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Stabilization of mixed frenkel-charge transfer excitons extended across both strands of guanine-cytosine DNA duplexes (62 views)

Huix-Rotllant M, Brazard J, Improta R, Burghardt I, Markovitsi D

J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic), 2015; 6(12): 2247-2251.

The photoreactive pathways that may lead to DNA damage depend crucially upon the nature of the excited electronic states. The study of alternating guanine-cytosine duplexes by fluorescence spectroscopy and quantum mechanical calculations identifies a novel type of excited states that can be populated following UVB excitation. These states, denoted High-energy Emitting Long-lived Mixed (HELM) states, extend across both strands and arise from mixing between cytosine Frenkel excitons and guanine-to-cytosine charge transfer states. They emit at energies higher than ππ∗ states localized on single bases, survive for several nanoseconds, are sensitive to the ionic strength of the solution, and are strongly affected by the structural transition from the B form to the Z form. Their impact on the formation of lesions of the genetic code needs to be assessed. © 2015 American Chemical Society.

Affiliations ▼
*** IBB - CNR Affiliation

CNRS, IRAMIS, LIDYL, Laboratoire Francis Perrin, URA 2453, Gif-sur-Yvette, France

Institut für Physikalische U. Theoretische Chemie, Goethe-Universität, Max-von-Laue-Strasse 7, Frankfurt am Main, Germany

Istituto Biostrutture e Bioimmagini- Consiglio Nazionale Delle Ricerche, Via Mezzocannone 16, Napoli, Italy

Details ▼
Impact factor: 7.458, 5-year impact factor: 7.536

Paper type: Journal Article,

Keywords: Cytosine, Dna, Excitons, Fluorescence Spectroscopy, Guanine, Quantum Chemistry, Charge Transfer, Ionic Strength, Positive Ions, Charge Transfer Excitons, Charge Transfer State, Excited Electronic State, Guanine Cytosines, Quantum-Mechanical Calculation, Structural Transitions, Quantum Theory,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84934918877&partnerID=40&md5=f40e68c492fb142121bb35f77f522a75

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16 Records (14 excluding Abstracts and Conferences).
Total impact factor: 59.72 (53.476 excluding Abstracts and Conferences).
Total 5-year impact factor: 58.177 (51.893 excluding Abstracts and Conferences).

Your bibliography query: (([btitle, keywords, abstract] CYTOSINE)) AND NOT [id] = 52891

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