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Stabilization of mixed frenkel-charge transfer excitons extended across both strands of guanine-cytosine DNA duplexes (101 visite)

Huix-Rotllant M, Brazard J, Improta R, Burghardt I, Markovitsi D

J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic), 2015; 6(12): 2247-2251.

Tipo di articolo: Journal Article,

Impact factor: 8.539

Impact factor a 5 anni: 7.803


Parole chiave: Cytosine, Dna, Excitons, Fluorescence Spectroscopy, Guanine, Quantum Chemistry, Charge Transfer, Ionic Strength, Positive Ions, Charge Transfer Excitons, Charge Transfer State, Excited Electronic State, Guanine Cytosines, Quantum-Mechanical Calculation, Structural Transitions, Quantum Theory,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84934918877&partnerID=40&md5=f40e68c492fb142121bb35f77f522a75

The photoreactive pathways that may lead to DNA damage depend crucially upon the nature of the excited electronic states. The study of alternating guanine-cytosine duplexes by fluorescence spectroscopy and quantum mechanical calculations identifies a novel type of excited states that can be populated following UVB excitation. These states, denoted High-energy Emitting Long-lived Mixed (HELM) states, extend across both strands and arise from mixing between cytosine Frenkel excitons and guanine-to-cytosine charge transfer states. They emit at energies higher than ππ∗ states localized on single bases, survive for several nanoseconds, are sensitive to the ionic strength of the solution, and are strongly affected by the structural transition from the B form to the Z form. Their impact on the formation of lesions of the genetic code needs to be assessed. © 2015 American Chemical Society.
*** IBB - CNR ***

CNRS, IRAMIS, LIDYL, Laboratoire Francis Perrin, URA 2453, Gif-sur-Yvette, France

Institut für Physikalische U. Theoretische Chemie, Goethe-Universität, Max-von-Laue-Strasse 7, Frankfurt am Main, Germany

Istituto Biostrutture e Bioimmagini- Consiglio Nazionale Delle Ricerche, Via Mezzocannone 16, Napoli, Italy
Banyasz, A., Douki, T., Improta, R., Gustavsson, T., Onidas, D., Vayá, I., Perron, M., Markovitsi, D., Electronic Excited States Responsible for Dimer Formation Upon UV Absorption Directly by Thymine Strands: Joint Experimental and Theoretical Study (2012) J. Am. Chem. Soc., 134, pp. 14834-1484

Esposito, L., Banyasz, A., Douki, T., Perron, M., Markovitsi, D., Improta, R., Effect of C5-Methylation of Cytosine on the Photoreactivity of DNA: A Joint Experimental and Computational Study of TCG Trinucleotides (2014) J. Am. Chem. Soc., 136, pp. 10838-10841

Sobolewski, A.L., Domcke, W., Hattig, C., Tautomeric Selectivity of the Excited-State Lifetime of Guanine/Cytosine Base Pairs: The Role of Electron-Driven Proton-Transfer Processes (2005) Proc. Natl. Acad. Sci. U.S.A., 102, pp. 17903-17906

Schwalb, N.K., Temps, F., Base Sequence and Higher-Order Structure Induce the Complex Excited-State Dynamics in DNA (2008) Science, 322, pp. 243-245

Kwok, W.M., Ma, C.S., Phillips, D.L., "Bright" and "dark" Excited States of an Alternating at Oligomer Characterized by Femtosecond Broadband Spectroscopy (2009) J. Phys. Chem. B, 113, pp. 11527-11534

Markovitsi, D., Gustavsson, T., Vayá, I., Fluorescence of DNA Duplexes: From Model Helices to Natural DNA (2010) J. Phys. Chem. Lett., 1, pp. 3271-3276

Kohler, B., Nonradiative Decay Mechanisms in DNA Model Systems (2010) J. Phys. Chem. Lett., 1, pp. 2047-2053

Plasser, F., Aquino, A., Lischka, H., Nachtigallová, D., Electronic Excitation Processes in Single-Strand and Double-Strand DNA: A Computational Approach (2015) Top. Curr. Chem., 356, pp. 1-38

Bucher, D.B., Schlueter, A., Carell, T., Zinth, W., Watson-Crick Base Pairing Controls Excited-State Decay in Natural DNA (2014) Angew. Chem., Int. Ed., 53, pp. 11366-11369

Fiebig, T., Exciting DNA (2009) J. Phys. Chem. B, 113, pp. 9348-9349

Santoro, F., Barone, V., Improta, R., Excited States Decay of the A-T DNA: A PCM/TD-DFT Study in Aqueous Solution of the (9-Methyl-Adenine)2·(1-Methyl-Thymine)2 Stacked Tetramer (2009) J. Am. Chem. Soc., 131, pp. 15232-15245

Olaso-Gonzalez, G., Merchan, M., Serrano-Andres, L., The Role of Adenine Excimers in the Photophysics of Oligonucleotides (2009) J. Am. Chem. Soc., 131, pp. 4368-4377

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Improta, R., Barone, V., Interplay between "neutral" and "charge-Transfer" Excimers Rules the Excited State Decay in Adenine-Rich Polynucleotides (2012) Angew. Chem., Int. Ed., pp. 12016-12019

Lu, Y., Lan, Z., Thiel, W., Hydrogen Bonding Regulates the Monomeric Nonradiative Decay of Adenine in DNA Strands (2011) Angew. Chem., Int. Ed., 50, pp. 6864-6867

Brazard, J., Thazhathveetil, A., Vayá, I., Lewis, F., Gustavsson, T., Markovitsi, D., Electronic Excited States of Guanine-Cytosine Hairpins and Duplexes Studied by Fluorescence Spectroscopy (2013) Photochem. Photobiol. Sci., 12, pp. 1453-1459

Vayá, I., Miannay, F.A., Gustavsson, T., Markovitsi, D., High Energy Long-Lived Excited States in DNA Double Strands (2010) ChemPhysChem, 11, pp. 987-989

Segers-Nolten, G.M.J., Sijtsema, N.M., Otto, C., Evidence for Hoogsteen GC Base Pairs in the Proton-Induced Transition from Right-Handed to Left-Handed Poly(dG-dC)·Poly(dG-dC) (1997) Biochemistry, 36, pp. 13241-13247

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Miannay, F.A., Banyasz, A., Gustavsson, T., Markovitsi, D., Ultrafast Excited State Deactivation and Energy Transfer in Guanine-Cytosine DNA Double Helices (2007) J. Am. Chem. Soc., 129, pp. 14574-14575

Changenet-Barret, P., Hua, Y., Markovitsi, D., Electronic Excitations in Guanine Quadruplexes (2015) Top. Curr. Chem., 356, pp. 183-202

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Gaussian Inc. Wallingford, CT

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15 Records (15 escludendo Abstract e Conferenze).
Impact factor totale: 69.257 (69.257 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 71.094 (71.094 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Cytosine" OR [btitle] "Excitons" OR [btitle] "Fluorescence Spectroscopy" OR [btitle] "Quantum Chemistry" OR [btitle] "Charge Transfer") AND NOT [id] = 52891)







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