Cationic porphyrins are tunable gatekeepers of the 20S proteasome
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Cationic porphyrins are tunable gatekeepers of the 20S proteasome (492 visite) (PDF privato 163 visite)

Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R

Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.



Tipo di articolo: Journal Article,

Impact factor: 8.668, Impact factor a 5 anni: 8.733

Url: http://dx.doi.org/10.1039/C5SC03312H

Parole chiave: Aromatic Compounds, Binding Energy, Bioinformatics, Enzyme Kinetics, Isomers, Porphyrins, Reconfigurable Hardware, Aromatic Residues, Bioinformatic Analysis, Catalytic Chambers, Cationic Porphyrin, Gating Mechanisms, Ligand Interactions, Negatively Charged, Regulatory Mechanism, Enzyme Inhibition,

Affiliazioni:

*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini – CNR UOS di Catania, Via P. Gaifami 18, 95126 Catania, Italy.
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Dipartimento di Farmacia Università di Napoli “Federico II”, Via D. Montesano, 49 I-80131 Napoli, Italy.


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    <span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">The 20S proteasome is a barrel-shaped enzymatic assembly playing a critical role in proteome maintenance. Access of proteasome substrates to the catalytic chamber is finely regulated through gating mechanisms which involve aromatic and negatively charged residues located at the N-terminal tails of α subunits. However, despite the importance of gates in regulating proteasome function, up to now very few molecules have been shown to interfere with the equilibrium by which the catalytic channel exchanges between the open and closed states. In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine experimental (enzyme kinetics, UV stopped flow and NMR) and computational (bioinformatic analysis and docking studies) approaches to inspect proteasome inhibition by </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">meso</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-tetrakis(4-</span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">N</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-methylpyridyl)-porphyrin (H</span><small style="font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;"><sub>2</sub></small><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">T4) and its two </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">ortho</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">- and </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">meta</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-isomers. We show that in a first, fast binding event H</span><small style="font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;"><sub>2</sub></small><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">T4 accommodates in a pocket made of negatively charged and aromatic residues present in α1 (Asp10, Phe9), α3 (Tyr5), α5 (Asp9, Tyr8), α6 (Asp7, Tyr6) and α7 (Asp9, Tyr8) subunits thereby stabilizing the closed conformation. A second, slower binding mode involves interaction with the grooves which separate the α- from the β-rings. Of note, the proteasome inhibition by </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">ortho</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">- and </span><span class="italic" style="font-size: 16px; font-style: italic; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">meta</span><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">-H</span><small style="font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;"><sub>2</sub></small><span style="font-size: 16px; font-family: 'Times New Roman', Helvetica, sans-serif; line-height: 24px;">T4 decreases significantly if compared to the parent compound, thus underscoring the role played by spatial distribution of the four peripheral positive charges in regulating proteasome–ligand interactions. We think that our results may pave the way to further studies aimed at rationalizing the molecular basis of novel, and more sophisticated, proteasome regulatory mechanisms.</span>
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    Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
    * Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (222 visite)
    J Biol Chem (ISSN: 0021-9258, 1083-351x), 2008 Oct 10; 283(41): 27799-27809.
    Impact Factor: 5.52
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceri R, Fasciglione G, D'Urso A, Marini S, Purrello R, Coletta M
    * Kinetic investigation of porphyrin interaction with chiral templates reveals unexpected features of the induction and self-propagation mechanism of chiral memory (165 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10476-10477.
    Impact Factor: 8.091
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
    * Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (171 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
    Impact Factor: 8.091
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
    * Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (226 visite)
    Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
    Impact Factor: 2.565
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
    * Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (148 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
    Impact Factor: 3.379
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
    * Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (163 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
    Impact Factor: 2.531
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
    * In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (211 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
    Impact Factor: 2.823
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
    * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (148 visite)
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
    Impact Factor: 4.399
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
    * Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (177 visite)
    Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
    Impact Factor: 10.879
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
    * Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (142 visite)
    Chirality (ISSN: 0899-0042), 2007 Sep; 19(8): 642-646.
    Impact Factor: 2.436
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
    * White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (164 visite)
    Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
    Impact Factor: 4.101
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (134 visite)
    Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
    Impact Factor: 3.664
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Vitagliano L, Ruggiero A, Pedone C, Berisio R
    * A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (196 visite)
    J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
    Impact Factor: 4.472
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
    * Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (189 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
    Impact Factor: 5.33
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Matassa R, Carbone M, Lauceri R, Purrello R, Caminiti R
    * Supramolecular structure of extrinsically chiral porphyrin hetero-assemblies and achiral analogues (156 visite)
    Adv Mater (ISSN: 0935-9648), 2007; 19(22): 3961-3967.
    Impact Factor: 8.191
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    Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
    * Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (134 visite)
    Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2006 Dec 15; 400: 521-530.
    Impact Factor: 4.1
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
    * Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (215 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
    Impact Factor: 3.633
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Cappiello M, Alterio  V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * A new spot test for sulfhydryl-containing compounds (181 visite)
    Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
    Impact Factor: 2.305
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
    * Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (182 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
    Impact Factor: 3.633
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Arena G, Casnati A, Contino A, Magrì A, Sansone F, Sciotto D, Ungaro R
    * Inclusion of naturally occurring amino acids in water soluble calix[4]arenes: A microcalorimetric and 1H NMR investigation supported by molecular modeling (159 visite)
    Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Jan 21; 4(2): 243-249.
    Impact Factor: 2.874
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
    * Erratum: Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (Proteins: Structure, Function and Bioinformatics (2006) 62 (604-616)) (131 visite)
    Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006; 65(2): 524-524.
    Impact Factor: 3.73
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Berisio R, Loguercio S, De Simone A, Zagari A, Vitagliano L
    * Polyproline helices in protein structures: A statistical survey (150 visite)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2006; 13(8): 847-854.
    Impact Factor: 1.13
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S-I
    * Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex (178 visite)
    J Biol Chem (ISSN: 0021-9258, 1083-351x), 2005 Oct 7; 280(40): 34278-34287.
    Impact Factor: 5.854
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Angela M, Massimo De N, Rosaria L, Roberto P
    * Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (200 visite)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
    Impact Factor: 2.286
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Esposito L, Daggett V
    * Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (210 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
    Impact Factor: 3.848
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
    * Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (161 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
    Impact Factor: 2.545
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceria R, Purrellob R
    * Transfer, memory and amplification of chirality in porphyrin aggregates (121 visite)
    Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
    Impact Factor: 1.715
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
    * Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (150 visite)
    J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
    Impact Factor: 3.3
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
    * Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (164 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Caridi A, Cufari A, Lovino R, Palumbo R, Tedesco I
    * Influence of Yeast on Polyphenol Composition of Wine (99 visite)
    Food Technol Biotechnol (ISSN: 1330-9862), 2004 Jan; 42(1): 37-40.
    Impact Factor: 0.475
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
    * A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (199 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
    * Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (247 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
    * Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (215 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
    Impact Factor: 2.863
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
    * Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (177 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
    Impact Factor: 6.201
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
    * From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (159 visite)
    J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
    Impact Factor: 9.023
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Saracino GAA, Tedeschi A, D'Errico G, Improta R, Franco L, Ruzzi M, Corvaia C, Barone V
    * Solvent polarity and pH effects on the magnetic properties of ionizable nitroxide radicals: A combined computational and experimental study of 2, 2, 5, 5-tetramethyl-3-carboxypyrrolidine and 2, 2, 6, 6-tetramethyl-4-carboxypiperidine nitroxides (128 visite)
    J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2002; 106(44): 10700-10706.
    Impact Factor: 2.765
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lauceri R, Purrello R, Shetty SJ, Vicente MGH
    * Interactions of anionic carboranylated porphyrins with DNA [3] (119 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2001 Jun 20; 123(24): 5835-5836.
    Impact Factor: 6.079
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    Garzillo AM, Colao MC, Buonocore V, Oliva R, Falcigno L, Saviano M, Santoro AM, Zappala R, Bonomo RP, Bianco C, Giardina P, Palmieri G, Sannia G
    * Structural and kinetic characterization of native laccases from Pleurotas ostreatus, Rigidoporus lignosus, and Trametes trogii (136 visite)
    Journal Of Protein Chemistry (ISSN: 0277-8033), 2001 Apr; 20(3): 191-201.
    Impact Factor: 1.021
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Bonomo RP, Boudet AM, Cozzolino R, Rizzarelli E, Santoro AM, Sterjiades R, Zappalà R
    A comparative study of two isoforms of laccase secreted by the 'white- rot' fungus Rigidoporus lignosus, exhibiting significant structural and functional differences (138 visite)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1998 Sep; 71(3-4): 205-211.
    Impact Factor: 1.162
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
    New synthetic tools for peptide-tetraphenylporphyrin derivatives (124 visite)
    Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
    Impact Factor: 0.557
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
    Miniaturized hemoproteins (151 visite)
    Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
    Impact Factor: 2.086
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Purrello R, Bellacchio E, Gurrieri S, Lauceri R, Raudino A, Monsù Scolaro L, Santoro AM
    Ph Modulation Of Porphyrins Self-Assembly Onto Polylisine (112 visite)
    Journal Of Physical Chemistry B, 1998; N/D: 8852-8857.
    Impact Factor: 0
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    Colasanti A, Kisslinger A, Kusch D, Liuzzi R, Mastrocinque M, Montforts FP, Quarto M, Riccio P, Roberti G, Villani F
    In vitro photo-activation of newly synthesized chlorin derivatives with red-light-emitting diodes (124 visite)
    J Photochem Photobiol B (ISSN: 1011-1344print, 1011-1344linking), 1997 Mar; 38(1): 54-60.
    Impact Factor: 1.381
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    Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
    Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (183 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
    Impact Factor: 2.425
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Mastruzzo L, Woisard A, Ma DD, Rizzarelli E, Favre A, Le Doan T
    TARGETED PHOTOCHEMICAL MODIFICATION OF HIV-DERIVED OLIGORIBONUCLEOTIDES BY ANTISENSE OLIGODEOXYNUCLEOTIDES LINKED TO PORPHYRINS (139 visite)
    Photochem Photobiol (ISSN: 0031-8655), 1994 Oct; 60(4): 316-322.
    Impact Factor: 2.426
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    Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
    Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (116 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
    Impact Factor: 2.425
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    93 Records (92 escludendo Abstract e Conferenze).
    Impact factor totale: 397.266 (393.536 escludendo Abstract e Conferenze).
    Impact factor a 5 anni totale: 415.903 (412.939 escludendo Abstract e Conferenze).







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    Ultima modifica di Marco Comerci in data Wednesday 20 April 2016, 12:08:17
    492 visite. Ultima visita in data Friday 08 November 2019, 19:34:52