbital fat volume measurements were obtained with coefficients of variation below 5\\%. The mean operator difference in total fat volume measurements was 0.56\\%. Patients had significantly higher intra-orbital fat volumes than controls (p<0.001 using Student's t test). Fat volumes and clinical score were significantly correlated (p<0.001). The semi-automated method described here can provide accurate, reproducible intra-orbital fat measurements with low inter-operator variation and good correlation with clinical data.
Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study
Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study
Larobina M, Megna R, Solla R
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* Evidence of Brown Adipose Tissue Activity Assessed by 18F-FDG-PET/CT in Females with Constitutional Leanness (221 visite)
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Impact Factor: 5.114
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Fonti R, Sgambati D, Vaccaro A, Pasanisi F, De Caprio C, Salvatore M, Pace L, Contaldo F
* Evidence Of Brown Adipose Tissue Astivity Assessed By 18f-Fdg-Pet/Ct In Females With Constitutional Leanness (229 visite)
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Impact Factor: 5.114
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Pace L, Nicolai E, D'Amico D, Ibello F, Della Morte AM, Salvatore B, Pizzuti LM, Salvatore M, Soricelli A
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Impact Factor: 3.844
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Merlino A, Russo Krauss I, Albino A, Pica A, Vergara A, Masullo M, De Vendittis E, Sica F
* Improving Protein Crystal Quality by the Without-Oil Microbatch Method: Crystallization and Preliminary X-ray Diffraction Analysis of Glutathione Synthetase from Pseudoalteromonas haloplanktis (341 visite)
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Impact Factor: 2.598
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Alfano B, Comerci M, Larobina M, Prinster A, Hornak JP, Selvan SE, Amato U, Quarantelli M, Tedeschi G, Brunetti A, Salvatore M
* An MRI digital brain phantom for validation of segmentation methods (459 visite) (PDF 652 visite)
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Impact Factor: 4.424
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Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (338 visite)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
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Mancini M, Prinster A, Annuzzi G, Liuzzi R, Giacco R, Medagli C, Cremone M, Clemente G, Maurea S, Riccardi G, Rivellese AA, Salvatore M
* Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy (321 visite)
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Impact Factor: 2.588
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Petretta M, Soricelli A, Storto G, Cuocolo A
* Assessment of coronary flow reserve using single photon emission computed tomography with technetium 99m-labeled tracers (330 visite)
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Impact Factor: 2.442
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (512 visite)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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Wolak A, Slomka PJ, Fish MB, Lorenzo S, Acampa W, Berman DS, Germano G
* Quantitative myocardial-perfusion SPECT: Comparison of three state-of-the-art software packages (352 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2008 Jan; 15(1): 27-34.
Impact Factor: 2.442
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Alfano B, Comerci M, De Pietro G, Esposito A
* An ontology-based technique for validation of MRI brain segmentation methods (354 visite) (PDF 234 visite)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2007; 4805LNCS(PART1): 566-575.
Impact Factor: 0.302
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (268 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Savastano S, Pivonello R, Acampa W, Salvatore M, Lombardi G, Colao A, Fenzi G
* Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy (278 visite)
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Impact Factor: 6.02
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La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (463 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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Quarantelli M, Ciarmiello A, Morra VB, Orefice G, Larobina M, Lanzillo R, Schiavone V, Salvatore E, Alfano B, Brunetti A
* Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (403 visite) (PDF 226 visite)
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Impact Factor: 6.192
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Imbriaco M, Ignarra R, De Rosa N, Lambiase G, Romano M, Ragozzino A
* Parosteal lipoma of the rib: CT findings and pathologic correlation (261 visite)
Clinical Imaging (ISSN: 0899-7071, 1873-4499), 2003; 27(6): 435-437.
Impact Factor: 0.658
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Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, Brunetti A, Galderisi S, Alfano B
* Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia (337 visite) (PDF 199 visite)
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Impact Factor: 5.624
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (339 visite)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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* Myocardial viability assessment in regions of left ventricular dysfunction. Part II: The present and future of echocardiography and magnetic resonance imaging (234 visite)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2001 Jul; 22(7): 731-735.
Impact Factor: 1.19
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Ciarmiello A, Brunetti A, Larobina M, Quarantelli M, Ziviello M, Alfano B, Salvatore M
* Assessment of scanner performance and normalization of estimated relaxation rate values (269 visite) (PDF 231 visite)
Magn Reson Imaging (ISSN: 0730-725x), 2001 Jan; 19(1): 123-128.
Impact Factor: 2.037
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Larobina M, Quarantelli M, Tedeschi E, Brunetti A, Alfano B, Salvatore M
Validation of an automated regional brain segmentation method using a stereotactic Talairach approach (417 visite)
Surgery International Congress Series Car 97 (ISSN: 0531-5131), 1999; 1191: N/D-N/D.
Impact Factor: 1.438
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Pace L, Perrone-Filardi P, Mainenti PP, Cuocolo A, Vezzuto P, Prastaro M, Varrone A, De Luca G, Soricelli A, Betocchi S, Chiariello M, Salvatore M
Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis (289 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Nov; 39(11): 1869-1874.
Impact Factor: 3.064
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Cappabianca S, Iscaro FM, Sirignano C, Napoli E, Del Vecchio W
[Magnetic resonance in the identification and assessment of extent and severity of bone contusion damage: comparison of several types of imaging (SE/T1, GE/T2 and SE/T1) with fat suppression] (232 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Nov; 96(5): 439-445.
Impact Factor: 0.967
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Cappabianca S, Iscaro FM, Sirignano C, Napoli E, Del Vecchio W
Magnetic Resonance Imaging In The Identification And Assessment Of Bone Contusion Extent And Severity: Comparison Between T1-W Se, T2?-W Ge And T1-W (219 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(5): 439-445.
Impact Factor: 0.967
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Cittadini A, Fazio S, Stromer H, Cuocolo A, Sabatini D, Imbriaco M, Sacca L, Douglas PS
New method for optimal echo determination of right ventricular filling: Scintigraphic validation and application in hypertension (203 visite)
Circulationcirculation (ISSN: 0009-7322), 1994; 90(4PART2): N/D-N/D.
Impact Factor: 9.762
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (506 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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38 Records (33 escludendo Abstract e Conferenze).
Impact factor totale: 145.476 (123.746 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 150.306 (125.22 escludendo Abstract e Conferenze).
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Larobina M, Megna R, Solla R
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Parisi V, Petraglia L, D'Esposito V, Cabaro S, Rengo G, Caruso A, Grimaldi MG, Baldascino F, De Bellis A, Vitale D, Formisano R, Ferro A, Paolillo S, Davin L, Lancellotti P, Formisano P, Perrone Filardi P, Ferrara N, Leosco D
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Greco A, Zannetti A, Pappata S, Albanese S, Coda AR, Ragucci M, Nardelli A, Brunetti A, Cuocolo A, Salvatore M
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Parisi V, Rengo G, Perrone-filardi P, Pagano G, Femminella GD, Paolillo S, Petraglia L, Gambino G, Caruso A, Grimaldi MG, Baldascino F, Nolano M, Elia A, Cannavo A, De Bellis A, Coscioni E, Pellegrino T, Cuocolo A, Ferrara N, Leosco D
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Le Moli R, Muscia V, Tumminia A, Frittitta L, Buscema M, Palermo F, Sciacca L, Squatrito S, Vigneri R
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
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Impact Factor: 6.31
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Quarantelli M, Giardino G, Prinster A, Aloj G, Carotenuto B, Cirillo E, Marsili A, Salvatore E, Del Giudice E, Pignata C
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
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* Evidence of Brown Adipose Tissue Activity Assessed by 18F-FDG-PET/CT in Females with Constitutional Leanness (221 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
Dettagli Esporta in BibTeX Esporta in EndNote
Fonti R, Sgambati D, Vaccaro A, Pasanisi F, De Caprio C, Salvatore M, Pace L, Contaldo F
* Evidence Of Brown Adipose Tissue Astivity Assessed By 18f-Fdg-Pet/Ct In Females With Constitutional Leanness (229 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012; 39: S401-S401.
Impact Factor: 5.114
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Pace L, Nicolai E, D'Amico D, Ibello F, Della Morte AM, Salvatore B, Pizzuti LM, Salvatore M, Soricelli A
* Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations (410 visite)
Molecular Imaging And Biology (ISSN: 1860-2002, 1536-1632), 2011 Oct; 13(5): 1029-1035.
Impact Factor: 3.844
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Merlino A, Russo Krauss I, Albino A, Pica A, Vergara A, Masullo M, De Vendittis E, Sica F
* Improving Protein Crystal Quality by the Without-Oil Microbatch Method: Crystallization and Preliminary X-ray Diffraction Analysis of Glutathione Synthetase from Pseudoalteromonas haloplanktis (341 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2011 Sep; 12(9): 6312-6319.
Impact Factor: 2.598
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Alfano B, Comerci M, Larobina M, Prinster A, Hornak JP, Selvan SE, Amato U, Quarantelli M, Tedeschi G, Brunetti A, Salvatore M
* An MRI digital brain phantom for validation of segmentation methods (459 visite) (PDF 652 visite)
Med Image Anal (ISSN: 1361-8415, 1361-8423, 1361-8415linking), 2011 Jun; 15(3): 329-339.
Impact Factor: 4.424
Dettagli Esporta in BibTeX Esporta in EndNote
Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (338 visite)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
Dettagli Esporta in BibTeX Esporta in EndNote
Mancini M, Prinster A, Annuzzi G, Liuzzi R, Giacco R, Medagli C, Cremone M, Clemente G, Maurea S, Riccardi G, Rivellese AA, Salvatore M
* Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with (1)H magnetic resonance spectroscopy (321 visite)
Metab Clin Exp (ISSN: 1532-8600, 0026-0495), 2009 Dec; 58(12): 1724-1730.
Impact Factor: 2.588
Dettagli Esporta in BibTeX Esporta in EndNote
Petretta M, Soricelli A, Storto G, Cuocolo A
* Assessment of coronary flow reserve using single photon emission computed tomography with technetium 99m-labeled tracers (330 visite)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2008 May; 15(3): 456-465.
Impact Factor: 2.442
Dettagli Esporta in BibTeX Esporta in EndNote
Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (512 visite)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
Dettagli Esporta in BibTeX Esporta in EndNote
Wolak A, Slomka PJ, Fish MB, Lorenzo S, Acampa W, Berman DS, Germano G
* Quantitative myocardial-perfusion SPECT: Comparison of three state-of-the-art software packages (352 visite)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2008 Jan; 15(1): 27-34.
Impact Factor: 2.442
Dettagli Esporta in BibTeX Esporta in EndNote
Alfano B, Comerci M, De Pietro G, Esposito A
* An ontology-based technique for validation of MRI brain segmentation methods (354 visite) (PDF 234 visite)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2007; 4805LNCS(PART1): 566-575.
Impact Factor: 0.302
Dettagli Esporta in BibTeX Esporta in EndNote
Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (268 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
Dettagli Esporta in BibTeX Esporta in EndNote
Savastano S, Pivonello R, Acampa W, Salvatore M, Lombardi G, Colao A, Fenzi G
* Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy (278 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2005 Apr; 90(4): 2440-2444.
Impact Factor: 6.02
Dettagli Esporta in BibTeX Esporta in EndNote
La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (463 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
Dettagli Esporta in BibTeX Esporta in EndNote
Quarantelli M, Ciarmiello A, Morra VB, Orefice G, Larobina M, Lanzillo R, Schiavone V, Salvatore E, Alfano B, Brunetti A
* Brain tissue volume changes in relapsing-remitting multiple sclerosis: Correlation with lesion load (403 visite) (PDF 226 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2003 Feb; 18(2): 360-366.
Impact Factor: 6.192
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Imbriaco M, Ignarra R, De Rosa N, Lambiase G, Romano M, Ragozzino A
* Parosteal lipoma of the rib: CT findings and pathologic correlation (261 visite)
Clinical Imaging (ISSN: 0899-7071, 1873-4499), 2003; 27(6): 435-437.
Impact Factor: 0.658
Dettagli Esporta in BibTeX Esporta in EndNote
Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, Brunetti A, Galderisi S, Alfano B
* Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia (337 visite) (PDF 199 visite)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 17(1): 373-384.
Impact Factor: 5.624
Dettagli Esporta in BibTeX Esporta in EndNote
Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (339 visite)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Acampa W, Petretta M, Cuocolo A
* Myocardial viability assessment in regions of left ventricular dysfunction. Part II: The present and future of echocardiography and magnetic resonance imaging (234 visite)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2001 Jul; 22(7): 731-735.
Impact Factor: 1.19
Dettagli Esporta in BibTeX Esporta in EndNote
Ciarmiello A, Brunetti A, Larobina M, Quarantelli M, Ziviello M, Alfano B, Salvatore M
* Assessment of scanner performance and normalization of estimated relaxation rate values (269 visite) (PDF 231 visite)
Magn Reson Imaging (ISSN: 0730-725x), 2001 Jan; 19(1): 123-128.
Impact Factor: 2.037
Dettagli Esporta in BibTeX Esporta in EndNote
Larobina M, Quarantelli M, Tedeschi E, Brunetti A, Alfano B, Salvatore M
Validation of an automated regional brain segmentation method using a stereotactic Talairach approach (417 visite)
Surgery International Congress Series Car 97 (ISSN: 0531-5131), 1999; 1191: N/D-N/D.
Impact Factor: 1.438
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Perrone-Filardi P, Mainenti PP, Cuocolo A, Vezzuto P, Prastaro M, Varrone A, De Luca G, Soricelli A, Betocchi S, Chiariello M, Salvatore M
Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis (289 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Nov; 39(11): 1869-1874.
Impact Factor: 3.064
Dettagli Esporta in BibTeX Esporta in EndNote
Cappabianca S, Iscaro FM, Sirignano C, Napoli E, Del Vecchio W
[Magnetic resonance in the identification and assessment of extent and severity of bone contusion damage: comparison of several types of imaging (SE/T1, GE/T2 and SE/T1) with fat suppression] (232 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998 Nov; 96(5): 439-445.
Impact Factor: 0.967
Dettagli Esporta in BibTeX Esporta in EndNote
Cappabianca S, Iscaro FM, Sirignano C, Napoli E, Del Vecchio W
Magnetic Resonance Imaging In The Identification And Assessment Of Bone Contusion Extent And Severity: Comparison Between T1-W Se, T2?-W Ge And T1-W (219 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(5): 439-445.
Impact Factor: 0.967
Dettagli Esporta in BibTeX Esporta in EndNote
Cittadini A, Fazio S, Stromer H, Cuocolo A, Sabatini D, Imbriaco M, Sacca L, Douglas PS
New method for optimal echo determination of right ventricular filling: Scintigraphic validation and application in hypertension (203 visite)
Circulationcirculation (ISSN: 0009-7322), 1994; 90(4PART2): N/D-N/D.
Impact Factor: 9.762
Dettagli Esporta in BibTeX Esporta in EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (506 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
Dettagli Esporta in BibTeX Esporta in EndNote
38 Records (33 escludendo Abstract e Conferenze).
Impact factor totale: 145.476 (123.746 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 150.306 (125.22 escludendo Abstract e Conferenze).
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