Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study
Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study(114 visite) Coppo C, Bonfanti D, Bo S, Giordanino C, Gallo M, Cococcia S, Ciccone G, Smedile A, Ciancio A, Bugianesi E, Fagoonee S, Pellicano R, Rizzetto M, Saracco GM
Parole chiave: Chronic Hepatitis C; Cirrhosis; Diabetes Mellitus; Macroangiopathy; Microangiopathy, Alpha Fetoprotein, Hepatitis B Surface Antigen, Insulin, Insulin Sensitizing Agent, Interferon, Oral Antidiabetic Agent, Ribavirin, Adult, Antiviral Therapy, Article, Autonomic Neuropathy, Body Mass, Cohort Analysis, Controlled Study, Coronary Artery Disease, Diabetic Foot, Diabetic Microangiopathy, Diabetic Nephropathy, Diabetic Neuropathy, Diabetic Patient, Diabetic Retinopathy, Disease Duration, Family History, Female, Follow Up, Heart Infarction, Hepatitis C Virus, Human, Human Tissue, Incidence, Insulin Treatment, Liver Cancer, Liver Cirrhosis, Liver Histology, Long Term Care, Major Clinical Study, Middle Aged, Non Insulin Dependent Diabetes Mellitus, Obesity, Outcome Assessment, Peripheral Occlusive Artery Disease, Priority Journal, Retrospective Study, Risk Assessment, Risk Factor, Smoking, Treatment Duration, Cardiovascular Diseases, Comorbidity, Complication, Type 2, Diabetic Angiopathies, Pathology, Cohort Studies, Retrospective Studies,
Affiliazioni:
*** IBB - CNR *** Gastroenterology Unit, Department of Oncology, University of Turin, Turin, Italy Department of Medical Sciences, University of Turin, Turin, Italy Unit of Cancer Epidemiology, University of Turin, Molinette Hospital and CPO Piemonte, Turin, Italy Gastro-Hepatology Unit, Department of Medical Sciences, University of Turin, Turin, Italy Institute for Biostructures and Bioimages (CNR), Molecular Biotechnology Center, University of Turin, Italy
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<h4>BACKGROUND: </h4><br>Patients<br> with chronic hepatitis C have an increased risk of diabetes mellitus <br>but the type and risk of developing diabetes-related complications have <br>not yet been evaluated.<br><h4>METHODS: </h4><br>In<br> order to compare the incidence of diabetic microangiopathy in patients <br>with new onset diabetes without microangiopathy we recruited 54 <br>hepatitis C virus (HCV)-positive and 119 HCV-negative patients from <br>January 2005 to December 2006. All patients were followed-up every 6 <br>months for liver and diabetic complications and incidence of <br>cardiovascular diseases up to December 2012 when data were <br>retrospectively analyzed.<br><h4>RESULTS: </h4><br>The<br> two cohorts were comparable at enrolment except for mean body mass <br>index, obesity rate and family history of diabetes (p=0.007). After 7.2 <br>years of follow-up, 13 HCV-positive (24.1%) and 37 HCV-negative patients<br> (31%) showed at least one microangiopathic complication (p=0.34); 5 <br>HCV-positive (9.3%) and 13 HCV-negative patients (10.8%) reported <br>cardiovascular diseases (p=0.2); 14 HCV-positive (24.5%) compared to 0 <br>HCV-negative patients developed liver-related complications (p=0.0003). <br>One HCV-positive patient died due to liver cancer, 1 HCV-negative <br>patient died from myocardial infarction (p=0.3). Increasing age <br>(HR=1.04, 95% CI: 1.00-1.07, p=0.04) and smoking (HR=2.94, 95% CI: <br>1.06-8.17, p=0.04) were positively associated to diabetic complications.<br><h4>CONCLUSIONS: </h4><br>Incidence of microangiopathy is not significantly different in diabetics with or without chronic hepatitis C.<br>
78 Records (73 escludendo Abstract e Conferenze). Impact factor totale: 305.497 (287.162 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 306.213 (288.413 escludendo Abstract e Conferenze).
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