Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme (227 views visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2016; N/D: 1-10.
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Paper type Tipo di articolo: Journal Article,
Impact factor: 2.894, 5-year impact factor Impact factor a 5 anni: 2.681
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84962145344&partnerID=40&md5=4da59018e31bc36a7100526355df83d8
Keywords Parole chiave: Cisplatin, Hen Egg White Lysozyme, Metallodrugs, Platinum-Based Drugs, Protein–ligand Interactions,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, via Cintia, Naples, Italy
CNR Institute of Biostructure and Bioimages, via Mezzocannone 16, Naples, Italy
References Riferimenti:
Not available. Non disponibili.
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2016; N/D: 1-10.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.894, 5-year impact factor Impact factor a 5 anni: 2.681
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84962145344&partnerID=40&md5=4da59018e31bc36a7100526355df83d8
Keywords Parole chiave: Cisplatin, Hen Egg White Lysozyme, Metallodrugs, Platinum-Based Drugs, Protein–ligand Interactions,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, via Cintia, Naples, Italy
CNR Institute of Biostructure and Bioimages, via Mezzocannone 16, Naples, Italy
References Riferimenti:
Not available. Non disponibili.
Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme
The products of the reaction between cisplatin (CDDP) and the model protein hen egg white lysozyme (HEWL) at 20, 37 and 55 °C in pure water were studied by UV–Vis absorption spectroscopy, intrinsic fluorescence and circular dichroism, dynamic and electrophoretic light scattering and inductively coupled plasma mass spectrometry. X-ray structures were also solved for the adducts formed at 20 and 55 °C. Data demonstrate that high temperature facilitates the formation of CDDP-HEWL adducts, where Pt atoms bind ND1 atom of His15 or NE2 atom of His15 and NH1 atom of Arg14. Our study suggests that high human body temperature (fever) could increase the rate of drug binding to proteins thus enhancing possible toxic side effects related to CDDP administration. © 2016 SBIC
The products of the reaction between cisplatin (CDDP) and the model protein hen egg white lysozyme (HEWL) at 20, 37 and 55 °C in pure water were studied by UV–Vis absorption spectroscopy, intrinsic fluorescence and circular dichroism, dynamic and electrophoretic light scattering and inductively coupled plasma mass spectrometry. X-ray structures were also solved for the adducts formed at 20 and 55 °C. Data demonstrate that high temperature facilitates the formation of CDDP-HEWL adducts, where Pt atoms bind ND1 atom of His15 or NE2 atom of His15 and NH1 atom of Arg14. Our study suggests that high human body temperature (fever) could increase the rate of drug binding to proteins thus enhancing possible toxic side effects related to CDDP administration. © 2016 SBIC
Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme
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Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme
Merlino A, Marzo T, Messori L
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7 Records (7 escludendo Abstract e Conferenze).
Impact factor totale: 35.216 (35.216 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 34.542 (34.542 escludendo Abstract e Conferenze).
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Merlino A, Marzo T, Messori L
* Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy (221 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 May 23; 23(29): 6942-6947.
Impact Factor: 5.16
Dettagli Esporta in BibTeX Esporta in EndNote
Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (309 visite)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
Dettagli Esporta in BibTeX Esporta in EndNote
Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (315 visite)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
Dettagli Esporta in BibTeX Esporta in EndNote
Marasco D, Messori L, Marzo T, Merlino A
* Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme (693 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(22): 10392-10398.
Impact Factor: 4.177
Dettagli Esporta in BibTeX Esporta in EndNote
Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A
* Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (328 visite)
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Impact Factor: 2.134
Dettagli Esporta in BibTeX Esporta in EndNote
Messori L, Cinellu MA, Merlino A
* Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c) (292 visite)
Acs Med Chem Lett (ISSN: 1948-5875), 2014 Jul 31; 5(10): 1110-1113.
Impact Factor: 3.12
Dettagli Esporta in BibTeX Esporta in EndNote
Vergara A, D’Errico G, Montesarchio D, Mangiapia G, Paduano L, Merlino A
* Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu (313 visite)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2013 Apr 15; 52(8): 4157-4159.
Impact Factor: 4.794
Dettagli Esporta in BibTeX Esporta in EndNote
7 Records (7 escludendo Abstract e Conferenze).
Impact factor totale: 35.216 (35.216 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 34.542 (34.542 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Gennaro Angrisano on in data Sunday 12 July 2020, 13:14:47
227 views visite. Last view on Ultima visita in data Tuesday 11 May 2021, 13:25:48
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