Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome (144 visite)
Int Forum Allergy Rh (ISSN: 2042-6976), 2015 May 7; 5(9): 855-861.
Tipo di articolo: Journal Article,
Impact factor: 2.35, Impact factor a 5 anni: 2.433
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928967033&partnerID=40&md5=998afe74debeace2a7156d0e4a949af5
Parole chiave: Kallmann Syndrome, Sniffin, Sticks, Cortical Thickness, N-Butanol, Odor Discrimination, Odor Identification, Odor Threshold, Olfactory Bulb Volume, Olfactory Sulcus Depth, Adult, Article, Cohort Analysis, Controlled Study, Cortical Thickness (brain), Functional Assessment, Human, Nuclear Magnetic Resonance Imaging, Olfactory Test Kit, Organ Size, Phenotype, Priority Journal, Rhinencephalon, Scoring System, Smelling, Sniffin Stick Test, Adolescent, Child, Middle Aged, Olfaction Disorders, Pathology, Young Adult,
Affiliazioni:
*** IBB - CNR ***
Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
Department of Advanced Biomedical Sciences-Neuroradiology "Federico II" University Napoli Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Venezia Italy
Department of Statistical Sciences University of Padova Padova Italy
Department of Cardiothoracic Sciences Second University of Napoli Napoli Italy
Institute of Biostructure and Bioimaging, National Research Council, School of Medicine Federico II University Napoli Italy
Department of Medicine (DIMED) University of Padova Padova Italy
Department of Neuroradiology University of Salerno Salerno Italy
Riferimenti:
Seminara, S.B., Hayes, F.J., Crowley Jr, W.F., Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations (1998) Endocr Rev, 19, pp. 521-53
Della Valle, E., Vezzani, S., Rochira, V., Prevalence of olfactory and other developmental anomalies in patients with central hypogonadotropic hypogonadism (2013) Front Endocrinol (Lausanne), 4, p. 70
Okubo, K., Sakai, F., Lau, E.L., Forebrain gonadotropin-releasing hormone neuronal development: insights from transgenic medaka and the relevance to X-linked Kallmann syndrome (2006) Endocrinology, 147, pp. 1076-1084
Hummel, T., Sekinger, B., Wolf, S.R., "Sniffin' Sticks": olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold (1997) Chem Senses, 22, pp. 39-52
Doty, R.L., Shaman, P., Dann, M., Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function (1984) Physiol Behav, 32, pp. 489-502
Hummel, T., Kobal, G., Gudziol, H., Mackay-Sim, A., Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3000 subjects (2007) Eur Arch Otorhinolaryngol, 264, pp. 237-243
Nguyen, A.D., Pelavin, P.E., Shenton, M.E., Olfactory sulcal depth and olfactory bulb volume in patients with schizophrenia: an MRI study (2011) Brain Imaging Behav, 5, pp. 252-261
Wang, J., You, H., Liu, J.F., Association of olfactory bulb volume and olfactory sulcus depth with olfactory function in patients with Parkinson disease (2011) AJNR Am J Neuroradiol, 32, pp. 677-681
Yousem, D.M., Geckle, R.J., Bilker, W., MR evaluation of patients with congenital hyposmia or anosmia (1996) AJR Am J Roentgenol, 166, pp. 439-443
Duprez, T.P., Rombaux, P., Imaging the olfactory tract (Cranial Nerve #1) (2010) Eur J Radiol, 74, pp. 288-298
Koenigkam-Santos, M., Santos, A.C., Versiani, B.R., Quantitative magnetic resonance imaging evaluation of the olfactory system in Kallmann syndrome: correlation with a clinical smell test (2011) Neuroendocrinology, 94, pp. 209-217
Hummel, T., Haehner, A., Hummel, C., Lateralized differences in olfactory bulb volume relate to lateralized differences in olfactory function (2013) Neuroscience, 237, pp. 51-55
Abolmaali, N.D., Hietschold, V., Vogl, T.J., MR evaluation in patients with isolated anosmia since birth or early childhood (2002) AJNR Am J Neuroradiol, 23, pp. 157-164
Yousem, D.M., Turner, W.J., Li, C., Kallmann syndrome: MR evaluation of olfactory system (1993) AJNR Am J Neuroradiol, 14, pp. 839-843
Manara, R., Salvalaggio, A., Favaro, A., Brain changes in Kallmann syndrome (2014) AJNR Am J Neuroradiol, 35, pp. 1700-1706
Hummel, T., Konnerth, C.G., Rosenheim, K., Kobal, G., Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss (2001) Ann Otol Rhinol Laryngol, 110, pp. 976-981
Bhagavath, B., Podolsky, R.H., Ozata, M., Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism (2006) Fertil Steril, 85, pp. 706-713
Briner, H.R., Simmen, D., Jones, N., Impaired sense of smell in patients after nasal surgery (2003) Clin Otolaryngol Allied Sci, 28, pp. 417-419
Tsukatani, T., Reiter, E.R., Miwa, T., Costanzo, R.M., Comparison of diagnostic findings using different olfactory test methods (2005) Laryngoscope, 115, pp. 1114-1117
Jagtap, V.S., Sarathi, V., Lila, A.R., An objective olfactory evaluation and its correlation with magnetic resonance imaging findings in Asian Indian patients with idiopathic hypogonadotropic hypogonadism (2013) Endocr Pract, 19, pp. 669-674
Quinton, R., Duke, V.M., de Zoysa, P.A., The neuroradiology of Kallmann's syndrome: a genotypic and phenotypic analysis (1996) J Clin Endocrinol Metab, 81, pp. 3010-3017
Vogl, T.J., Stemmler, J., Heye, B., Kallman syndrome versus idiopathic hypogonadotropic hypogonadism at MR imaging (1994) Radiology, 191, pp. 53-57
Madan, R., Sawlani, V., Gupta, S., Phadke, R.V., MRI findings in Kallmann syndrome (2004) Neurol India, 52, pp. 501-503
Wustenberg, E.G., Fleischer, A., Gerbert, B., Abolmaali, N., Hüttenbrink, K.B., Hummel, T., [Normal sense of smell in Kallmann syndrome. A case report] (2001) Laryngorhinootologie, 80, pp. 85-89. , German]
Frasnelli, J., Fark, T., Lehmann, J., Brain structure is changed in congenital anosmia (2013) Neuroimage, 83, pp. 1074-1080
Truwit, C.L., Barkovich, A.J., Grumbach, M.M., Martini, J.J., MR imaging of Kallmann syndrome, a genetic disorder of neuronal migration affecting the olfactory and genital systems (1993) AJNR Am J Neuroradiol, 14, pp. 827-838
Hummel, T., Damm, M., Vent, J., Depth of olfactory sulcus and olfactory function (2003) Brain Res, 975, pp. 85-89
Huart, C., Meusel, T., Gerber, J., The depth of the olfactory sulcus is an indicator of congenital anosmia (2011) AJNR Am J Neuroradiol, 32, pp. 1911-1914
Int Forum Allergy Rh (ISSN: 2042-6976), 2015 May 7; 5(9): 855-861.
Tipo di articolo: Journal Article,
Impact factor: 2.35, Impact factor a 5 anni: 2.433
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928967033&partnerID=40&md5=998afe74debeace2a7156d0e4a949af5
Parole chiave: Kallmann Syndrome, Sniffin, Sticks, Cortical Thickness, N-Butanol, Odor Discrimination, Odor Identification, Odor Threshold, Olfactory Bulb Volume, Olfactory Sulcus Depth, Adult, Article, Cohort Analysis, Controlled Study, Cortical Thickness (brain), Functional Assessment, Human, Nuclear Magnetic Resonance Imaging, Olfactory Test Kit, Organ Size, Phenotype, Priority Journal, Rhinencephalon, Scoring System, Smelling, Sniffin Stick Test, Adolescent, Child, Middle Aged, Olfaction Disorders, Pathology, Young Adult,
Affiliazioni:
*** IBB - CNR ***
Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
Department of Advanced Biomedical Sciences-Neuroradiology "Federico II" University Napoli Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Venezia Italy
Department of Statistical Sciences University of Padova Padova Italy
Department of Cardiothoracic Sciences Second University of Napoli Napoli Italy
Institute of Biostructure and Bioimaging, National Research Council, School of Medicine Federico II University Napoli Italy
Department of Medicine (DIMED) University of Padova Padova Italy
Department of Neuroradiology University of Salerno Salerno Italy
Riferimenti:
Seminara, S.B., Hayes, F.J., Crowley Jr, W.F., Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations (1998) Endocr Rev, 19, pp. 521-53
Della Valle, E., Vezzani, S., Rochira, V., Prevalence of olfactory and other developmental anomalies in patients with central hypogonadotropic hypogonadism (2013) Front Endocrinol (Lausanne), 4, p. 70
Okubo, K., Sakai, F., Lau, E.L., Forebrain gonadotropin-releasing hormone neuronal development: insights from transgenic medaka and the relevance to X-linked Kallmann syndrome (2006) Endocrinology, 147, pp. 1076-1084
Hummel, T., Sekinger, B., Wolf, S.R., "Sniffin' Sticks": olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold (1997) Chem Senses, 22, pp. 39-52
Doty, R.L., Shaman, P., Dann, M., Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function (1984) Physiol Behav, 32, pp. 489-502
Hummel, T., Kobal, G., Gudziol, H., Mackay-Sim, A., Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3000 subjects (2007) Eur Arch Otorhinolaryngol, 264, pp. 237-243
Nguyen, A.D., Pelavin, P.E., Shenton, M.E., Olfactory sulcal depth and olfactory bulb volume in patients with schizophrenia: an MRI study (2011) Brain Imaging Behav, 5, pp. 252-261
Wang, J., You, H., Liu, J.F., Association of olfactory bulb volume and olfactory sulcus depth with olfactory function in patients with Parkinson disease (2011) AJNR Am J Neuroradiol, 32, pp. 677-681
Yousem, D.M., Geckle, R.J., Bilker, W., MR evaluation of patients with congenital hyposmia or anosmia (1996) AJR Am J Roentgenol, 166, pp. 439-443
Duprez, T.P., Rombaux, P., Imaging the olfactory tract (Cranial Nerve #1) (2010) Eur J Radiol, 74, pp. 288-298
Koenigkam-Santos, M., Santos, A.C., Versiani, B.R., Quantitative magnetic resonance imaging evaluation of the olfactory system in Kallmann syndrome: correlation with a clinical smell test (2011) Neuroendocrinology, 94, pp. 209-217
Hummel, T., Haehner, A., Hummel, C., Lateralized differences in olfactory bulb volume relate to lateralized differences in olfactory function (2013) Neuroscience, 237, pp. 51-55
Abolmaali, N.D., Hietschold, V., Vogl, T.J., MR evaluation in patients with isolated anosmia since birth or early childhood (2002) AJNR Am J Neuroradiol, 23, pp. 157-164
Yousem, D.M., Turner, W.J., Li, C., Kallmann syndrome: MR evaluation of olfactory system (1993) AJNR Am J Neuroradiol, 14, pp. 839-843
Manara, R., Salvalaggio, A., Favaro, A., Brain changes in Kallmann syndrome (2014) AJNR Am J Neuroradiol, 35, pp. 1700-1706
Hummel, T., Konnerth, C.G., Rosenheim, K., Kobal, G., Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss (2001) Ann Otol Rhinol Laryngol, 110, pp. 976-981
Bhagavath, B., Podolsky, R.H., Ozata, M., Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism (2006) Fertil Steril, 85, pp. 706-713
Briner, H.R., Simmen, D., Jones, N., Impaired sense of smell in patients after nasal surgery (2003) Clin Otolaryngol Allied Sci, 28, pp. 417-419
Tsukatani, T., Reiter, E.R., Miwa, T., Costanzo, R.M., Comparison of diagnostic findings using different olfactory test methods (2005) Laryngoscope, 115, pp. 1114-1117
Jagtap, V.S., Sarathi, V., Lila, A.R., An objective olfactory evaluation and its correlation with magnetic resonance imaging findings in Asian Indian patients with idiopathic hypogonadotropic hypogonadism (2013) Endocr Pract, 19, pp. 669-674
Quinton, R., Duke, V.M., de Zoysa, P.A., The neuroradiology of Kallmann's syndrome: a genotypic and phenotypic analysis (1996) J Clin Endocrinol Metab, 81, pp. 3010-3017
Vogl, T.J., Stemmler, J., Heye, B., Kallman syndrome versus idiopathic hypogonadotropic hypogonadism at MR imaging (1994) Radiology, 191, pp. 53-57
Madan, R., Sawlani, V., Gupta, S., Phadke, R.V., MRI findings in Kallmann syndrome (2004) Neurol India, 52, pp. 501-503
Wustenberg, E.G., Fleischer, A., Gerbert, B., Abolmaali, N., Hüttenbrink, K.B., Hummel, T., [Normal sense of smell in Kallmann syndrome. A case report] (2001) Laryngorhinootologie, 80, pp. 85-89. , German]
Frasnelli, J., Fark, T., Lehmann, J., Brain structure is changed in congenital anosmia (2013) Neuroimage, 83, pp. 1074-1080
Truwit, C.L., Barkovich, A.J., Grumbach, M.M., Martini, J.J., MR imaging of Kallmann syndrome, a genetic disorder of neuronal migration affecting the olfactory and genital systems (1993) AJNR Am J Neuroradiol, 14, pp. 827-838
Hummel, T., Damm, M., Vent, J., Depth of olfactory sulcus and olfactory function (2003) Brain Res, 975, pp. 85-89
Huart, C., Meusel, T., Gerber, J., The depth of the olfactory sulcus is an indicator of congenital anosmia (2011) AJNR Am J Neuroradiol, 32, pp. 1911-1914
Background: The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical thickness close to the OS, and olfactory phenotype. Methods: Olfaction was assessed administering Sniffin' Sticks®, in 38 KS patients and 17 controls (by means of Screening 12 test®). All subjects underwent magnetic resonance imaging (MRI) to study OB volume, sulcus depth, and cortical thickness. Results: Compared to controls, KS patients showed smaller OB volume (p<0.0001), reduced sulcus depth (p<0.0001), and thicker cortex in the region close to the OS (p<0.0001). Anosmic KS patients had smaller OB than controls and hyposmic KS patients; there was no difference between hyposmic KS patients and controls. OB volume correlated with Sniffin' Sticks score (r = 0.64; p < 0.001), OS depth (p<0.0001) and, inversely, with cortical thickness changes (p<0.0001). Sniffin' Sticks showed an inverse correlation with cortical thickness (r = -0.5; p<0.0001) and a trend toward a statistically significant correlation with OS depth. Conclusion: The present study provides further evidence of the strict relationship between olfaction and OB volume. The strong correlation between OB volume and the overlying cortical changes highlights the key role of rhinencephalon in forebrain embryogenesis. © 2015 ARS-AAOA, LLC.
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