The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids(85 visite) Cerutti E, Viale A, Nervi C, Gobetto R, Aime S
J PHYS CHEM A (ISSN: 1089-5639), 2015 Nov 19; 119(46): 11271-11279.
Tipo di articolo: Abstract, Journal Article,
Impact factor: 2.883, Impact factor a 5 anni: 2.709
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*** IBB - CNR *** Department of Molecular Biotechnologies and Health Sciences, University of Torino , Via Nizza 52, 10126 Torino, Italy.,
A series of dehydroamino acids endowed with different protective groups at the amino and carboxylate moieties and with different substituents at the double bond have been reacted with parahydrogen. The observed ParaHydrogen Induced Polarization (PHIP) effects in the (1)H NMR spectra are strongly dependent on the amino protecting group. DFT calculations allowed us to establish a relationship between the structures of the reaction intermediates (whose energies depend on the amido substitution) and the observed PHIP patterns.