Home Ricerca Sedi Chi siamo Organigramma Personale Contatti Didattica Login Documenti EN
Progetti in evidenza
INCIPIT
(Link esterno)

ISTAPCA
(1182 visite)

Fondo Europeo Pesca
(591 visite)

Euro-BioImaging
(Link esterno)

Fondazione Veronesi
(Link esterno)

LightDyNAmics
(1050 visite)

 INMiND
(1160 visite)

Instruct-IT
(Link esterno)

 PRIN
(1294 visite)

 eHealthNet
(1062 visite)

Ponrec
(1004 visite)

MFAG Grant
(1097 visite)

MERIT
(Link esterno)


Collegamenti



Excited-State Dynamics of DNA Duplexes with Different H-Bonding Motifs (76 visite)

Zhang Y, De La Harpe K, Beckstead AA, Martínez-fernández L, Improta R, Kohler B

J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic), 2016; 7(6): 950-954.

Tipo di articolo: Journal Article,

Impact factor: 9.353

Impact factor a 5 anni: 8.334


Parole chiave: Free Radical Reactions, Quantum Theory, Decay Mechanisms, Electron Transfer, Excited State Lifetimes, Excited-State Dynamics, Quantum-Mechanical Calculation, Rate-Limiting Steps, Time-Resolved Infrared, Watson-Crick Base Pairs,

Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84962539733&partnerID=40&md5=891122c1c847208f50bb37e34f2b4a8c

The excited-state dynamics of three distinct forms of the d(GC)9·d(GC)9 DNA duplex were studied by combined time-resolved infrared experiments and quantum mechanical calculations. In the B- and Z-forms, bases on opposite strands form Watson-Crick (WC) base pairs but stack differently because of salt-induced changes in backbone conformation. At low pH, the two strands associate by Hoogsteen (HG) base pairing. Ultraviolet-induced intrastrand electron transfer (ET) triggers interstrand proton transfer (PT) in the B- and Z-forms, but the PT pathway is blocked in the HG duplex. Despite the different decay mechanisms, a common excited-state lifetime of ∼30 ps is observed in all three duplex forms. The ET-PT pathway in the WC duplexes and the solely intrastrand ET pathway in the HG duplex yield the same pair of π-stacked radicals on one strand. Back ET between these radicals is proposed to be the rate-limiting step behind excited-state deactivation in all three duplexes. © 2016 American Chemical Society.
*** IBB - CNR ***

Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, United States

Department of Physics, United States Air Force Academy, USAF AcademyCO, United States

Consiglio Nationale Delle Ricerche, Istituto di Biostrutture e Bioimmagini, Naples, Italy
Zhang, Y., De La Harpe, K., Beckstead, A.A., Improta, R., Kohler, B., UV-Induced Proton Transfer between DNA Strands (2015) J. Am. Chem. Soc., 137, pp. 7059-706

Doorley, G.W., Wojdyla, M., Watson, G.W., Towrie, M., Parker, A.W., Kelly, J.M., Quinn, S.J., Tracking DNA Excited States by Picosecond-Time-Resolved Infrared Spectroscopy: Signature Band for a Charge-Transfer Excited State in Stacked Adenine-Thymine Systems (2013) J. Phys. Chem. Lett., 4, pp. 2739-2744

Stuhldreier, M.C., Temps, F., Ultrafast Photo-Initiated Molecular Quantum Dynamics in the DNA Dinucleotide d(ApG) Revealed by Broadband Transient Absorption Spectroscopy (2013) Faraday Discuss., 163, pp. 173-188

Bucher, D.B., Pilles, B.M., Carell, T., Zinth, W., Charge Separation and Charge Delocalization Identified in Long-Living States of Photoexcited DNA (2014) Proc. Natl. Acad. Sci. U. S. A., 111, pp. 4369-4374

Pilles, B.M., Bucher, D.B., Liu, L.Z., Gilch, P., Zinth, W., Schreier, W.J., Identification of charge separated states in thymine single strands (2014) Chem. Commun., 50, pp. 15623-15626

Zhang, Y., Dood, J., Beckstead, A.A., Li, X.B., Nguyen, K.V., Burrows, C.J., Improta, R., Kohler, B., Efficient UV-Induced Charge Separation and Recombination in an 8-Oxoguanine-Containing Dinucleotide (2014) Proc. Natl. Acad. Sci. U. S. A., 111, pp. 11612-11617

Pohl, F.M., Jovin, T.M., Salt-Induced Cooperative Conformational Change of a Synthetic DNA: Equilibrium and Kinetic Studies with Poly(dG-dC) (1972) J. Mol. Biol., 67, pp. 375-396

Taboury, J.A., Liquier, J., Taillandier, E., Characterization of DNA Structures by Infrared-Spectroscopy: Double Helical Forms of Poly(dG-dC)·Poly(dG-dC), Poly(dD8G-dC)·Poly(dD8G-dC), and Poly(dG-dm5C)·Poly(dG-dm5C) (1985) Can. J. Chem., 63, pp. 1904-1909

Segers-Nolten, G.M.J., Sijtsema, N.M., Otto, C., Evidence for Hoogsteen GC Base Pairs in the Proton-Induced Transition from Right-Handed to Left-Handed poly(dG-dC)·poly(dG-dC) (1997) Biochemistry, 36, pp. 13241-13247

De La Harpe, K., Crespo-Hernández, C.E., Kohler, B., The Excited-State Lifetimes in a G·C DNA Duplex Are Nearly Independent of Helix Conformation and Base-Pairing Motif (2009) ChemPhysChem, 10, pp. 1421-1425

Doorley, G.W., McGovern, D.A., George, M.W., Towrie, M., Parker, A.W., Kelly, J.M., Quinn, S.J., Picosecond Transient Infrared Study of the Ultrafast Deactivation Processes of Electronically Excited B-DNA and Z-DNA Forms of [poly(dG-dC)]2 (2009) Angew. Chem., Int. Ed., 48, pp. 123-127

Schreier, W.J., Schrader, T.E., Koller, F.O., Gilch, P., Crespo-Hernández, C.E., Swaminathan, V.N., Carell, T., Kohler, B., Thymine Dimerization in DNA is an Ultrafast Photoreaction (2007) Science, 315, pp. 625-629

Zhang, Y., Chen, J., Kohler, B., Hydrogen Bond Donors Accelerate Vibrational Cooling of Hot Purine Derivatives in Heavy Water (2013) J. Phys. Chem. A, 117, pp. 6771-6780

Van Stokkum, I.H.M., Larsen, D.S., Van Grondelle, R., Global and target analysis of time-resolved spectra (2004) Biochim. Biophys. Acta, Bioenerg., 1657, pp. 82-104

Snellenburg, J.J., Laptenok, S.P., Seger, R., Mullen, K.M., Van Stokkum, I.H.M., Glotaran: A Java-Based Graphical User Interface for the R Package TIMP (2012) J. Stat. Software, 49, pp. 1-22

Ko, C., Hammes-Schiffer, S., Charge-Transfer Excited States and Proton Transfer in Model Guanine-Cytosine DNA Duplexes in Water (2013) J. Phys. Chem. Lett., 4, pp. 2540-2545

Huix-Rotllant, M., Brazard, J., Improta, R., Burghardt, I., Markovitsi, D., Stabilization of Mixed Frenkel-Charge Transfer Excitons Extended Across Both Strands of Guanine-Cytosine DNA Duplexes (2015) J. Phys. Chem. Lett., 6, pp. 2247-2251

Izatt, R.M., Christensen, J.J., Rytting, J.H., Sites and Thermodynamic Quantities Associated with Proton and Metal Ion Interaction with Ribonucleic Acid, Deoxyribonucleic Acid, and Their Constituent Bases, Nucleosides, and Nucleotides (1971) Chem. Rev., 71, pp. 439-481

Parker, A.W., Lin, C.Y., George, M.W., Towrie, M., Kuimova, M.K., Infrared Characterization of the Guanine Radical Cation: Finger Printing DNA Damage (2010) J. Phys. Chem. B, 114, pp. 3660-3667

Steenken, S., Electron-Transfer-Induced Acidity Basicity and Reactivity Changes of Purine and Pyrimidine-Bases. Consequences of Redox Processes for DNA Base Pairs (1992) Free Radical Res. Commun., 16, pp. 349-379

Bucher, D.B., Schlueter, A., Carell, T., Zinth, W., Watson-Crick Base Pairing Controls Excited-State Decay in Natural DNA (2014) Angew. Chem., Int. Ed., 53, pp. 11366-11369

Nessun risultato.
Nessun risultato.

Contiene: [X]      Estesa         Autori: [X]      Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
* Photoinduced Electron Transfer in DNA: Charge Shift Dynamics between 8-Oxo-Guanine Anion and Adenine (132 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2015; 119(24): 7491-7502.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Barone V, Newton MD, Improta R
* Dissociative electron transfer in donor - Peptide - Acceptor systems: Results for kinetic parameters from a density functional/polarizable continuum model (78 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jun 29; 110(25): 12632-12639.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Improta R, Barone V, Newton MD
* A Parameter Free Quantum Mechanical Approach To The Calculation Of Electron Transfer Rates For Large Systems In Solution (77 visite)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2006 Jun 12; 7(6): 1211-1215.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Improta R, Antonello S, Formaggio F, Maran F, Rega N, Barone V
* Understanding Electron Transfer across Negatively-Charged Aib Oligopeptides (180 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2005 Jan 20; 109(2): 1023-1033.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Barone V, Formaggio F, Improta R, Polo F, Maran F
* Electron transfer to and conformational preferences of Aib oligo-peptides (111 visite)
Proc Electrochem Soc, 2004; 10: 29-32.
Dettagli    Esporta in BibTeX    Esporta in EndNote



5 Records (5 escludendo Abstract e Conferenze).
Impact factor totale: 14.784 (14.784 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 13.555 (13.555 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Gennaro Angrisano in data Wednesday 11 May 2016, 18:49:53
76 visite. Ultima visita in data Sunday 21 October 2018, 1:29:47

Webmaster and developer: Marco Comerci
Per problemi e suggerimenti: adminibb.cnr.it
Ultimo aggiornamento: Thursday 15 November 2018, 17:18:12