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Generation and characterization of monoclonal antibodies against a cyclic variant of Hepatitis C Virus E2 epitope 412-422 (88 visite) (PDF pubblico 62 visite)

Sandomenico A, Leonardi A, Berisio R, Sanguigno L, Foca G, Foca A, Ruggiero A, Doti N, Muscariello L, Barone D, Farina C, Owsianka A, Vitagliano L, Patel AH, Ruvo M

J Virol (ISSN: 1098-5514electronic, 0022-538xlinking), 2016 Jan 27; 90(7): 3745-3759.

Tipo di articolo: Journal Article,

Impact factor: 4.663

Impact factor a 5 anni: 4.272


Parole chiave: Non disponibili.

Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84960970619&partnerID=40&md5=3d81594004333ceaab06bfa63de086d6

Hepatitis C virus (HCV) E2 envelope glycoprotein is crucial for virus entry into hepatocytes. A conserved region of E2 encompassing amino acids 412-423 and containing Trp420, a residue critical for virus entry, is recognized by several broadly neutralizing antibodies. Peptides embodying this epitope I sequence adopt a beta-hairpin conformation when bound to neutralizing monoclonal antibodies (MAbs) AP33 and HCV-1. We therefore generated new mouse MAbs that were able to bind to a cyclic peptide containing E2 residues 412-422 (C-Epitope I) but not to the linear counterpart. These MAbs bound to purified E2 with affinities of about 50 nM, but they were unable to neutralize virus infection. Structural analysis of the complex between C-Epitope I and one of our MAbs (C2) show that the Trp420 side chain is largely buried in the combining site and that the Asn417 side chain, which is glycosylated in E2 and solvent-exposed in other complexes, is slightly buried upon C2 binding. Also, the orientation of the cyclic peptide in the antibody combining site is rotated by 180 degrees compared to other complexes. All these structural features, however, do not explain the lack of neutralization activity. This is instead ascribed to the high selectivity of the new MAbs for the cyclic epitope and to their inability to interact with the epitope in more flexible and extended conformations, which recent data suggest play a role in the mechanisms of neutralization escape. IMPORTANCE: Hepatitis C virus (HCV) remains a major health care burden affecting almost 3% of the global population. The conserved epitope I comprising residues 412-423 of the viral E2 glycoprotein, is a valid vaccine candidate because antibodies recognizing this region exhibit potent neutralizing activity. This epitope adopts a beta-hairpin conformation when bound to neutralizing MAbs. We explored the potential of cyclic peptides mimicking this structure to elicit anti-HCV antibodies. MAbs that specifically recognize a cyclic variant of the epitope bind to soluble E2 with lower affinity than other blocking antibodies and don't neutralize virus. The structure of the complex between one such MAb and the cyclic epitope, together with new structural data showing the linear peptide bound to neutralizing MAbs in extended conformations, suggests that the epitope displays a conformational flexibility that contributes to neutralization escape. Such features can be of major importance for the design of epitope-based anti-HCV vaccines.
*** IBB - CNR ***

Institute of Biostructures and Bioimaging, CNR and CIRPeB, University of Naples Federico II, Napoli, Italy., Dept. of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Napoli, Italy., Institute of Biostructures and Bioimaging, CNR and CIRPeB, University of Naples Federico II, Napoli, Italy Dept. of Pharmacy, University of Naples Federico II, Napoli, Italy., Kedrion SpA, Lucca, Italy., Institute of Biostructures and Bioimaging, CNR and CIRPeB, University of Naples Federico II, Napoli, Italy Second University of Naples., Medical Research Council - University of Glasgow Centre for Virus Research, Glasgow, UK., Medical Research Council - University of Glasgow Centre for Virus Research, Glasgow, UK. menotti.ruvo@unina.it arvind.patel@glasgow.ac.uk., Institute of Biostructures and Bioimaging, CNR and CIRPeB, University of Naples Federico II, Napoli, Italy menotti.ruvo@unina.it arvind.patel@glasgow.ac.uk.,

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy

Department of Pharmacy, University of Naples Federico II, Naples, Italy

Bioker Multimedica, Naples, Italy
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* Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen (47 visite) (PDF 71 visite)
Sandomenico A, Focà A, Sanguigno L, Caporale A, Focà G, Pignalosa A, Corvino G, Caragnano A, Beltrami AP, Antoniali G, Tell G, Leonardi A, Ruvo M
Medicine Research And Experimental (ISSN: 1942-0862, 1942-0870e), 2016 Aug; 8: 1575-1589.
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* High-frequency ultrasound-guided injection for the generation of a novel orthotopic mouse model of human thyroid carcinoma (95 visite)
Greco A, Albanese S, Auletta L, Mirabelli P, Zannetti A, D'Alterio C, Di Maro G, Orlandella FM, Salvatore G, Soricelli A, Salvatore M
Thyroid (ISSN: 1557-9077electronic, 1050-7256linking), 2016 Feb 4; 26(4): 552-558.
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* Human IgG1 antibodies suppress angiogenesis in a target-independent manner (204 visite)
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J
Signal Transduct Target Ther (ISSN: 2059-3635print), 2016; 1: N/D-N/D.
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* Effects of a novel Nodal-targeting monoclonal antibody in melanoma (143 visite) (PDF 86 visite)
Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2015 Oct 27; 6(33): 34071-34086.
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* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (210 visite) (PDF 111 visite)
Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
Int J Mol Sci (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2015 Sep 7; 16(9): 21342-21362.
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* An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization (191 visite)
Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2015 Apr 22; 13(17): 4859-4868.
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* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (162 visite) (PDF 103 visite)
Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
Nuclear Medicine And Biology (ISSN: 0969-8051, 1872-9614, 0883-2897), 2015 Mar; 42(3): 309-316.
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* Generation and Characterization of a Transgenic Mouse Carrying a Functional Human beta -Globin Gene with the IVSI-6 Thalassemia Mutation (44 visite)
Breveglieri G, Mancini I, Bianchi N, Lampronti I, Salvatori F, Fabbri E, Zuccato C, Cosenza LC, Montagner G, Borgatti M, Altruda F, Fagoonee S, Carandina G, Rubini M, Aiello V, Breda L, Rivella S, Gambari R, Finotti A
Biomed Res Int (ISSN: 2314-6141electronic, 2314-6133), 2015; 2015: 687635-687635.
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* Platinum(II) Complexes with O, S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding (59 visite)
Mügge C, Marzo T, Massai L, Hildebrandt J, Ferraro G, Rivera-Fuentes P, Metzler-Nolte N, Merlino A, Messori L, Weigand W
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2015; 54(17): 8560-8570.
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* EIS measurements for characterization of muscular tissue by means of equivalent electrical parameters (85 visite)
Clemente F, Romanò MF, Bifulco P, Cesarelli M
Measurement (ISSN: 0263-2241), 2014 Dec; 58: 476-482.
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* Functional and structural characterization of protein disulfide oxidoreductase from Thermus thermophilus HB27 (116 visite)
Pedone E, Fiorentino G, Pirone L, Contursi P, Bartolucci S, Limauro D
Extremophilesextremophiles (ISSN: 1431-0651, 1433-4909), 2014 Jul; 18(4): 723-731.
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* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (121 visite)
Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
Extremophilesextremophiles (ISSN: 1431-0651, 1433-4909), 2014 Mar; 18(2): 219-228.
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* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (110 visite)
Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
Bioorg Med Chem (ISSN: 1464-3391, 0968-0896, 1464-3391electronic), 2014 Feb 1; 22(3): 960-966.
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* Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant (88 visite)
Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 30-36.
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* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (93 visite)
Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
J Enzyme Inhib Med Chem (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
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* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (99 visite)
De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2014; 73: 210-216.
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* Parametric MR dynamic imaging for breast lesions characterization and prediction of lymph nodes involvement (112 visite)
Ciarmiello A, Gaeta MC, Meniconi M, Milano A, Alfano B, Del Vecchio S, Salvatore M
Curr Radiopharm Bentham Science Publishers B V (ISSN: 1874-4710, 1874-4729), 2014; 7(2): 91-99.
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* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (75 visite)
Clemente F, Arpaia P, Manna C
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
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* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (85 visite)
Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
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* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (104 visite)
Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
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* A Novel Interdomain Interface In Crystallins: Structural Characterization Of The Beta Gamma-Crystallin From Geodia Cydonium At 0. 99 Angstrom Resolution (117 visite)
Vergara A, Grassi M, Sica F, Pizzo E, D’Alessio G, Mazzarella L, Merlino A
Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2013 Jun; 69(6): 960-967.
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* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (98 visite)
Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
Biochim Biophys Acta (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
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* Biochemical and structural characterization of recombinant short-chain NAD(H)-dependent dehydrogenase/reductase from Sulfolobus acidocaldarius highly enantioselective on diaryl diketone benzil (99 visite)
Pennacchio A, Sannino V, Sorrentino G, Rossi M, Raia CA,  Esposito L
Applied Microbiology And Biotechnology (ISSN: 0175-7598), 2013 May; 97(9): 1-16.
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* Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (91 visite)
Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
J Proteome Res Journal Of Proteome Research (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
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* De novo sequencing and characterization of a novel Bowman Birk inhibitor from Lathyrus sativus L. seeds by electrospray mass spectrometry (77 visite)
Tamburino R, Severino V, Sandomenico A, Ruvo M, Parente A, Chambery A, Di Maro A
(ISSN: 1742-206x), 2012 Oct 30; 8(12): 3232-3241.
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* Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio (81 visite)
Maurea S, Cuocolo A, Imbriaco M, Pellegrino T, Fusari M, Cuocolo R, Liuzzi R, Salvatore M
Ann Nucl Med (ISSN: 1864-6433, 0914-7187, 1864-6433electronic), 2012 Oct; 26(8): 670-675.
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* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (130 visite)
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
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* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (104 visite)
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
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* Subacute combined degeneration of the spinal cord in a vegan (68 visite)
De Rosa A, Rossi F, Lieto M, Bruno R, De Renzo A, Palma V, Quarantelli M, De Michele G
Clin Neurol Neurosurg (ISSN: 0303-8467), 2012 Sep; 114(7): 1000-1002.
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* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (74 visite)
Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
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* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (73 visite)
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
Bioconjugate Chemistry (ISSN: 1043-1802, 1520-4812), 2012 Mar 21; 23(3): 382-391.
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* Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus (139 visite)
Falanga A, Tarallo R, Vitiello G, Vitiello M, Perillo E, Cantisani M, D'Errico G, Galdiero M, Galdiero S
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2012 Feb 23; 7(2): N/D-N/D.
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* Choroid plexus carcinoma: Prenatal characterization by 3-dimensional sonography and magnetic resonance imaging perinatal management, and natural history (65 visite)
Vassallo M, Giuseppe M, Quarantelli M, Pastore G, Paladini D
Journal Of Ultrasound In Medicine (ISSN: 0278-4297, 1550-9613), 2012 Feb; 31(2): 337-340.
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* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (79 visite)
Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
Journal Of Structural Biology (ISSN: 1047-8477), 2012 Feb; 177(2): 506-512.
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* 18F-FDG PET and PET/CT in the Localization and Characterization of Lesions in Patients with Ovarian Cancer (78 visite)
Caprio MG, Capacchione D, Mainolfi C, Spera AM, Salvatore B, Cella L, Salvatore M, Pace L
Translational Medicine @ Unisa, 2012 Jan 18; 2: 28-35.
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* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (119 visite)
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
J Biol Chem Journal Of Biological Chemistry (ISSN: 1083-351x, 0021-9258), 2011 Dec 2; 286(48): 41680-41691.
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* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (71 visite)
Roviello GN, Musumeci D, Bucci EM, Pedone C
Int J Pharm International Journal Of Pharmaceutics (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
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* Progression of striatal and extrastriatal degeneration in multiple system atrophy: a longitudinal diffusion-weighted MR study (94 visite)
Pellecchia MT, Barone P, Vicidomini C, Mollica C, Salvatore E, Ianniciello M, Liuzzi R, Longo K, Picillo M, De Michele G, Filla A, Brunetti A, Salvatore M, Pappata S
Mov Disord (ISSN: 1531-8257, 0885-3185), 2011 Jun; 26(7): 1303-1309.
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* Quantitative Imaging Characterization Of Hypersecreting Or Non-Hypersecreting Adrenal Adenomas: Comparison Between Iodine-131 Nor-Cholesterol Uptake And Magnetic Resonance Signal Intensity Ratios (52 visite)
Maurea S, Imbriaco M, Mollica C, Pace L, Salvatore M
Nuclear Medicine Communications (ISSN: 1473-5628, 0143-3636), 2011 Jun; 32(6): 535-541.
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* Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition (81 visite)
Pirone L, Correale S, De Paola I, Zaccaro L, De Simone G, Vitagliano L, Pedone E, Di Gaetano S
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
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* Electrochemical characterization of ordered arrays of metallo-porphyrins in aqueous solution (88 visite)
Tabbì G, Di Mauro G, Purrello R, Bonomo RP
Dalton Trans (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Apr 28; 40(16): 4223-4229.
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* Description and Characterization of a Highly Stable Enthalpic Intermediate State in Mouse Prion Protein Folding (51 visite)
Benetti F, Biarnes X, Attanasio F, Rizzarelli E, Laio A, Legname G
Prion (ISSN: 1933-6896), 2011 Apr; 5: N/D-N/D.
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* Predictive factors of neutralizing antibodies development in relapsing-remitting multiple sclerosis patients on interferon Beta-1b therapy (62 visite) (PDF 77 visite)
Lanzillo R, Orefice G, Prinster A, Ventrella G, Liuzzi R, Scarano V, Florio C, Vacca G, Brunetti A, Alfano B, Brescia Morra V, Bonavita V
Neurol Sci (ISSN: 1590-1874, 1590-3478), 2011 Apr; 32(2): 287-292.
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* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (92 visite)
Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
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* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (93 visite)
Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
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* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (62 visite)
Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
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* Hereditary Fructose Intolerance: Functional Study of Two Novel ALDOB Natural Variants and Characterization of a Partial Gene Deletion (105 visite)
Esposito G, Imperato MR, Ieno L, Sorvillo R, Benigno V, Parenti G, Parini R, Vitagliano L, Zagari A, Salvatore F
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2010 Dec; 31(12): 1294-1303.
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* Structural characterization of triorganotin(IV) complexes with sodium fusidate and DFT calculations (60 visite)
Abbate M, Casella G, Fiore T, Grasso G, Pellerito C, Scopelliti M, Spinella A, Pellerito L
J Organomet Chem (ISSN: 0022-328x), 2010 May 1; 695(9): 1405-1413.
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* Design, synthesis, and functional characterization of new cyclepeptides inhibitors for C-X-C chemokine receptor-4 (CXCR4) (48 visite)
Scala S, Portella L, Napolitano M, Consales C, Polimeno MN, D'Alterio C,  Palma G, Arra C, Vitale R, Amodeo P,  De Luca S, Monfrecola L, Castello G
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2010 Apr; 51: N/D-N/D.
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* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (65 visite)
Monfregola L, Saviano M, De Luca S
International Journal Of Peptide Research And Therapeutics (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
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* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (126 visite)
De Simone G, Supuran CT
Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
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* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (72 visite)
Roviello GN, Musumeci D, Pedone C, Bucci EM
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
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* Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima (78 visite)
Luchansky MS, Der BS, D'Auria S, Pocsfalvi G, Iozzino L, Marasco D, Dattelbaum JD
Molecular Biosystems (ISSN: 1742-206x), 2010; 6(1): 142-151.
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* Exploring Phm Active Site: Characterization Of Novel Pba-Derived Inhibitors Using A Combined Experimental And Computational Approach (53 visite)
Langella E, Pierre S, Ghattas W, Giorgi M, Rglier M, Saviano M,  Esposito L, Hardr R
Chemmedchem, 2010; 5: 1568-1576.
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* VEGFR1(D2) in drug discovery: Expression and molecular characterization (71 visite)
Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
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* Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes (130 visite)
Malviya G, D'Alessandria C, Bonanno E, Vexler V, Massari R, Trotta C, Scopinaro F, Dierckx R, Signore A
Journal Of Nuclear Medicine (ISSN: 1535-5667electronic, 0161-5505linking), 2009 Oct; 50(10): 1683-1691.
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* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (87 visite)
Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
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* Prion Proteins Leading to Neurodegeneration (vol 5, pg 579, 2008) (56 visite)
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
Current Alzheimer Research (ISSN: 1567-2050), 2009 Jun; 6(3): N/D-N/D.
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* Regulated BMP-4 Expression for Bone Regeneration by Thymidine Kinase and Ganciclovir Treatments (56 visite)
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Brunetti A, Montanaro D, Troncone G, Salvatore F, Pastore L
Molecular Therapy (ISSN: 1525-0016, 1525-0024), 2009 May; 17: N/D-N/D.
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* Functional and structural characterization of novel mutations and genotype-phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy (69 visite)
Daniele A, Scala I, Cardillo G, Pennino C, Ungaro C, Sibilio M, Parenti G, Esposito L, Zagari A, Andria G, Salvatore F
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(7): 2048-2059.
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* Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging (84 visite) (PDF 92 visite)
Maurea S, Soricelli A, Salvatore M
Curr Radiopharm Bentham Science Publishers B V (ISSN: 1874-4710, 1874-4729), 2009; 2(1): 56-62.
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* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (135 visite)
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
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* Prion proteins leading to neurodegeneration (98 visite)
La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
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* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (81 visite)
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Oct 10; 283(41): 27799-27809.
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* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (77 visite)
Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
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* Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography (88 visite)
Woo LWL, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK, Di Fiore A, Supuran CT, De Simone G, Purohit A, Reed MJ, Potter BVL
Mol Cancer Ther Molecular Cancer Therapeutics (ISSN: 1535-7163, 1538-8514electronic), 2008 Sep; 7(8): 2435-2444.
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* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (104 visite)
Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
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* Synthesis and in vitro and in vivo characterization of NGF mimetic peptides (54 visite)
Sarmientos P, Morelli G, Alberghina L, Colangelo A, Martegani E, Vitagliano L, Papa M, Tornesello AL
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (62 visite)
Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
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* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (73 visite)
Limauro D, Pedone E, Galdi I, Bartolucci S
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
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* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (63 visite)
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
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* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (149 visite)
D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
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* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (70 visite)
Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
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* Spectroscopic And Crystallographic Characterization Of A Tetrameric Hemoglobin Oxidation Pathway Reveals Structural Features Of A Functional Intermediate R/T State (55 visite)
Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
Biophys J, 2008; 94: 4031-4040.
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* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (61 visite)
Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
Methods Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
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* Spectroscopic And Crystallographic Characterization Of Hemichromes In Tetrameric Hemoglobins (70 visite)
Vergara A, Vitagliano L, Di Prisco G, Verde C, Mazzarella L
Methods In Enzymology, 2008; 436: 421-440.
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* Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein α2-helical 180-195 segment and comparison with full-length α2-helix-derived peptides (77 visite)
Ronga L, Palladino P, Saviano G, Tancredi T, Benedetti E, Ragone R, Rossi F
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008; 14(10): 1096-1102.
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* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (78 visite)
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
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* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (86 visite)
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
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* AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin (104 visite)
Grasso G, Rizzarelli E, Spoto G
J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2007 Dec; 42(12): 1590-1598.
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* Structural characterization of ferric hemoglobins from three Antarctic fish species of the suborder notothenioidei (58 visite)
Vergara A, Franzese M, Merlino A, Vitagliano L, Verde C, Di Prisco G, Lee HC, Peisach J, Mazzarella L
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Oct; 93(8): 2822-2829.
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* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (66 visite)
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
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* Tracking the dynamics of secondary degeneration after stroke (45 visite)
Pappata S
J Neurol Neurosurg Psychiatry (ISSN: 0022-3050), 2007 Jun; 78(6): 554-554.
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* MRI characterization of myocardial tissue in patients with Fabry's disease (83 visite)
Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
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* Oc158: Multimodal Diagnostic Flow Chart For Prenatal Characterization Of Cns Abnormalities In A Tertiary Referral Center: The Role Of Mri (60 visite)
Paladini D, Sglavo G, Quarantelli M, Vassallo M, Nappi C
Ultrasound Obstet Gynecol, 2007; 30: 415-416.
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* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (51 visite)
Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
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* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (89 visite)
Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
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* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (75 visite)
Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
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* 18F-FDG PET and PET/CT in the localization and characterization of lesions in patients with ovarian cancer (58 visite)
Caprio MG, Capacchione D, Mainolfi CG, Salvatore B, Varrone A, Cella L, Pace L, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
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* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (91 visite)
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
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* Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17 (65 visite)
Salvatore E, Varrone A, Sansone V, Nolano M, Bruni AC, De Rosa A, Santoro L, Pappata S, Filla A, De Michele G
Mov Disord (ISSN: 0885-3185, 1531-8257), 2006 Jun; 21(6): 872-875.
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* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (71 visite)
Limauro D, Pedone E, Pirone L, Bartolucci S
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
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* Development and characterization of an integrated silicon micro flow cytometer (54 visite)
Bernini E De Nuccio R, Brescia F, Minardo A, Zeni L, Sarro PM, Palumbo R, Scarf MR
Analytical And Bioanalytical Chemistry (ISSN: 1618-2642), 2006; 386(5): 1267-1272.
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* In Situ Ap/Maldi-Ms Characterization Of Anchored Mmps (63 visite)
Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
J Mass Spectrom, 2006; 41: 1561-1569.
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* Spectroscopic characterization of PEG-amylin derivatives (66 visite)
Impellizzeri G, La Mendola D, Magrì A, Maccarrone G, Pappalardo G, Rizzarelli E
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
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* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (99 visite)
D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
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* Characterization of a novel RGD-containing peptide with improved selectivity for imaging alpha v beta 3 integrin expression (83 visite)
Del Vecchio S, Zannetti A, Del Gatto A, Grieco P, Iommelli F, Zaccaro L, Panico M, Saviano M, Blystone SD, Pedone C, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
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* Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops (47 visite)
Maglio O, Nastri F, Calhoun JR, Lahr S, Wade H, Pavone V, Degrado WF, Lombardi A
J Biol Inorg Chem (ISSN: 0949-8257print, 0949-8257linking, 1432-1327electronic), 2005 Aug; 10(5): 539-549.
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* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (60 visite)
Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
Protein And Peptide Letters (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
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* Spectroscopic characterization of PEG amylin derivatives (70 visite)
La Mendola D, Magrì A, Pappalardo G, Impellizzeri G, Maccarrone G, Rizzarelli E
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(4): N/D-N/D.
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* Structural Characterization Of Functionalized B-Cyclodestrins (72 visite)
Saviano M, Vitale RM, Pedone C, Iacovino R, La Mendola D, Pappalardo G, Vecchio G, Rizzarelli E
Acta Crystallogr D Biol Crystallogr, 2005; N/D: N/D-N/D.
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* Structural Characterization Of The Oxidation Pathway Of Antarctic Fish Hemoglobins (56 visite)
Vitagliano L, Bonomi G, Franzese M, Merlino A, Vergara A, Verde C, Di Prisco G, Mazzarella L
Acta Crystallogr D Biol Crystallogr, 2005; N/D: N/D-N/D.
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* Imino acids and collagen triple helix stability: Characterization of collagen-like polypeptides containing Hyp-Hyp-Gly sequence repeats (64 visite)
Berisio R, Granata V, Vitagliano L, Zagari A
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Sep 22; 126(37): 11402-11403.
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* Imino acids and collagen triple helix stability: characterization of collagen-like polypeptides containing Hyp-Hyp-Gly sequence repeats (67 visite)
Berisio R, Granata V, Vitagliano L, Zagari A
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking), 2004 Sep 22; 126(37): 11402-11403.
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* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (84 visite)
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
Journal Of Neuroscience (ISSN: 0270-6474, 0361-803x), 2004 Jun 30; 24(26): 6021-6027.
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* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (60 visite)
De Luca S, Morelli G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
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* Characterization of Collagen-Like Heterotrimers: Implications for Triple-Helix Stability (84 visite)
Berisio R, Granata V, Vitagliano L, Zagari A
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 682-688.
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* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (79 visite)
Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
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* Characterization of multicomponent aggregate containing a bioactive peptide and a Gd complex (53 visite)
Accardo A, Tesauro D, Roscigno P, Paduano L, Gianolio E, Morelli G, Benedetti E
Peptide Revolution, 2004; N/D: N/D-N/D.
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* Criteria for the design and biological characterization of radiolabeled peptide-based pharmaceuticals (157 visite)
Benedetti E, Morelli G, Accardo A, Mansi R, Tesauro D, Aloj L
Biodrugs (ISSN: 1173-8804), 2004; 18(5): 279-295.
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* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (84 visite) (PDF 92 visite)
Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
Q J Nucl Med Mol Imaging (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
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* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (86 visite)
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
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* Characterization of melanoidins from a glucose-glycine model system (65 visite)
Borrelli RC, Fogliano V, Monti SM, Ames JM
Eur Food Res Technol (ISSN: 1438-2377), 2002 Sep; 215(3): 210-215.
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* Novel ligands for the affinity-chromatographic purification of antibodies (115 visite)
Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
(ISSN: 0165-022x), 2001 Oct 30; 49(1-3): 481-490.
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* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (65 visite)
Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D,  De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
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* Characterization of phenolic compounds in virgin olive oil and their effect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system (65 visite)
Monti SM, Ritieni A, Sacchi R, Skog K, Borgen E, Fogliano V
J Agric Food Chem (ISSN: 0021-8561), 2001 Sep; 49(8): 3969-3975.
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* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (65 visite)
De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
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* Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (58 visite)
Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
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* Scintimammography with Tc-99m-MIBI versus dynamic MRI for non-invasive characterization of breast masses (107 visite)
Imbriaco M, Del Vecchio S, Riccardi A, Pace L, Di Salle F, Di Gennaro F, Salvatore M, Sodano A
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2001 Jan; 28(1): 56-63.
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Chemical characterization of Sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice (85 visite)
Gurrieri S, Miceli L, Lanza CM, Tomaselli F, Bonomo RP, Rizzarelli E
J Agric Food Chem (ISSN: 0021-8561), 2000 Nov; 48(11): 5424-5431.
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MS-2 fibrosarcoma characterization by laser induced autofluorescence (59 visite)
Colasanti A, Kisslinger A, Fabbrocini G, Liuzzi R, Quarto M, Riccio P, Roberti G, Villani F
Lasers Surg Med (ISSN: 0196-8092print, 0196-8092linking), 2000; 26(5): 441-448.
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[The identification of the criteria of malignancy and the tissue characterization of expansive processes in periskeletal soft tissues. The current role of magnetic resonance] (64 visite)
Cappabianca S, De Luca AM, Iscaro FM, Sirignano C, Cantarella R, Del Vecchio W, Grassi R
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1999 Sep; 98(3): 127-132.
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Abdominal Mass In Childhood: Characterization With Fine Needle Percutaneous Biopsy Guided With Computerized Tomography (54 visite)
Marano I, Soscia E, Salvatore M
Radiol Med, 1999 Apr; 97(4): 251-255.
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Polyclonal antibodies against fusaproliferin (47 visite)
Monti SM, Fogliano V, Randazzo G, Peluso G, Logrieco A, Ritieni A
Can J Microbiol (ISSN: 0008-4166), 1999 Jan; 45(1): 45-50.
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99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (65 visite)
Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
Nuclear Medicine And Biology (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
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Developing Synthetic Hemoprotein Mimetics: Design, Synthesis and Characterization of Heme-Peptide Conjugates (59 visite)
Lombardi A, Nastri F, D'Andrea LD, Maglio O, D'Auria G, Pedone C, Pavone V
Peptides - Frontiers Of Peptide Science, 1999; ConferenceBook: 91-93.
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Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (46 visite)
Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Nucl Med Biol, 1999; 26: 681-686.
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Cerebral blood flow in spinocerebellar degenerations: a single photon emission tomography study in 28 patients (62 visite)
De Michele G, Mainenti PP, Soricelli A, Di Salle F, Salvatore E, Longobardi MR, Postiglione A, Salvatore M, Filla A
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 1998 Sep; 245(9): 603-608.
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Conformational Characterization Of Peptides Rich In The Cycloaliphatic C Alpha, Alpha-Disubstituted Glycine 1-Aminocyclononane-1-Carboxylic Acid (77 visite)
Gatos M, Formaggio F, Crisma M, Valle G, Toniolo C, Bonora GM, Saviano M, Iacovino R, Menchise V, Galdiero S, Pedone C, Benedetti E
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1997 Sep; 3(5): 367-382.
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β-Amino acid residues: Conformational characterization of an N- and C-protected homo-β-(S)-leucine (52 visite)
Benedetti E, Iacovino R, Pedone C, Rossi F, Saviano M, Isernia C, Montesarchio D, DeNapoli L, Piccialli G
International Journal Of Peptide Research And Therapeutics (ISSN: 0929-5666, 1573-3149), 1997 Jun; 4(3): 129-134.
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Characterization of adrenal tumors using F-18 FDG PET imaging: Comparison between benign and malignant lesions (107 visite) (PDF 92 visite)
Maurea S, Mainolfi C, Bazzicalupo L, Panico M, Imparato C, Alfano B, Ziviello M, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): 25-29.
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Hemoprotein models based on a covalent helix-heme-helix sandwich: 1. Design, synthesis, and characterization (66 visite)
Nastri F, Lombardi A, Morelli G, Maglio O, D'Auria G, Pedone C, Pavone V
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 340-349.
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Hemoprotein models based on a covalent helix-heme-helix sandwich: 2. Structural characterization of Co(III) mimochrome I Δ and Λ isomers (64 visite)
D'Auria G, Maglio O, Nastri F, Lombardi A, Mazzeo M, Morelli G, Paolillo L, Pedone C, Pavone V
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 1997; 3(3): 350-362.
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Functional characterization of brain tumors: An overview of the potential clinical value (110 visite) (PDF 94 visite)
Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Nuclear Medicine And Biology (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
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Synthesis And Structural Characterization Of 6i, 6ii-Diamino-6i, 6ii-Dideoxy-Cyclomaltoheptaose, A Difunctionalized Beta-Cyclodextrin (70 visite)
Di Blasio B, Galdiero S, Saviano M, Pedone C, Benedetti E, Rizzarelli E, Pedotti S, Vecchio G, Gibbons WA
Carbohydr Res, 1996 Feb 28; 282(1): 41-52.
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A Platinum(II) Diamino-β-cyclodextrin Complex: A Crystallographic and Solution Study. Synthesis and Structural Characterization of a Platinum(II) Complex of 6A, 6B-Diamino-6A, 6B-dideoxycyclomaltoheptaose (67 visite)
Cucinotta V, Grasso G, Pedotti S, Rizzarelli E, Vecchio G, Di Blasio B, Isernia C, Saviano M, Pedone C
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996; 35(26): 7535-7540.
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Characterization of the mucins produced by normal human colonocytes in primary culture (55 visite)
Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
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Functionalized cyclodextrins: Synthesis and structural characterization of 6-deoxy-6-{4-[N-tert-butoxycarbonyl-2-aminoethyl]-imidazolyl}-cyclomaltoheptaose (72 visite)
Di Blasio B, Galdiero S, Saviano M, De Simone G, Benedetti E, Pedone C, Gibbons WA, Deschenaux R, Rizzarelli E, Vecchio G
Supramol Chem Supramolecular Chemistry (ISSN: 1061-0278), 1996; 7(1): 47-54.
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Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (72 visite)
Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
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IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (65 visite)
Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Nuclear Medicine And Biology (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
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MRI detects acute degeneration of the nigrostriatal dopamine system after MPTP exposure in hemiparkinsonian monkeys (60 visite)
Miletich RS, Bankiewicz KS, Quarantelli M, Plunkett RJ, Frank J, Kopin IJ, Di Chiro G
Ann Neurol (ISSN: 0364-5134), 1994 Jun; 35(6): 689-697.
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Multiparametric characterization of lesions of the white matter in multiple sclerosis patients (53 visite)
BRUNETTI A, TEDESCHI G, ALFANO B, DICOSTANZO A, ALOJ L, ARPAIA M, COVELLI E, BONAVITA S, SALVATORE M
Neuroradiology 1994, 1994; N/D: N/D-N/D.
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METABOLIC CHARACTERIZATION OF CEREBRAL METASTASIS USING MR PROTON SPECTROSCOPY (61 visite)
BRUNETTI A, ALFANO B, STEFANO M, CARACO C, ARPAIA M, BRUNI G, ELMO M, COVELLI E, FREZZA P, SALVATORE M
Neuroradiology 1993, 1993; N/D: N/D-N/D.
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Thermodynamic and Spectroscopic Characterization, and in vitro O2- Scavenger Activity of Copper(II) Complexes with Glycyl-L-histidyl-glycyl-L-histidine (61 visite)
Bonomo RP, Bonsignore F, Conte E, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E
J Chem Soc (ISSN: 1364-5447), 1993; 8: 1295-1300.
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Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (56 visite)
Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
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Isolation and characterization of human embryonic osteoblasts (50 visite)
Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Calcif Tissue Int (ISSN: 0171-967xprint, 0171-967xlinking), 1992 Nov; 51(5): 356-362.
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MENSTRUAL EPILEPSY - DIAGNOSTIC CHARACTERIZATION BY POSITRON EMISSION TOMOGRAPHY AND QUANTITATIVE EEG (65 visite)
BRUNETTI A, TEDESCHI G, SORICELLI A, SALVIA S, ALFANO B, COVELLI E, ALOJ L, BONAVITA V, SALVATORE M
Neuroradiologia 1992 Vol Ii, 1992; N/D: N/D-N/D.
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Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (72 visite)
D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Tumori (ISSN: 0300-8916, 0300-8916print), 1991 Oct 31; 77(5): 449-451.
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Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (58 visite)
Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
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Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (88 visite)
Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
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Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (72 visite)
Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
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Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (44 visite)
Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
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NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (61 visite)
Del Vecchio S, Reynolds JC
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
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TOXICITY, IMMUNOGENICITY, AND TUMOR RADIOIMMUNODETECTING ABILITY OF 2 HUMAN MONOCLONAL-ANTIBODIES IN PATIENTS WITH METASTATIC COLORECTAL-CARCINOMA (58 visite)
Steis RG, Carrasquillo JA, Mccabe R, Bookman MA, Reynolds JC, Larson SM, Smith JW 2nd, Clark JW, Dailey V, Del Vecchio S
(ISSN: 0732-183x), 1990 Mar; 8(3): 476-490.
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Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (53 visite)
Trischitta V, Wong KY,  Brunetti A, Scalisi R, Vigneri R, Goldfine ID
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 1989 Mar 25; 264(9): 5041-5046.
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ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (57 visite)
Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
Nuclear Medicine And Biology (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
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Detection of colon cancer with radiolabelled monoclonal antibodies (72 visite)
Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Nuclear Medicine And Biology (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
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Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (68 visite)
Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
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INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (52 visite)
DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
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Studies on gliadin related peptides. I. Synthesis, purification and 1H n. m. r. characterization of the pentapeptide H-Tyr-(Gln)3-Pro-OH (60 visite)
Pavone V, Rossi F, Pucci P, Andini S, Ferrara L, Di Blasio B, Pedone C
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print), 1983 Oct; 22(4): 482-488.
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172 Records (150 escludendo Abstract e Conferenze).
Impact factor totale: 531.329 (475.04 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 611.862 (518.765 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Generation" OR [btitle] "characterization" OR [btitle] "monoclonal" OR [btitle] "antibodies") AND NOT [id] = 53117)







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