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Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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Unique Footprint in the scl1. 3 Locus Affects Adhesion and Biofilm Formation of the Invasive M3-Type Group A Streptococcus (121 visite)

Bachert BA, Choi SJ, Lasala PR, Harper TI, Mcnitt DH, Boehm DT, Caswell CC, Ciborowski P, Keene DR, Flores AR, Musser JM, Squeglia F, Marasco D, Berisio R, Lukomski S

Front Cell Infect Microbiol (ISSN: 2235-2988electronic, 2235-2988linking), 2016 Aug 31; 6: 90-90.

Tipo di articolo: Journal Article, , Impact factor: 4.3, Impact factor a 5 anni: 4.918, Url: Non disponibile.

Parole chiave: Ecm, M3-Type Streptococci, Scl1, Streptococcus Pyogenes, Biofilm, Colonization,

Affiliazioni: *** IBB - CNR ***
Department of Microbiology, Immunology, and Cell Biology, West Virginia University Morgantown, WV, USA., Department of Pathology, West Virginia University Morgantown, WV, USA., Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE, USA., Shriners Hospital for Children Portland, OR, USA., Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Texas Children's HospitalHouston, TX, USA; Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute and Hospital SystemHouston, TX, USA., Department of Pathology and Genomic Medicine, Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute and Hospital System Houston, TX, USA., Institute of Biostructures and Bioimaging, National Research Council Naples, Italy., Department of Pharmacy, University of Naples Frederico II Naples, Italy.,


Riferimenti: Non disponibile.

The streptococcal collagen-like proteins 1 and 2 (Scl1 and Scl2) are major surface adhesins that are ubiquitous among group A Streptococcus (GAS). Invasive M3-type strains, however, have evolved two unique conserved features in the scl1 locus: (i) an IS1548 element insertion in the scl1 promoter region and (ii) a nonsense mutation within the scl1 coding sequence. The scl1 transcript is drastically reduced in M3-type GAS, contrasting with a high transcription level of scl1 allele in invasive M1-type GAS. This leads to a lack of Scl1 expression in M3 strains. In contrast, while scl2 transcription and Scl2 production are elevated in M3 strains, M1 GAS lack Scl2 surface expression. M3-type strains were shown to have reduced biofilm formation on inanimate surfaces coated with cellular fibronectin and laminin, and in human skin equivalents. Repair of the nonsense mutation and restoration of Scl1 expression on M3-GAS cells, restores biofilm formation on cellular fibronectin and laminin coatings. Inactivation of scl1 in biofilm-capable M28 and M41 strains results in larger skin lesions in a mouse model, indicating that lack of Scl1 adhesin promotes bacterial spread over localized infection. These studies suggest the uniquely evolved scl1 locus in the M3-type strains, which prevents surface expression of the major Scl1 adhesin, contributed to the emergence of the invasive M3-type strains. Furthermore these studies provide insight into the molecular mechanisms mediating colonization, biofilm formation, and pathogenesis of group A streptococci.
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Maurea S, Romeo V, Mainenti PP, Ginocchio MI, Frauenfelder G, Verde F, Liuzzi R, D'Armiento M, Sarno L, Morlando M, Petretta M, Martinelli P, Brunetti A
* Diagnostic accuracy of magnetic resonance imaging in assessing placental adhesion disorder in patients with placenta previa: Correlation with histological findings (26 visite)
Eur J Radiol (ISSN: 1872-7727electronic, 0720-048xlinking), 2018 Sep; 106: 77-84.
Impact Factor: 1.332
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Monti M, De Rosa V, Iommelli F, Carriero MV, Terlizzi C, Camerlingo R, Belli S, Fonti R, Di Minno G, Del Vecchio S
* Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins (20 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic), 2018 Aug 9; 19(8): N/D-N/D.
Impact Factor: 3.687
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Monti M, Iommelli F, De Rosa V, Carriero MV, Miceli R, Camerlingo R, Di Minno G, Del Vecchio S
* Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells (90 visite)
Plosone, 2017 Feb; N/D: 1-15.
Impact Factor: 3.54
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (117 visite)
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
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Squeglia F, Bachert B, Romanò MF, Lukomski S, Berisio R
* Crystallization and preliminary X-ray crystallographic analysis of the variable domain of Scl2. 3, a streptococcal collagen-like protein from invasive M3-type Streptococcus pyogenes (118 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013 Sep; 69(9): 1023-1025.
Impact Factor: 0.568
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Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (103 visite)
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
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6 Records (6 escludendo Abstract e Conferenze).
Impact factor totale: 16.57 (16.57 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 13.785 (13.785 escludendo Abstract e Conferenze).







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