To NFkappaB or not to NFkappaB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator(203 views visite) Sorriento D, Illario M, Finelli R, Iaccarino G
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2012 Oct 11; 4: 73-85.
Keywords Parole chiave: Grk5, Ikappab, Cancer, Transcription Factors,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunological Science, Federico II University of Naples, Italy.
References Riferimenti: Not available. Non disponibili.
To NFkappaB or not to NFkappaB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator
Nuclear factor kappaB (NFkappaB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFkappaB is constitutively expressed in tumours where it induces the expression of genes which promote cell proliferation, apoptotic events, angiogenesis, invasion and metastasis. Furthermore, many cancer cells show aberrant or constitutive NFkappaB activation that mediates resistance to chemo- and radio-therapy. Therefore, the inhibition of NFkappaB activity appears a potential therapeutic strategy for cancer treatment. In this review, we focus on the role of NFkappaB in carcinogenesis and summarize actual inhibitors of NFkappaB that could be potential therapeutic target in cancer therapy.
To NFkappaB or not to NFkappaB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(198 visite) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 DettagliEsporta in BibTeXEsporta in EndNote
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Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F * Results of clinical trials with SPEM(230 visite) Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50. Impact Factor:3.221 DettagliEsporta in BibTeXEsporta in EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(371 visite) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote
504 Records (440 escludendo Abstract e Conferenze). Impact factor totale: 1898.211 (1667.558 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 1832.082 (1574.343 escludendo Abstract e Conferenze).
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