Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (223 visite)
Carbohyd Res (ISSN: 0008-6215), 2015; 412: 20-27.
Tipo di articolo: Journal Article,
Impact factor: 1.817, Impact factor a 5 anni: 2.023
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84929346953&partnerID=40&md5=138fc8ddbe3fb56e9832a56a355d1cb3
Parole chiave: Drosophila Melanogaster, Innate Immunity, Lipopolysaccharide, Pseudomonas Entomophila, Structural Analysis, Antigens, Fatty Acids, Immunology, Antagonistic Activity, Fruit Flies, Immunological Properties, Repetitive Units, Bacteria, Galactose, Glucose, Heptose, Lipid A, O Antigen, Phenol, Pullulanase, Article, Chemical Analysis, Chemical Composition, Controlled Study, Enzyme Linked Immunosorbent Assay, Gel Permeation Chromatography, Hek293 Cell Line, Heteronuclear Multiple Bond Correlation, Heteronuclear Nuclear Magnetic Resonance, Heteronuclear Single Quantum Coherence, Human, Human Cell, Hydrolysis, Lipid Composition, Mass Fragmentography, Nonhuman, Nuclear Magnetic Resonance Spectroscopy, Nuclear Overhauser Effect, Polyacrylamide Gel Electrophoresis, Priority Journal, Proton Nuclear Magnetic Resonance, Tandem Mass Spectrometry, Bacteria (microorganisms),
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli federico II, Complesso Universitario Monte S.Angelo, Via Cintia 4, Napoli, Italy
Dipartimento di Biologia e Biotecnologie C. Darwin Sapienza-Università di Roma, Piazzale Aldo Moro, 5, Roma, Italy
Istituto di Chimica e Tecnologia Dei Polimeri-ICTP - CNR, Via P. Gaifami 18, Catania, Italy
Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00185 Roma - Italia, Roma, Italy
Dipartimento di Agraria, Via Università 100, Portici, NA, Italy
Riferimenti:
Vallet-Gely, I., Lemaitre, B., Boccard, F., (2008) Nat Rev Micro, 6, pp. 302-31
Vodovar, N., Vinals, M., Liehl, P., Basset, A., Degrouard, J., Soellman, P., (2005) PNAS, 102 (32), pp. 11414-11419
Opota, O., Vallet-Gély, I., Vincentelli, R., Kellenberger, C., Iacovache, I., Gonzalez, M.R., (2011) PLoS Pathog, 7 (9), p. e1002259
Chakrabarti, S., Liehl, P., Buchon, N., Lemaitre, B., (2012) Cell Host Microbe, 12 (1), pp. 60-70
Silipo, A., De Castro, C., Lanzetta, R., Parrilli, M., Molinaro, A., (2010) Prokaryotic Cell Wall Compounds - Structure and Biochemistry, p. 133. , H. Kçnig, H. Claus, A. Varma, Springer Heidelberg
De Castro, C., Holst, O., Lanzetta, R., Parrilli, M., Molinaro, A., (2012) Protein Pept Lett, 19 (10), pp. 1040-1044
Holst, O., Molinaro, A., (2009) Microbial Glycobiology: Structures Relevance and Applications, pp. 29-56. , A. Moran, P. Brennan, O. Holst, M. von Itszstein, Elsevier San Diego, CA
Alexander, C., Rietschel, E.T., (2001) J Endotoxin Res, 7, pp. 167-202
Molinaro, A., Holst, O., Di Lorenzo, F., Callaghan, M., Nurisso, A., D'Errico, G., (2015) Chem Eur J, 21, pp. 500-519
Silipo, A., Molinaro, A., (2011) Bacterial Lipopolysaccharides: Structure, Chemical Synthesis, Biogenesis and Interaction with Host Cells, pp. 1-20. , Y.A. Knirel, M.A. Valvano, Springer Wien
Leulier, F., Parquet, C., Pili-Floury, S., Ryu, J.H., Caroff, M., Lee, W.J., (2003) Nat Immunol, 4, pp. 478-484
Kaneko, T., Goldman, W.E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., (2004) IMD Pathw Immun, 20, pp. 637-649
Westphal, O., Jann, K., (1965) Methods Carbohydr Chem, 5, pp. 83-91
Nigro, G., Fazio, L.L., Martino, M.C., Rossi, G., Tattoli, I., Liparoti, I., (2008) Cell Microbiol, 10, pp. 682-695
Hanley, P., Musset, B., Renigunta, V., Limberg, S.H., Dalpke, A.H., Sus, R., (2004) Proc Natl Acad Sci U S A, 101 (25), pp. 9479-9484
De Castro, C., Parrilli, M., Holst, O., Molinaro, A., (2010) Methods Enzymol, 480, pp. 89-115
Leontein, K., Lönngren, J., (1978) Methods Carbohydr Chem, 62, pp. 359-362
States, D.J., Haberkorn, R.A., Ruben, D.J., (1982) J Magn Reson, 48, pp. 286-292
Bock, K., Pedersen, S., (1983) Adv Carbohydr Chem Biochem, 41, pp. 27-65
Sturiale, L., Palmigiano, A., Silipo, A., Knirel, Y.A., Anisimov, A.P., Lanzetta, R., (2011) J Mass Spectrom, 46, pp. 1135-1142
Sturiale, L., Garozzo, D., Silipo, A., Lanzetta, R., Parrilli, M., Molinaro, A., (2005) Rapid Commun Mass Spectrom, 19, pp. 1829-1834
Flad, H.D., Loppnow, H., Rietschel, E.T., Ulmer, A.J., (1993) Immunobiology, 187 (3-5), pp. 303-316
Raetz, R.H., Whitfield, C., (2002) Annu Rev Biochem, 71, pp. 635-700
Paciello, I., Silipo, A., Lembo-Fazio, L., Curcurù, L., Zumsteg, A., Noël, G., (2013) Proc Natl Acad Sci, 110, pp. E4345-E4354
Carbohyd Res (ISSN: 0008-6215), 2015; 412: 20-27.
Tipo di articolo: Journal Article,
Impact factor: 1.817, Impact factor a 5 anni: 2.023
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84929346953&partnerID=40&md5=138fc8ddbe3fb56e9832a56a355d1cb3
Parole chiave: Drosophila Melanogaster, Innate Immunity, Lipopolysaccharide, Pseudomonas Entomophila, Structural Analysis, Antigens, Fatty Acids, Immunology, Antagonistic Activity, Fruit Flies, Immunological Properties, Repetitive Units, Bacteria, Galactose, Glucose, Heptose, Lipid A, O Antigen, Phenol, Pullulanase, Article, Chemical Analysis, Chemical Composition, Controlled Study, Enzyme Linked Immunosorbent Assay, Gel Permeation Chromatography, Hek293 Cell Line, Heteronuclear Multiple Bond Correlation, Heteronuclear Nuclear Magnetic Resonance, Heteronuclear Single Quantum Coherence, Human, Human Cell, Hydrolysis, Lipid Composition, Mass Fragmentography, Nonhuman, Nuclear Magnetic Resonance Spectroscopy, Nuclear Overhauser Effect, Polyacrylamide Gel Electrophoresis, Priority Journal, Proton Nuclear Magnetic Resonance, Tandem Mass Spectrometry, Bacteria (microorganisms),
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli federico II, Complesso Universitario Monte S.Angelo, Via Cintia 4, Napoli, Italy
Dipartimento di Biologia e Biotecnologie C. Darwin Sapienza-Università di Roma, Piazzale Aldo Moro, 5, Roma, Italy
Istituto di Chimica e Tecnologia Dei Polimeri-ICTP - CNR, Via P. Gaifami 18, Catania, Italy
Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza-Università di Roma, Piazzale Aldo Moro 5, 00185 Roma - Italia, Roma, Italy
Dipartimento di Agraria, Via Università 100, Portici, NA, Italy
Riferimenti:
Vallet-Gely, I., Lemaitre, B., Boccard, F., (2008) Nat Rev Micro, 6, pp. 302-31
Vodovar, N., Vinals, M., Liehl, P., Basset, A., Degrouard, J., Soellman, P., (2005) PNAS, 102 (32), pp. 11414-11419
Opota, O., Vallet-Gély, I., Vincentelli, R., Kellenberger, C., Iacovache, I., Gonzalez, M.R., (2011) PLoS Pathog, 7 (9), p. e1002259
Chakrabarti, S., Liehl, P., Buchon, N., Lemaitre, B., (2012) Cell Host Microbe, 12 (1), pp. 60-70
Silipo, A., De Castro, C., Lanzetta, R., Parrilli, M., Molinaro, A., (2010) Prokaryotic Cell Wall Compounds - Structure and Biochemistry, p. 133. , H. Kçnig, H. Claus, A. Varma, Springer Heidelberg
De Castro, C., Holst, O., Lanzetta, R., Parrilli, M., Molinaro, A., (2012) Protein Pept Lett, 19 (10), pp. 1040-1044
Holst, O., Molinaro, A., (2009) Microbial Glycobiology: Structures Relevance and Applications, pp. 29-56. , A. Moran, P. Brennan, O. Holst, M. von Itszstein, Elsevier San Diego, CA
Alexander, C., Rietschel, E.T., (2001) J Endotoxin Res, 7, pp. 167-202
Molinaro, A., Holst, O., Di Lorenzo, F., Callaghan, M., Nurisso, A., D'Errico, G., (2015) Chem Eur J, 21, pp. 500-519
Silipo, A., Molinaro, A., (2011) Bacterial Lipopolysaccharides: Structure, Chemical Synthesis, Biogenesis and Interaction with Host Cells, pp. 1-20. , Y.A. Knirel, M.A. Valvano, Springer Wien
Leulier, F., Parquet, C., Pili-Floury, S., Ryu, J.H., Caroff, M., Lee, W.J., (2003) Nat Immunol, 4, pp. 478-484
Kaneko, T., Goldman, W.E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., (2004) IMD Pathw Immun, 20, pp. 637-649
Westphal, O., Jann, K., (1965) Methods Carbohydr Chem, 5, pp. 83-91
Nigro, G., Fazio, L.L., Martino, M.C., Rossi, G., Tattoli, I., Liparoti, I., (2008) Cell Microbiol, 10, pp. 682-695
Hanley, P., Musset, B., Renigunta, V., Limberg, S.H., Dalpke, A.H., Sus, R., (2004) Proc Natl Acad Sci U S A, 101 (25), pp. 9479-9484
De Castro, C., Parrilli, M., Holst, O., Molinaro, A., (2010) Methods Enzymol, 480, pp. 89-115
Leontein, K., Lönngren, J., (1978) Methods Carbohydr Chem, 62, pp. 359-362
States, D.J., Haberkorn, R.A., Ruben, D.J., (1982) J Magn Reson, 48, pp. 286-292
Bock, K., Pedersen, S., (1983) Adv Carbohydr Chem Biochem, 41, pp. 27-65
Sturiale, L., Palmigiano, A., Silipo, A., Knirel, Y.A., Anisimov, A.P., Lanzetta, R., (2011) J Mass Spectrom, 46, pp. 1135-1142
Sturiale, L., Garozzo, D., Silipo, A., Lanzetta, R., Parrilli, M., Molinaro, A., (2005) Rapid Commun Mass Spectrom, 19, pp. 1829-1834
Flad, H.D., Loppnow, H., Rietschel, E.T., Ulmer, A.J., (1993) Immunobiology, 187 (3-5), pp. 303-316
Raetz, R.H., Whitfield, C., (2002) Annu Rev Biochem, 71, pp. 635-700
Paciello, I., Silipo, A., Lembo-Fazio, L., Curcurù, L., Zumsteg, A., Noël, G., (2013) Proc Natl Acad Sci, 110, pp. E4345-E4354
The structure and the immunology of the lipopolysaccharide (LPS) of Pseudomonas entomophila, an entomopathogenic bacterium isolated from the fruit fly Drosophila melanogaster, was characterized. The O-antigen portion was established and resulted to be built up of a repetitive unit constituted by four monosaccharide residues, all L configured, all deoxy at C-6 and with an acetamido function at C-2: →3)-α-l-FucNAc-(1→4)-α-l-FucNAc-(1→3)-α-l-FucNAc-(1→3)-β-l-QuiNAc-(1→ The structural analysis of lipid A, showed a mixture of different species. The diphosphorylated glucosamine backbone carries six fatty acids consistent with the composition C10:0 3(OH), C12:0 2(OH) and C12:0 3(OH), whereas other species differs by the number of phosphates and/or of fatty acids. The immunology experiments demonstrated that the LPS structure of P. entomophila displayed a low ability to engage the TLR4-mediated signaling correlated to a significant antagonistic activity toward hexa-acylated LPS structures. © 2015 Elsevier Ltd. All rights reserved.
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (241 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Berisio R
* Editorial: cell processes in bacterial diseases (273 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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De Natale C, Minerva V, Patti L, Mazzarella R, Ciano O, Maione S, Luongo D, Naviglio D, Marotta G, Turco S, Ciati R, Melegari C, Rivellese AA, Riccardi G
* Effects Of Baked Products Enriched With N-3 Fatty Acids, Folates, β -Glucans, And Tocopherol In Patients With Mild Mixed Hyperlipidemia (185 visite)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2012 Oct; 31(5): 311-319.
Impact Factor: 1.738
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Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (257 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2012 Sep 17; 7(8): N/D-N/D.
Impact Factor: 3.73
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Monti DM(1), Di Gaetano S, Del Giudice R, Giangrande C, Amoresano A, Monti M, Arciello A, Piccoli R
* Apolipoprotein A-I amyloidogenic variant L174S, expressed and isolated from stably transfected mammalian cells, is associated with fatty acids (180 visite)
Amyloid (ISSN: 1350-6129), 2012 Mar; 19(1): 21-27.
Impact Factor: 4.436
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (301 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (243 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (276 visite)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
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Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, Capparelli R
* Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins (1185 visite)
J Pept Sci (ISSN: 1099-1387, 1075-2617, 1075-2617print), 2011 Dec 2; 17(5): 348-352.
Impact Factor: 1.799
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Monfregola L, Bugatti V, Amodeo P, De Luca S, Vittoria V
* Physical and Water Sorption Properties of Chemically Modified Pectin with an Environmentally Friendly Process (194 visite)
Biomacromolecules (ISSN: 1525-7797), 2011 Jun; 12(6): 2311-2318.
Impact Factor: 5.479
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (299 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Monfregola L, Leone M, Vittoria V, Amodeo P, De Luca S
* Chemical modification of pectin: Environmental friendly process for new potential material development (202 visite)
Polym Chem (ISSN: 1759-9954), 2011; 2(4): 800-804.
Impact Factor: 5.321
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (273 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R
* Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (278 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2010 Sep 3; 5(9): 1568-1576.
Impact Factor: 3.306
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (287 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (259 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Esposito C, Carullo C, Pedone E, Graziano G, Del Vecchio P, Berisio R
* Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination (298 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
Impact Factor: 3.601
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (245 visite)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Guler OO, De Simone G, Supuran CT
* Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (317 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
Impact Factor: 4.63
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Supuran CT, Di Fiore A, Alterio V, Monti SM, De Simone G
* Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII (305 visite)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2010; 16(29): 3246-3254.
Impact Factor: 4.774
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (214 visite)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
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Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis- sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (288 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2009 Oct 8; 52(19): 5990-5998.
Impact Factor: 4.802
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Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
* Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (324 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
Impact Factor: 9.432
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D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (255 visite)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
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Di Fiore A, Fiorentino G, Vitale RM, Ronca R, Amodeo P, Pedone C, Bartolucci S, De Simone G
* Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in Archaea by MarR family proteins (321 visite)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 May 8; 388(3): 559-569.
Impact Factor: 3.871
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (310 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (216 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (228 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT
* Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (275 visite)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2008 Jun 12; 51(11): 3230-3237.
Impact Factor: 4.898
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Daniele A, Cardillo G, Pennino C, Carbone MT, Scognamiglio D, Esposito L, Correra A, Castaldo G, Zagari A, Salvatore F
* Five human phenylalanine hydroxylase proteins identified in mild hyperphenylalaninemia patients are disease-causing variants (238 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2008 Jun; 1782(6): 378-384.
Impact Factor: 2.233
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (302 visite)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (261 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (247 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (476 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (253 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
* Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (263 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
Impact Factor: 5.115
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (274 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (283 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
* Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (272 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
Impact Factor: 5.854
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Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (342 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
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Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (253 visite)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (225 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (285 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
* A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (282 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Feb 20; 279(8): 6815-6823.
Impact Factor: 6.355
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (284 visite)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (320 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
Impact Factor: 1.377
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De Falco S, Ruvo M, Verdoliva A, Scarallo A, Raimondo D, Raucci A, Fassina G
* N-terminal myristylation of HBV preS1 domain enhances receptor recognition (269 visite)
J Pept Res (ISSN: 1397-002x, 1397-002xlinking), 2001 May; 57(5): 390-400.
Impact Factor: 1.522
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (367 visite)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Saviano M, Isernia C, Rossi F, Di Blasio B, Iacovino R, Mazzeo M, Pedone C, Benedetti E
Solid state structural analysis of the cyclooctapeptide cyclo-(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-D-Ala-Val(8)) (293 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 189-199.
Impact Factor: 2.405
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (240 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Monti SM, Fogliano V, Randazzo G, Peluso G, Logrieco A, Ritieni A
Polyclonal antibodies against fusaproliferin (207 visite)
Can J Microbiol (ISSN: 0008-4166), 1999 Jan; 45(1): 45-50.
Impact Factor: 1.072
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Pavone V, De Simone G, Nastri F, Galdiero S, Staiano N, Lombardi A, Pedone C
Multiple binding mode of reversible synthetic thrombin inhibitors. A comparative structural analysis (350 visite)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 1998 Sep; 379(8-9): 987-1006.
Impact Factor: 2.636
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Lombardi A, Maglio O, Benedetti B, Di Blasio E, Saviano M, Nastri F, Pedone C, Pavone V
Pt(II) Complexes of Amino Acids and Peptides. II. Structural Analysis of trans-[Cl2-Pt-(H-Aib-OH)2] (311 visite)
Inorg Chim Acta, 1992; 196: 241-246.
Impact Factor: 0
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (325 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (276 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Steis RG, Carrasquillo JA, Mccabe R, Bookman MA, Reynolds JC, Larson SM, Smith JW, Clark JW, Dailey V, Del Vecchio S
Toxicity, immunogenicity, and tumor radioimmunodetecting ability of two human monoclonal antibodies in patients with metastatic colorectal carcinoma (191 visite)
J Clin Oncol (ISSN: 0732-183x, 0732-183xlinking), 1990 Mar; 8(3): 476-490.
Impact Factor: 7.878
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (262 visite)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (218 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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Manna R, Salvatore M, Scuderi F, Papa G, Marietti G, Greco AV, Ghirlanda G, Gambassi G
Negative correlation between ICA persistence and beta cell restoration after IDDM diagnosis (199 visite)
Diabetes Res (ISSN: 0265-5985), 1988 Nov; 9(3): 101-103.
Impact Factor: 0
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (349 visite)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
Dettagli Esporta in BibTeX Esporta in EndNote
92 Records (89 escludendo Abstract e Conferenze).
Impact factor totale: 397.245 (384.167 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 406.382 (397.405 escludendo Abstract e Conferenze).
Impact factor totale: 397.245 (384.167 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 406.382 (397.405 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Sunday 12 July 2020, 13:14:50
223 visite. Ultima visita in data Friday 24 July 2020, 20:50:32
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