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Stabilization of mixed frenkel-charge transfer excitons extended across both strands of guanine-cytosine DNA duplexes (65 views)

Huix-Rotllant M, Brazard J, Improta R, Burghardt I, Markovitsi D

J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic), 2015; 6(12): 2247-2251.

Abstract
The photoreactive pathways that may lead to DNA damage depend crucially upon the nature of the excited electronic states. The study of alternating guanine-cytosine duplexes by fluorescence spectroscopy and quantum mechanical calculations identifies a novel type of excited states that can be populated following UVB excitation. These states, denoted High-energy Emitting Long-lived Mixed (HELM) states, extend across both strands and arise from mixing between cytosine Frenkel excitons and guanine-to-cytosine charge transfer states. They emit at energies higher than ππ∗ states localized on single bases, survive for several nanoseconds, are sensitive to the ionic strength of the solution, and are strongly affected by the structural transition from the B form to the Z form. Their impact on the formation of lesions of the genetic code needs to be assessed. © 2015 American Chemical Society.

Affiliations ▼
*** IBB - CNR Affiliation

CNRS, IRAMIS, LIDYL, Laboratoire Francis Perrin, URA 2453, Gif-sur-Yvette, France

Institut für Physikalische U. Theoretische Chemie, Goethe-Universität, Max-von-Laue-Strasse 7, Frankfurt am Main, Germany

Istituto Biostrutture e Bioimmagini- Consiglio Nazionale Delle Ricerche, Via Mezzocannone 16, Napoli, Italy

Details ▼
Impact factor: 8.539, 5-year impact factor: 7.803

Paper type: Journal Article,

Keywords: Cytosine, Dna, Excitons, Fluorescence Spectroscopy, Guanine, Quantum Chemistry, Charge Transfer, Ionic Strength, Positive Ions, Charge Transfer Excitons, Charge Transfer State, Excited Electronic State, Guanine Cytosines, Quantum-Mechanical Calculation, Structural Transitions, Quantum Theory,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84934918877&partnerID=40&md5=f40e68c492fb142121bb35f77f522a75

References ▼
Banyasz, A., Douki, T., Improta, R., Gustavsson, T., Onidas, D., Vayá, I., Perron, M., Markovitsi, D., Electronic Excited States Responsible for Dimer Formation Upon UV Absorption Directly by Thymine Strands: Joint Experimental and Theoretical Study (2012) J. Am. Chem. Soc., 134, pp. 14834-1484

Esposito, L., Banyasz, A., Douki, T., Perron, M., Markovitsi, D., Improta, R., Effect of C5-Methylation of Cytosine on the Photoreactivity of DNA: A Joint Experimental and Computational Study of TCG Trinucleotides (2014) J. Am. Chem. Soc., 136, pp. 10838-10841

Sobolewski, A.L., Domcke, W., Hattig, C., Tautomeric Selectivity of the Excited-State Lifetime of Guanine/Cytosine Base Pairs: The Role of Electron-Driven Proton-Transfer Processes (2005) Proc. Natl. Acad. Sci. U.S.A., 102, pp. 17903-17906

Schwalb, N.K., Temps, F., Base Sequence and Higher-Order Structure Induce the Complex Excited-State Dynamics in DNA (2008) Science, 322, pp. 243-245

Kwok, W.M., Ma, C.S., Phillips, D.L., "Bright" and "dark" Excited States of an Alternating at Oligomer Characterized by Femtosecond Broadband Spectroscopy (2009) J. Phys. Chem. B, 113, pp. 11527-11534

Markovitsi, D., Gustavsson, T., Vayá, I., Fluorescence of DNA Duplexes: From Model Helices to Natural DNA (2010) J. Phys. Chem. Lett., 1, pp. 3271-3276

Kohler, B., Nonradiative Decay Mechanisms in DNA Model Systems (2010) J. Phys. Chem. Lett., 1, pp. 2047-2053

Plasser, F., Aquino, A., Lischka, H., Nachtigallová, D., Electronic Excitation Processes in Single-Strand and Double-Strand DNA: A Computational Approach (2015) Top. Curr. Chem., 356, pp. 1-38

Bucher, D.B., Schlueter, A., Carell, T., Zinth, W., Watson-Crick Base Pairing Controls Excited-State Decay in Natural DNA (2014) Angew. Chem., Int. Ed., 53, pp. 11366-11369

Fiebig, T., Exciting DNA (2009) J. Phys. Chem. B, 113, pp. 9348-9349

Santoro, F., Barone, V., Improta, R., Excited States Decay of the A-T DNA: A PCM/TD-DFT Study in Aqueous Solution of the (9-Methyl-Adenine)2·(1-Methyl-Thymine)2 Stacked Tetramer (2009) J. Am. Chem. Soc., 131, pp. 15232-15245

Olaso-Gonzalez, G., Merchan, M., Serrano-Andres, L., The Role of Adenine Excimers in the Photophysics of Oligonucleotides (2009) J. Am. Chem. Soc., 131, pp. 4368-4377

Conti, I., Altoe, P., Stenta, M., Garavelli, M., Orlandi, G., Adenine Deactivation in DNA Resolved at the CASPT2//CASSCF/AMBER Level (2010) Phys. Chem. Chem. Phys., 12, pp. 5016-5023

Improta, R., Barone, V., Interplay between "neutral" and "charge-Transfer" Excimers Rules the Excited State Decay in Adenine-Rich Polynucleotides (2012) Angew. Chem., Int. Ed., pp. 12016-12019

Lu, Y., Lan, Z., Thiel, W., Hydrogen Bonding Regulates the Monomeric Nonradiative Decay of Adenine in DNA Strands (2011) Angew. Chem., Int. Ed., 50, pp. 6864-6867

Brazard, J., Thazhathveetil, A., Vayá, I., Lewis, F., Gustavsson, T., Markovitsi, D., Electronic Excited States of Guanine-Cytosine Hairpins and Duplexes Studied by Fluorescence Spectroscopy (2013) Photochem. Photobiol. Sci., 12, pp. 1453-1459

Vayá, I., Miannay, F.A., Gustavsson, T., Markovitsi, D., High Energy Long-Lived Excited States in DNA Double Strands (2010) ChemPhysChem, 11, pp. 987-989

Segers-Nolten, G.M.J., Sijtsema, N.M., Otto, C., Evidence for Hoogsteen GC Base Pairs in the Proton-Induced Transition from Right-Handed to Left-Handed Poly(dG-dC)·Poly(dG-dC) (1997) Biochemistry, 36, pp. 13241-13247

Onidas, D., Markovitsi, D., Marguet, S., Sharonov, A., Gustavsson, T., Fluorescence Properties of DNA Nucleosides and Nucleotides: A Refined Steady-State and Femtosecond Investigation (2002) J. Phys. Chem. B, 106, pp. 11367-11374

Miannay, F.A., Banyasz, A., Gustavsson, T., Markovitsi, D., Ultrafast Excited State Deactivation and Energy Transfer in Guanine-Cytosine DNA Double Helices (2007) J. Am. Chem. Soc., 129, pp. 14574-14575

Changenet-Barret, P., Hua, Y., Markovitsi, D., Electronic Excitations in Guanine Quadruplexes (2015) Top. Curr. Chem., 356, pp. 183-202

Zhao, Y., Truhlar, D.G., Density Functionals with Broad Applicability in Chemistry (2008) Acc. Chem. Res., 41, pp. 157-167

Tomasi, J., Mennucci, B., Cammi, R., Quantum Mechanical Continuum Solvation Models (2005) Chem. Rev., 105, pp. 2999-3093

Frisch, M.J., Trucks, G.W., Schlegel, H.B., Scuseria, G.E., Robb, M.A., Cheeseman, J.R., Scalmani, G., Fox, D.J., (2009) Gaussian 09, , revision A.02

Gaussian Inc. Wallingford, CT

(2012), http://www.turbomole.com, Turbomole. University of Karlsruhe and Forschungszentrum Karlsruhe GmbH, versionLu, X.J., Olson, W.K., (2003) Nucleic Acids Res., 31, pp. 5108-5121

Emanuele, E., Zakrzewska, K., Markovitsi, D., Lavery, R., Millie, P., Exciton States of Dynamic DNA Double Helices: Alternating dCdG Sequences (2005) J. Phys. Chem. B, 109, pp. 16109-16118

Schirmer, J., Beyond the Random-Phase Approximation - A New Approximation Scheme for the Polarization Propagator (1982) Phys. Rev. A, 26, pp. 2395-2416

Hättig, C., (2005) Adv. Quantum Chem., 50, pp. 37-60

Plasser, F., Lischka, H., Analysis of Excitonic and Charge Transfer Interactions from Quantum Chemical Calculations (2012) J. Chem. Theory Comput., 8, pp. 2777-2789

Bouvier, B., Gustavsson, T., Markovitsi, D., Millié, P., Dipolar Coupling between Electronic Transitions of the DNA Bases and Its Relevance to Exciton States in Double Helices (2002) Chem. Phys., 275, pp. 75-92

Bouvier, B., Dognon, J.P., Lavery, R., Markovitsi, D., Millié, P., Onidas, D., Zakrzewska, K., Influence of Conformational Dynamics on the Exciton States of DNA Oligomers (2003) J. Phys. Chem. B, 107, pp. 13512-13522

Bittner, E.R., Frenkel Exciton Model of Ultrafast Excited State Dynamics in at DNA Double Helices (2007) J. Photochem. Photobiol. A: Chem., 190, pp. 328-334

Burin, A.L., Dickman, J.A., Uskov, D.B., Hebbard, C.F.F., Schatz, G.C., Optical Absorption Spectra and Monomer Interaction in Polymers: Investigation of Exciton Coupling in DNA Hairpins (2008) J. Chem. Phys., 129, p. 091102

Starikov, E.B., Cuniberti, G., Tanaka, S., Conformation Dependence of DNA Exciton Parentage (2009) J. Phys. Chem. B, 113, pp. 10428-10435

Voityuk, A.A., Effects of Dynamic Disorder on Exciton Delocalization and Photoinduced Charge Separation in DNA (2013) Photochem. Photobiol. Sci., 12, pp. 1303-1309

Spata, V.A., Matsika, S., Bonded Excimer Formation in π-Stacked 9-Methyladenine Dimers (2013) J. Phys. Chem. A, 117, pp. 8718-8728

Vayá, I., Gustavsson, T., Douki, T., Berlin, Y., Markovitsi, D., Electronic Excitation Energy Transfer between Nucleobases of Natural DNA (2012) J. Am. Chem. Soc., 134, pp. 11366-11368

Scholes, G.D., Rumbles, G., Excitons in Nanoscale Systems (Vol 5, Pg 683, 2006) (2006) Nat. Mater., 5, pp. 920-920

Romero, E., Augulis, R., Novoderezhkin, V.I., Ferretti, M., Thieme, J., Zigmantas, D., Van Grondelle, R., Quantum Coherence in Photosynthesis for Efficient Solar-Energy Conversion (2014) Nat. Phys., 10, pp. 677-683

Wahadoszamen, M., Margalit, I., Ara, A.M., Van Grondelle, R., Noy, D., The Role of Charge-Transfer States in Energy Transfer and Dissipation within Natural and Artificial Bacteriochlorophyll Proteins (2014) Nat. Commun., 5, p. 5287

Reid, O.G., Pensack, R.D., Song, Y., Scholes, G.D., Rumbles, G., Charge Photogeneration in Neat Conjugated Polymers (2014) Chem. Mater., 26, pp. 561-575


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16 Records (14 excluding Abstracts and Conferences).
Total impact factor: 53.61 (47.197 excluding Abstracts and Conferences).
Total 5-year impact factor: 58.957 (52.772 excluding Abstracts and Conferences).



Your bibliography query: (([btitle, keywords, abstract] CYTOSINE)) AND NOT [id] = 52891



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