A four-year longitudinal study on restless legs syndrome in Parkinson disease(120 visite) Moccia M, Erro R, Picillo M, Santangelo G, Spina E, Allocca R, Longo K, Amboni M, Palladino R, Assante R, Pappata S, Pellecchia MT, Barone P, Vitale C
SLEEP (ISSN: 0161-8105), 2016; 39(2): 405-412.
Tipo di articolo: Journal Article,
Impact factor: 4.923, Impact factor a 5 anni: 5.671
Parole chiave: Dat, Parkinson, Progression, Restless, Sleep, Spect,
Affiliazioni:
*** IBB - CNR *** Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom Department of Neurological and Movement Sciences, Policlinico Borgo Roma, University of Verona, Verona, Italy Department of Medicine, Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, University of Salerno, Salerno, Italy Morton and Gloria Shulman Movement Disorders Clinic and Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada Department of Psychology, Neuropsychology Laboratory, Second University of Naples, Caserta, Italy IDC Hermitage-Capodimonte, Naples, Italy Department of Primary Care and Public Health, Imperial College, London, United Kingdom Department of Public Health, Federico II University, Naples, Italy Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy
Riferimenti:
Allen, R., Picchietti, D., Hening, W., Restless legs syndrome: Diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health (2003) Sleep Med, 4, pp. 101-11
Gómez-Esteban, J.C., Zarranz, J.J., Tijero, B., Restless legs syndrome in Parkinson's disease (2007) Mov Disord, 22, pp. 1912-1916
Connor, J.R., Wang, X.S., Allen, R.P., Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome (2009) Brain, 132, pp. 2403-2412
Peralta, C.M., Frauscher, B., Seppi, K., Restless legs syndrome in Parkinson's disease (2009) Mov Disord, 24, pp. 2076-2080
Ondo, W.G., Vuong, K.D., Jankovic, J., Exploring the relationship between Parkinson disease and restless legs syndrome (2002) Arch Neurol, 59, pp. 421-424
Verbaan, D., Van Rooden, S.M., Van Hilten, J.J., Rijsman, R.M., Prevalence and clinical profile of restless legs syndrome in Parkinson's disease (2010) Mov Disord, 25, pp. 2142-2147
Nomura, T., Inoue, Y., Nakashima, K., Clinical characteristics of Restless legs syndrome in patients with Parkinson's disease (2006) J Neurol Sci, 250, pp. 39-44
Rijsman, R.M., Schoolderman, L.F., Rundervoort, R.S., Louter, M., Restless legs syndrome in Parkinson's disease (2014) Parkinsonism Relat Disord, 20, pp. S5-S9
Calzetti, S., Negrotti, A., Bonavina, G., Angelini, M., Marchesi, E., Absence of co-morbidity of Parkinson disease and restless legs syndrome: A case-control study in patients attending a movement disorders clinic (2009) Neurol Sci, 30, pp. 119-122
Loo, H.-V., Tan, E.-K., Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease (2008) J, Neurol Sci, 266, pp. 145-149
Tan, E., Lum, S., Wong, M., Restless legs syndrome in Parkinson's disease (2002) J Neurol Sci, 196, pp. 33-36
Wong, J.C., Li, Y., Schwarzschild, M.A., Ascherio, A., Gao, X., Restless legs syndrome: An early clinical feature of Parkinson disease in men (2014) Sleep, 37, pp. 369-372
Dragan, E.M., Chen, Z., Ondo, W.G., Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson's disease: A pilot study (2015) Int J Neurosci, 125, pp. 526-530
Gjerstad, M.D., Tysnes, O.B., Larsen, J.P., Increased risk of leg motor restlessness but not RLS in early Parkinson disease (2011) Neurology, 77, pp. 1941-1946
Angelini, M., Negrotti, A., Marchesi, E., Bonavina, G., Calzetti, S., A study of the prevalence of restless legs syndrome in previously untreated Parkinson's disease patients: Absence of co-morbid association (2011) J Neurol Sci, 310, pp. 286-288
Bhalsing, K., Suresh, K., Muthane, U.B., Pal, P.K., Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: A case-control study (2013) Parkinsonism Relat Disord, 19, pp. 426-430
Lee, J.E., Shin, H.-W., Kim, K.S., Sohn, Y.H., Factors contributing to the development of restless legs syndrome in patients with Parkinson disease (2009) Mov Disord, 24, pp. 579-582
Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J., Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases (1992) J Neurol Neurosurg Psychiatry, 55, pp. 181-184
Berardelli, A., Wenning, G.K., Antonini, A., EFNS/MDS-ES recommendations for the diagnosis of Parkinson's disease (2013) Eur J Neurol, 20, pp. 16-34
Armstrong, M.J., Litvan, I., Lang, A.E., Bak, T.H., Bhatia, K.P., Reich, S.G., Criteria for the diagnosis of corticobasal degeneration criteria for the diagnosis of corticobasal degeneration (2013) Neurology, 80, pp. 496-503
Gilman, S., Wenning, G., Low, P., Second consensus statement on the diagnosis of multiple system atrophy (2008) Neurology, 71, pp. 670-676
Dubois, B., Burn, D., Goetz, C., Diagnostic procedures for Parkinson's disease dementia: Recommendations from the Movement Disorder Society Task Force (2007) Mov Disord, 22, pp. 2314-2324
McKeith, I.G., Galasko, D., Kosaka, K., Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop (1996) Neurology, 47, pp. 1113-1124
Chaudhuri, K.R., Martinez-Martin, P., Quantitation of non-motor symptoms in Parkinson's disease (2008) Eur J Neurol, 15, pp. 2-7
Tomlinson, C.L., Stowe, R., Patel, S., Rick, C., Gray, R., Clarke, C.E., Systematic review of levodopa dose equivalency reporting in Parkinson's disease (2010) Mov Disord, 25, pp. 2649-2653
Walters, A., Frauscher, B., Allen, R., Review of Diagnostic Instruments for the Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED): Critique and recommendations (2014) J Clin Sleep Med, 10, pp. 1343-1349
Beneš, H., Kohnen, R., Validation of an algorithm for the diagnosis of restless legs syndrome: The Restless Legs Syndrome-Diagnostic Index (RLS-DI) (2009) Sleep Med, 10, pp. 515-523
Walters, A.S., LeBrocq, C., Dhar, A., Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome (2003) Sleep Med, 4, pp. 121-132
England, J.D., Gronseth, G.S., Franklin, G., Distal symmetrical polyneuropathy: Definition for clinical research (2005) Muscle Nerve, 31, pp. 113-123
Moccia, M., Pellecchia, M.T., Erro, R., Restless legs syndrome is a common feature of adult celiac disease (2010) Mov Disord, 25, pp. 877-881
Hening, W.A., Allen, R.P., Washburn, M., Lesage, S.R., Earley, C.J., The four diagnostic criteria for restless legs syndrome are unable to exclude confounding conditions (2009) Sleep Med, 10, pp. 976-981. , "mimics
Diederichs, C.P., Wellmann, J., Bartels, D.B., Ellert, U., Hoffmann, W., Berger, K., How to weight chronic diseases in multimorbidity indices? Development of a new method on the basis of individual data from five population-based studies (2012) J Clin Epidemiol, 65, pp. 679-685
Szentkirályi, A., Völzke, H., Hoffmann, W., Multimorbidity and the risk of restless legs syndrome in 2 prospective cohort studies (2014) Neurology, 82, pp. 2026-2033
Moccia, M., Pappatà, S., Erro, R., Uric acid relates to dopamine transporter availability in Parkinson's disease (2015) Acta Neurol Scand, 123, pp. 127-131
Garcia-Borreguero, D., Egatz, R., Winkelmann, J., Berger, K., Epidemiology of restless legs syndrome: The current status (2006) Sleep Med Rev, 10, pp. 153-167
De Vito, K., Li, Y., Batool-Anwar, S., Ning, Y., Han, J., Gao, X., Prospective study of obesity, hypertension, high cholesterol, and risk of restless legs syndrome (2014) Mov Disord, 29, pp. 1044-1052
Budhiraja, P., Budhiraja, R., Goodwin, J.L., Incidence of restless legs syndrome and its correlates (2012) J Clin Sleep Med, 8, pp. 119-124
Szentkiralyi, A., Fendrich, K., Hoffmann, W., Happe, S., Berger, K., Incidence of restless legs syndrome in two population-based cohort studies in Germany (2011) Sleep Med, 12, pp. 815-820
Slow, E.J., Postuma, R.B., Lang, A.E., Implications of nocturnal symptoms towards the early diagnosis of Parkinson's disease (2014) J Neural Transm, 121, pp. 49-57
Connor, J.R., Boyer, P.J., Menzies, S.L., Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome (2003) Neurology, 61, pp. 304-309
Earley, C.J., Barker, B.P., Horská, A., Allen, R.P., MRI-determined regional brain iron concentrations in early- And late-onset restless legs syndrome (2006) Sleep Med, 7, pp. 458-461
Friedman, A., Galazka-Friedman, J., Koziorowski, D., Iron as a cause of Parkinson disease - A myth or a well established hypothesis? (2009) Parkinsonism Relat Disord, 15, pp. S212-S214
Godau, J., Sojer, M., Transcranial sonography in restless legs syndrome (2010) Int Rev Neurobiol, 90, pp. 199-215
Schmidauer, C., Sojer, M., Seppi, K., Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome (2005) Ann Neurol, 58, pp. 630-634
Kwon, D.Y., Seo, W.K., Yoon, H.K., Park, M.H., Koh, S.B., Park, K.W., Transcranial brain sonography in Parkinson's disease with restless legs syndrome (2010) Mov Disord, 25, pp. 1373-1378
Pedroso, J.L., Bor-Seng-Shu, E., Felicio, A.C., Severity of restless legs syndrome is inversely correlated with echogenicity of the substantia nigra in different neurodegenerative movement disorders. A preliminary observation (2012) J Neurol Sci, 319, pp. 59-62
Rye, D.B., Parkinson's disease and RLS: The dopaminergic bridge (2004) Sleep Med, 5, pp. 317-328
Allen, R.P., Barker, P.B., Wehrl, F., Song, H.K., Earley, C.J., MRI measurement of brain iron in patients with restless legs syndrome (2001) Neurology, 56, pp. 263-265
Walters, A.S., Rye, D.B., Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke (2009) Sleep, 32, pp. 589-597
Hawkes, C.H., Del, T.K., Braak, H., A timeline for Parkinson's disease (2010) Parkinsonism Relat Disord, 16, pp. 79-84
Rios, R.S., Wolfson, C., Galatas, C., Validation of the nonmotor symptoms questionnaire (2012) Parkinsonism Relat Disord, 18, pp. 54-58. , NMS-Quest
Perez, L.S., Rossi, M., Cardinali, D.P., Merello, M., Validation of the sleep related items of the Non-motor Symptoms Questionnaire for Parkinson's disease (2008) Parkinsonism Relat Disord, 14, pp. 641-645. , NMSQuest
Shneyder, N., Adler, C.H., Hentz, J.G., Autonomic complaints in patients with restless legs syndrome (2013) Sleep Med, 14, pp. 1413-1416
Fereshtehnejad, S., Shafieesabet, M., Shahidi, G., Delbari, A., Lökk, J., Restless legs syndrome in patients with Parkinson's disease: A comparative study on prevalence, clinical characteristics, quality of life and nutritional status (2015) Acta Neurol Scand, 131, pp. 211-218
Oh, Y.S., Kim, J.S., Park, I.S., Association between nocturnal/supine hypertension and restless legs syndrome in patients with Parkinson's disease (2014) J Neurol Sci, 344, pp. 186-189
Neikrug, A.B., Maglione, J.E., Liu, L., Effects of sleep disorders on the non-motor symptoms of Parkinson disease (2013) J Clin Sleep Med, 9, pp. 1119-1129
Högl, B., Gschliesser, V., RLS assessment and sleep questionnaires in practice - lessons learned from Parkinson's disease (2007) Sleep Med, 8, pp. 7-12
Study Objectives: Restless legs syndrome (RLS) prevalence estimates range from 0% to 52% in Parkinson disease (PD), but the causal relationship between the two disorders is still debated. The present study aims to evaluate RLS prevalence in de novo PD subjects, its incidence during the first 4 years from diagnosis, and possible relationships with clinical, laboratory, and neuroradiological data. Methods: One hundred nine newly diagnosed, drug-naïve PD subjects were evaluated at the time of PD diagnosis, and after 2- And 4-years. RLS diagnosis was performed with the RLS Diagnostic Index at each visit. Motor features, additional non-motor symptoms (NMS), and concomitant dopaminergic and nondopaminergic treatments were also gathered. Moreover, at baseline, 65 subjects were randomly selected to undergo a FP-CIT SPECT to study dopamine transporter availability. Results: RLS prevalence rose from 4.6% at baseline evaluation to 6.5% after 2 years and to 16.3% after 4 years (P = 0.007). A multinomial logistic stepwise regression model selected NMS Questionnaire items more likely to be associated with RLS at diagnosis (insomnia, OR = 15.555; P = 0.040) and with occurrence of RLS during follow-up (dizziness, OR = 1.153; P = 0.022; and daytime sleepiness; OR = 9.557; P = 0.001), as compared to patients without RLS. Older age was more likely associated to increased RLS occurrence during follow-up in a random effect logistic regression model (OR = 1.187; P = 0.036). A multinomial logistic stepwise model found increased dopaminergic transporter availability of affected caudate and putamen to be more likely associated with RLS presence at diagnosis (n = 5; OR = 75.711; P = 0.077), and RLS occurrence during follow-up (n = 16; OR = 12.004; P = 0.059), respectively, as compared to patients without RLS (n = 88). Conclusions: RLS is present since PD diagnosis, and increases in prevalence during the course of PD. PD subjects with RLS have higher age at PD onset, more preserved dopaminergic pathways, and worse sleep and cardiovascular disturbances.
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(163 visite) Parkinsonism Relat Disord (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 DettagliEsporta in BibTeXEsporta in EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease(9 visite) Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026. Impact Factor:0.913 DettagliEsporta in BibTeXEsporta in EndNote
126 Records (112 escludendo Abstract e Conferenze). Impact factor totale: 532.646 (477.557 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 537.629 (473.991 escludendo Abstract e Conferenze).
ibb.cnr.it
