Predicting radiation-induced valvular heart damage (307 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.73, 5-year impact factor: 3.417
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946231187&doi=10.3109%2f0284186X.2015.1016624&partnerID=40&md5=7976d66ac90f6334f3dcadb8f001ac92
Keywords: Bleomycin, Dacarbazine, Doxorubicin, Epirubicin, Etoposide, Prednisone, Vinblastine, Adolescent, Adult, Aged, Aorta Valve Disease, Area Under The Curve, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Chemoradiotherapy, Controlled Study, Dosimetry, Female, Follow Up, Heart Injury, Heart Volume, Hodgkin Disease, Human, Least Absolute Shrinkage And Selection Operator, Lung Toxicity, Lung Volume, Major Clinical Study, Mitral Valve Disease, Outcome Assessment, Prediction, Priority Journal, Probability, Radiation Induced Valvular Heart Damage, Radiation Injury, Radiation Safety, Receiver Operating Characteristic, Treatment Planning, Treatment Response, Valvular Heart Disease, Diagnostic Imaging, Echocardiography, Heart Valve, Heart Valve Diseases, Middle Aged, Radiation Dose, Radiation Injuries, Radiation Response, Regression Analysis, Statistical Model, Statistics And Numerical Data, Young Adult, Area Under Curve, Follow-Up Studies, Logistic Models, Radiation Dosage, Roc Curve, Heart Valve Diseases Diagnostic Imaging Etiology , Heart Valves Radiation Effects , Hodgkin Disease Drug Therapy Radiotherapy , Lung Radiation Effects , Radiation Injuries Diagnostic Imaging Etiology , Radiotherapy Statistics,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Council of Research (CNR) , Naples , Italy.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States
Department of Clinical Medicine and Surgery, Federico II University School of Medicine, Naples, Italy
a Institute of Biostructure and Bioimaging, National Council of Research (CNR) , Naples , Italy.
b Department of Advanced Biomedical Sciences , Federico II University School of Medicine , Naples , Italy.
c Department of Medical Physics , Memorial Sloan Kettering Cancer Center , New York , New York , USA.
d Department of Clinical Medicine and Surgery , Federico II University School of Medicine , Naples , Italy.
References:
Jaworski, C., Mariani, J.A., Wheeler, G., Kaye, D.M., Cardiac complications of thoracic irradiation (2013) J Am Coll Cardiol, 61, pp. 2319-232
Lancellotti, P., Nkomo, V.T., Badano, L.P., Bergler-Klein, J., Bogaert, J., Davin, L., Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: A report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography (2013) Eur Heart J Cardiovasc Imaging, 14, pp. 721-740
Ghobadi, G., Van Der Veen, S., Bartelds, B., De Boer, R.A., Dickinson, M.G., De Jong, J.R., Physiological interaction of heart and lung in thoracic irradiation (2012) Int J Radiat Oncol Biol Phys, 84, pp. e639-e646
Van Luijk, P., Faber, H., Meertens, H., Schippers, J.M., Langendijk, J.A., Brandenburg, S., The impact of heart irradiation on dose-volume effects in the rat lung (2007) Int J Radiat Oncol Biol Phys, 69, pp. 552-559
Andratschke, N., Maurer, J., Molls, M., Trott, K.R., Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention (2011) Radiother Oncol, 100, pp. 160-166
Cella, L., Palma, G., Deasy, J.O., Oh, J.H., Liuzzi, R., Davino, V., Complication probability models for radiation-induced heart valvular dysfunction: Do heart-lung interactions play a role? (2014) PloS One, 9, p. e111753
Cella, L., Liuzzi, R., Davino, V., Conson, M., Di Biase, A., Picardi, M., Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (2013) Acta Oncol
Lee, T.F., Chao, P.J., Ting, H.M., Chang, L., Huang, Y.J., Wu, J.M., Using multivariate regression model with least absolute shrinkage and selection operator (LASSO) to predict the incidence of xerostomia after intensity-modulated radiotherapy for head and neck cancer (2014) PloS One, 9, p. e89700
Xu, C.J., Van Der Schaaf, A., Schilstra, C., Langendijk, J.A., Van'T Veld, A.A., Impact of statistical learning methods on the predictive power of multivariate normal tissue complication probability models (2012) Int J Radiat Oncol Biol Phys, 82, pp. e677-e684
Feng, M., Moran, J.M., Koelling, T., Chughtai, A., Chan, J.L., Freedman, L., Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer (2011) Int J Radiat Oncol Biol Phys, 79, pp. 10-18
Kong, F.M., Ritter, T., Quint, D.J., Senan, S., Gaspar, L.E., Komaki, R.U., Consideration of dose limits for organs at risk of thoracic radiotherapy: Atlas for lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus (2011) Int J Radiat Oncol Biol Phys, 81, pp. 1442-1457
Deasy, J.O., Blanco, A.I., Clark, V.H., CERR: A computational environment for radiotherapy research (2003) Med Phys, 30, pp. 979-985
El Naqa, I., Suneja, G., Lindsay, P.E., Hope, A.J., Alaly, J.R., Vicic, M., Dose response explorer: An integrated open-source tool for exploring and modelling radiotherapy dose-volume outcome relationships (2006) Phys Med Biol, 51, pp. 5719-5735
Aziz, N.M., Rowland, J.H., Trends and advances in cancer survivorship research: Challenge and opportunity (2003) Semin Radiat Oncol, 13, pp. 248-266
Veinot, J.P., Edwards, W.D., Pathology of radiation-induced heart disease: A surgical and autopsy study of 27 cases (1996) Hum Pathol, 27, pp. 766-773
Heidenreich, P.A., Hancock, S.L., Lee, B.K., Mariscal, C.S., Schnittger, I., Asymptomatic cardiac disease following mediastinal irradiation (2003) J Am Coll Cardiol, 42, pp. 743-749
Wethal, T., Lund, M.B., Edvardsen, T., Fossa, S.D., Pripp, A.H., Holte, H., Valvular dysfunction and left ventricular changes in Hodgkin's lymphoma survivors. A longitudinal study (2009) Br J Cancer, 101, pp. 575-581
Adams, M.J., Lipshultz, S.E., Schwartz, C., Fajardo, L.F., Coen, V., Constine, L.S., Radiation-associated cardiovascular disease: Manifestations and management (2003) Semin Radiat Oncol, 13, pp. 346-356
Briere, T., Tucker, S., Liao, Z., Martel, M., Small lung size increases the risk of radiation pneumonitis in lung cancer patients (2013) Med Phys, 40, p. 453
Nkomo, V.T., Gardin, J.M., Skelton, T.N., Gottdiener, J.S., Scott, C.G., Enriquez-Sarano, M., Burden of valvular heart diseases: A population-based study (2006) Lancet, 368, pp. 1005-1011
Zou, H., Hastie, T., Regularization and variable selection via the elastic net (2005) J R Statist Soc B, 67, pp. 301-307
Huang, E.X., Hope, A.J., Lindsay, P.E., Trovo, M., El Naqa, I., Deasy, J.O., Heart irradiation as a risk factor for radiation pneumonitis (2011) Acta Oncol, 50, pp. 51-60
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.73, 5-year impact factor: 3.417
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946231187&doi=10.3109%2f0284186X.2015.1016624&partnerID=40&md5=7976d66ac90f6334f3dcadb8f001ac92
Keywords: Bleomycin, Dacarbazine, Doxorubicin, Epirubicin, Etoposide, Prednisone, Vinblastine, Adolescent, Adult, Aged, Aorta Valve Disease, Area Under The Curve, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Chemoradiotherapy, Controlled Study, Dosimetry, Female, Follow Up, Heart Injury, Heart Volume, Hodgkin Disease, Human, Least Absolute Shrinkage And Selection Operator, Lung Toxicity, Lung Volume, Major Clinical Study, Mitral Valve Disease, Outcome Assessment, Prediction, Priority Journal, Probability, Radiation Induced Valvular Heart Damage, Radiation Injury, Radiation Safety, Receiver Operating Characteristic, Treatment Planning, Treatment Response, Valvular Heart Disease, Diagnostic Imaging, Echocardiography, Heart Valve, Heart Valve Diseases, Middle Aged, Radiation Dose, Radiation Injuries, Radiation Response, Regression Analysis, Statistical Model, Statistics And Numerical Data, Young Adult, Area Under Curve, Follow-Up Studies, Logistic Models, Radiation Dosage, Roc Curve, Heart Valve Diseases Diagnostic Imaging Etiology , Heart Valves Radiation Effects , Hodgkin Disease Drug Therapy Radiotherapy , Lung Radiation Effects , Radiation Injuries Diagnostic Imaging Etiology , Radiotherapy Statistics,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Council of Research (CNR) , Naples , Italy.
Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States
Department of Clinical Medicine and Surgery, Federico II University School of Medicine, Naples, Italy
a Institute of Biostructure and Bioimaging, National Council of Research (CNR) , Naples , Italy.
b Department of Advanced Biomedical Sciences , Federico II University School of Medicine , Naples , Italy.
c Department of Medical Physics , Memorial Sloan Kettering Cancer Center , New York , New York , USA.
d Department of Clinical Medicine and Surgery , Federico II University School of Medicine , Naples , Italy.
References:
Jaworski, C., Mariani, J.A., Wheeler, G., Kaye, D.M., Cardiac complications of thoracic irradiation (2013) J Am Coll Cardiol, 61, pp. 2319-232
Lancellotti, P., Nkomo, V.T., Badano, L.P., Bergler-Klein, J., Bogaert, J., Davin, L., Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: A report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography (2013) Eur Heart J Cardiovasc Imaging, 14, pp. 721-740
Ghobadi, G., Van Der Veen, S., Bartelds, B., De Boer, R.A., Dickinson, M.G., De Jong, J.R., Physiological interaction of heart and lung in thoracic irradiation (2012) Int J Radiat Oncol Biol Phys, 84, pp. e639-e646
Van Luijk, P., Faber, H., Meertens, H., Schippers, J.M., Langendijk, J.A., Brandenburg, S., The impact of heart irradiation on dose-volume effects in the rat lung (2007) Int J Radiat Oncol Biol Phys, 69, pp. 552-559
Andratschke, N., Maurer, J., Molls, M., Trott, K.R., Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention (2011) Radiother Oncol, 100, pp. 160-166
Cella, L., Palma, G., Deasy, J.O., Oh, J.H., Liuzzi, R., Davino, V., Complication probability models for radiation-induced heart valvular dysfunction: Do heart-lung interactions play a role? (2014) PloS One, 9, p. e111753
Cella, L., Liuzzi, R., Davino, V., Conson, M., Di Biase, A., Picardi, M., Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (2013) Acta Oncol
Lee, T.F., Chao, P.J., Ting, H.M., Chang, L., Huang, Y.J., Wu, J.M., Using multivariate regression model with least absolute shrinkage and selection operator (LASSO) to predict the incidence of xerostomia after intensity-modulated radiotherapy for head and neck cancer (2014) PloS One, 9, p. e89700
Xu, C.J., Van Der Schaaf, A., Schilstra, C., Langendijk, J.A., Van'T Veld, A.A., Impact of statistical learning methods on the predictive power of multivariate normal tissue complication probability models (2012) Int J Radiat Oncol Biol Phys, 82, pp. e677-e684
Feng, M., Moran, J.M., Koelling, T., Chughtai, A., Chan, J.L., Freedman, L., Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer (2011) Int J Radiat Oncol Biol Phys, 79, pp. 10-18
Kong, F.M., Ritter, T., Quint, D.J., Senan, S., Gaspar, L.E., Komaki, R.U., Consideration of dose limits for organs at risk of thoracic radiotherapy: Atlas for lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus (2011) Int J Radiat Oncol Biol Phys, 81, pp. 1442-1457
Deasy, J.O., Blanco, A.I., Clark, V.H., CERR: A computational environment for radiotherapy research (2003) Med Phys, 30, pp. 979-985
El Naqa, I., Suneja, G., Lindsay, P.E., Hope, A.J., Alaly, J.R., Vicic, M., Dose response explorer: An integrated open-source tool for exploring and modelling radiotherapy dose-volume outcome relationships (2006) Phys Med Biol, 51, pp. 5719-5735
Aziz, N.M., Rowland, J.H., Trends and advances in cancer survivorship research: Challenge and opportunity (2003) Semin Radiat Oncol, 13, pp. 248-266
Veinot, J.P., Edwards, W.D., Pathology of radiation-induced heart disease: A surgical and autopsy study of 27 cases (1996) Hum Pathol, 27, pp. 766-773
Heidenreich, P.A., Hancock, S.L., Lee, B.K., Mariscal, C.S., Schnittger, I., Asymptomatic cardiac disease following mediastinal irradiation (2003) J Am Coll Cardiol, 42, pp. 743-749
Wethal, T., Lund, M.B., Edvardsen, T., Fossa, S.D., Pripp, A.H., Holte, H., Valvular dysfunction and left ventricular changes in Hodgkin's lymphoma survivors. A longitudinal study (2009) Br J Cancer, 101, pp. 575-581
Adams, M.J., Lipshultz, S.E., Schwartz, C., Fajardo, L.F., Coen, V., Constine, L.S., Radiation-associated cardiovascular disease: Manifestations and management (2003) Semin Radiat Oncol, 13, pp. 346-356
Briere, T., Tucker, S., Liao, Z., Martel, M., Small lung size increases the risk of radiation pneumonitis in lung cancer patients (2013) Med Phys, 40, p. 453
Nkomo, V.T., Gardin, J.M., Skelton, T.N., Gottdiener, J.S., Scott, C.G., Enriquez-Sarano, M., Burden of valvular heart diseases: A population-based study (2006) Lancet, 368, pp. 1005-1011
Zou, H., Hastie, T., Regularization and variable selection via the elastic net (2005) J R Statist Soc B, 67, pp. 301-307
Huang, E.X., Hope, A.J., Lindsay, P.E., Trovo, M., El Naqa, I., Deasy, J.O., Heart irradiation as a risk factor for radiation pneumonitis (2011) Acta Oncol, 50, pp. 51-60
Predicting radiation-induced valvular heart damage
Purpose. To develop a predictive multivariate normal tissue complication probability (NTCP) model for radiation-induced heart valvular damage (RVD). The influence of combined heart-lung irradiation on RVD development was included.Material and methods. Multivariate logistic regression modeling with the least absolute shrinkage and selection operator (LASSO) was used to build an NTCP model to predict RVD based on a cohort of 90 Hodgkin lymphoma patients treated with sequential chemo-radiation therapy. In addition to heart irradiation factors, clinical variables, along with left and right lung dose-volume histogram statistics, were included in the analysis. To avoid overfitting, 10-fold cross-validation (CV) was used for LASSO logistic regression modeling, with 50 reshuffled cycles. Model performance was assessed using the area under the receiver operating characteristic (ROC) curve (AUC) and Spearman's correlation coefficient (Rs).Results. At a median follow-up time of 55 months (range 12-92 months) after the end of radiation treatment, 27 of 90 patients (30%) manifested at least one kind of RVD (mild or moderate), with a higher incidence of left-sided valve defects (64%). Fourteen prognostic factors were frequently selected (more than 100/500 model fits) by LASSO, which included mainly heart and left lung dosimetric variables along with their volume variables. The averaged cross-validated performance was AUC-CV = 0.685 and Rs = 0.293. The overall performance of a final NTCP model for RVD obtained applying LASSO logistic regression to the full dataset was satisfactory (AUC = 0.84, Rs = 0.55, p < 0.001).Conclusion. LASSO proved to be an improved and flexible modeling method for variable selection. Applying LASSO, we showed, for the first time, the importance of jointly considering left lung irradiation and left lung volume size in the prediction of subclinical radiation-related heart disease resulting in RVD. © 2015 © 2015 Informa Healthcare.
Purpose. To develop a predictive multivariate normal tissue complication probability (NTCP) model for radiation-induced heart valvular damage (RVD). The influence of combined heart-lung irradiation on RVD development was included.Material and methods. Multivariate logistic regression modeling with the least absolute shrinkage and selection operator (LASSO) was used to build an NTCP model to predict RVD based on a cohort of 90 Hodgkin lymphoma patients treated with sequential chemo-radiation therapy. In addition to heart irradiation factors, clinical variables, along with left and right lung dose-volume histogram statistics, were included in the analysis. To avoid overfitting, 10-fold cross-validation (CV) was used for LASSO logistic regression modeling, with 50 reshuffled cycles. Model performance was assessed using the area under the receiver operating characteristic (ROC) curve (AUC) and Spearman's correlation coefficient (Rs).Results. At a median follow-up time of 55 months (range 12-92 months) after the end of radiation treatment, 27 of 90 patients (30%) manifested at least one kind of RVD (mild or moderate), with a higher incidence of left-sided valve defects (64%). Fourteen prognostic factors were frequently selected (more than 100/500 model fits) by LASSO, which included mainly heart and left lung dosimetric variables along with their volume variables. The averaged cross-validated performance was AUC-CV = 0.685 and Rs = 0.293. The overall performance of a final NTCP model for RVD obtained applying LASSO logistic regression to the full dataset was satisfactory (AUC = 0.84, Rs = 0.55, p < 0.001).Conclusion. LASSO proved to be an improved and flexible modeling method for variable selection. Applying LASSO, we showed, for the first time, the importance of jointly considering left lung irradiation and left lung volume size in the prediction of subclinical radiation-related heart disease resulting in RVD. © 2015 © 2015 Informa Healthcare.
Predicting radiation-induced valvular heart damage
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Predicting radiation-induced valvular heart damage
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* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (437 views)
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Impact Factor: 5.925
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (414 views)
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Impact Factor: 5.58
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (413 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (510 views)
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Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (396 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (323 views)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (591 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (423 views)
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Impact Factor: 4.411
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (377 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F
* Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (332 views)
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Impact Factor: 1.303
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Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
Impact Factor: 4.532
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (608 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (370 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (412 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (221 views)
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Impact Factor: 4.498
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (234 views)
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Impact Factor: 0.996
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (422 views)
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Impact Factor: 5.873
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Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C
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Romano M, Giojelli A, Tamburrini O, Salvatore M
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Impact Factor: 1.368
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (425 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (451 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M
Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (431 views)
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Impact Factor: 8.228
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (248 views)
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (303 views)
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Impact Factor: 3.491
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (290 views)
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Impact Factor: 1.181
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (549 views)
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Impact Factor: 8.426
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Manna R, Salvatore M, Pantoli D, Vecchio FM, Greco AV, Carosella L, Schiavino D, Ghirlanda G
Malignant histiocytosis: Report of three cases (353 views)
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Impact Factor: 0.351
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* GlucoCEST MRI for the Evaluation Response to Chemotherapeutic and Metabolic Treatments in a Murine Triple-Negative Breast Cancer: A Comparison with[(18)F]F-FDG-PET (10 views)
Mol Imaging Biol (ISSN: 1536-1632linking), 2021 Aug 12; N/D: N/D-N/D.
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Mercurio V, Cuomo A, Della Pepa R, Ciervo D, Cella L, Pirozzi F, Parrella P, Campi G, Franco R, Varricchi G, Abete P, Marone G, Petretta M, Bonaduce D, Pacelli R, Picardi M, Tocchetti CG
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Impact Factor: 7.581
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (441 views)
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Impact Factor: 5.158
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (414 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Rizzitelli S, Giustetto P, Cutrin JC, Delli Castelli D, Boffa C, Ruzza M, Menchise V, Molinari F, Aime S, Terreno E
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J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Impact Factor: 7.441
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Galdiero S, Falanga A, Morelli G, Galdiero M
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Impact Factor: 5.158
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
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Ruggiero L, Fiorillo C, Tessa A, Manganelli F, Iodice R, Dubbioso R, Vitale F, Storti E, Soscia E, Santorelli F, Santoro L
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
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Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
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Impact Factor: 4.383
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Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
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Impact Factor: 5.48
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Accardo A, Tesauro D, Morelli G
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Impact Factor: 1.554
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Ferraro F, Marano E, Petruzzi J, Tedeschi E, Santulli L, Elefante A
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Maurea S, Fiumara G, Pellegrino T, Zampella E, Assante R, Mainenti PP, Cuocolo A
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
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Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
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Impact Factor: 1.862
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Accardo A, Ringhieri P, Tesauro D, Morelli G
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Impact Factor: 3.159
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
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Impact Factor: 2.768
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Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
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Impact Factor: 4.524
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
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Impact Factor: 3.463
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (437 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (414 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
View Export to BibTeX Export to EndNote
Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (413 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (510 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (396 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (323 views)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (591 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (423 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (377 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Peca C, Pacelli R, Elefante A, Del Basso De Caro ML, Vergara P, Mariniello G, Giamundo A, Maiuri F
* Early clinical and neuroradiological worsening after radiotherapy and concomitant temozolomide in patients with glioblastoma: Tumour progression or radionecrosis? (332 views)
Clin Neurol Neurosurg (ISSN: 0303-8467), 2009 May; 111(4): 331-334.
Impact Factor: 1.303
View Export to BibTeX Export to EndNote
Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
* EANM/ESC guidelines for radionuclide imaging of cardiac function (526 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (608 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (370 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (412 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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De Renzo A, Perna F, Persico M, Mainolfi C, Pace L
* 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of early response in a primary hepatic lymphoma (221 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2006 Jun; 133(6): 580-580.
Impact Factor: 4.498
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Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (234 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (422 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C
* Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (264 views)
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
Impact Factor: 2.045
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Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (416 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2003 Apr; 105(4): 350-355.
Impact Factor: 1.368
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (425 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (451 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Ciarmiello A, Del Vecchio S, Silvestro P, Potena MI, Carriero MV, Thomas R, Botti G, D'Aiuto G, Salvatore M
Tumor clearance of technetium 99m-sestamibi as a predictor of response to neoadjuvant chemotherapy for locally advanced breast cancer (431 views)
Journal Of Clinical Oncology (ISSN: 0732-183x), 1998 May; 16(5): 1677-1683.
Impact Factor: 8.228
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (248 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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MAUREA S, LASTORIA S, CARACO C, INDOLFI P, CASALE F, DITULLIO M, SALVATORE M
IODINE-131-MIBG IMAGING TO MONITOR CHEMOTHERAPY RESPONSE IN ADVANCED NEUROBLASTOMA - COMPARISON WITH LABORATORY ANALYSIS (303 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Sep; 35(9): 1429-1435.
Impact Factor: 3.491
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (290 views)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (549 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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Manna R, Salvatore M, Pantoli D, Vecchio FM, Greco AV, Carosella L, Schiavino D, Ghirlanda G
Malignant histiocytosis: Report of three cases (353 views)
Br J Clin Pract (ISSN: 0007-0947), 1988 Feb; 42(2): 82-86.
Impact Factor: 0.351
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52 Records (50 excluding Abstracts).
Total impact factor: 193.051 (184.142 excluding Abstracts).
Total 5 year impact factor: 205.427 (195.942 excluding Abstracts).
Total impact factor: 193.051 (184.142 excluding Abstracts).
Total 5 year impact factor: 205.427 (195.942 excluding Abstracts).
307 views. Last view on Sunday 13 February 2022, 23:04:34
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