Cationic porphyrins are tunable gatekeepers of the 20S proteasome
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Cationic porphyrins are tunable gatekeepers of the 20S proteasome (558 visite) (PDF privato 204 visite)

Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R

Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.



Tipo di articolo: Journal Article,

Impact factor: 8.668, Impact factor a 5 anni: 8.733

Url: http://dx.doi.org/10.1039/C5SC03312H

Parole chiave: Aromatic Compounds, Binding Energy, Bioinformatics, Enzyme Kinetics, Isomers, Porphyrins, Reconfigurable Hardware, Aromatic Residues, Bioinformatic Analysis, Catalytic Chambers, Cationic Porphyrin, Gating Mechanisms, Ligand Interactions, Negatively Charged, Regulatory Mechanism, Enzyme Inhibition,

Affiliazioni:

*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini – CNR UOS di Catania, Via P. Gaifami 18, 95126 Catania, Italy.
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Dipartimento di Farmacia Università di Napoli “Federico II”, Via D. Montesano, 49 I-80131 Napoli, Italy.


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    <span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">The 20S proteasome is a barrel-shaped enzymatic assembly playing a critical role in proteome maintenance. Access of proteasome substrates to the catalytic chamber is finely regulated through gating mechanisms which involve aromatic and negatively charged residues located at the N-terminal tails of α subunits. However, despite the importance of gates in regulating proteasome function, up to now very few molecules have been shown to interfere with the equilibrium by which the catalytic channel exchanges between the open and closed states. In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine experimental (enzyme kinetics, UV stopped flow and NMR) and computational (bioinformatic analysis and docking studies) approaches to inspect proteasome inhibition by </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">meso</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-tetrakis(4-</span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">N</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-methylpyridyl)-porphyrin (H</span><small style="font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;"><sub>2</sub></small><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">T4) and its two </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">ortho</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">- and </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">meta</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-isomers. We show that in a first, fast binding event H</span><small style="font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;"><sub>2</sub></small><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">T4 accommodates in a pocket made of negatively charged and aromatic residues present in α1 (Asp10, Phe9), α3 (Tyr5), α5 (Asp9, Tyr8), α6 (Asp7, Tyr6) and α7 (Asp9, Tyr8) subunits thereby stabilizing the closed conformation. A second, slower binding mode involves interaction with the grooves which separate the α- from the β-rings. Of note, the proteasome inhibition by </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">ortho</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">- and </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">meta</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-H</span><small style="font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;"><sub>2</sub></small><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">T4 decreases significantly if compared to the parent compound, thus underscoring the role played by spatial distribution of the four peripheral positive charges in regulating proteasome–ligand interactions. We think that our results may pave the way to further studies aimed at rationalizing the molecular basis of novel, and more sophisticated, proteasome regulatory mechanisms.</span>
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    Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
    * Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (364 visite)
    Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
    Impact Factor: 5.52
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
    * Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (301 visite)
    Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
    Impact Factor: 5.52
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceri R, Fasciglione G, D'Urso A, Marini S, Purrello R, Coletta M
    * Kinetic investigation of porphyrin interaction with chiral templates reveals unexpected features of the induction and self-propagation mechanism of chiral memory (278 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10476-10477.
    Impact Factor: 8.091
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
    * Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (286 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
    Impact Factor: 8.091
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
    * Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (326 visite)
    Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
    Impact Factor: 2.565
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
    * Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (228 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
    Impact Factor: 3.379
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
    * Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (258 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
    Impact Factor: 2.531
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
    * In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (279 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
    Impact Factor: 2.823
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
    * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (226 visite)
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
    Impact Factor: 4.399
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
    * Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (275 visite)
    Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
    Impact Factor: 10.879
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
    * Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (201 visite)
    Chirality (ISSN: 0899-0042), 2007 Sep; 19(8): 642-646.
    Impact Factor: 2.436
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
    * White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (216 visite)
    Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
    Impact Factor: 4.101
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (213 visite)
    Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
    Impact Factor: 3.664
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Vitagliano L, Ruggiero A, Pedone C, Berisio R
    * A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (263 visite)
    J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
    Impact Factor: 4.472
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
    * Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (290 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
    Impact Factor: 5.33
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Matassa R, Carbone M, Lauceri R, Purrello R, Caminiti R
    * Supramolecular structure of extrinsically chiral porphyrin hetero-assemblies and achiral analogues (229 visite)
    Adv Mater (ISSN: 0935-9648), 2007; 19(22): 3961-3967.
    Impact Factor: 8.191
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    Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
    * Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (227 visite)
    Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2006 Dec 15; 400: 521-530.
    Impact Factor: 4.1
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
    * Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (350 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
    Impact Factor: 3.633
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Cappiello M, Alterio  V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * A new spot test for sulfhydryl-containing compounds (297 visite)
    Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
    Impact Factor: 2.305
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    Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (288 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
    Impact Factor: 3.633
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    Arena G, Casnati A, Contino A, Magrì A, Sansone F, Sciotto D, Ungaro R
    * Inclusion of naturally occurring amino acids in water soluble calix[4]arenes: A microcalorimetric and 1H NMR investigation supported by molecular modeling (269 visite)
    Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Jan 21; 4(2): 243-249.
    Impact Factor: 2.874
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    Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
    * Erratum: Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (Proteins: Structure, Function and Bioinformatics (2006) 62 (604-616)) (166 visite)
    Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006; 65(2): 524-524.
    Impact Factor: 3.73
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Berisio R, Loguercio S, De Simone A, Zagari A, Vitagliano L
    * Polyproline helices in protein structures: A statistical survey (219 visite)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2006; 13(8): 847-854.
    Impact Factor: 1.13
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
    * Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (272 visite)
    Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Oct 7; 280(40): 34278-34287.
    Impact Factor: 5.854
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Angela M, Massimo De N, Rosaria L, Roberto P
    * Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (292 visite)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
    Impact Factor: 2.286
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Esposito L, Daggett V
    * Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (290 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
    Impact Factor: 3.848
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
    * Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (266 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
    Impact Factor: 2.545
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceria R, Purrellob R
    * Transfer, memory and amplification of chirality in porphyrin aggregates (209 visite)
    Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
    Impact Factor: 1.715
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
    * Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (231 visite)
    J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
    Impact Factor: 3.3
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
    * Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (256 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Caridi A, Cufari A, Lovino R, Palumbo R, Tedesco I
    * Influence of Yeast on Polyphenol Composition of Wine (155 visite)
    Food Technol Biotechnol (ISSN: 1330-9862), 2004 Jan; 42(1): 37-40.
    Impact Factor: 0.475
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
    * A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (306 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
    * Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (449 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
    * Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (337 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
    * Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (262 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
    Impact Factor: 6.201
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
    * From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (351 visite)
    J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
    Impact Factor: 9.023
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Saracino GAA, Tedeschi A, D'Errico G, Improta R, Franco L, Ruzzi M, Corvaia C, Barone V
    * Solvent polarity and pH effects on the magnetic properties of ionizable nitroxide radicals: A combined computational and experimental study of 2, 2, 5, 5-tetramethyl-3-carboxypyrrolidine and 2, 2, 6, 6-tetramethyl-4-carboxypiperidine nitroxides (201 visite)
    J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2002; 106(44): 10700-10706.
    Impact Factor: 2.765
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceri R, Purrello R, Shetty SJ, Vicente MGH
    * Interactions of anionic carboranylated porphyrins with DNA [3] (184 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2001 Jun 20; 123(24): 5835-5836.
    Impact Factor: 6.079
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    Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
    * Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (260 visite)
    Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
    Impact Factor: 1.021
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Bonomo RP, Boudet AM, Cozzolino R, Rizzarelli E, Santoro AM, Sterjiades R, Zappalà R
    A comparative study of two isoforms of laccase secreted by the 'white- rot' fungus Rigidoporus lignosus, exhibiting significant structural and functional differences (202 visite)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1998 Sep; 71(3-4): 205-211.
    Impact Factor: 1.162
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
    New synthetic tools for peptide-tetraphenylporphyrin derivatives (203 visite)
    Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
    Impact Factor: 0.557
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
    Miniaturized hemoproteins (257 visite)
    Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
    Impact Factor: 2.086
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Purrello R, Bellacchio E, Gurrieri S, Lauceri R, Raudino A, Monsù Scolaro L, Santoro AM
    Ph Modulation Of Porphyrins Self-Assembly Onto Polylisine (160 visite)
    Journal Of Physical Chemistry B, 1998; N/D: 8852-8857.
    Impact Factor: 0
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    Colasanti A, Kisslinger A, Kusch D, Liuzzi R, Mastrocinque M, Montforts FP, Quarto M, Riccio P, Roberti G, Villani F
    In vitro photo-activation of newly synthesized chlorin derivatives with red-light-emitting diodes (187 visite)
    J Photochem Photobiol B (ISSN: 1011-1344print, 1011-1344linking), 1997 Mar; 38(1): 54-60.
    Impact Factor: 1.381
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
    Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (284 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
    Impact Factor: 2.425
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Mastruzzo L, Woisard A, Ma DD, Rizzarelli E, Favre A, Le Doan T
    TARGETED PHOTOCHEMICAL MODIFICATION OF HIV-DERIVED OLIGORIBONUCLEOTIDES BY ANTISENSE OLIGODEOXYNUCLEOTIDES LINKED TO PORPHYRINS (211 visite)
    Photochem Photobiol (ISSN: 0031-8655), 1994 Oct; 60(4): 316-322.
    Impact Factor: 2.426
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    Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
    Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (295 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
    Impact Factor: 2.425
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    94 Records (93 escludendo Abstract e Conferenze).
    Impact factor totale: 399.864 (396.134 escludendo Abstract e Conferenze).
    Impact factor a 5 anni totale: 418.52 (415.556 escludendo Abstract e Conferenze).







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    Ultima modifica di Marco Comerci in data Sunday 12 July 2020, 13:14:47
    558 visite. Ultima visita in data Saturday 25 July 2020, 7:31:51