A four-year longitudinal study on restless legs syndrome in Parkinson disease(138 visite) Moccia M, Erro R, Picillo M, Santangelo G, Spina E, Allocca R, Longo K, Amboni M, Palladino R, Assante R, Pappata S, Pellecchia MT, Barone P, Vitale C
Sleep (ISSN: 0161-8105), 2016; 39(2): 405-412.
Tipo di articolo: Journal Article,
Impact factor: 4.923, Impact factor a 5 anni: 5.671
Parole chiave: Dat, Parkinson, Progression, Restless, Sleep, Spect,
Affiliazioni:
*** IBB - CNR *** Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom Department of Neurological and Movement Sciences, Policlinico Borgo Roma, University of Verona, Verona, Italy Department of Medicine, Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, University of Salerno, Salerno, Italy Morton and Gloria Shulman Movement Disorders Clinic and Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada Department of Psychology, Neuropsychology Laboratory, Second University of Naples, Caserta, Italy IDC Hermitage-Capodimonte, Naples, Italy Department of Primary Care and Public Health, Imperial College, London, United Kingdom Department of Public Health, Federico II University, Naples, Italy Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
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Study Objectives: Restless legs syndrome (RLS) prevalence estimates range from 0% to 52% in Parkinson disease (PD), but the causal relationship between the two disorders is still debated. The present study aims to evaluate RLS prevalence in de novo PD subjects, its incidence during the first 4 years from diagnosis, and possible relationships with clinical, laboratory, and neuroradiological data. Methods: One hundred nine newly diagnosed, drug-naïve PD subjects were evaluated at the time of PD diagnosis, and after 2- And 4-years. RLS diagnosis was performed with the RLS Diagnostic Index at each visit. Motor features, additional non-motor symptoms (NMS), and concomitant dopaminergic and nondopaminergic treatments were also gathered. Moreover, at baseline, 65 subjects were randomly selected to undergo a FP-CIT SPECT to study dopamine transporter availability. Results: RLS prevalence rose from 4.6% at baseline evaluation to 6.5% after 2 years and to 16.3% after 4 years (P = 0.007). A multinomial logistic stepwise regression model selected NMS Questionnaire items more likely to be associated with RLS at diagnosis (insomnia, OR = 15.555; P = 0.040) and with occurrence of RLS during follow-up (dizziness, OR = 1.153; P = 0.022; and daytime sleepiness; OR = 9.557; P = 0.001), as compared to patients without RLS. Older age was more likely associated to increased RLS occurrence during follow-up in a random effect logistic regression model (OR = 1.187; P = 0.036). A multinomial logistic stepwise model found increased dopaminergic transporter availability of affected caudate and putamen to be more likely associated with RLS presence at diagnosis (n = 5; OR = 75.711; P = 0.077), and RLS occurrence during follow-up (n = 16; OR = 12.004; P = 0.059), respectively, as compared to patients without RLS (n = 88). Conclusions: RLS is present since PD diagnosis, and increases in prevalence during the course of PD. PD subjects with RLS have higher age at PD onset, more preserved dopaminergic pathways, and worse sleep and cardiovascular disturbances.
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128 Records (114 escludendo Abstract e Conferenze). Impact factor totale: 538.353 (483.264 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 540.648 (477.01 escludendo Abstract e Conferenze).
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