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ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (435 visite)

Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF

J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.

Tipo di articolo: Journal Article, , Impact factor: 3.348, Impact factor a 5 anni: 3.207, Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84954202975&partnerID=40&md5=b452999b8983a065457be0c9911b8325

Parole chiave: Atox1, Chelating Drugs, Colon Cancer, Copper, Ionophores, Adenosine Triphosphatase, Chaperone, Chelating Agent, Cloxiquine, Copper Chelating Agent, Copper Ion, Copper Ionophore, Tetrakis(2 Pyridylmethyl)ethylenediamine, Peroxiredoxin 3, Unclassified Drug, Article, Caco 2 Cell Line, Cell Level, Controlled Study, Copper Protein Binding, Cytosol, Cytotoxicity, Drug Sensitivity, Gene Silencing, Homeostasis, Human, Human Cell, In Vitro Study, Intracellular Transport, Protein Depletion, Protein Expression, Protein Function, Rna Interference, Trans Golgi Network,

Affiliazioni: *** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, Unit of Medical Biochemistry, University of Catania, Via S. Sofia 64, Catania, Italy
Institute of Biostructures and Bioimaging, National Council of Research, UOS Catania, Italy


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Copper is a catalytic cofactor required for the normal function of many enzymes involved in fundamental biological processes but highly cytotoxic when in excess. Therefore its homeostasis and distribution is strictly regulated by a network of transporters and intracellular chaperones. ATOX1 (antioxidant protein 1) is a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network. In the present study the Caco-2 cell line, a colon carcinoma cell line, was used as an in vitro model to evaluate if ATOX1 deficiency could affect sensitivity to experimentally induced copper dyshomeostasis. Silencing of ATOX1 increased toxicity of a short treatment with a high concentration of Cu2 +. Copper ionophores, such as 5-chloro-8-hydroxyquinoline, induced a copper-dependent cell toxicity which was significantly potentiated after ATOX1 silencing. The copper chelator TPEN (N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine) produced a form of cell toxicity that was reversed by the addition of Cu2 +. ATOX1 silencing increased Caco-2 cell sensitivity to TPEN toxicity. Our results suggest the possibility of a therapy with copper-chelating or ionophore drugs in subtypes of tumors showing specific alterations in ATOX1 expression. © 2016 Elsevier Inc. All rights reserved.
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10 Records (7 escludendo Abstract e Conferenze).
Impact factor totale: 33.509 (18.544 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 38.752 (21.444 escludendo Abstract e Conferenze).







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