To NFkappaB or not to NFkappaB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator(126 visite) Sorriento D, Illario M, Finelli R, Iaccarino G
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2012 Oct 11; 4: 73-85.
Tipo di articolo: Journal Article,
Impact factor: 2.256, Impact factor a 5 anni: 2.015
Url: Non disponibile.
Parole chiave: Grk5, Ikappab, Cancer, Transcription Factors,
*** IBB - CNR *** Department of Clinical Medicine, Cardiovascular and Immunological Science, Federico II University of Naples, Italy.
Nuclear factor kappaB (NFkappaB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFkappaB is constitutively expressed in tumours where it induces the expression of genes which promote cell proliferation, apoptotic events, angiogenesis, invasion and metastasis. Furthermore, many cancer cells show aberrant or constitutive NFkappaB activation that mediates resistance to chemo- and radio-therapy. Therefore, the inhibition of NFkappaB activity appears a potential therapeutic strategy for cancer treatment. In this review, we focus on the role of NFkappaB in carcinogenesis and summarize actual inhibitors of NFkappaB that could be potential therapeutic target in cancer therapy.
25 Records (24 escludendo Abstract e Conferenze). Impact factor totale: 114.495 (110.144 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 114.21 (109.827 escludendo Abstract e Conferenze).