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Stabilization of mixed frenkel-charge transfer excitons extended across both strands of guanine-cytosine DNA duplexes (119 visite)

Huix-Rotllant M, Brazard J, Improta R, Burghardt I, Markovitsi D

J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic), 2015; 6(12): 2247-2251.

Tipo di articolo: Journal Article,

Impact factor: 8.539

Impact factor a 5 anni: 7.803

Parole chiave: Cytosine, Dna, Excitons, Fluorescence Spectroscopy, Guanine, Quantum Chemistry, Charge Transfer, Ionic Strength, Positive Ions, Charge Transfer Excitons, Charge Transfer State, Excited Electronic State, Guanine Cytosines, Quantum-Mechanical Calculation, Structural Transitions, Quantum Theory,

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84934918877&partnerID=40&md5=f40e68c492fb142121bb35f77f522a75

The photoreactive pathways that may lead to DNA damage depend crucially upon the nature of the excited electronic states. The study of alternating guanine-cytosine duplexes by fluorescence spectroscopy and quantum mechanical calculations identifies a novel type of excited states that can be populated following UVB excitation. These states, denoted High-energy Emitting Long-lived Mixed (HELM) states, extend across both strands and arise from mixing between cytosine Frenkel excitons and guanine-to-cytosine charge transfer states. They emit at energies higher than ππ∗ states localized on single bases, survive for several nanoseconds, are sensitive to the ionic strength of the solution, and are strongly affected by the structural transition from the B form to the Z form. Their impact on the formation of lesions of the genetic code needs to be assessed. © 2015 American Chemical Society.
*** IBB - CNR ***

CNRS, IRAMIS, LIDYL, Laboratoire Francis Perrin, URA 2453, Gif-sur-Yvette, France

Institut für Physikalische U. Theoretische Chemie, Goethe-Universität, Max-von-Laue-Strasse 7, Frankfurt am Main, Germany

Istituto Biostrutture e Bioimmagini- Consiglio Nazionale Delle Ricerche, Via Mezzocannone 16, Napoli, Italy
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[Pulisci modulo]
Martinez-fernandez L, Pepino AJ, Segarra-marti J, Jovaisaite J, Vaya I, Nenov A, Markovitsi D, Gustavsson T, Banyasz A, Garavelli M, Improta R
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Banyasz A, Esposito L, Douki T, Perron M, Lepori C, Improta R, Markovitsi D
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Vayá I, Brazard J, Huix-rotllant M, Thazhathveetil AK, Lewis FD, Gustavsson T, Burghardt I, Improta R, Markovitsi D
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Changenet-Barret P, Gustavsson T, Improta R, Markovitsi D
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Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
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Hua Y, Changenet-Barret P, Improta R, Vaya I, Gustavsson T, Kotlyar AB, Zikich D, Sket P, Plavec J, Markovitsi D
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Biemann L, Kovalenko SA, Kleinermanns K, Mahrwald R, Markert M, Improta R
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
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Caraglia M, Correale P, Genua G, Pepe S, Del Vecchio S, Esposito G, Bianco AR, Tagliaferri P
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15 Records (15 escludendo Abstract e Conferenze).
Impact factor totale: 69.257 (69.257 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 71.094 (71.094 escludendo Abstract e Conferenze).

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