The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice
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The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (90 visite)

Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F

Pharmacol Res (ISSN: 1096-1186electronic, 1043-6618linking), 2016 Apr; 106: 10-20.

Tipo di articolo: Journal Article,

Impact factor: 4.48

Impact factor a 5 anni: 4.497


Parole chiave: Alzheimer, S Disease, Cell Cycle, Flavopiridol, Flavopiridol (pubchem Cid: 9910986), Memory Deficit, Oligomers, Beta-Amyloid, β-Amyloid,

Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84958280806&partnerID=40&md5=f8641bd7b0cd2a98f09add524f2a1687

The ectopic re-activation of cell cycle in neurons is an early event in the pathogenesis of Alzheimer's disease (AD), which could lead to synaptic failure and ensuing cognitive deficits before frank neuronal death. Cytostatic drugs that act as cyclin-dependent kinase (CDK) inhibitors have been poorly investigated in animal models of AD. In the present study, we examined the effects of flavopiridol, an inhibitor of CDKs currently used as antineoplastic drug, against cell cycle reactivation and memory loss induced by intracerebroventricular injection of Aß1-42 oligomers in CD1 mice. Cycling neurons, scored as NeuN-positive cells expressing cyclin A, were found both in the frontal cortex and in the hippocampus of Aβ-injected mice, paralleling memory deficits. Starting from three days after Aβ injection, flavopiridol (0.5, 1 and 3 mg/kg) was intraperitoneally injected daily, for eleven days. Here we show that a treatment with flavopiridol (0.5 and 1 mg/kg) was able to rescue the loss of memory induced by Aβ1-42, and to prevent the occurrence of ectopic cell-cycle events in the mouse frontal cortex and hippocampus. This is the first evidence that a cytostatic drug can prevent cognitive deficits in a non-transgenic animal model of AD. © 2016 Elsevier Ltd. All rights reserved.
*** IBB - CNR ***

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy; IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy., National Research Council, Institute of Neurological Sciences (ISN-CNR), Catania, Italy., Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; Pharmacokinetic Unit, Unifarm Research Center, Catania, Italy., IRCCS Neuromed, Pozzilli IS, Italy; Department of Physiology and Pharmacology, University of Rome Sapienza, Italy., National Research Council, Institute of Biostructure and Bioimaging (IBB-CNR), Catania, Italy; Department of Drug Sciences, University of Catania, Catania, Italy., IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, Troina, EN, Italy; Department of Drug Sciences, University of Catania, Catania, Italy. Electronic address: carafil@hotmail.com.,
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J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2013 Sep; 260(9): 2405-2406.
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* Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis (107 visite)
McNeill A, Wu RM, Tzen KY, Aguiar PC, Arbelo JM, Barone P, Bhatia K, Barsottini O, Bonifati V, Bostantjopoulou S, Bressan R, Cossu G, Cortelli P, Felicio A, Ferraz HB, Herrera J, Houlden H, Hoexter M, Isla C, Lees A, Lorenzo-Betancor O, Mencacci NE, Pastor P, Pappata S, Pellecchia MT, Silveria-Moriyama L, Varrone A, Foltynie T, Schapira AH
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2013 Jul 23; 8(7): e69190-e69190.
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* Long-Term Clinical Results And Mri Changes After Tendon Ball Arthroplasty For Advanced Kienbock'S Disease (91 visite)
Mariconda M, Soscia E, Sirignano C, Smeraglia F, Soldati A, Balato G
J Hand Surg Eur Vol (ISSN: 2043-6289, 0266-7681, 2043-6289electronic), 2013 Jun; 38(5): 508-514.
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* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (102 visite)
Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
Inflammatory Bowel Dis (ISSN: 1078-0998), 2013 Apr; 19(4): 991-998.
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* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (118 visite)
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
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* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (93 visite)
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
Int J Mol Sci (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
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* Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients (103 visite)
Erro R, Pappata S, Amboni M, Vicidomini C, Longo K, Santangelo G, Picillo M, Vitale C, Moccia M, Giordano F, Brunetti A, Pellecchia MT, Salvatore M, Barone P
Parkinsonism Relat Disord (ISSN: 1873-5126, 1353-8020, 1873-5126electronic), 2012 Nov; 18(9): 1034-1038.
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* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (100 visite) (PDF 111 visite)
Pascual B, Prieto E, Arbizu J, Marti-climent JM, Peñuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
Brain (ISSN: 0006-8950), 2012 Sep; 135(9): 2817-2825.
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* The inorganic perspectives of neurotrophins and Alzheimer's disease (159 visite)
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
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* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (180 visite)
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
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* Lymph node fine needle cytology in the diagnosis of infectious diseases and instrumental guides: Ultrasound and computed tomography (79 visite)
Pizzuti LM, Todaro P, Caleo A, Pace L, Vajro P
Infez Med (ISSN: 1124-9390), 2012; 20(SUPPL.3): 26-29.
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* Co-existence of primary hyperparathyroidism and Parkinson's disease in three patients: An incidental finding? (111 visite)
De Rosa A, Rinaldi C, Tucci T, Pappata S, Rossi F, Morra VB, Faggiano A, Colao A, De Michele G
Parkinsonism Relat Disord (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2011 Dec; 17(10): 771-773.
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* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (130 visite)
Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
Hum Brain Mapp (ISSN: 1065-9471), 2011 Oct; 32(10): 1626-1636.
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* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (89 visite)
Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
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* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (212 visite)
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
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* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (114 visite)
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
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* The Inorganic Side of Alzheimer's Disease (92 visite)
Pappalardo G, Milardi D, Rizzarelli E, Sovago I
Neurodegeneration (ISSN: 2041-3203), 2011; (7): N/D-N/D.
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* Magnetic resonance cholangiography with mangafodipir trisodium in Caroli's disease with pancreas involvement (87 visite)
Maurea S, Mollica C, Imbriaco M, Fusari M, Camera L, Salvatore M
Jop (ISSN: 1590-8577, 1590-0857), 2010 Sep 06; 11(5): 460-463.
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* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (101 visite)
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
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* Radiation Induced Thyroid Disorders After Radiotherapy For Hodgkin S Disease: A Dosimetric Analysis (88 visite)
Cella L, Conson M, Liuzzi R, Caterino M, De Rosa N, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
Radiotherapy And Oncology (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2010; 96: N/D-N/D.
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* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (113 visite)
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
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* Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy (42 visite)
De Rosa A, Criscuolo C, Mancini P, De Martino M, Giordano IA, Pappata S, Filla A, De Michele G
Parkinsonism Relat Disord (ISSN: 1353-8020print, 1353-8020linking, 1873-5126electronic), 2009 Mar; 15(3): 242-244.
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* Cardiac performance during exercise in patients with Fabry's disease (85 visite)
Spinelli L, Nicolai E, Acampa W, Imbriaco M, Pisani A, Rao MA, Scopacasa F, Cianciaruso B, De Luca N, Cuocolo A
European Journal Of Clinical Investigation (ISSN: 0014-2972, 1365-2362), 2008 Dec; 38(12): 910-917.
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* Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (86 visite)
De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
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* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (87 visite)
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
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* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (139 visite)
Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
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* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (86 visite)
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
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* MRI characterization of myocardial tissue in patients with Fabry's disease (92 visite)
Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
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* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (78 visite)
Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2007 Jan 12; 282(2): 831-835.
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* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (94 visite)
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
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* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (114 visite)
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
Journal Of Neuroscience (ISSN: 0270-6474, 0361-803x), 2006; 26(43): 10949-10957.
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* Anterior Cingulate Hypoperfusion Can Differentiate Progressive Supranuclear Palsy From Parkinson's Disease; Voxel-Based Analysis And CBA-Based PCA Analysis Of 99mTc-ECD SPECT Data (76 visite)
Varrone A, Pagani M, Salmaso D, Salvatore E, Sansone V, Nobili F, Rodriguez G, Barone P, Larsson SA, De Michele G, Filla A, Pappata S, Salvatore M
European Journal Of Nuclear Medicine And Molecular Imaging, 2005 Sep; 32: N/D-N/D.
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* Noninvasive diagnosis of small bowel Crohn's disease: Combined use of bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (77 visite)
Rispo A, Imbriaco M, Celentano L, Cozzolino A, Camera L, Mainenti PP, Manguso F, Sabbatini F, D'Amico P, Castiglione F
Inflammatory Bowel Dis (ISSN: 1078-0998), 2005 Apr; 11(4): 376-382.
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* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (83 visite)
Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
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* Partial volume effect correction of rCBF SPET studies in mild cognitive impairment and Alzheimer's disease (96 visite)
Varrone A, Pappata S, Quarantelli M, Sansone V, Mollica C, Lore E, Carlomagno S, Iavarone A, Postiglione A, Alfano B, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
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* Small bowel Crohn's disease: Comparison of enteroclysis, bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy (89 visite)
Rispo A, Imbriaco M, Celentano L, Cozzolino A, Mainenti PP, Camera L, Di Girolamo E, De Falco T, Castiglione F
Eur Rev Med Pharmacol Sci (ISSN: 1128-3602), 2004 Sep; 8(5): 219-224.
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* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (90 visite)
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
Journal Of Neuroscience (ISSN: 0270-6474, 0361-803x), 2004 Jun 30; 24(26): 6021-6027.
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* Giant cell tumor and Paget's disease of bone in one family: geographic clustering (74 visite)
Rendina D, Mossetti G, Soscia E, Sirignano C, Insabato L, Viceconti R, Ignarra R, Salvatore M, Nunziata V
Clinical Orthopaedics And Related Research (ISSN: 0009-921x), 2004 Apr; (421): 218-224.
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* Small bowel Crohn's disease: Enteroclysis, bowel sonography and Tc-99m-HMPAO leukocyte scintigraphy at comparison (75 visite)
Castiglione F, Rispo A, Imbriaco M, Celentano L, Cozzolino A, Camera L, Mainenti PP, Manguso F, Di Girolamo E, Mazzacca G
Gastroenterology (ISSN: 0016-5085), 2004 Apr; 126(4): N/D-N/D.
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* Imaging of dopaminergic dysfunction with [I-123]FP-CIT SPECT in early-onset Parkinson's disease (68 visite)
Varrone A, Pappata S, Amboni M, Pellecchia M, Salvatore E, Salvatore M
Mov Disord (ISSN: 0885-3185, 1531-8257), 2004; 19: N/D-N/D.
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* Parkinson's disease - Correlation between MRI analyses, perfusion SPECT with I-123FP-CIT SPECT and the clinical stage of the disease (65 visite)
Covelli E, Brunetti A, Tedeschi E, Sullo P, Mazzarella G, Nuzzo M, Lombardi E, Di Lauro A, Belfiore G
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2003 May; 16: N/D-N/D.
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* Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: A prospective study (82 visite)
Di Somma C, Pivonello R, Loche S, Faggiano A, Klain M, Salvatore M, Lombardi G, Colao A
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Mar; 58(3): 302-308.
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* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (106 visite)
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
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* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (113 visite) (PDF 108 visite)
Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
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* Voxel-based comparison of 99mTc-HMPAO SPECT images in Alzheimer and fronto-temporal dementia revealed distinct patterns of CBF alterations (77 visite)
Pappata S, Varrone A, Caraco C, Soricelli A, Brunetti A, Milan G, Postiglione A, Alfano B, Salvatore M
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
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* [Castleman's disease: CT and MR findings in a case localized in the portocaval space] (73 visite)
Camera L, Selva G, Puzziello A, Sparano L, Ignarra R, Quarantelli M
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2001 Sep; 102(3): 186-188.
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Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (161 visite) (PDF 137 visite)
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Journal Of Magnetic Resonance Imaging (ISSN: 1053-1807), 2000 Mar; 11(3): 260-266.
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Measurement of global drain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (140 visite)
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli E, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Journal Of Magnetic Resonance Imaging (ISSN: 1053-1807), 2000 Mar; 11(3): N/D-N/D.
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Accuracy of enteroclysis in Crohn's disease of the small bowel: A retrospective study (75 visite)
Cirillo LC, Camera L, Della Noce M, Castiglione F, Mazzacca G, Salvatore M
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic), 2000; 10(12): 1894-1898.
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Comparison Between Cortical Distribution Of I-123 Iomazenil And Tc-99m Hmpao In Patients With Alzheimer'S Disease Using Spect (64 visite)
Varrone A, Soricelli A, Postiglione A, Salvatore M
Clin Nucl Med, 1999 Sep; 24(9): 660-665.
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Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (76 visite)
Varrone A, Soricelli A, Postiglione A, Salvatore M
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
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Diagnostic items and treatment of Plummer's disease: A study on 180 patients (84 visite)
Messina G, Viceconti N, Trinti B
Clinica Terapeutica (ISSN: 0009-9074), 1998 May; 149(3): 191-195.
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Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (74 visite)
Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
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Benzodiazepine receptor distribution in Alzheimer's disease with (123)I-iomazenil by SPECT (78 visite)
Varrone A, Soricelli A, Postiglione A, Salvatore M, Lassen N
Textbook Of Spect In Neurology And Psychiatry, 1997; N/D: N/D-N/D.
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Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease (64 visite)
Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N
Radiology (ISSN: 0033-8419, 1527-1315), 1996 Nov; 201: N/D-N/D.
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Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (71 visite)
Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
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Preliminary evaluation of distribution volume for 123I-Iomazenil in Alzheimer's disease as a measure of neuronal loss (62 visite)
Soricelli A, Postiglione A, Mainenti PP, GrivetFojaja M, Discepolo A, Varrone A, Salvatore M, Lassen N
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
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Usefulness of monitoring left ventricular function by an ambulatory radionuclide detector (VEST) in patients with Parkinson's disease and postural hypotension (57 visite)
NAPPI A, CUOCOLO A, MAROTTA T, FERRARA L, IAZZETTA N, PACE L, NICOLAI E, DEMICHELE G, SALVATORE M, CAMPANELLA G, POSTIGLIONE A
Alzheimer S And Parkinson S Diseases (ISSN: 0099-9962), 1995; 44: N/D-N/D.
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BRAIN PERFUSION AT REST AND DURING COGNITIVE ACTIVATION IN PATIENTS WITH DEMENTIA OF ALZHEIMERS TYPE (77 visite)
SORICELLI A, TEDESCHI E, POSTIGLIONE A, GROSSI D, BRUNETTI A, ROMANO M, CASTELLI L, MAINENTI PP, SALVATORE M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
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Ambulatory monitoring of left ventricular function in patients with Parkinson's disease and postural hypotension (85 visite)
Nappi A, Cuocolo A, Iazzetta N, Ferrara LA, Marotta T, Pace L, Nicolai E, De Michele G, Campanella G, Salvatore M, Postiglione A
Eur J Nucl Med Mol Imaging (ISSN: 0340-6997, 1619-7070, 1619-7089), 1994; 21(12): 1312-1317.
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82 Records (63 escludendo Abstract e Conferenze).
Impact factor totale: 262.896 (202.624 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 282.017 (205.758 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Alzheimer" OR [btitle] "S Disease" OR [btitle] "Cell Cycle" OR [btitle] "Flavopiridol" OR [btitle] "Flavopiridol (pubchem Cid: 9910986)") AND NOT [id] = 53162)







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