Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization(223 views visite) Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
Keywords Parole chiave: G Protein Coupled Receptor Kinases, Cell Metabolism, Energy, Mitochondria,
Affiliations Affiliazioni: *** IBB - CNR ***
1Department of Advanced Biomedical Science, Federico II University, Naples, Italy; 2Department of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy; 3Columbia University Medical Center, College of Physicians & Surgeons, New York Presbyterian Hospital - Manhattan New York, NY, USA; 4Department of Traslational Medical Science, Federico II University of Naples, Naples, Italy; 5Department of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy; ; IRCCS Multimedica, Milano, Italy.
References Riferimenti: Not available. Non disponibili.
Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization
G protein coupled receptor kinase 2 (GRK2) has a key role in cellular function by regulating different intracellular mechanisms in a kinase dependent or independent manner. In this review we have dealt with the recently discovered roles of GRK2 in the regulation of cell metabolism. In particular, we have focused on recent findings about the mitochondrial role of GRK2 in the regulation of energy metabolism. Few findings exist about this topic that all concur to identify a mitochondrial localization of GRK2, leading to the rising of the following question: is GRK2 detrimental or advantageous for mitochondrial function? By the review of available literature, a new concept arises about GRK2 role into the cell,which is that of a stress protein acutely activated by cellular stress whose specific subcellular localization, in particular mitochondrial localization, results in compensatory metabolic responses. Thus, the possibility to regulate GRK2 trafficking within the cell is a promising strategy to regulate the adaptative effects of the kinase on cell metabolism.
Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization
Chattopadhyay A, Cogdell R, Crespo-hernandez CE, Datta A, De A, Haacke S, Hariharan M, Helliwell J, Hughes A, Improta R, Jones M, Joseph J, Karsili T, Kohler B, Krishnan R, Kuriakose A, L , M , Markovitsi D, Medhi H, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schertler GFX, Schlichting I, Segarra-marti J, Swaminathan R, V , V , Van Grondelle R, Venkatraman RK, Venkatramani R, Watts A * Light induced charge and energy transport in nucleic acids and proteins: general discussion(121 visite) Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 153-180. Impact Factor:4.194 DettagliEsporta in BibTeXEsporta in EndNote
Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G * Adrenergic Receptors(212 visite) Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote
147 Records (140 escludendo Abstract e Conferenze). Impact factor totale: 646.721 (625.103 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 680.953 (657.658 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:14:51 223 views visite. Last view on Ultima visita in data Monday 29 March 2021, 5:54:26