Targeting mitochondria as therapeutic strategy for metabolic disorders (358 visite)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Tipo di articolo: Journal Article,
Impact factor: 1.219, Impact factor a 5 anni: 1.3
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84897529482&partnerID=40&md5=781b3d445901ad130a68f46c5cd4a215
Parole chiave: Insulin, Mitochondrial Dna, Protein P53, Reactive Oxygen Metabolite, Resveratrol, Ubiquinone, Apoptosis, Cell Energy, Exercise, Human, Hypoxia, Insulin Resistance, Lifestyle Modification, Metabolic Disorder, Metabolic Syndrome X, Mitochondrial Dna Disorder, Neoplasm, Oxidative Phosphorylation, Review, Drug Effects, Genetics, Metabolic Diseases, Mutation, Reactive Oxygen Species,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, Italy
Dipartimento di Medicina e Chirurgia, Università Degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy
IRCCS Multimedica, Via Fantoli 16/15, 20138 Milano, Italy
Riferimenti:
Kim, J.-A., Wei, Y., Sowers, J.R., Role of mitochondrial dysfunction in insulin resistance (2008) Circulation Research, 102 (4), pp. 401-414. , DOI 10.1161/CIRCRESAHA.107.165472, PII 000030122008022900000
Chance, B., Sies, H., Boveris, A., Hydroperoxide metabolism in mammalian organs (1979) Physiological Reviews, 59 (3), pp. 527-605
Evans, J.L., Goldfine, I.D., Maddux, B.A., Grodsky, G.M., Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes (2002) Endocrine Reviews, 23 (5), pp. 599-622. , DOI 10.1210/er.2001-0039
Carreras, M.C., Franco, M.C., Peralta, J.G., Poderoso, J.J., Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease (2004) Molecular Aspects of Medicine, 25 (1-2), pp. 125-139. , DOI 10.1016/j.mam.2004.02.014, PII S0098299704000159
Wallace, D.C., A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine (2005) Annual Review of Genetics, 39, pp. 359-407. , DOI 10.1146/annurev.genet.39.110304.095751
Green, K., Brand, M.D., Murphy, M.P., Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes (2004) Diabetes, 53 (SUPPL. 1), pp. S110-S118
Melov, S., Schneider, J.A., Day, B.J., Hinerfeld, D., Coskun, P., Mirra, S.S., Crapo, J.D., Wallace, D.C., A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase (1998) Nature Genetics, 18 (2), pp. 159-163. , DOI 10.1038/ng0298-159
James, A.M., Murphy, M.P., How mitochondrial damage affects cell function (2002) Journal of Biomedical Science, 9 (5-6), pp. 475-487
Sies, H., Strategies of antioxidant defense (1993) European Journal of Biochemistry, 215 (2), pp. 213-219
Pieczenik, S.R., Neustadt, J., Mitochondrial dysfunction and molecular pathways of disease (2007) Experimental and Molecular Pathology, 83 (1), pp. 84-92. , DOI 10.1016/j.yexmp.2006.09.008, PII S0014480006001328
Wei, Y.-H., Lu, C.-Y., Lee, H.-C., Pang, C.-Y., Ma, Y.-S., Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function (1998) Annals of the New York Academy of Sciences, 854, pp. 155-170. , DOI 10.1111/j.1749-6632.1998.tb09899.x
Duchen, M.R., Mitochondria in health and disease: Perspectives on a new mitochondrial biology (2004) Molecular Aspects of Medicine, 25 (4), pp. 365-451. , DOI 10.1016/j.mam.2004.03.001, PII S0098299704000366
Harper, M.-E., Bevilacqua, L., Hagopian, K., Weindruch, R., Ramsey, J.J., Ageing, oxidative stress, and mitochondrial uncoupling (2004) Acta Physiologica Scandinavica, 182 (4), pp. 321-331. , DOI 10.1111/j.1365-201X.2004.01370.x
Liu, J., Killilea, D.W., Ames, B.N., Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-α-lipoic acid (2002) Proceedings of the National Academy of Sciences of the United States of America, 99 (4), pp. 1876-1881. , DOI 10.1073/pnas.261709098
Nakamura, K., Fushimi, K., Kouchi, H., Mihara, K., Miyazaki, M., Ohe, T., Namba, M., Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α and angiotensin II (1998) Circulation, 98 (8), pp. 794-799
Suematsu, N., Tsutsui, H., Wen, J., Kang, D., Ikeuchi, M., Ide, T., Hayashidani, S., Takeshita, A., Oxidative stress mediates tumor necrosis factor-α-induced mitochondrial DNA damage and dysfunction in cardiac myocytes (2003) Circulation, 107 (10), pp. 1418-1423. , DOI 10.1161/01.CIR.0000055318.09997.1F
Ames, B.N., Delaying the mitochondrial decay of aging (2004) Annals of the New York Academy of Sciences, 1019, pp. 406-411. , DOI 10.1196/annals.1297.073
Ames, B.N., Atamna, H., Killilea, D.W., Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging (2005) Molecular Aspects of Medicine, 26 (4-5 SPEC. ISS.), pp. 363-378. , DOI 10.1016/j.mam.2005.07.007, PII S0098299705000415
Atamna, H., Newberry, J., Erlitzki, R., Schultz, C.S., Ames, B.N., Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts (2007) Journal of Nutrition, 137 (1), pp. 25-30. , http://jn.nutrition.org/cgi/reprint/137/1/25
Atamna, H., Heme, iron, and the mitochondrial decay of ageing (2004) Ageing Research Reviews, 3 (3), pp. 303-318. , DOI 10.1016/j.arr.2004.02.002, PII S1568163704000121
Hu, F., Liu, F., Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases? (2011) Cellular Signalling, 23 (10), pp. 1528-1533. , 2-s2.0-79960740086 10.1016/j.cellsig.2011.05.008
Bugger, H., Abel, E.D., Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome (2008) Clinical Science, 114 (3-4), pp. 195-210. , DOI 10.1042/CS20070166
Kelley, D.E., He, J., Menshikova, E.V., Ritov, V.B., Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes (2002) Diabetes, 51 (10), pp. 2944-2950. , 2-s2.0-0036788293
Wiederkehr, A., Wollheim, C.B., Minireview: Implication of mitochondria in insulin secretion and action (2006) Endocrinology, 147 (6), pp. 2643-2649. , http://endo.endojournals.org/cgi/reprint/147/6/2643, DOI 10.1210/en.2006-0057
Højlund, K., Mogensen, M., Sahlin, K., Beck-Nielsen, H., Mitochondrial dysfunction in type 2 diabetes and obesity (2008) Endocrinology and Metabolism Clinics of North America, 37 (3), pp. 713-731. , 2-s2.0-50449084335 10.1016/j.ecl.2008.06.006
Ashrafian, H., Frenneaux, M.P., Opie, L.H., Metabolic mechanisms in heart failure (2007) Circulation, 116 (4), pp. 434-448. , DOI 10.1161/CIRCULATIONAHA.107.702795, PII 0000301720070724000013
De Pauw, A., Tejerina, S., Raes, M., Keijer, J., Arnould, T., Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations (2009) The American Journal of Pathology, 175 (3), pp. 927-939. , 2-s2.0-70349240364 10.2353/ajpath.2009.081155
Lowell, B.B., Shulman, G.I., Mitochondrial dysfunction and type 2 diabetes (2005) Science, 307 (5708), pp. 384-387. , DOI 10.1126/science.1104343
Rong, J.X., Qiu, Y., Hansen, M.K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Ryan, T.E., Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone (2007) Diabetes, 56 (7), pp. 1751-1760. , http://diabetes.diabetesjournals.org/cgi/reprint/56/7/1751, DOI 10.2337/db06-1135
Short, K.R., Bigelow, M.L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., Nair, K.S., Decline in skeletal muscle mitochondrial function with aging in humans (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (15), pp. 5618-5623. , DOI 10.1073/pnas.0501559102
Dumas, J.-F., Simard, G., Flamment, M., Ducluzeau, P.-H., Ritz, P., Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans? (2009) Diabetes and Metabolism, 35 (3), pp. 159-167. , 2-s2.0-67349265189 10.1016/j.diabet.2009.02.002
Pagel-Langenickel, I., Bao, J., Pang, L., Sack, M.N., The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance (2010) Endocrine Reviews, 31 (1), pp. 25-51. , 2-s2.0-76149131004 10.1210/er.2009-0003
Fromenty, B., Pessayre, D., Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity (1995) Pharmacology and Therapeutics, 67 (1), pp. 101-154. , 2-s2.0-0029127584 10.1016/0163-7258(95)00012-6
Perez-Carreras, M., Del Hoyo, P., Martin, M.A., Rubio, J.C., Martin, A., Castellano, G., Colina, F., Solis-Herruzo, J.A., Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis (2003) Hepatology, 38 (4), pp. 999-1007. , DOI 10.1053/jhep.2003.50398
Pessayre, D., Fromenty, B., NASH: A mitochondrial disease (2005) Journal of Hepatology, 42 (6), pp. 928-940. , DOI 10.1016/j.jhep.2005.03.004, PII S0168827805001704
Mitchell, C., Robin, M.-A., Mayeuf, A., Mahrouf-Yorgov, M., Mansouri, A., Hamard, M., Couton, D., Gilgenkrantz, H., Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice (2009) The American Journal of Pathology, 175 (5), pp. 1929-1937. , 2-s2.0-73649128871 10.2353/ajpath.2009.090332
Rossmeisl, M., Syrovy, I., Baumruk, F., Flachs, P., Janovska, P., Kopecky, J., Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue (2000) The FASEB Journal, 14 (12), pp. 1793-1800. , 2-s2.0-0033823015
He, W., Newman, J.C., Wang, M.Z., Ho, L., Verdin, E., Mitochondrial sirtuins: Regulators of protein acylation and metabolism (2012) Trends in Endocrinology and Metabolism, 23 (9), pp. 467-476
Hirschey, M.D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D.B., Grueter, C.A., Verdin, E., SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (2010) Nature, 464 (7285), pp. 121-125. , 2-s2.0-77950806433 10.1038/nature08778
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., Chang, Y., Sirtuin 3, a new target of PGC-1 α, plays an important role in the suppression of ROS and mitochondrial biogenesis (2010) PLoS ONE, 5 (7). , 2-s2.0-77955347446 10.1371/journal.pone.0011707 e11707
Reaven, G.M., The insulin resistance syndrome: Definition and dietary approaches to treatment (2005) Annual Review of Nutrition, 25, pp. 391-406. , DOI 10.1146/annurev.nutr.24.012003.132155
Gastaldi, G., Giacobino, J.-P., Ruiz, J., Metabolic syndrome, a mitochondrial desease? (2008) Revue Medicale Suisse, 4 (160), pp. 1387-1391
Ruderman, N.B., Carling, D., Prentki, M., Cacicedo, J.M., AMPK, insulin resistance, and the metabolic syndrome (2013) The Journal of Clinical Investigation, 123 (7), pp. 2764-2772
Maassen, J.A., 'T Hart, L.M., Van Essen, E., Heine, R.J., Nijpels, G., Jahangir Tafrechi, R.S., Raap, A.K., Lemkes, H.H.P.J., Mitochondrial diabetes: Molecular mechanisms and clinical presentation (2004) Diabetes, 53 (SUPPL. 1), pp. S103-S109
Morino, K., Petersen, K.F., Dufour, S., Befroy, D., Frattini, J., Shatzkes, N., Neschen, S., Shulman, G.I., Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents (2005) Journal of Clinical Investigation, 115 (12), pp. 3587-3593. , http://www.jci.org/cgi/reprint/115/12/3587, DOI 10.1172/JCI25151
Choksi, K.B., Boylston, W.H., Rabek, J.P., Widger, W.R., Papaconstantinou, J., Oxidatively damaged proteins of heart mitochondrial electron transport complexes (2004) Biochimica et Biophysica Acta - Molecular Basis of Disease, 1688 (2), pp. 95-101. , DOI 10.1016/j.bbadis.2003.11.007
Smith Jr., S.C., Multiple risk factors for cardiovascular disease and diabetes mellitus (2007) American Journal of Medicine, 120 (3 SUPPL. 1), pp. S3-S11. , DOI 10.1016/j.amjmed.2007.01.002, PII S0002934307000320, Modifying Cardiovascular and Metabolic Risk Factors: The Role of Endocannabinoid System and Cannabinoid Receptors
Cooper, S.A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., Sowers, J.R., Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance (2007) American Journal of Physiology - Heart and Circulatory Physiology, 293 (4), pp. H2009-H2023. , http://ajpheart.physiology.org/cgi/reprint/293/4/H2009, DOI 10.1152/ajpheart.00522.2007
Sowers, J.R., Insulin resistance and hypertension (2004) American Journal of Physiology - Heart and Circulatory Physiology, 286 (5), pp. H1597-H1602. , DOI 10.1152/ajpheart.00026.2004
Bach, D., Pich, S., Soriano, F.X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J.R., Zorzano, A., Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism: A novel regulatory mechanism altered in obesity (2003) Journal of Biological Chemistry, 278 (19), pp. 17190-17197. , DOI 10.1074/jbc.M212754200
Walder, K., Kerr-Bayles, L., Civitarese, A., Jowett, J., Curran, J., Elliott, K., Trevaskis, J., Collier, G.R., The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes (2005) Diabetologia, 48 (3), pp. 459-468. , DOI 10.1007/s00125-005-1675-9
Cantó, C., Auwerx, J., PGC-1 α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure (2009) Current Opinion in Lipidology, 20 (2), pp. 98-105. , 2-s2.0-64549127790 10.1097/MOL.0b013e328328d0a4
Mensink, M., Hesselink, M.K.C., Russell, A.P., Schaart, G., Sels, J.-P., Schrauwen, P., Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus (2007) International Journal of Obesity, 31 (8), pp. 1302-1310. , DOI 10.1038/sj.ijo.0803567, PII 0803567
Mootha, V.K., Lindgren, C.M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Groop, L.C., PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes (2003) Nature Genetics, 34 (3), pp. 267-273. , DOI 10.1038/ng1180
Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M.A., Brownlee, M., Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage (2000) Nature, 404 (6779), pp. 787-790. , DOI 10.1038/35008121
Yamagishi, S.-I., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., Brownlee, M., Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A (2001) Journal of Biological Chemistry, 276 (27), pp. 25096-25100. , 2-s2.0-0035816639 10.1074/jbc.M007383200
Boss, O., Hagen, T., Lowell, B.B., Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism (2000) Diabetes, 49 (2), pp. 143-156
Krebs, M., Roden, M., Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature (2005) Diabetes, Obesity and Metabolism, 7 (6), pp. 621-632. , DOI 10.1111/j.1463-1326.2004.00439.x
Houstis, N., Rosen, E.D., Lander, E.S., Reactive oxygen species have a causal role in multiple forms of insulin resistance (2006) Nature, 440 (7086), pp. 944-948. , 2-s2.0-33645860825 10.1038/nature04634
Reaven, G.M., Chen, Y.-D.I., Insulin resistance, its consequences, and coronary heart disease: Must we choose one culprit (1996) Circulation, 93 (10), pp. 1780-1783
Kostis, J.B., Sanders, M., The association of heart failure with insulin resistance and the development of type 2 diabetes (2005) American Journal of Hypertension, 18 (5), pp. 731-737. , DOI 10.1016/j.amjhyper.2004.11.038, PII S0895706104011938
Boudina, S., Sena, S., O'Neill, B.T., Tathireddy, P., Young, M.E., Abel, E.D., Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity (2005) Circulation, 112 (17), pp. 2686-2695. , DOI 10.1161/CIRCULATIONAHA.105.554360
Szczepaniak, L.S., Dobbins, R.L., Metzger, G.J., Sartoni-D'Ambrosia, G., Arbique, D., Vongpatanasin, W., Unger, R., Victor, R.G., Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging (2003) Magnetic Resonance in Medicine, 49 (3), pp. 417-423. , DOI 10.1002/mrm.10372
Christoffersen, C., Bollano, E., Lindegaard, M.L.S., Bartels, E.D., Goetze, J.P., Andersen, C.B., Nielsen, L.B., Cardiac lipid accumulation associated with diastolic dysfunction in obese mice (2003) Endocrinology, 144 (8), pp. 3483-3490. , DOI 10.1210/en.2003-0242
Seyfried, T.N., Shelton, L.M., Cancer as a metabolic disease (2010) Nutrition and Metabolism, 77. , 2-s2.0-77649277719 10.1186/1743-7075-7-7
Kwong, J.Q., Henning, M.S., Starkov, A.A., Manfredi, G., The mitochondrial respiratory chain is a modulator of apoptosis (2007) Journal of Cell Biology, 179 (6), pp. 1163-1177. , http://www.jcb.org/cgi/reprint/179/6/1163, DOI 10.1083/jcb.200704059
Wu, Y.-T., Wu, S.-B., Lee, W.-Y., Wei, Y.-H., Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases (2010) Annals of the New York Academy of Sciences, 1201, pp. 147-156. , 2-s2.0-77955291455 10.1111/j.1749-6632.2010.05631.x
John, A.P., Dysfunctional mitochondria, not oxygen insufficiency, cause cancer cells to produce inordinate amounts of lactic acid: The impact of this on the treatment of cancer (2001) Medical Hypotheses, 57 (4), pp. 429-431. , DOI 10.1054/mehy.2001.1335
Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Rigoni, A., Vacchelli, E., Michaud, M., Kroemer, G., Mitochondrial gateways to cancer (2010) Molecular Aspects of Medicine, 31 (1), pp. 1-20. , 2-s2.0-77649338652 10.1016/j.mam.2009.08.002
Foster, C.S., Spoerri, P.E., Glees, P., Spoerri, O., The mode of mitochondrial degeneration in gliomas (1978) Acta Neurochirurgica, 43 (3-4), pp. 229-237
Rasmussen, A.K., Chatterjee, A., Rasmussen, L.J., Singh, K.K., Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae (2003) Nucleic Acids Research, 31 (14), pp. 3909-3917. , DOI 10.1093/nar/gkg446
Cuezva, J.M., Krajewska, M., De Heredia, M.L., Krajewski, S., Santamaria, G., Kim, H., Zapata, J.M., Reed, J.C., The bioenergetic signature of cancer: A marker of tumor progression (2002) Cancer Research, 62 (22), pp. 6674-6681
Pelicano, H., Lu, W., Zhou, Y., Zhang, W., Chen, Z., Hu, Y., Huang, P., Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism (2009) Cancer Research, 69 (6), pp. 2375-2383. , 2-s2.0-65549142759 10.1158/0008-5472.CAN-08-3359
Zhu, X., Peng, X., Guan, M.-X., Yan, Q., Pathogenic mutations of nuclear genes associated with mitochondrial disorders (2009) Acta Biochimica et Biophysica Sinica, 41 (3), pp. 179-187. , 2-s2.0-65249092667 10.1093/abbs/gmn021
Altenberg, B., Greulich, K.O., Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes (2004) Genomics, 84 (6), pp. 1014-1020. , DOI 10.1016/j.ygeno.2004.08.010, PII S0888754304002277
Warburg, O., On the origin of cancer cells (1956) Science, 123 (3191), pp. 309-314. , 2-s2.0-12444279265
Osthus, R.C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Dang, C.V., Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc (2000) Journal of Biological Chemistry, 275 (29), pp. 21797-21800. , DOI 10.1074/jbc.C000023200
Flier, J.S., Mueckler, M.M., Usher, P., Lodish, H.F., Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes (1987) Science, 235 (4795), pp. 1492-1495
Shim, H., Dolde, C., Lewis, B.C., Wu, C.-S., Dang, G., Jungmann, R.A., Dalla-Favera, R., Dang, C.V., C-Myc transactivation of LDH-A: Implications for tumor metabolism and growth (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (13), pp. 6658-6663. , DOI 10.1073/pnas.94.13.6658
Salem, A.F., Whitaker-Menezes, D., Lin, Z., Martinez-Outschoorn, U.E., Tanowitz, H.B., Al-Zoubi, M.S., Howell, A., Lisanti, M.P., Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells Cell Cycle, 11 (13), pp. 2545-2556
Balliet, R.M., Capparelli, C., Guido, C., Pestell, T.G., Martinez-Outschoorn, U.E., Lin, Z., Whitaker-Menezes, D., Lisanti, M.P., Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: Understanding the aging and cancer connection (2011) Cell Cycle, 10 (23), pp. 4065-4073. , 2-s2.0-82855170859 10.4161/cc.10.23.18254
Henze, A.-T., Acker, T., Feedback regulators of hypoxia-inducible factors and their role in cancer biology (2010) Cell Cycle, 9 (14), pp. 2749-2763. , 2-s2.0-77956805884 10.4161/cc.9.14.12249
Hockel, M., Vaupel, P., Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects (2001) Journal of the National Cancer Institute, 93 (4), pp. 266-276
Amelio, I., Melino, G., The "sharp" blade against HIF-mediated metastasis Cell Cycle, 11 (24), pp. 4530-4535
Briston, T., Yang, J., Ashcroft, M., HIF-1 α localization with mitochondria: A new role for an old favorite? (2011) Cell Cycle, 10 (23), pp. 4170-4171. , 2-s2.0-82855181978 10.4161/cc.10.23.18565
Bertozzi, D., Iurlaro, R., Sordet, O., Marinello, J., Zaffaroni, N., Capranico, G., Characterization of novel antisense HIF-1 α transcripts in human cancers (2011) Cell Cycle, 10 (18), pp. 3189-3197. , 2-s2.0-80052885284 10.4161/cc.10.18.17183
Rapisarda, A., Shoemaker, R.H., Melillo, G., Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads (2009) Cell Cycle, 8 (24), pp. 4040-4043. , 2-s2.0-74849127957
Maxwell, P.H., HIF-1's relationship to oxygen: Simple yet sophisticated (2004) Cell Cycle, 3 (2), pp. 156-159
Ma, J., Zhang, Q., Chen, S., Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1alpha accumulation via increased production of reactive oxygen species (2013) PLoS ONE, 8 (7). , e69485
Compton, S., Kim, C., Griner, N.B., Potluri, P., Scheffler, I.E., Sen, S., Jerry, D.J., Yadava, N., Mitochondrial dysfunction impairs tumor suppressor p53 expression/function (2011) Journal of Biological Chemistry, 286 (23), pp. 20297-20312. , 2-s2.0-79957994581 10.1074/jbc.M110.163063
Schwartzenberg-Bar-Yoseph, F., Armoni, M., Karnieli, E., The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression (2004) Cancer Research, 64 (7), pp. 2627-2633. , DOI 10.1158/0008-5472.CAN-03-0846
Szatrowski, T.P., Nathan, C.F., Production of large amounts of hydrogen peroxide by human tumor cells (1991) Cancer Research, 51 (3), pp. 794-798. , 2-s2.0-0026021362
Moreno-Sanchez, R., Rodriguez-Enriquez, S., Marin-Hernandez, A., Saavedra, E., Energy metabolism in tumor cells (2007) FEBS Journal, 274 (6), pp. 1393-1418. , DOI 10.1111/j.1742-4658.2007.05686.x
Pelicano, H., Martin, D.S., Xu, R.-H., Huang, P., Glycolysis inhibition for anticancer treatment (2006) Oncogene, 25 (34), pp. 4633-4646. , DOI 10.1038/sj.onc.1209597, PII 1209597
Bauer, G., Tumor cell-protective catalase as a novel target for rational therapeutic approaches based on specific intercellular ROS signaling Anticancer Research, 32 (7), pp. 2599-2624
Ishikawa, K., Takenaga, K., Akimoto, M., Koshikawa, N., Yamaguchi, A., Imanishi, H., Nakada, K., Hayashi, J.-I., ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis (2008) Science, 320 (5876), pp. 661-664. , DOI 10.1126/science.1156906
Carew, J.S., Zhou, Y., Albitar, M., Carew, J.D., Keating, M.J., Huang, P., Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: Clinical significance and therapeutic implications (2003) Leukemia, 17 (8), pp. 1437-1447. , DOI 10.1038/sj.leu.2403043
Indo, H.P., Davidson, M., Yen, H.-C., Suenaga, S., Tomita, K., Nishii, T., Higuchi, M., Majima, H.J., Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage (2007) Mitochondrion, 7 (1-2), pp. 106-118. , DOI 10.1016/j.mito.2006.11.026, PII S1567724906002248, Mitochondria and Life
Tan, D.-J., Bai, R.-K., Wong, L.-J.C., Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer (2002) Cancer Research, 62 (4), pp. 972-976
Polyak, K., Li, Y., Zhu, H., Lengauer, C., Willson, J.K.V., Markowitz, S.D., Trush, M.A., Vogelstein, B., Somatic mutations of the mitochondrial genome in human colorectal tumours (1998) Nature Genetics, 20 (3), pp. 291-293. , DOI 10.1038/3108
Liu, V.W.S., Hong Hui Shi, Cheung, A.N.Y., Pui Man Chiu, Tsin Wah Leung, Nagley, P., Ling Wong Wong, Ngan, H.Y.S., High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas (2001) Cancer Research, 61 (16), pp. 5998-6001
Sanchez-Cespedes, M., Parrella, P., Nomoto, S., Cohen, D., Xiao, Y., Esteller, M., Jeronimo, C., Sidransky, D., Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors (2001) Cancer Research, 61 (19), pp. 7015-7019
Fliss, M.S., Usadel, H., Caballero, O.L., Wu, L., Buta, M.R., Eleff, S.M., Jen, J., Sidransky, D., Facile detection of mitochondrial DNA mutations in tumors and bodily fluids (2000) Science, 287 (5460), pp. 2017-2019. , DOI 10.1126/science.287.5460.2017
Reed, J.C., Molecular biology of chronic lymphocytic leukemia (1998) Seminars in Oncology, 25 (1), pp. 11-18
Sharief, M.K., Douglas, M., Noori, M., Semra, Y.K., The expression of pro- and anti-apoptosis Bcl-2 family proteins in lymphocytes from patients with multiple sclerosis (2002) Journal of Neuroimmunology, 125 (1-2), pp. 155-162. , DOI 10.1016/S0165-5728(02)00024-3, PII S0165572802000243
Heiser, D., Labi, V., Erlacher, M., Villunger, A., The Bcl-2 protein family and its role in the development of neoplastic disease (2004) Experimental Gerontology, 39 (8), pp. 1125-1135. , DOI 10.1016/j.exger.2004.04.011, PII S0531556504001822
Takeuchi, O., Fisher, J., Suh, H., Harada, H., Malynn, B.A., Korsmeyer, S.J., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (32), pp. 11272-11277. , DOI 10.1073/pnas.0504783102
Traver, D., Akashi, K., Weissman, I.L., Lagasse, E., Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia (1998) Immunity, 9 (1), pp. 47-57. , DOI 10.1016/S1074-7613(00)80587-7
Schumacher, B., Hofmann, K., Boulton, S., Gartner, A., The C. Elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis (2001) Current Biology, 11 (21), pp. 1722-1727. , DOI 10.1016/S0960-9822(01)00534-6
Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Sinclair, D.A., Resveratrol improves health and survival of mice on a high-calorie diet (2006) Nature, 444 (7117), pp. 337-342. , DOI 10.1038/nature05354, PII NATURE05354
Pearson, K.J., Baur, J.A., Lewis, K.N., Peshkin, L., Price, N.L., Labinskyy, N., Swindell, W.R., De Cabo, R., Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span (2008) Cell Metabolism, 8 (2), pp. 157-168. , 2-s2.0-48349144852 10.1016/j.cmet.2008.06.011
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Auwerx, J., Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α (2006) Cell, 127 (6), pp. 1109-1122. , DOI 10.1016/j.cell.2006.11.013, PII S0092867406014280
Milne, J.C., Lambert, P.D., Schenk, S., Carney, D.P., Smith, J.J., Gagne, D.J., Jin, L., Westphal, C.H., Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes (2007) Nature, 450 (7170), pp. 712-716. , DOI 10.1038/nature06261, PII NATURE06261
Winder, W.W., Holmes, B.F., Rubink, D.S., Jensen, E.B., Chen, M., Holloszy, J.O., Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle (2000) Journal of Applied Physiology, 88 (6), pp. 2219-2226
Fujii, N., Jessen, N., Goodyear, L.J., AMP-activated protein kinase and the regulation of glucose transport (2006) The American Journal of Physiology, 291 (5), pp. E867-E877. , 2-s2.0-33751195101 10.1152/ajpendo.00207.2006
Ruderman, N.B., Saha, A.K., Kraegen, E.W., Minireview: Malonyl CoA, AMP-activated protein kinase, and adiposity (2003) Endocrinology, 144 (12), pp. 5166-5171. , DOI 10.1210/en.2003-0849
Mayers, R.M., Leighton, B., Kilgour, E., PDH kinase inhibitors: A novel therapy for Type II diabetes? (2005) Biochemical Society Transactions, 33 (2), pp. 367-370. , DOI 10.1042/BST0330367
Fink, B.D., O'Malley, Y., Dake, B.L., Ross, N.C., Prisinzano, T.E., Sivitz, W.I., Mitochondrial targeted coenzyme Q, superoxide, and fuel selectivity in endothelial cells (2009) PLoS ONE, 4 (1). , 2-s2.0-64149103303 10.1371/journal.pone.0004250 e4250
Yorek, M.A., The role of oxidative stress in diabetic vascular and neural disease (2003) Free Radical Research, 37 (5), pp. 471-480. , DOI 10.1080/1071576031000083161
Maguire, J.J., Wilson, D.S., Packer, L., Mitochondrial electron transport-linked tocopheroxyl radical reduction (1989) Journal of Biological Chemistry, 264 (36), pp. 21462-21465
Yi, X., Maeda, N., α-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet (2006) Diabetes, 55 (8), pp. 2238-2244. , http://diabetes.diabetesjournals.org/cgi/content/full/55/8/2238, DOI 10.2337/db06-0251
Mehta, K., Van Thiel, D.H., Shah, N., Mobarhan, S., Nonalcoholic fatty liver disease: Pathogenesis and the role of antioxidants (2002) Nutrition Reviews, 60 (9), pp. 289-293. , DOI 10.1301/002966402320387224
Li, M., Peterson, S., Husney, D., Inaba, M., Guo, K., Eri, T., Morita, T., Abraham, N.G., Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: Possible role of carbon monoxide and bilirubin (2007) Antioxidants and Redox Signaling, 9 (7), pp. 855-863. , DOI 10.1089/ars.2007.1568
Kelso, G.F., Porteous, C.M., Coulter, C.V., Hughes, G., Porteous, W.K., Ledgerwood, E.C., Smith, R.A.J., Murphy, M.P., Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties (2001) Journal of Biological Chemistry, 276 (7), pp. 4588-4596. , 2-s2.0-0035895888 10.1074/jbc.M009093200
Adlam, V.J., Harrison, J.C., Porteous, C.M., James, A.M., Smith, R.A.J., Murphy, M.P., Sammut, I.A., Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury (2005) FASEB Journal, 19 (9), pp. 1088-1095. , DOI 10.1096/fj.05-3718com
Jauslin, M.L., Meier, T., Smith, R.A., Murphy, M.P., Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants (2003) The FASEB Journal, 17 (13), pp. 1972-1974
Saretzki, G., Murphy, M.P., Von Zglinicki, T., MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress (2003) Aging Cell, 2 (2), pp. 141-143. , 2-s2.0-0041419866
Dhanasekaran, A., Kotamraju, S., Kalivendi, S.V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., Kalyanaraman, B., Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis (2004) Journal of Biological Chemistry, 279 (36), pp. 37575-37587. , DOI 10.1074/jbc.M404003200
Schafer, M., Schafer, C., Ewald, N., Piper, H.M., Noll, T., Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia (2003) Circulation Research, 92 (9), pp. 1010-1015. , DOI 10.1161/01.RES.0000070882.81508.FC
Knowler, W.C., Barrett-Connor, E., Fowler, S.E., Hamman, R.F., Lachin, J.M., Walker, E.A., Nathan, D.M., Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin (2002) New England Journal of Medicine, 346 (6), pp. 393-403. , DOI 10.1056/NEJMoa012512
Henriksen, E.J., Invited review: Effects of acute exercise and exercise training on insulin resistance (2002) Journal of Applied Physiology, 93 (2), pp. 788-796
Reznick, R.M., Shulman, G.I., The role of AMP-activated protein kinase in mitochondrial biogenesis (2006) Journal of Physiology, 574 (1), pp. 33-39. , DOI 10.1113/jphysiol.2006.109512
Röckl, K.S.C., Witczak, C.A., Goodyear, L.J., Signaling mechanisms in skeletal muscle: Acute responses and chronic adaptations to exercise (2008) IUBMB Life, 60 (3), pp. 145-153. , 2-s2.0-44049092767 10.1002/iub.21
Fulda, S., Exploiting mitochondrial apoptosis for the treatment of cancer (2010) Mitochondrion, 10 (6), pp. 598-603. , 2-s2.0-78149359030 10.1016/j.mito.2010.05.001
Hagland, H., Nikolaisen, J., Hodneland, L.I., Gjertsen, B.T., Bruserud, O., Tronstad, K.J., Targeting mitochondria in the treatment of human cancer: A coordinated attack against cancer cell energy metabolism and signalling (2007) Expert Opinion on Therapeutic Targets, 11 (8), pp. 1055-1069. , DOI 10.1517/14728222.11.8.1055
Bonnet, S., Archer, S.L., Allalunis-Turner, J., Haromy, A., Beaulieu, C., Thompson, R., Lee, C.T., Michelakis, E.D., A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth (2007) Cancer Cell, 11 (1), pp. 37-51. , DOI 10.1016/j.ccr.2006.10.020, PII S1535610806003722
Schulz, T.J., Thierbach, R., Voigt, A., Drewes, G., Mietzner, B., Steinberg, P., Pfeiffer, A.F.H., Ristow, M., Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited (2006) Journal of Biological Chemistry, 281 (2), pp. 977-981. , 2-s2.0-33644868755 10.1074/jbc.M511064200
Holinger, E.P., Chittenden, T., Lutz, R.J., Bak BH3 peptides antagonize Bcl-x(L) function and induce apoptosis through cytochrome c-independent activation of caspases (1999) Journal of Biological Chemistry, 274 (19), pp. 13298-13304. , DOI 10.1074/jbc.274.19.13298
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Tipo di articolo: Journal Article,
Impact factor: 1.219, Impact factor a 5 anni: 1.3
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84897529482&partnerID=40&md5=781b3d445901ad130a68f46c5cd4a215
Parole chiave: Insulin, Mitochondrial Dna, Protein P53, Reactive Oxygen Metabolite, Resveratrol, Ubiquinone, Apoptosis, Cell Energy, Exercise, Human, Hypoxia, Insulin Resistance, Lifestyle Modification, Metabolic Disorder, Metabolic Syndrome X, Mitochondrial Dna Disorder, Neoplasm, Oxidative Phosphorylation, Review, Drug Effects, Genetics, Metabolic Diseases, Mutation, Reactive Oxygen Species,
Affiliazioni:
*** IBB - CNR ***
Dipartimento di Scienze Biomediche Avanzate, Università Federico II, Via Pansini 5, 80131 Napoli, Italy
Dipartimento di Medicina e Chirurgia, Università Degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy
IRCCS Multimedica, Via Fantoli 16/15, 20138 Milano, Italy
Riferimenti:
Kim, J.-A., Wei, Y., Sowers, J.R., Role of mitochondrial dysfunction in insulin resistance (2008) Circulation Research, 102 (4), pp. 401-414. , DOI 10.1161/CIRCRESAHA.107.165472, PII 000030122008022900000
Chance, B., Sies, H., Boveris, A., Hydroperoxide metabolism in mammalian organs (1979) Physiological Reviews, 59 (3), pp. 527-605
Evans, J.L., Goldfine, I.D., Maddux, B.A., Grodsky, G.M., Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes (2002) Endocrine Reviews, 23 (5), pp. 599-622. , DOI 10.1210/er.2001-0039
Carreras, M.C., Franco, M.C., Peralta, J.G., Poderoso, J.J., Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease (2004) Molecular Aspects of Medicine, 25 (1-2), pp. 125-139. , DOI 10.1016/j.mam.2004.02.014, PII S0098299704000159
Wallace, D.C., A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine (2005) Annual Review of Genetics, 39, pp. 359-407. , DOI 10.1146/annurev.genet.39.110304.095751
Green, K., Brand, M.D., Murphy, M.P., Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes (2004) Diabetes, 53 (SUPPL. 1), pp. S110-S118
Melov, S., Schneider, J.A., Day, B.J., Hinerfeld, D., Coskun, P., Mirra, S.S., Crapo, J.D., Wallace, D.C., A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase (1998) Nature Genetics, 18 (2), pp. 159-163. , DOI 10.1038/ng0298-159
James, A.M., Murphy, M.P., How mitochondrial damage affects cell function (2002) Journal of Biomedical Science, 9 (5-6), pp. 475-487
Sies, H., Strategies of antioxidant defense (1993) European Journal of Biochemistry, 215 (2), pp. 213-219
Pieczenik, S.R., Neustadt, J., Mitochondrial dysfunction and molecular pathways of disease (2007) Experimental and Molecular Pathology, 83 (1), pp. 84-92. , DOI 10.1016/j.yexmp.2006.09.008, PII S0014480006001328
Wei, Y.-H., Lu, C.-Y., Lee, H.-C., Pang, C.-Y., Ma, Y.-S., Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function (1998) Annals of the New York Academy of Sciences, 854, pp. 155-170. , DOI 10.1111/j.1749-6632.1998.tb09899.x
Duchen, M.R., Mitochondria in health and disease: Perspectives on a new mitochondrial biology (2004) Molecular Aspects of Medicine, 25 (4), pp. 365-451. , DOI 10.1016/j.mam.2004.03.001, PII S0098299704000366
Harper, M.-E., Bevilacqua, L., Hagopian, K., Weindruch, R., Ramsey, J.J., Ageing, oxidative stress, and mitochondrial uncoupling (2004) Acta Physiologica Scandinavica, 182 (4), pp. 321-331. , DOI 10.1111/j.1365-201X.2004.01370.x
Liu, J., Killilea, D.W., Ames, B.N., Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-α-lipoic acid (2002) Proceedings of the National Academy of Sciences of the United States of America, 99 (4), pp. 1876-1881. , DOI 10.1073/pnas.261709098
Nakamura, K., Fushimi, K., Kouchi, H., Mihara, K., Miyazaki, M., Ohe, T., Namba, M., Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α and angiotensin II (1998) Circulation, 98 (8), pp. 794-799
Suematsu, N., Tsutsui, H., Wen, J., Kang, D., Ikeuchi, M., Ide, T., Hayashidani, S., Takeshita, A., Oxidative stress mediates tumor necrosis factor-α-induced mitochondrial DNA damage and dysfunction in cardiac myocytes (2003) Circulation, 107 (10), pp. 1418-1423. , DOI 10.1161/01.CIR.0000055318.09997.1F
Ames, B.N., Delaying the mitochondrial decay of aging (2004) Annals of the New York Academy of Sciences, 1019, pp. 406-411. , DOI 10.1196/annals.1297.073
Ames, B.N., Atamna, H., Killilea, D.W., Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging (2005) Molecular Aspects of Medicine, 26 (4-5 SPEC. ISS.), pp. 363-378. , DOI 10.1016/j.mam.2005.07.007, PII S0098299705000415
Atamna, H., Newberry, J., Erlitzki, R., Schultz, C.S., Ames, B.N., Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts (2007) Journal of Nutrition, 137 (1), pp. 25-30. , http://jn.nutrition.org/cgi/reprint/137/1/25
Atamna, H., Heme, iron, and the mitochondrial decay of ageing (2004) Ageing Research Reviews, 3 (3), pp. 303-318. , DOI 10.1016/j.arr.2004.02.002, PII S1568163704000121
Hu, F., Liu, F., Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases? (2011) Cellular Signalling, 23 (10), pp. 1528-1533. , 2-s2.0-79960740086 10.1016/j.cellsig.2011.05.008
Bugger, H., Abel, E.D., Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome (2008) Clinical Science, 114 (3-4), pp. 195-210. , DOI 10.1042/CS20070166
Kelley, D.E., He, J., Menshikova, E.V., Ritov, V.B., Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes (2002) Diabetes, 51 (10), pp. 2944-2950. , 2-s2.0-0036788293
Wiederkehr, A., Wollheim, C.B., Minireview: Implication of mitochondria in insulin secretion and action (2006) Endocrinology, 147 (6), pp. 2643-2649. , http://endo.endojournals.org/cgi/reprint/147/6/2643, DOI 10.1210/en.2006-0057
Højlund, K., Mogensen, M., Sahlin, K., Beck-Nielsen, H., Mitochondrial dysfunction in type 2 diabetes and obesity (2008) Endocrinology and Metabolism Clinics of North America, 37 (3), pp. 713-731. , 2-s2.0-50449084335 10.1016/j.ecl.2008.06.006
Ashrafian, H., Frenneaux, M.P., Opie, L.H., Metabolic mechanisms in heart failure (2007) Circulation, 116 (4), pp. 434-448. , DOI 10.1161/CIRCULATIONAHA.107.702795, PII 0000301720070724000013
De Pauw, A., Tejerina, S., Raes, M., Keijer, J., Arnould, T., Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations (2009) The American Journal of Pathology, 175 (3), pp. 927-939. , 2-s2.0-70349240364 10.2353/ajpath.2009.081155
Lowell, B.B., Shulman, G.I., Mitochondrial dysfunction and type 2 diabetes (2005) Science, 307 (5708), pp. 384-387. , DOI 10.1126/science.1104343
Rong, J.X., Qiu, Y., Hansen, M.K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Ryan, T.E., Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone (2007) Diabetes, 56 (7), pp. 1751-1760. , http://diabetes.diabetesjournals.org/cgi/reprint/56/7/1751, DOI 10.2337/db06-1135
Short, K.R., Bigelow, M.L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., Nair, K.S., Decline in skeletal muscle mitochondrial function with aging in humans (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (15), pp. 5618-5623. , DOI 10.1073/pnas.0501559102
Dumas, J.-F., Simard, G., Flamment, M., Ducluzeau, P.-H., Ritz, P., Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans? (2009) Diabetes and Metabolism, 35 (3), pp. 159-167. , 2-s2.0-67349265189 10.1016/j.diabet.2009.02.002
Pagel-Langenickel, I., Bao, J., Pang, L., Sack, M.N., The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance (2010) Endocrine Reviews, 31 (1), pp. 25-51. , 2-s2.0-76149131004 10.1210/er.2009-0003
Fromenty, B., Pessayre, D., Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity (1995) Pharmacology and Therapeutics, 67 (1), pp. 101-154. , 2-s2.0-0029127584 10.1016/0163-7258(95)00012-6
Perez-Carreras, M., Del Hoyo, P., Martin, M.A., Rubio, J.C., Martin, A., Castellano, G., Colina, F., Solis-Herruzo, J.A., Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis (2003) Hepatology, 38 (4), pp. 999-1007. , DOI 10.1053/jhep.2003.50398
Pessayre, D., Fromenty, B., NASH: A mitochondrial disease (2005) Journal of Hepatology, 42 (6), pp. 928-940. , DOI 10.1016/j.jhep.2005.03.004, PII S0168827805001704
Mitchell, C., Robin, M.-A., Mayeuf, A., Mahrouf-Yorgov, M., Mansouri, A., Hamard, M., Couton, D., Gilgenkrantz, H., Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice (2009) The American Journal of Pathology, 175 (5), pp. 1929-1937. , 2-s2.0-73649128871 10.2353/ajpath.2009.090332
Rossmeisl, M., Syrovy, I., Baumruk, F., Flachs, P., Janovska, P., Kopecky, J., Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue (2000) The FASEB Journal, 14 (12), pp. 1793-1800. , 2-s2.0-0033823015
He, W., Newman, J.C., Wang, M.Z., Ho, L., Verdin, E., Mitochondrial sirtuins: Regulators of protein acylation and metabolism (2012) Trends in Endocrinology and Metabolism, 23 (9), pp. 467-476
Hirschey, M.D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D.B., Grueter, C.A., Verdin, E., SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (2010) Nature, 464 (7285), pp. 121-125. , 2-s2.0-77950806433 10.1038/nature08778
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., Chang, Y., Sirtuin 3, a new target of PGC-1 α, plays an important role in the suppression of ROS and mitochondrial biogenesis (2010) PLoS ONE, 5 (7). , 2-s2.0-77955347446 10.1371/journal.pone.0011707 e11707
Reaven, G.M., The insulin resistance syndrome: Definition and dietary approaches to treatment (2005) Annual Review of Nutrition, 25, pp. 391-406. , DOI 10.1146/annurev.nutr.24.012003.132155
Gastaldi, G., Giacobino, J.-P., Ruiz, J., Metabolic syndrome, a mitochondrial desease? (2008) Revue Medicale Suisse, 4 (160), pp. 1387-1391
Ruderman, N.B., Carling, D., Prentki, M., Cacicedo, J.M., AMPK, insulin resistance, and the metabolic syndrome (2013) The Journal of Clinical Investigation, 123 (7), pp. 2764-2772
Maassen, J.A., 'T Hart, L.M., Van Essen, E., Heine, R.J., Nijpels, G., Jahangir Tafrechi, R.S., Raap, A.K., Lemkes, H.H.P.J., Mitochondrial diabetes: Molecular mechanisms and clinical presentation (2004) Diabetes, 53 (SUPPL. 1), pp. S103-S109
Morino, K., Petersen, K.F., Dufour, S., Befroy, D., Frattini, J., Shatzkes, N., Neschen, S., Shulman, G.I., Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents (2005) Journal of Clinical Investigation, 115 (12), pp. 3587-3593. , http://www.jci.org/cgi/reprint/115/12/3587, DOI 10.1172/JCI25151
Choksi, K.B., Boylston, W.H., Rabek, J.P., Widger, W.R., Papaconstantinou, J., Oxidatively damaged proteins of heart mitochondrial electron transport complexes (2004) Biochimica et Biophysica Acta - Molecular Basis of Disease, 1688 (2), pp. 95-101. , DOI 10.1016/j.bbadis.2003.11.007
Smith Jr., S.C., Multiple risk factors for cardiovascular disease and diabetes mellitus (2007) American Journal of Medicine, 120 (3 SUPPL. 1), pp. S3-S11. , DOI 10.1016/j.amjmed.2007.01.002, PII S0002934307000320, Modifying Cardiovascular and Metabolic Risk Factors: The Role of Endocannabinoid System and Cannabinoid Receptors
Cooper, S.A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., Sowers, J.R., Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance (2007) American Journal of Physiology - Heart and Circulatory Physiology, 293 (4), pp. H2009-H2023. , http://ajpheart.physiology.org/cgi/reprint/293/4/H2009, DOI 10.1152/ajpheart.00522.2007
Sowers, J.R., Insulin resistance and hypertension (2004) American Journal of Physiology - Heart and Circulatory Physiology, 286 (5), pp. H1597-H1602. , DOI 10.1152/ajpheart.00026.2004
Bach, D., Pich, S., Soriano, F.X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J.R., Zorzano, A., Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism: A novel regulatory mechanism altered in obesity (2003) Journal of Biological Chemistry, 278 (19), pp. 17190-17197. , DOI 10.1074/jbc.M212754200
Walder, K., Kerr-Bayles, L., Civitarese, A., Jowett, J., Curran, J., Elliott, K., Trevaskis, J., Collier, G.R., The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes (2005) Diabetologia, 48 (3), pp. 459-468. , DOI 10.1007/s00125-005-1675-9
Cantó, C., Auwerx, J., PGC-1 α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure (2009) Current Opinion in Lipidology, 20 (2), pp. 98-105. , 2-s2.0-64549127790 10.1097/MOL.0b013e328328d0a4
Mensink, M., Hesselink, M.K.C., Russell, A.P., Schaart, G., Sels, J.-P., Schrauwen, P., Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus (2007) International Journal of Obesity, 31 (8), pp. 1302-1310. , DOI 10.1038/sj.ijo.0803567, PII 0803567
Mootha, V.K., Lindgren, C.M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Groop, L.C., PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes (2003) Nature Genetics, 34 (3), pp. 267-273. , DOI 10.1038/ng1180
Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M.A., Brownlee, M., Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage (2000) Nature, 404 (6779), pp. 787-790. , DOI 10.1038/35008121
Yamagishi, S.-I., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., Brownlee, M., Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A (2001) Journal of Biological Chemistry, 276 (27), pp. 25096-25100. , 2-s2.0-0035816639 10.1074/jbc.M007383200
Boss, O., Hagen, T., Lowell, B.B., Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism (2000) Diabetes, 49 (2), pp. 143-156
Krebs, M., Roden, M., Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature (2005) Diabetes, Obesity and Metabolism, 7 (6), pp. 621-632. , DOI 10.1111/j.1463-1326.2004.00439.x
Houstis, N., Rosen, E.D., Lander, E.S., Reactive oxygen species have a causal role in multiple forms of insulin resistance (2006) Nature, 440 (7086), pp. 944-948. , 2-s2.0-33645860825 10.1038/nature04634
Reaven, G.M., Chen, Y.-D.I., Insulin resistance, its consequences, and coronary heart disease: Must we choose one culprit (1996) Circulation, 93 (10), pp. 1780-1783
Kostis, J.B., Sanders, M., The association of heart failure with insulin resistance and the development of type 2 diabetes (2005) American Journal of Hypertension, 18 (5), pp. 731-737. , DOI 10.1016/j.amjhyper.2004.11.038, PII S0895706104011938
Boudina, S., Sena, S., O'Neill, B.T., Tathireddy, P., Young, M.E., Abel, E.D., Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity (2005) Circulation, 112 (17), pp. 2686-2695. , DOI 10.1161/CIRCULATIONAHA.105.554360
Szczepaniak, L.S., Dobbins, R.L., Metzger, G.J., Sartoni-D'Ambrosia, G., Arbique, D., Vongpatanasin, W., Unger, R., Victor, R.G., Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging (2003) Magnetic Resonance in Medicine, 49 (3), pp. 417-423. , DOI 10.1002/mrm.10372
Christoffersen, C., Bollano, E., Lindegaard, M.L.S., Bartels, E.D., Goetze, J.P., Andersen, C.B., Nielsen, L.B., Cardiac lipid accumulation associated with diastolic dysfunction in obese mice (2003) Endocrinology, 144 (8), pp. 3483-3490. , DOI 10.1210/en.2003-0242
Seyfried, T.N., Shelton, L.M., Cancer as a metabolic disease (2010) Nutrition and Metabolism, 77. , 2-s2.0-77649277719 10.1186/1743-7075-7-7
Kwong, J.Q., Henning, M.S., Starkov, A.A., Manfredi, G., The mitochondrial respiratory chain is a modulator of apoptosis (2007) Journal of Cell Biology, 179 (6), pp. 1163-1177. , http://www.jcb.org/cgi/reprint/179/6/1163, DOI 10.1083/jcb.200704059
Wu, Y.-T., Wu, S.-B., Lee, W.-Y., Wei, Y.-H., Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases (2010) Annals of the New York Academy of Sciences, 1201, pp. 147-156. , 2-s2.0-77955291455 10.1111/j.1749-6632.2010.05631.x
John, A.P., Dysfunctional mitochondria, not oxygen insufficiency, cause cancer cells to produce inordinate amounts of lactic acid: The impact of this on the treatment of cancer (2001) Medical Hypotheses, 57 (4), pp. 429-431. , DOI 10.1054/mehy.2001.1335
Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Rigoni, A., Vacchelli, E., Michaud, M., Kroemer, G., Mitochondrial gateways to cancer (2010) Molecular Aspects of Medicine, 31 (1), pp. 1-20. , 2-s2.0-77649338652 10.1016/j.mam.2009.08.002
Foster, C.S., Spoerri, P.E., Glees, P., Spoerri, O., The mode of mitochondrial degeneration in gliomas (1978) Acta Neurochirurgica, 43 (3-4), pp. 229-237
Rasmussen, A.K., Chatterjee, A., Rasmussen, L.J., Singh, K.K., Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae (2003) Nucleic Acids Research, 31 (14), pp. 3909-3917. , DOI 10.1093/nar/gkg446
Cuezva, J.M., Krajewska, M., De Heredia, M.L., Krajewski, S., Santamaria, G., Kim, H., Zapata, J.M., Reed, J.C., The bioenergetic signature of cancer: A marker of tumor progression (2002) Cancer Research, 62 (22), pp. 6674-6681
Pelicano, H., Lu, W., Zhou, Y., Zhang, W., Chen, Z., Hu, Y., Huang, P., Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism (2009) Cancer Research, 69 (6), pp. 2375-2383. , 2-s2.0-65549142759 10.1158/0008-5472.CAN-08-3359
Zhu, X., Peng, X., Guan, M.-X., Yan, Q., Pathogenic mutations of nuclear genes associated with mitochondrial disorders (2009) Acta Biochimica et Biophysica Sinica, 41 (3), pp. 179-187. , 2-s2.0-65249092667 10.1093/abbs/gmn021
Altenberg, B., Greulich, K.O., Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes (2004) Genomics, 84 (6), pp. 1014-1020. , DOI 10.1016/j.ygeno.2004.08.010, PII S0888754304002277
Warburg, O., On the origin of cancer cells (1956) Science, 123 (3191), pp. 309-314. , 2-s2.0-12444279265
Osthus, R.C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Dang, C.V., Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc (2000) Journal of Biological Chemistry, 275 (29), pp. 21797-21800. , DOI 10.1074/jbc.C000023200
Flier, J.S., Mueckler, M.M., Usher, P., Lodish, H.F., Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes (1987) Science, 235 (4795), pp. 1492-1495
Shim, H., Dolde, C., Lewis, B.C., Wu, C.-S., Dang, G., Jungmann, R.A., Dalla-Favera, R., Dang, C.V., C-Myc transactivation of LDH-A: Implications for tumor metabolism and growth (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (13), pp. 6658-6663. , DOI 10.1073/pnas.94.13.6658
Salem, A.F., Whitaker-Menezes, D., Lin, Z., Martinez-Outschoorn, U.E., Tanowitz, H.B., Al-Zoubi, M.S., Howell, A., Lisanti, M.P., Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells Cell Cycle, 11 (13), pp. 2545-2556
Balliet, R.M., Capparelli, C., Guido, C., Pestell, T.G., Martinez-Outschoorn, U.E., Lin, Z., Whitaker-Menezes, D., Lisanti, M.P., Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: Understanding the aging and cancer connection (2011) Cell Cycle, 10 (23), pp. 4065-4073. , 2-s2.0-82855170859 10.4161/cc.10.23.18254
Henze, A.-T., Acker, T., Feedback regulators of hypoxia-inducible factors and their role in cancer biology (2010) Cell Cycle, 9 (14), pp. 2749-2763. , 2-s2.0-77956805884 10.4161/cc.9.14.12249
Hockel, M., Vaupel, P., Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects (2001) Journal of the National Cancer Institute, 93 (4), pp. 266-276
Amelio, I., Melino, G., The "sharp" blade against HIF-mediated metastasis Cell Cycle, 11 (24), pp. 4530-4535
Briston, T., Yang, J., Ashcroft, M., HIF-1 α localization with mitochondria: A new role for an old favorite? (2011) Cell Cycle, 10 (23), pp. 4170-4171. , 2-s2.0-82855181978 10.4161/cc.10.23.18565
Bertozzi, D., Iurlaro, R., Sordet, O., Marinello, J., Zaffaroni, N., Capranico, G., Characterization of novel antisense HIF-1 α transcripts in human cancers (2011) Cell Cycle, 10 (18), pp. 3189-3197. , 2-s2.0-80052885284 10.4161/cc.10.18.17183
Rapisarda, A., Shoemaker, R.H., Melillo, G., Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads (2009) Cell Cycle, 8 (24), pp. 4040-4043. , 2-s2.0-74849127957
Maxwell, P.H., HIF-1's relationship to oxygen: Simple yet sophisticated (2004) Cell Cycle, 3 (2), pp. 156-159
Ma, J., Zhang, Q., Chen, S., Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1alpha accumulation via increased production of reactive oxygen species (2013) PLoS ONE, 8 (7). , e69485
Compton, S., Kim, C., Griner, N.B., Potluri, P., Scheffler, I.E., Sen, S., Jerry, D.J., Yadava, N., Mitochondrial dysfunction impairs tumor suppressor p53 expression/function (2011) Journal of Biological Chemistry, 286 (23), pp. 20297-20312. , 2-s2.0-79957994581 10.1074/jbc.M110.163063
Schwartzenberg-Bar-Yoseph, F., Armoni, M., Karnieli, E., The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression (2004) Cancer Research, 64 (7), pp. 2627-2633. , DOI 10.1158/0008-5472.CAN-03-0846
Szatrowski, T.P., Nathan, C.F., Production of large amounts of hydrogen peroxide by human tumor cells (1991) Cancer Research, 51 (3), pp. 794-798. , 2-s2.0-0026021362
Moreno-Sanchez, R., Rodriguez-Enriquez, S., Marin-Hernandez, A., Saavedra, E., Energy metabolism in tumor cells (2007) FEBS Journal, 274 (6), pp. 1393-1418. , DOI 10.1111/j.1742-4658.2007.05686.x
Pelicano, H., Martin, D.S., Xu, R.-H., Huang, P., Glycolysis inhibition for anticancer treatment (2006) Oncogene, 25 (34), pp. 4633-4646. , DOI 10.1038/sj.onc.1209597, PII 1209597
Bauer, G., Tumor cell-protective catalase as a novel target for rational therapeutic approaches based on specific intercellular ROS signaling Anticancer Research, 32 (7), pp. 2599-2624
Ishikawa, K., Takenaga, K., Akimoto, M., Koshikawa, N., Yamaguchi, A., Imanishi, H., Nakada, K., Hayashi, J.-I., ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis (2008) Science, 320 (5876), pp. 661-664. , DOI 10.1126/science.1156906
Carew, J.S., Zhou, Y., Albitar, M., Carew, J.D., Keating, M.J., Huang, P., Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: Clinical significance and therapeutic implications (2003) Leukemia, 17 (8), pp. 1437-1447. , DOI 10.1038/sj.leu.2403043
Indo, H.P., Davidson, M., Yen, H.-C., Suenaga, S., Tomita, K., Nishii, T., Higuchi, M., Majima, H.J., Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage (2007) Mitochondrion, 7 (1-2), pp. 106-118. , DOI 10.1016/j.mito.2006.11.026, PII S1567724906002248, Mitochondria and Life
Tan, D.-J., Bai, R.-K., Wong, L.-J.C., Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer (2002) Cancer Research, 62 (4), pp. 972-976
Polyak, K., Li, Y., Zhu, H., Lengauer, C., Willson, J.K.V., Markowitz, S.D., Trush, M.A., Vogelstein, B., Somatic mutations of the mitochondrial genome in human colorectal tumours (1998) Nature Genetics, 20 (3), pp. 291-293. , DOI 10.1038/3108
Liu, V.W.S., Hong Hui Shi, Cheung, A.N.Y., Pui Man Chiu, Tsin Wah Leung, Nagley, P., Ling Wong Wong, Ngan, H.Y.S., High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas (2001) Cancer Research, 61 (16), pp. 5998-6001
Sanchez-Cespedes, M., Parrella, P., Nomoto, S., Cohen, D., Xiao, Y., Esteller, M., Jeronimo, C., Sidransky, D., Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors (2001) Cancer Research, 61 (19), pp. 7015-7019
Fliss, M.S., Usadel, H., Caballero, O.L., Wu, L., Buta, M.R., Eleff, S.M., Jen, J., Sidransky, D., Facile detection of mitochondrial DNA mutations in tumors and bodily fluids (2000) Science, 287 (5460), pp. 2017-2019. , DOI 10.1126/science.287.5460.2017
Reed, J.C., Molecular biology of chronic lymphocytic leukemia (1998) Seminars in Oncology, 25 (1), pp. 11-18
Sharief, M.K., Douglas, M., Noori, M., Semra, Y.K., The expression of pro- and anti-apoptosis Bcl-2 family proteins in lymphocytes from patients with multiple sclerosis (2002) Journal of Neuroimmunology, 125 (1-2), pp. 155-162. , DOI 10.1016/S0165-5728(02)00024-3, PII S0165572802000243
Heiser, D., Labi, V., Erlacher, M., Villunger, A., The Bcl-2 protein family and its role in the development of neoplastic disease (2004) Experimental Gerontology, 39 (8), pp. 1125-1135. , DOI 10.1016/j.exger.2004.04.011, PII S0531556504001822
Takeuchi, O., Fisher, J., Suh, H., Harada, H., Malynn, B.A., Korsmeyer, S.J., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (32), pp. 11272-11277. , DOI 10.1073/pnas.0504783102
Traver, D., Akashi, K., Weissman, I.L., Lagasse, E., Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia (1998) Immunity, 9 (1), pp. 47-57. , DOI 10.1016/S1074-7613(00)80587-7
Schumacher, B., Hofmann, K., Boulton, S., Gartner, A., The C. Elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis (2001) Current Biology, 11 (21), pp. 1722-1727. , DOI 10.1016/S0960-9822(01)00534-6
Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Sinclair, D.A., Resveratrol improves health and survival of mice on a high-calorie diet (2006) Nature, 444 (7117), pp. 337-342. , DOI 10.1038/nature05354, PII NATURE05354
Pearson, K.J., Baur, J.A., Lewis, K.N., Peshkin, L., Price, N.L., Labinskyy, N., Swindell, W.R., De Cabo, R., Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span (2008) Cell Metabolism, 8 (2), pp. 157-168. , 2-s2.0-48349144852 10.1016/j.cmet.2008.06.011
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Auwerx, J., Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α (2006) Cell, 127 (6), pp. 1109-1122. , DOI 10.1016/j.cell.2006.11.013, PII S0092867406014280
Milne, J.C., Lambert, P.D., Schenk, S., Carney, D.P., Smith, J.J., Gagne, D.J., Jin, L., Westphal, C.H., Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes (2007) Nature, 450 (7170), pp. 712-716. , DOI 10.1038/nature06261, PII NATURE06261
Winder, W.W., Holmes, B.F., Rubink, D.S., Jensen, E.B., Chen, M., Holloszy, J.O., Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle (2000) Journal of Applied Physiology, 88 (6), pp. 2219-2226
Fujii, N., Jessen, N., Goodyear, L.J., AMP-activated protein kinase and the regulation of glucose transport (2006) The American Journal of Physiology, 291 (5), pp. E867-E877. , 2-s2.0-33751195101 10.1152/ajpendo.00207.2006
Ruderman, N.B., Saha, A.K., Kraegen, E.W., Minireview: Malonyl CoA, AMP-activated protein kinase, and adiposity (2003) Endocrinology, 144 (12), pp. 5166-5171. , DOI 10.1210/en.2003-0849
Mayers, R.M., Leighton, B., Kilgour, E., PDH kinase inhibitors: A novel therapy for Type II diabetes? (2005) Biochemical Society Transactions, 33 (2), pp. 367-370. , DOI 10.1042/BST0330367
Fink, B.D., O'Malley, Y., Dake, B.L., Ross, N.C., Prisinzano, T.E., Sivitz, W.I., Mitochondrial targeted coenzyme Q, superoxide, and fuel selectivity in endothelial cells (2009) PLoS ONE, 4 (1). , 2-s2.0-64149103303 10.1371/journal.pone.0004250 e4250
Yorek, M.A., The role of oxidative stress in diabetic vascular and neural disease (2003) Free Radical Research, 37 (5), pp. 471-480. , DOI 10.1080/1071576031000083161
Maguire, J.J., Wilson, D.S., Packer, L., Mitochondrial electron transport-linked tocopheroxyl radical reduction (1989) Journal of Biological Chemistry, 264 (36), pp. 21462-21465
Yi, X., Maeda, N., α-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet (2006) Diabetes, 55 (8), pp. 2238-2244. , http://diabetes.diabetesjournals.org/cgi/content/full/55/8/2238, DOI 10.2337/db06-0251
Mehta, K., Van Thiel, D.H., Shah, N., Mobarhan, S., Nonalcoholic fatty liver disease: Pathogenesis and the role of antioxidants (2002) Nutrition Reviews, 60 (9), pp. 289-293. , DOI 10.1301/002966402320387224
Li, M., Peterson, S., Husney, D., Inaba, M., Guo, K., Eri, T., Morita, T., Abraham, N.G., Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: Possible role of carbon monoxide and bilirubin (2007) Antioxidants and Redox Signaling, 9 (7), pp. 855-863. , DOI 10.1089/ars.2007.1568
Kelso, G.F., Porteous, C.M., Coulter, C.V., Hughes, G., Porteous, W.K., Ledgerwood, E.C., Smith, R.A.J., Murphy, M.P., Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties (2001) Journal of Biological Chemistry, 276 (7), pp. 4588-4596. , 2-s2.0-0035895888 10.1074/jbc.M009093200
Adlam, V.J., Harrison, J.C., Porteous, C.M., James, A.M., Smith, R.A.J., Murphy, M.P., Sammut, I.A., Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury (2005) FASEB Journal, 19 (9), pp. 1088-1095. , DOI 10.1096/fj.05-3718com
Jauslin, M.L., Meier, T., Smith, R.A., Murphy, M.P., Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants (2003) The FASEB Journal, 17 (13), pp. 1972-1974
Saretzki, G., Murphy, M.P., Von Zglinicki, T., MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress (2003) Aging Cell, 2 (2), pp. 141-143. , 2-s2.0-0041419866
Dhanasekaran, A., Kotamraju, S., Kalivendi, S.V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., Kalyanaraman, B., Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis (2004) Journal of Biological Chemistry, 279 (36), pp. 37575-37587. , DOI 10.1074/jbc.M404003200
Schafer, M., Schafer, C., Ewald, N., Piper, H.M., Noll, T., Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia (2003) Circulation Research, 92 (9), pp. 1010-1015. , DOI 10.1161/01.RES.0000070882.81508.FC
Knowler, W.C., Barrett-Connor, E., Fowler, S.E., Hamman, R.F., Lachin, J.M., Walker, E.A., Nathan, D.M., Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin (2002) New England Journal of Medicine, 346 (6), pp. 393-403. , DOI 10.1056/NEJMoa012512
Henriksen, E.J., Invited review: Effects of acute exercise and exercise training on insulin resistance (2002) Journal of Applied Physiology, 93 (2), pp. 788-796
Reznick, R.M., Shulman, G.I., The role of AMP-activated protein kinase in mitochondrial biogenesis (2006) Journal of Physiology, 574 (1), pp. 33-39. , DOI 10.1113/jphysiol.2006.109512
Röckl, K.S.C., Witczak, C.A., Goodyear, L.J., Signaling mechanisms in skeletal muscle: Acute responses and chronic adaptations to exercise (2008) IUBMB Life, 60 (3), pp. 145-153. , 2-s2.0-44049092767 10.1002/iub.21
Fulda, S., Exploiting mitochondrial apoptosis for the treatment of cancer (2010) Mitochondrion, 10 (6), pp. 598-603. , 2-s2.0-78149359030 10.1016/j.mito.2010.05.001
Hagland, H., Nikolaisen, J., Hodneland, L.I., Gjertsen, B.T., Bruserud, O., Tronstad, K.J., Targeting mitochondria in the treatment of human cancer: A coordinated attack against cancer cell energy metabolism and signalling (2007) Expert Opinion on Therapeutic Targets, 11 (8), pp. 1055-1069. , DOI 10.1517/14728222.11.8.1055
Bonnet, S., Archer, S.L., Allalunis-Turner, J., Haromy, A., Beaulieu, C., Thompson, R., Lee, C.T., Michelakis, E.D., A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth (2007) Cancer Cell, 11 (1), pp. 37-51. , DOI 10.1016/j.ccr.2006.10.020, PII S1535610806003722
Schulz, T.J., Thierbach, R., Voigt, A., Drewes, G., Mietzner, B., Steinberg, P., Pfeiffer, A.F.H., Ristow, M., Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited (2006) Journal of Biological Chemistry, 281 (2), pp. 977-981. , 2-s2.0-33644868755 10.1074/jbc.M511064200
Holinger, E.P., Chittenden, T., Lutz, R.J., Bak BH3 peptides antagonize Bcl-x(L) function and induce apoptosis through cytochrome c-independent activation of caspases (1999) Journal of Biological Chemistry, 274 (19), pp. 13298-13304. , DOI 10.1074/jbc.274.19.13298
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting. © 2014 Daniela Sorriento et al.
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Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
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Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G
* Clinical proof of concept for a safe and effective NF-kappaB-targeting strategy in multiple myeloma (135 visite)
Br J Haematol (ISSN: 1365-2141electronic, 0007-1048linking), 2018 Sep 26; N/D: N/D-N/D.
Impact Factor: 4.498
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Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L
* RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer (106 visite)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jun 15; 24(12): 2886-2900.
Impact Factor: 6.488
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (145 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D
* A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage (160 visite) (PDF 79 visite)
Bba-Gen Subjects (ISSN: 0005-2736print, 0005-2736linking), 2018 Mar 17; N/D: 1793-1902.
Impact Factor: 4.647
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Farina B, Sturlese M, Mascanzoni F, Caporale A, Monti A, Sorbo GD, Fattorusso R, Ruvo M, Doti N
* Binding mode of AIF(370–394) peptide to CypA: insights from NMR, label-free and molecular docking studies (172 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2018; 475(14): 2377-2393.
Impact Factor: 4.897
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (183 visite)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Doti N, Ruvo M
* Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death (258 visite)
Neural Regen Res (ISSN: 1673-5374), 2017 Sep; 12(9): 1428-1429.
Impact Factor: 2.234
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Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (196 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Aug 02; 1861(11PtA): 2843-2851.
Impact Factor: 4.28
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Farina B, Di Sorbo G, Chambery A, Caporale A, Leoni G, Russo R, Mascanzoni F, Raimondo D, Fattorusso R, Ruvo M, Doti N
* Structural and biochemical insights of CypA and AIF interaction (247 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Apr 25; 7(1): 1138-1138.
Impact Factor: 4.122
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Milardi D
Associazione di derivati di Resveratrolo per la prevenzione e il trattamento di malattie da disordine conformazionale proteico (241 visite)
Italian Patent - Brevetto Italiano, 2016 Jul; N/D: 102016000073131-102016000073131.
Impact Factor: 0
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (490 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (362 visite)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (140 visite)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
* New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (250 visite)
Br J Cancer (ISSN: 0007-0920, 0007-0920print), 2015 Jan 6; 112(1): 77-85.
Impact Factor: 5.569
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (160 visite)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (271 visite)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (277 visite)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Lolicato F, Raudino A, Milardi D, La Rosa C
* Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (364 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 92: 876-881.
Impact Factor: 3.902
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (271 visite)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (354 visite)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R
* Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant (257 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 30-36.
Impact Factor: 3.444
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De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (207 visite)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
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Hayafune M, Berisio R, Marchetti R, Silipo A, Kayama M, Desaki Y, Arima S, Squeglia F, Ruggiero A, Tokuyasu K, Molinaro A, Kaku H, Shibuya N
* Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization (313 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Jan 21; 111(3): E404-E404.
Impact Factor: 9.674
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (362 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (352 visite)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Russo E, Guerra A, Marotta V, Faggiano A, Colao A, Del Vecchio S, Tonacchera M, Vitale M
* Radioiodide induces apoptosis in human thyroid tissue in culture (245 visite)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2013 Dec; 44(3): 729-734.
Impact Factor: 3.527
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Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
* RedOx status, proteasome and APEH: Insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells (265 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013 Nov 19; 8(11): N/D-N/D.
Impact Factor: 3.534
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Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (275 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
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Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (271 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (333 visite)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (218 visite)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (295 visite)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (312 visite)
Exp Physiol Experimental Physiology (ISSN: 1469-445x, 0958-0670), 2013 Mar; 98(3): 645-651.
Impact Factor: 2.871
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (349 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (265 visite)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (264 visite)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
* Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (201 visite)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
Impact Factor: 2.689
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Costa B, Bendinelli S, Gabelloni P, Da Pozzo E, Daniele S, Scatena F, Vanacore R, Campiglia P, Bertamino A, Gomez-Monterrey I, Sorriento D, Del Giudice C, Iaccarino G, Novellino E, Martini C
* Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor (210 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013; 8(8): e72281-e72281.
Impact Factor: 3.534
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (260 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (354 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (364 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Sciacca MF, Chillemi R, Sciuto S, Pappalardo M, La Rosa C, Grasso D, Milardi D
* Interactions of two O-phosphorylresveratrol derivatives with model membranes (199 visite)
Arch Biochem Biophys (ISSN: 1096-0384, 0003-3986), 2012 May; 521(1-2): 111-116.
Impact Factor: 0
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Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
* Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (328 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
Impact Factor: 5.614
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (447 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (337 visite)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Langlois C, Del Gatto A, Arseneault G, Lafrance-vanasse J, De Simone M, Morse T, De Paola I, Lussier-price M, Legault P, Pedone C, Zaccaro L, Omichinski JG
* Structure-based design of a potent artificial transactivation domain based on p53 (286 visite)
J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), 2012 Jan 25; 134(3): 1715-1723.
Impact Factor: 5.65
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (418 visite)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (295 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Gargiulo S, Greco A, Gramanzini M, Petretta MP, Ferro A, Larobina M, Panico M, Brunetti A, Cuocolo A
* PET/CT imaging in mouse models of myocardial ischemia (446 visite)
J Biomed Biotechnol (ISSN: 1110-7251, 1110-7243), 2012; 2012: 541872-541872.
Impact Factor: 2.88
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (377 visite)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (327 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (295 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (387 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (222 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (369 visite)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (318 visite)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (285 visite)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (321 visite)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (443 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (258 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (295 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (239 visite)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (251 visite)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (243 visite)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (214 visite)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (216 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (302 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (233 visite)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (249 visite)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (502 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Palumbo R, Brescia F, Capasso D, Sannino A, Sarti M, Capri M, Grassilli E, Scarfì MR
* Exposure to 900 MHz radiofrequency radiation induces caspase 3 activation in proliferating human lymphocytes (217 visite)
Radiat Res (ISSN: 0033-7587), 2008 Sep; 170(3): 327-334.
Impact Factor: 3.043
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (293 visite)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (346 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (227 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (189 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (270 visite)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (256 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (247 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (276 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (229 visite)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (476 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (239 visite)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (253 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (253 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (283 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (262 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (265 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (287 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
Dettagli Esporta in BibTeX Esporta in EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (293 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (176 visite)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (345 visite)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (209 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (297 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M
* Functional imaging of multidrug resistance in breast cancer (276 visite)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2006; 21(SUPPL.1): 24-27.
Impact Factor: 0.313
Dettagli Esporta in BibTeX Esporta in EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (283 visite)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
* Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (272 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
Impact Factor: 5.854
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (401 visite)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (293 visite)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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Pace L, Del Vecchio S, Salvatore M
* Technetium 99m sestamibi in multiple myeloma (155 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005 Jan; 234(1): 312-313.
Impact Factor: 5.377
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (277 visite)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (223 visite)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (231 visite)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (596 visite)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
Dettagli Esporta in BibTeX Esporta in EndNote
Pace L, Del Vecchio S, Salvatore M, Walker RC, Angtuaco E, Sethi R, Fassas A, Barlogie B
* Technetium 99m sestamibi in multiple myeloma [3] (multiple letters) (225 visite)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 2005; 234(1): 312-313.
Impact Factor: 5.377
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (296 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Salvatore B, Paone G, Fonti R, Iommelli F, De Renzo A, Rotoli B, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing non-Hodgkin's lymphoma patients during drug-induced apoptosis (234 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
Dettagli Esporta in BibTeX Esporta in EndNote
Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (223 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (372 visite)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (349 visite) (PDF 145 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
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Aloj L, Zannetti A, Caracó C, Del Vecchio S, Salvatore M
* Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (389 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004; 31(4): 521-527.
Impact Factor: 3.935
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (281 visite)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (219 visite)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Impact Factor: 5.873
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (366 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (302 visite)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (260 visite)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (311 visite)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (314 visite)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (234 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (236 visite)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
Dettagli Esporta in BibTeX Esporta in EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (367 visite)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Ciarmiello A, Zannetti A, Fonti R, Botti G, D'Aiuto G, Salvatore M
Efflux rate of Tc-99m-MIBI and apoptosis in untreated breast cancer patients (235 visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2000 May; 41(5): N/D-N/D.
Impact Factor: 3.617
Dettagli Esporta in BibTeX Esporta in EndNote
Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (250 visite)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (240 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
Dettagli Esporta in BibTeX Esporta in EndNote
Russo GL, Della Pietra V, Mercurio C, Palumbo R, Iacomino G, Russo M, Tosto M, Zappia V
Protective effects of butyric acid in colon cancer (162 visite)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1999; 472: 131-147.
Impact Factor: 0.446
Dettagli Esporta in BibTeX Esporta in EndNote
Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (220 visite)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
Dettagli Esporta in BibTeX Esporta in EndNote
Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (313 visite)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
Dettagli Esporta in BibTeX Esporta in EndNote
Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (331 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
Dettagli Esporta in BibTeX Esporta in EndNote
Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (273 visite)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
Dettagli Esporta in BibTeX Esporta in EndNote
Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (283 visite)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
Dettagli Esporta in BibTeX Esporta in EndNote
Morisco C, Nappi A, Argenziano L, Sarno D, Fonatana D, Imbriaco M, Nicolai E, Romano M, Rosiello G, Cuocolo A
Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: Effects of short-term Coenzyme Q10 treatment (218 visite)
Molecular Aspects Of Medicine (ISSN: 0098-2997, 1872-9452), 1994; 15(SUPPL.1): s155-s155.
Impact Factor: 2
Dettagli Esporta in BibTeX Esporta in EndNote
134 Records (118 escludendo Abstract e Conferenze).
Impact factor totale: 628.413 (565.818 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 648.54 (569.915 escludendo Abstract e Conferenze).
Impact factor totale: 628.413 (565.818 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 648.54 (569.915 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Sunday 12 July 2020, 13:14:52
358 visite. Ultima visita in data Monday 27 July 2020, 15:23:28
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