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Bond distances in polypeptide backbones depend on the local conformation (60 views)

Improta R, Vitagliano L, Esposito L

Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2015; 71: 1272-1283.

By combining quantum-mechanical analysis of small model peptides and statistical surveys of high-resolution protein structures, a systematic conformational dependence of bond lengths in polypeptide backbones has been unveiled which involves both the peptide bond (C-O and C-N) and those bonds centred on the Cα atom. All of these bond lengths indeed display a systematic variability in the ψ angle according to both calculations and surveys of protein structures. The overall agreement between the computed and the statistical data suggests that these trends are essentially driven by local effects. The dependence of Cα distances on ψ is governed by interactions between the σ system of the Cα moiety and the C-O π system of the peptide bond. Maximum and minimum values for each bond distance are found for conformations with the specific bond perpendicular and parallel to the adjacent CONH peptide plane, respectively. On the other hand, the variability of the C-O and C-N distances is related to the strength of the interactions between the lone pair of the N atom and the C-O π∗ system, which is modulated by the ψ angle. The C-O and C-N distances are related but their trends are not strictly connected to peptide-bond planarity, although a correlation amongst all of these parameters is expected on the basis of the classical resonance model. © 2015 International Union of Crystallography.

Affiliations ▼
*** IBB - CNR Affiliation

Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, Napoli, Italy

Details ▼
Impact factor: 2.51, 5-year impact factor: 8.75

Paper type: Journal Article,

Keywords: Backbone Geometry, Bond Distances, Conformational Dependences, Peptide-Bond Resonance,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84931074135&partnerID=40&md5=475f4c2a85cbf45ef566e849526f6f38

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* Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity (4 views)
Balasco N, Esposito L, Thind AS, Guarracino MR, Vitagliano L
Biomed Res Int (ISSN: 2314-6141electronic), 2017; 2017: 2617629-2617629.
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* Interplay between peptide bond geometrical parameters in nonglobular structural contexts (64 views)
Esposito L, Balasco N, De Simone A, Berisio R, Vitagliano L
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: N/D-N/D.
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4 Records (3 excluding Abstracts and Conferences).
Total impact factor: 10.3 (6.208 excluding Abstracts and Conferences).
Total 5-year impact factor: 10.991 (6.454 excluding Abstracts and Conferences).

Your bibliography query: (([btitle, keywords, abstract] BACKBONE AND [btitle, keywords, abstract] GEOMETRY AND [btitle, keywords, abstract] BOND)) AND NOT [id] = 52880

Last modified by Luciana Esposito on Thursday 21 July 2016, 19:11:54
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