Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis(129 visite) Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Tipo di articolo: Journal Article,
Impact factor: 0.56, Impact factor a 5 anni: 0
Url: Non disponibile.
Parole chiave: Metastasis, Angiogenesis, Mirna, Grks, Camks,
*** IBB - CNR *** Department of Medicine and Surgery, University of Salerno, Salerno, Italy Department of Clinical and Translational Medicine, Federico II University, Napoli, Italy IBB, CNR, Napoli, Italy IOS e Coleman, Napoli, Italy
Cancer is a multistep process encompassing the transformation of normal epithelial cells to thestromal invasion and metastasis, with these last considered the final stage of the disease. Tumorinvasiveness is based on creation of a specific peri-tumoral environment which on turn dependsupon epithelial-stromal interactions, degradation of extracellular matrix and reorganization of fibrillarcomponents. Even though several aspects of the stromal and cellular remodeling have beenelucidated and described, such as the epithelial-mesenchymal transition (EMT) and extracellularmatrix degradation, all the underlying molecular mechanism are far to be elucidated in their complexity.In this review we focused on new actors such as microRNAs, G protein coupled receptorkinases (GRKs) and Calcium/calmodulin-dependent protein kinase (CaMKs) known to be involvedin several important physiological processes like development, cell differentiation and cell signaling,and more recently linked to tumor progression and invasion.
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(170 visite) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 DettagliEsporta in BibTeXEsporta in EndNote
132 Records (121 escludendo Abstract e Conferenze). Impact factor totale: 473.172 (443.64 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 503.582 (470.494 escludendo Abstract e Conferenze).