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Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (107 visite)
Chembiochem (ISSN: 1439-7633electronic, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Tipo di articolo: Journal Article,
Impact factor: 2.847
Impact factor a 5 anni: 2.751
Parole chiave: Alzheimer, S Disease, Amyloid Beta-Peptides, Inhibitors, Oligomers, Peptidomimetics, Trehalose,
Url: Non disponibile.
The inhibition of amyloid formation is a promising therapeutic approach for the treatment of neurodegenerative diseases. Peptide-based inhibitors, which have been widely investigated, are generally derived from original amyloid sequences. Most interestingly, trehalose, a nonreducing disaccharide of alpha-glucose, is effective in preventing the aggregation of numerous proteins. We have determined that the development of hybrid compounds could provide new molecules with improved properties that might synergically increase the potency of their single moieties. In this work, the ability of Ac-LPFFD-Th, a C-terminally trehalose-conjugated derivative, to slow down the Abeta aggregation process was investigated by means of different biophysical techniques, including thioflavin T fluorescence, dynamic light scattering, ESI-MS, and NMR spectroscopy. Moreover, we demonstrate that Ac-LPFFD-Th modifies the aggregation features of Abeta and protects neurons from Abeta oligomers' toxic insult.
*** IBB - CNR ***
PhD Program in Translational Biomedicine, University of Catania, Viale A. Doria 6, 95125, Catania, Italy., Institute of Biostructures and Bioimaging, CNR, Via P. Gaifami 18, 95126, Catania, Italy., Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16, 80134, Naples, Italy., Department of Drug Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy., Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8231, St. Louis, MO, 63110, USA., Department of Biomedical Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy., Institute of Crystallography, CNR, Via G. Amendola 122/O, 70126, Bari, Italy., Institute of Biostructures and Bioimaging, CNR, Via P. Gaifami 18, 95126, Catania, Italy. email@example.com., Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.,
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