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Cationic porphyrins are tunable gatekeepers of the 20S proteasome (473 visite) (PDF privato 145 visite)

Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R

Chem Sci (ISSN: 2041-6539, 2041-6520, 2041-6520linking), 2016; 7(2): 1286-1297.



Tipo di articolo: Journal Article,

Impact factor: 8.668, Impact factor a 5 anni: 8.733

Url: http://dx.doi.org/10.1039/C5SC03312H

Parole chiave: Aromatic Compounds, Binding Energy, Bioinformatics, Enzyme Kinetics, Isomers, Porphyrins, Reconfigurable Hardware, Aromatic Residues, Bioinformatic Analysis, Catalytic Chambers, Cationic Porphyrin, Gating Mechanisms, Ligand Interactions, Negatively Charged, Regulatory Mechanism, Enzyme Inhibition,

Affiliazioni:

*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini – CNR UOS di Catania, Via P. Gaifami 18, 95126 Catania, Italy.
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Dipartimento di Farmacia Università di Napoli “Federico II”, Via D. Montesano, 49 I-80131 Napoli, Italy.



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    The 20S proteasome is a barrel-shaped enzymatic assembly playing a critical role in proteome maintenance. Access of proteasome substrates to the catalytic chamber is finely regulated through gating mechanisms which involve aromatic and negatively charged residues located at the N-terminal tails of α subunits. However, despite the importance of gates in regulating proteasome function, up to now very few molecules have been shown to interfere with the equilibrium by which the catalytic channel exchanges between the open and closed states. In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine experimental (enzyme kinetics, UV stopped flow and NMR) and computational (bioinformatic analysis and docking studies) approaches to inspect proteasome inhibition by meso-tetrakis(4-N-methylpyridyl)-porphyrin (H2T4) and its two ortho- and meta-isomers. We show that in a first, fast binding event H2T4 accommodates in a pocket made of negatively charged and aromatic residues present in α1 (Asp10, Phe9), α3 (Tyr5), α5 (Asp9, Tyr8), α6 (Asp7, Tyr6) and α7 (Asp9, Tyr8) subunits thereby stabilizing the closed conformation. A second, slower binding mode involves interaction with the grooves which separate the α- from the β-rings. Of note, the proteasome inhibition by ortho- and meta-H2T4 decreases significantly if compared to the parent compound, thus underscoring the role played by spatial distribution of the four peripheral positive charges in regulating proteasome–ligand interactions. We think that our results may pave the way to further studies aimed at rationalizing the molecular basis of novel, and more sophisticated, proteasome regulatory mechanisms.
        Metals and small molecules in the regulation of the Ubiquitin Proteasome Pathway
    
    Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
        
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    Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
    Impact Factor: 3.451
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    Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
    * Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (3 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
    Impact Factor: 5.207
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    Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
    * Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (3 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
    Impact Factor: 5.476
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    Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
    * VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (10 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
    Impact Factor: 5.16
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    Conti I, Martinez-fernandez L, Esposito L, Hofinger S, Nenov A, Garavelli M, Improta R
    * Multiple Electronic and Structural Factors Control Cyclobutane Pyrimidine Dimer and 6-4 Thymine-Thymine Photodimerization in a DNA Duplex (53 visite)
    Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2017 Oct 26; 23(60): 15177-15188.
    Impact Factor: 5.476
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    Pepino AJ, Segarra-marti J, Nenov A, Improta R, Garavelli M
    * Resolving Ultrafast Photoinduced Deactivations in Water-Solvated Pyrimidine Nucleosides (61 visite)
    J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2017 Apr 20; 8(8): 1777-1783.
    Impact Factor: 9.353
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    Altug C, Gunes H, Nocentini A, Monti SM, Buonanno M, Supuran CT
    * Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties (68 visite)
    Bioorg Med Chem (ISSN: 1464-3391electronic, 0968-0896linking), 2017 Feb 15; 25(4): 1456-1464.
    Impact Factor: 2.93
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    Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
    * Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (3 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
    Impact Factor: 5.476
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    Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
    * Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (4 visite)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2017; 25(2): 539-544.
    Impact Factor: 2.822
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    Langella E, D'Ambrosio K, D'Ascenzio M, Carradori S, Monti SM, Supuran CT, De Simone G
    * A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases (115 visite)
    Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2016 Jan 4; 22(1): 97-100.
    Impact Factor: 5.317
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    Ferraro G, Pica A, Russo Krauss I, Pane F, Amoresano A, Merlino A
    * Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme (76 visite)
    J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2016; N/D: 1-10.
    Impact Factor: 2.894
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    Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
    * Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (120 visite)
    Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
    Impact Factor: 3.108
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    Roviello GN, Roviello V, Autiero I, Saviano M
    * Solid phase synthesis of TyrT, a thymine-tyrosine conjugate with poly(A) RNA-binding ability (245 visite)
    Rsc Adv (ISSN: 2046-2069), 2016; 6(33): 27607-27613.
    Impact Factor: 3.108
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    Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
    * Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (110 visite)
    Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
    Impact Factor: 3.108
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    Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
    * Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners (108 visite)
    Biomaterials (ISSN: 1878-5905electronic, 0142-9612linking), 2015 Oct 16; 75: 47-57.
    Impact Factor: 8.387
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    Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
    * The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (167 visite)
    Biochemistry (ISSN: 1520-4995electronic, 0006-2960linking), 2015 Sep 15; 54(36): 5646-5656.
    Impact Factor: 2.876
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    Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
    * An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization (235 visite)
    Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2015 Apr 22; 13(17): 4859-4868.
    Impact Factor: 3.559
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    Alterio V, Langella E, De Simone G, Monti SM
    * Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (161 visite)
    Marine Drugs (ISSN: 1660-3397electronic, 1660-3397linking), 2015 Apr; 13(4): 1688-1697.
    Impact Factor: 3.345
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    Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
    * Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (113 visite)
    Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
    Impact Factor: 5.771
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    Monti SM, Supuran CT,  De Simone G
    * DPP-4 inhibitors: a patent review (2012 - 2014) (108 visite)
    Expert Opinion On Therapeutic Patents (ISSN: 1354-3776, 1744-7674electronic, 1354-3776linking), 2015 Feb; 25(2): 209-236.
    Impact Factor: 4.626
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    GrassoG, Satriano C, Milardi D
    * A neglected modulator of insulin-degrading enzyme activity and conformation: The pH (155 visite)
    Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2015; 203-204: 33-40.
    Impact Factor: 2.363
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    Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
    * Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (3 visite)
    J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
    Impact Factor:
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    Ceruso M, Carta F, Osman SM, Alothman Z, Monti SM, Supuran CT
    * Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties (134 visite)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2015; 23(15): 4181-4187.
    Impact Factor: 2.923
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    Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
    * Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (143 visite)
    Head & Neck (ISSN: 1043-3074), 2015; 37(5): 763-770.
    Impact Factor: 2.76
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    Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
    * Recent developments of carbonic anhydrase inhibitors as potential drugs (124 visite)
    Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2015; 2015: 174178-174178.
    Impact Factor: 2.134
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    Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M
    * Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (104 visite)
    Rsc Adv (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
    Impact Factor: 3.289
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    Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A
    * Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (113 visite)
    Biometalsbiometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
    Impact Factor: 2.134
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    Fahleson T, Kauczor J, Norman P, Santoro F, Improta R, Coriani S
    * TD-DFT investigation of the magnetic circular dichroism spectra of some purine and pyrimidine bases of nucleic acids (133 visite)
    J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2015; 119(21): 5476-5489.
    Impact Factor: 2.883
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    Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
    * Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (110 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
    Impact Factor: 2.385
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    Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
    * Branched porphyrins as functional scaffolds for multisite bioconjugation (92 visite)
    Biotechnol Appl Biochem (ISSN: 1470-8744electronic, 0885-4513linking), 2014 Sep 21; N/D: N/D-N/D.
    Impact Factor: 1.362
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    Messori L, Cinellu MA, Merlino A
    * Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c) (124 visite)
    Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875print, 1948-5875linking), 2014 Jul 31; 5(10): 1110-1113.
    Impact Factor: 3.12
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    Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
    * Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (136 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
    Impact Factor: 2.385
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    Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
    * Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (132 visite)
    J Enzyme Inhib Med Chem (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
    Impact Factor: 2.332
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    Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
    * Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (142 visite)
    Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
    Impact Factor: 0.635
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    Lin L-L, Chen Y-Y, Chi M-C, Merlino A
    * Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (116 visite)
    Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2014; 1844(9): 1523-1529.
    Impact Factor: 2.747
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    Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
    * Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (133 visite)
    Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
    Impact Factor: 3.84
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    Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
    * The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (134 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
    Impact Factor: 2.385
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    De Simone G, Alterio V, Supuran CT
    * Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (160 visite)
    Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
    Impact Factor: 3.467
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    Monti SM, Supuran CT, De Simone G
    * Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (146 visite)
    Expert Opinion On Therapeutic Patents (ISSN: 1354-3776, 1744-7674electronic), 2013 Jun; 23(6): 737-749.
    Impact Factor: 3.441
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    Doti N, Raimondo D, Sabatella M, Ruvo M
    * Identification of Protease Inhibitors by a Fast Fluorimetric Assay (100 visite)
    Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2013 Jun; 54(2): 283-291.
    Impact Factor: 2.275
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    Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
    * A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (153 visite)
    Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2013 Apr 2; 52(14): 3926-3930.
    Impact Factor: 11.336
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    Di Natale G, Osz K, Kállay C, Pappalardo G, Sanna D, Impellizzeri G, Sóvágó I, Rizzarelli E
    * Affinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results (126 visite)
    Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2013 Mar 11; 19(11): 3751-3761.
    Impact Factor: 5.696
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    Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA
    * Evolutionary screening and adsorption behavior of engineered M13 bacteriophage and derived dodecapeptide for selective decoration of gold interfaces (127 visite)
    J Colloid Interface Sci (ISSN: 0021-9797, 1095-7103electronic, 0021-9797linking), 2013 Jan 1; 389(1): 220-229.
    Impact Factor: 1.646
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    Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
    * Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (145 visite)
    Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
    Impact Factor: 8.193
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    Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
    * Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (133 visite)
    Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
    Impact Factor: 2.61
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    Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
    * Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (130 visite)
    Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
    Impact Factor: 3.432
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    Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
    * The mode of action of anticancer gold-based drugs: a structural perspective (108 visite)
    Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
    Impact Factor: 6.718
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    Improta R
    * Photophysics and photochemistry of thymine deoxy-dinucleotide in water: A PCM/TD-DFT quantum mechanical study (116 visite)
    J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2012 Dec 13; 116(49): 14261-14274.
    Impact Factor: 3.607
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    Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
    * Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (134 visite)
    Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
    Impact Factor: 5.831
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    Berisio R
    * Editorial: cell processes in bacterial diseases (133 visite)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
    Impact Factor: 1.994
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    Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
    * Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (145 visite)
    Chemical Reviews (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
    Impact Factor: 41.298
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    Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
    * The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake (160 visite)
    Molecular Endocrinology (ISSN: 0888-8809, 1944-9917electronic), 2012 Sep; 26(9): 1578-1589.
    Impact Factor: 4.746
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    Ruggiero A, Smaldone G, Squeglia F, Berisio R
    * Enhanced crystallizability by protein engineering approaches: A general overview (1784 visite)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Jul; 19(7): 732-742.
    Impact Factor: 1.994
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    Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
    * Cationic porphyrins are reversible proteasome inhibitors (154 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
    Impact Factor: 10.677
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    De Simone G, Supuran CT
    * (In)organic anions as carbonic anhydrase inhibitors (134 visite)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129.
    Impact Factor: 3.197
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    Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM
    * Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (151 visite)
    Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1232-1241.
    Impact Factor: 3.142
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    Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M,  Leone M
    * Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (118 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
    Impact Factor: 3.377
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    Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
    * Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (102 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
    Impact Factor: 2.338
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    De Simone G
    * Editorial: Zinc Metallo-Enzymes As Target For Drug Design (116 visite)
    Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
    Impact Factor: 4.07
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    Monti SM, Maresca A, Viparelli F, Carta F, De Simone G, Muehlschlegel FA, Scozzafava A, Supuran CT
    * Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata (121 visite)
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    Impact Factor: 2.338
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    Merlino A, Vitiello G, Grimaldi M, Sica F, Busi E, Basosi R, D’Ursi A, Fragneto G, Paduano L, D’Errico G
    * Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study (122 visite)
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    Impact Factor: 3.607
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    Di Fiore A, Maresca A, Supuran CT, De Simone G
    * Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (101 visite)
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    Impact Factor: 6.378
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    Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
    * Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (131 visite)
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    Impact Factor: 6.044
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    Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
    * Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation (160 visite)
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    Impact Factor: 4.092
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    Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
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    Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
    * Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (209 visite)
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    Impact Factor: 9.97
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    Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
    * Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (107 visite)
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    Tabbì G, Di Mauro G, Purrello R, Bonomo RP
    * Electrochemical characterization of ordered arrays of metallo-porphyrins in aqueous solution (123 visite)
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    Impact Factor: 3.838
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    Roviello GN, Di Gaetano S, Capasso D, Franco S, Crescenzo C, Bucci EM, Pedone C
    * RNA-binding and viral reverse transcriptase inhibitory activity of a novel cationic diamino acid-based peptide (118 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2011 Apr 14; 54(7): 2095-2101.
    Impact Factor: 5.248
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    Ruggiero A, Squeglia F, Marasco D, Marchetti R, Molinaro A, Berisio R
    * X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus (130 visite)
    Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2011 Apr 1; 435(1): 33-41.
    Impact Factor: 4.897
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    Nastri F, Lista L, Ringhieri P, Vitale R, Faiella M, Andreozzi C, Travascio P, Maglio O, Lombardi A, Pavone V
    * A Heme-Peptide Metalloenzyme Mimetic with Natural Peroxidase-Like Activity (111 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Apr; 17(16): 4444-4453.
    Impact Factor: 5.925
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    Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
    * Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (168 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
    Impact Factor: 5.925
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    Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (109 visite)
    Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(42): 11636-11638.
    Impact Factor: 6.169
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    La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
    * Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (110 visite)
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    Impact Factor: 3.647
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    Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
    * Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (113 visite)
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    Impact Factor: 2.572
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    Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
    * An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (109 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2010 Oct 15; 285(42): 32568-32575.
    Impact Factor: 5.328
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    Viparelli F, Monti SM, De Simone G, Innocenti A, Scozzafava A, Xu Y, Morel FMM, Supuran CT
    * Inhibition Of The R1 Fragment Of The Cadmium-Containing Zeta-Class Carbonic Anhydrase From The Diatom Thalassiosira Weissflogii With Anions (134 visite)
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    Impact Factor: 2.661
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    Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
    * Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (148 visite)
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    Impact Factor: 3.647
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    Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R
    * Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (148 visite)
    Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2010 Sep 3; 5(9): 1568-1576.
    Impact Factor: 3.306
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    Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (100 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
    Impact Factor: 2.661
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    La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
    * A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (374 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
    Impact Factor: 5.476
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    Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
    * Free-Energy Profile for CO Binding to Separated Chains of Human and Trematomus newnesi Hemoglobin: Insights from Molecular Dynamics Simulations and Perturbed Matrix Method (119 visite)
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    Impact Factor: 3.603
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    Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
    * Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (129 visite)
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    Impact Factor: 4.106
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    De Simone G, Supuran CT
    * Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (161 visite)
    Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
    Impact Factor: 2.773
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    Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
    * Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (139 visite)
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    Impact Factor: 19.407
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    Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
    * Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (168 visite)
    J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
    Impact Factor: 3.068
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    Guler OO, De Simone G, Supuran CT
    * Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (201 visite)
    Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
    Impact Factor: 4.63
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    Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
    * Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (174 visite)
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    Impact Factor: 3.647
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    Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
    * Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (121 visite)
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    Impact Factor: 2.605
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    Vitagliano L, Stanzione F, De Simone A, Esposito L
    * Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (148 visite)
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    Impact Factor: 2.605
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    De Simone G, Scozzafava A, Supuran CT
    * Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (113 visite)
    Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
    Impact Factor: 2.473
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    Randazzo R, Lauceri R, Mammana A, D'Urso A, Purrello R
    * Interactions of Λ and Δ enantiomers of ruthenium(II) cationic complexes with achiral anionic porphyrins (120 visite)
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    Impact Factor: 2.677
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    Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
    * Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (136 visite)
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    Impact Factor: 5.52
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    Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
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    Impact Factor: 5.52
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    Marasco D, Perretta G, Sabatella M, Ruvo M
    * Past and Future Perspectives of Synthetic Peptide Libraries (115 visite)
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    Impact Factor: 3.011
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    Lauceri R, Fasciglione G, D'Urso A, Marini S, Purrello R, Coletta M
    * Kinetic investigation of porphyrin interaction with chiral templates reveals unexpected features of the induction and self-propagation mechanism of chiral memory (99 visite)
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    Impact Factor: 8.091
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    Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
    * Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (118 visite)
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    Impact Factor: 8.091
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    Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
    * Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (118 visite)
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    Impact Factor: 2.565
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    Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
    * Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (126 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
    Impact Factor: 3.379
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    D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT
    * Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (145 visite)
    J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2008 Jun 12; 51(11): 3230-3237.
    Impact Factor: 4.898
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    Supuran CT, Di Fiore A, De Simone G
    * Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (132 visite)
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    Impact Factor: 3.08
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    Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors (109 visite)
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    Impact Factor: 2.531
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    Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
    * Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (82 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
    Impact Factor: 2.531
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    Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
    * Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (115 visite)
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    Impact Factor: 2.276
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    Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
    * Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (130 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
    Impact Factor: 4.898
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    De Simone G, Di Fiore A, Supuran CT
    * Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (122 visite)
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
    Impact Factor: 4.399
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    D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
    * In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (188 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
    Impact Factor: 2.823
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    Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
    * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (113 visite)
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
    Impact Factor: 4.399
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    Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
    * Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (110 visite)
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    Impact Factor: 10.879
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    Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
    * The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (97 visite)
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    Impact Factor: 9.38
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    Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
    * Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (98 visite)
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    Impact Factor: 6.44
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    Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
    * Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (117 visite)
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    Impact Factor: 2.604
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    Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
    * Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (120 visite)
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    Impact Factor: 2.436
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    Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
    * White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (132 visite)
    Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
    Impact Factor: 4.101
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    Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
    * Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (116 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2007 Jun 29; 282(26): 19029-19041.
    Impact Factor: 5.581
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    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (99 visite)
    Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
    Impact Factor: 3.664
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    Vitagliano L, Ruggiero A, Pedone C, Berisio R
    * A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (159 visite)
    J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
    Impact Factor: 4.472
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    Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
    * Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (151 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
    Impact Factor: 4.895
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    Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
    * Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (143 visite)
    Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 83-90.
    Impact Factor: 3.259
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    De Simone G, Supuran CT
    * Antiobesity carbonic anhydrase inhibitors (158 visite)
    Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
    Impact Factor: 4.325
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    Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
    * Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (136 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
    Impact Factor: 5.33
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    Matassa R, Carbone M, Lauceri R, Purrello R, Caminiti R
    * Supramolecular structure of extrinsically chiral porphyrin hetero-assemblies and achiral analogues (134 visite)
    Adv Mater (ISSN: 0935-9648), 2007; 19(22): 3961-3967.
    Impact Factor: 8.191
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    Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
    * Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (106 visite)
    Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2006 Dec 15; 400: 521-530.
    Impact Factor: 4.1
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    Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
    * The chemical synthesis of the GstI protein by NCL on a X-Met site (122 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Dec 5; 83(5): 508-518.
    Impact Factor: 2.48
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    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (127 visite)
    J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
    Impact Factor: 2.945
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    Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
    * Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (121 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
    Impact Factor: 5.115
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    De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
    * Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (142 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
    Impact Factor: 5.115
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    Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (120 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
    Impact Factor: 7.696
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    Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
    * Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (117 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
    Impact Factor: 3.633
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    Cappiello M, Alterio  V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * A new spot test for sulfhydryl-containing compounds (155 visite)
    Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
    Impact Factor: 2.305
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    Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (161 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
    Impact Factor: 3.633
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    Arena G, Casnati A, Contino A, Magrì A, Sansone F, Sciotto D, Ungaro R
    * Inclusion of naturally occurring amino acids in water soluble calix[4]arenes: A microcalorimetric and 1H NMR investigation supported by molecular modeling (122 visite)
    Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Jan 21; 4(2): 243-249.
    Impact Factor: 2.874
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    Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (115 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
    Impact Factor: 2.538
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    Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
    * Erratum: Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (Proteins: Structure, Function and Bioinformatics (2006) 62 (604-616)) (107 visite)
    Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006; 65(2): 524-524.
    Impact Factor: 3.73
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    Berisio R, Loguercio S, De Simone A, Zagari A, Vitagliano L
    * Polyproline helices in protein structures: A statistical survey (102 visite)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2006; 13(8): 847-854.
    Impact Factor: 1.13
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    Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
    * Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (140 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2005 Oct 7; 280(40): 34278-34287.
    Impact Factor: 5.854
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    Angela M, Massimo De N, Rosaria L, Roberto P
    * Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (126 visite)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
    Impact Factor: 2.286
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    Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
    * Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (87 visite)
    Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
    Impact Factor: 3.415
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    De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
    * Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (117 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
    Impact Factor: 2.478
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    Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
    * Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (165 visite)
    Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
    Impact Factor: 5.108
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    Esposito L, Daggett V
    * Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (130 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
    Impact Factor: 3.848
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    De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
    * Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (106 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
    Impact Factor: 2.545
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    Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
    * Assignment of the binding site for haptoglobin on apolipoprotein A-I (98 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2005 Jan 14; 280(2): 1193-1198.
    Impact Factor: 5.854
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    Lauceria R, Purrellob R
    * Transfer, memory and amplification of chirality in porphyrin aggregates (82 visite)
    Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
    Impact Factor: 1.715
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    Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
    * Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (122 visite)
    J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
    Impact Factor: 3.3
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    Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
    * Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (132 visite)
    Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
    Impact Factor: 4.104
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    Sica F, Di Fiore A, Merlino A, Mazzarella L
    * Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (116 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2004 Sep 27; 279(35): 36753-36760.
    Impact Factor: 6.355
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    Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
    * Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (114 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
    Impact Factor: 2.863
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    De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
    * A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (111 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2004 Feb 20; 279(8): 6815-6823.
    Impact Factor: 6.355
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    Caridi A, Cufari A, Lovino R, Palumbo R, Tedesco I
    * Influence of Yeast on Polyphenol Composition of Wine (82 visite)
    Food Technol Biotechnol (ISSN: 1330-9862), 2004 Jan; 42(1): 37-40.
    Impact Factor: 0.475
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    De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
    * A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (128 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
    Impact Factor: 2.863
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    Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
    * Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (152 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
    Impact Factor: 2.863
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    Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
    * Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (127 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
    Impact Factor: 2.863
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    Berisio R, Schluenzen F, Harms J, Bashan A, Auerbach T, Baram D, Yonath A
    * Structural insight into the role of the ribosomal tunnel in cellular regulation (100 visite)
    Nat Struct Biol (ISSN: 1072-8368), 2003 May; 10(5): 366-370.
    Impact Factor: 11.579
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    Bonomo RP, Impellizzeri G, La Mendola D, Maccarone G, Pappalardo G, Santoro A, Tabbì G, Vecchio G, Rizzarelli E
    * Functional Mimics Of Cu, Zn-Superoxide Dismutase Enzymes, In Metal-Ligand Interactions In Nano-, Micro-, And Macro-Systems In Complex Environments (96 visite)
    In Complex Environmentsmetal Ligand Interactions (ISSN: 1568-2609, 1568-8260), 2003 Jan; 116: 41-63.
    Impact Factor: 5.664
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    Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
    * Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (130 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
    Impact Factor: 6.201
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    Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
    * From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (121 visite)
    J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
    Impact Factor: 9.023
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    Saracino GAA, Tedeschi A, D'Errico G, Improta R, Franco L, Ruzzi M, Corvaia C, Barone V
    * Solvent polarity and pH effects on the magnetic properties of ionizable nitroxide radicals: A combined computational and experimental study of 2, 2, 5, 5-tetramethyl-3-carboxypyrrolidine and 2, 2, 6, 6-tetramethyl-4-carboxypiperidine nitroxides (109 visite)
    J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2002; 106(44): 10700-10706.
    Impact Factor: 2.765
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    De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
    * Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (142 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2001 Sep 28; 276(39): 36613-36623.
    Impact Factor: 7.258
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    Lauceri R, Purrello R, Shetty SJ, Vicente MGH
    * Interactions of anionic carboranylated porphyrins with DNA [3] (93 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2001 Jun 20; 123(24): 5835-5836.
    Impact Factor: 6.079
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    Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
    * Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (111 visite)
    Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
    Impact Factor: 1.021
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    Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
    Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (116 visite)
    Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
    Impact Factor: 8.46
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    Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
    From natural to synthetic multisite thrombin inhibitors (99 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
    Impact Factor: 2.331
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    Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
    Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (119 visite)
    Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
    Impact Factor: 2.189
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    Bonomo RP, Boudet AM, Cozzolino R, Rizzarelli E, Santoro AM, Sterjiades R, Zappalà R
    A comparative study of two isoforms of laccase secreted by the 'white- rot' fungus Rigidoporus lignosus, exhibiting significant structural and functional differences (115 visite)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1998 Sep; 71(3-4): 205-211.
    Impact Factor: 1.162
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    De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
    New synthetic tools for peptide-tetraphenylporphyrin derivatives (87 visite)
    Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
    Impact Factor: 0.557
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    Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
    Miniaturized hemoproteins (90 visite)
    Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
    Impact Factor: 2.086
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    Purrello R, Bellacchio E, Gurrieri S, Lauceri R, Raudino A, Monsù Scolaro L, Santoro AM
    Ph Modulation Of Porphyrins Self-Assembly Onto Polylisine (78 visite)
    Journal Of Physical Chemistry B, 1998; N/D: 8852-8857.
    Impact Factor: 0
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    Colasanti A, Kisslinger A, Kusch D, Liuzzi R, Mastrocinque M, Montforts FP, Quarto M, Riccio P, Roberti G, Villani F
    In vitro photo-activation of newly synthesized chlorin derivatives with red-light-emitting diodes (86 visite)
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    Impact Factor: 1.381
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    Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
    Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (122 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
    Impact Factor: 2.425
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    Mastruzzo L, Woisard A, Ma DD, Rizzarelli E, Favre A, Le Doan T
    TARGETED PHOTOCHEMICAL MODIFICATION OF HIV-DERIVED OLIGORIBONUCLEOTIDES BY ANTISENSE OLIGODEOXYNUCLEOTIDES LINKED TO PORPHYRINS (84 visite)
    Photochem Photobiol (ISSN: 0031-8655), 1994 Oct; 60(4): 316-322.
    Impact Factor: 2.426
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    Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
    Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (90 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
    Impact Factor: 2.425
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    175 Records (171 escludendo Abstract e Conferenze).
    Impact factor totale: 763.709 (749.208 escludendo Abstract e Conferenze).
    Impact factor a 5 anni totale: 779.144 (765.024 escludendo Abstract e Conferenze).







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