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Bond distances in polypeptide backbones depend on the local conformation (71 visite)

Improta R, Vitagliano L, Esposito L

Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2015; 71: 1272-1283.

Tipo di articolo: Journal Article,

Impact factor: 2.51

Impact factor a 5 anni: 8.75

Parole chiave: Backbone Geometry, Bond Distances, Conformational Dependences, Peptide-Bond Resonance,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84931074135&partnerID=40&md5=475f4c2a85cbf45ef566e849526f6f38

By combining quantum-mechanical analysis of small model peptides and statistical surveys of high-resolution protein structures, a systematic conformational dependence of bond lengths in polypeptide backbones has been unveiled which involves both the peptide bond (C-O and C-N) and those bonds centred on the Cα atom. All of these bond lengths indeed display a systematic variability in the ψ angle according to both calculations and surveys of protein structures. The overall agreement between the computed and the statistical data suggests that these trends are essentially driven by local effects. The dependence of Cα distances on ψ is governed by interactions between the σ system of the Cα moiety and the C-O π system of the peptide bond. Maximum and minimum values for each bond distance are found for conformations with the specific bond perpendicular and parallel to the adjacent CONH peptide plane, respectively. On the other hand, the variability of the C-O and C-N distances is related to the strength of the interactions between the lone pair of the N atom and the C-O π∗ system, which is modulated by the ψ angle. The C-O and C-N distances are related but their trends are not strictly connected to peptide-bond planarity, although a correlation amongst all of these parameters is expected on the basis of the classical resonance model. © 2015 International Union of Crystallography.
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Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, Napoli, Italy
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Experimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (70 visite)
Esposito L, Vitagliano L, Zagari A, Mazzarella L
Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.
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1 Records (1 escludendo Abstract e Conferenze).
Impact factor totale: 2.442 (2.442 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 2.604 (2.604 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Backbone Geometry" OR [btitle] "Bond Distances" OR [btitle] "Conformational Dependences" OR [btitle] "Peptide-Bond Resonance" OR [btitle] "distances") AND NOT [id] = 52880)

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