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Stabilization of mixed frenkel-charge transfer excitons extended across both strands of guanine-cytosine DNA duplexes (78 visite)

Huix-Rotllant M, Brazard J, Improta R, Burghardt I, Markovitsi D

J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic), 2015; 6(12): 2247-2251.

Tipo di articolo: Journal Article,

Impact factor: 8.539

Impact factor a 5 anni: 7.803

Parole chiave: Cytosine, Dna, Excitons, Fluorescence Spectroscopy, Guanine, Quantum Chemistry, Charge Transfer, Ionic Strength, Positive Ions, Charge Transfer Excitons, Charge Transfer State, Excited Electronic State, Guanine Cytosines, Quantum-Mechanical Calculation, Structural Transitions, Quantum Theory,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84934918877&partnerID=40&md5=f40e68c492fb142121bb35f77f522a75

The photoreactive pathways that may lead to DNA damage depend crucially upon the nature of the excited electronic states. The study of alternating guanine-cytosine duplexes by fluorescence spectroscopy and quantum mechanical calculations identifies a novel type of excited states that can be populated following UVB excitation. These states, denoted High-energy Emitting Long-lived Mixed (HELM) states, extend across both strands and arise from mixing between cytosine Frenkel excitons and guanine-to-cytosine charge transfer states. They emit at energies higher than ππ∗ states localized on single bases, survive for several nanoseconds, are sensitive to the ionic strength of the solution, and are strongly affected by the structural transition from the B form to the Z form. Their impact on the formation of lesions of the genetic code needs to be assessed. © 2015 American Chemical Society.
*** IBB - CNR ***

CNRS, IRAMIS, LIDYL, Laboratoire Francis Perrin, URA 2453, Gif-sur-Yvette, France

Institut für Physikalische U. Theoretische Chemie, Goethe-Universität, Max-von-Laue-Strasse 7, Frankfurt am Main, Germany

Istituto Biostrutture e Bioimmagini- Consiglio Nazionale Delle Ricerche, Via Mezzocannone 16, Napoli, Italy
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15 Records (15 escludendo Abstract e Conferenze).
Impact factor totale: 69.257 (69.257 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 71.094 (71.094 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Cytosine" OR [btitle] "Excitons" OR [btitle] "Fluorescence Spectroscopy" OR [btitle] "Quantum Chemistry" OR [btitle] "Charge Transfer") AND NOT [id] = 52891)

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