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Benzoxaborole as a new chemotype for carbonic anhydrase inhibition (101 visite)

Alterio V, Cadoni R, Esposito D, Vullo D, Fiore AD, Monti SM, Caporale A, Ruvo M, Sechi M, Dumy P, Supuran CT, De Simone G, Winum JY

Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2016 Sep 29; 52(80): 11983-11986.



Tipo di articolo: Journal Article,

Impact factor: 6.319, Impact factor a 5 anni: 6.238

Url: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc06399c#!divRelatedContent

Parole chiave: Non disponibili.

Affiliazioni:

*** IBB - CNR ***
Istituto di Biostrutture e Bioimagini-CNR, Naples, Italy. 
  • Institut des Biomolécules Max Mousseron (IBMM) UMR5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
  • Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.
  • Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Sassari, Italy.
  • Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.



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    In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.
    
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    Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
    * Cationic porphyrins are tunable gatekeepers of the 20S proteasome (473 visite) (PDF 145 visite)
    Chem Sci (ISSN: 2041-6539, 2041-6520, 2041-6520linking), 2016; 7(2): 1286-1297.
    Impact Factor: 8.668
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    Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Prakash A, Tiwari M, Supuran CT
    * Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1, 3, 4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors (90 visite)
    J Enzyme Inhib Med Chem, 2016; 17: 1-6.
    Impact Factor: 3.428
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    Mollica A, Locatelli M, Macedonio G, Carradori S, Sobolev AP, De Salvador RF, Monti SM, Buonanno M, Zengin G, Angeli A, Supuran CT
    * Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars (101 visite)
    J Enzyme Inhib Med Chem, 2016; 31(sup4): N/D-N/D.
    Impact Factor: 3.428
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    Palladino P, Aura AM, Spoto G
    * Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (161 visite)
    Analytical And Bioanalytical Chemistry (ISSN: 1618-2642), 2016; 408(3): 849-854.
    Impact Factor: 3.431
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    De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
    * Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (328 visite)
    Clin Cancer Res (ISSN: 1078-0432linking, 1078-0432electronic, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
    Impact Factor: 8.738
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    La Regina G, Coluccia A, Famiglini V, Pelliccia S, Monti L, Vullo D, Nuti E, Alterio V, De Simone G, Monti SM, Pan P, Parkkila S, Supuran CT, Rossello A, Silvestri R
    * Discovery of 1, 1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors (131 visite)
    J Med Chem (ISSN: 1520-4804electronic, 0022-2623linking, 0022-2623print), 2015 Nov 12; 58(21): 8564-8572.
    Impact Factor: 5.589
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    Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
    * A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (575 visite) (PDF 171 visite)
    Cancer Lett (ISSN: 1872-7980electronic, 0304-3835linking), 2015 Oct 27; 370(1): 100-107.
    Impact Factor: 5.992
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    Di Fiore A, Vergara A, Caterino M, Alterio V, Monti SM, Ombouma J, Dumy P, Vullo D, Supuran CT, Winum JY, De Simone G
    * Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors (147 visite) (PDF 134 visite)
    Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2015 Jul 2; 51(57): 11519-11522.
    Impact Factor: 6.567
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    De Simone G, Monti SM, Alterio V, Buonanno M, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C, Di Fiore A
    * Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense (109 visite)
    Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2015 May 1; 25(9): 2002-2006.
    Impact Factor: 2.486
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    Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT
    * X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor (149 visite)
    Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2015 Apr 7; 13(13): 4064-4069.
    Impact Factor: 3.559
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    De Simone G, Di Fiore A, Capasso C, Supuran CT
    * The zinc coordination pattern in the eta-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families (233 visite)
    Bioorg Med Chem Lett (ISSN: 1464-3405electronic, 0960-894xlinking), 2015 Apr 1; 25(7): 1385-1389.
    Impact Factor: 2.486
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    Alterio V, Langella E, De Simone G, Monti SM
    * Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (161 visite)
    Marine Drugs (ISSN: 1660-3397electronic, 1660-3397linking), 2015 Apr; 13(4): 1688-1697.
    Impact Factor: 3.345
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    Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
    * In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (209 visite) (PDF 150 visite)
    Nucl Med Biol (ISSN: 0969-8051, 1872-9614, 0883-2897), 2015 Mar; 42(3): 309-316.
    Impact Factor: 2.429
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    Monti SM, Supuran CT,  De Simone G
    * DPP-4 inhibitors: a patent review (2012 - 2014) (108 visite)
    Expert Opinion On Therapeutic Patents (ISSN: 1354-3776, 1744-7674electronic, 1354-3776linking), 2015 Feb; 25(2): 209-236.
    Impact Factor: 4.626
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    Supuran CT, Capasso C, De Simone G
    * Carbonic Anhydrase II as Target for Drug Design (105 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 51-90.
    Impact Factor: 0
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    Monti SM, Supuran CT, De Simone G, Di Fiore A
    * Carbonic Anhydrase VII (81 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 151-168.
    Impact Factor: 0
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    Supuran CT, De Simone G
    Carbonic Anhydrases: An Overview (90 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 3-13.
    Impact Factor: 0
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    D'Ambrosio K, De Simone G, Supuran CT
    * Human Carbonic Anhydrases: Catalytic Properties, Structural Features, and Tissue Distribution (95 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 17-30.
    Impact Factor: 0
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    D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G
    * Out of the active site binding pocket for carbonic anhydrase inhibitors (157 visite) (PDF 134 visite)
    Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jan 7; 51(2): 302-305.
    Impact Factor: 6.567
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    Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
    * New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (117 visite)
    Br J Cancer (ISSN: 0007-0920, 1532-1827electronic, 0007-0920print), 2015 Jan 6; 112(1): 77-85.
    Impact Factor: 5.569
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    Galdiero S, Falanga A, Morelli G, Galdiero M
    * gH625: A milestone in understanding the many roles of membranotropic peptides (170 visite)
    Biochim Biophys Acta (ISSN: 0005-2736, 0006-3002, 0925-4439), 2015 Jan; 1848(PA): 16-25.
    Impact Factor: 3.687
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    Yousif AM, Minopoli M, Bifulco K, Ingangi V, Di Carluccio G, Merlino F, Motti ML, Grieco P, Carriero MV
    * Cyclization of the urokinase receptor-derived Ser-Arg-Ser-Arg-Tyr peptide generates a potent inhibitor of trans-endothelial migration of monocytes (142 visite)
    Plosone (ISSN: 1932-6203, 1932-6203electronic), 2015; 10(5): N/D-N/D.
    Impact Factor: 3.057
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    Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
    * Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (3 visite)
    J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
    Impact Factor:
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    Ceruso M, Carta F, Osman SM, Alothman Z, Monti SM, Supuran CT
    * Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties (134 visite)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2015; 23(15): 4181-4187.
    Impact Factor: 2.923
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    Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
    * Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (127 visite)
    Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
    Impact Factor: 5.008
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    Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
    * Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (143 visite)
    Head & Neck (ISSN: 1043-3074), 2015; 37(5): 763-770.
    Impact Factor: 2.76
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    Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
    * Recent developments of carbonic anhydrase inhibitors as potential drugs (124 visite)
    Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2015; 2015: 174178-174178.
    Impact Factor: 2.134
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    Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M
    * Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (104 visite)
    Rsc Adv (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
    Impact Factor: 3.289
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    Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
    * Thermostable carbonic anhydrases in biotechnological applications (139 visite)
    Int J Mol Sc (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2015; 16(7): 15456-15480.
    Impact Factor: 3.257
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    Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
    * Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor (157 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2014 Jul 24; 57(14): 5965-5974.
    Impact Factor: 5.447
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Musumeci D, Roviello GN, Montesarchio D
    * An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (174 visite)
    Pharmacology & Therapeutics (ISSN: 0163-7258), 2014 Mar; 141(3): 347-357.
    Impact Factor: 9.723
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    Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
    * Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (149 visite)
    Bioorg Med Chem (ISSN: 1464-3391, 0968-0896, 1464-3391electronic), 2014 Feb 1; 22(3): 960-966.
    Impact Factor: 2.793
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    Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
    * Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (146 visite)
    Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
    Impact Factor: 5.014
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
    * Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (132 visite)
    J Enzyme Inhib Med Chem (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
    Impact Factor: 2.332
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    Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
    * Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (142 visite)
    Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
    Impact Factor: 0.635
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    De Simone G, Pizika G, Monti SM, Di Fiore A, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT, Alterio V
    * Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors (118 visite)
    Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 523210-523210.
    Impact Factor: 1.579
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
    * The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (134 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
    Impact Factor: 2.385
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    Alterio V, Monti SM, De Simone G
    * Thermal-stable carbonic anhydrases: a structural overview (157 visite)
    Subcell Biochem (ISSN: 0306-0225), 2014; 75: 387-404.
    Impact Factor: 33.116
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    Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
    * Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates (181 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520.
    Impact Factor: 5.48
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    De Rosa V, Iommelli F, Votta G, Monti M, Ortosecco G, Fonti R, Mainolfi C, Stoppelli M, Del Vecchio S
    * Changes of Glycolytic Pathway in Response to Efficient Inhibition of EGFR Signaling in Non-small Cell Lung Cancer (NSCLC) (96 visite)
    Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
    Impact Factor: 5.217
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    Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
    * Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (128 visite)
    Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013 Sep 13; 8(9): N/D-N/D.
    Impact Factor: 3.534
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Alterio V, Supuran CT
    * Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (159 visite)
    Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
    Impact Factor: 3.467
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    Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
    * Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (151 visite)
    Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
    Impact Factor: 4.906
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    Monti SM, Supuran CT, De Simone G
    * Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (146 visite)
    Expert Opinion On Therapeutic Patents (ISSN: 1354-3776, 1744-7674electronic), 2013 Jun; 23(6): 737-749.
    Impact Factor: 3.441
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    Doti N, Raimondo D, Sabatella M, Ruvo M
    * Identification of Protease Inhibitors by a Fast Fluorimetric Assay (100 visite)
    Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2013 Jun; 54(2): 283-291.
    Impact Factor: 2.275
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    Di Fiore A, Capasso C, De Luca V, Monti SM, Carginale V, Supuran CT, Scozzafava A, Pedone C, Rossi M, De Simone G
    * X-ray structure of the first 'extremo-alpha-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 (120 visite)
    Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jun; 69(6): 1150-1159.
    Impact Factor: 7.232
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    Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
    * A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (153 visite)
    Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2013 Apr 2; 52(14): 3926-3930.
    Impact Factor: 11.336
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Monti SM, De Simone G, Dathan NA, Ludwig M, Vullo D, Scozzafava A, Capasso C, Supuran CT
    * Kinetic And Anion Inhibition Studies Of A Beta-Carbonic Anhydrase (fbica 1) From The C-4 Plant Flaveria Bidentis (143 visite)
    Bioorg Med Chem Lett (ISSN: 0960-894x), 2013 Mar 15; 23(6): 1626-1630.
    Impact Factor: 2.331
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    Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
    * Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (145 visite)
    Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
    Impact Factor: 8.193
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    Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
    * Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (122 visite)
    J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
    Impact Factor: 5.001
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    Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
    * Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (133 visite)
    Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
    Impact Factor: 2.61
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    Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
    * Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (130 visite)
    Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
    Impact Factor: 3.432
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    Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
    * Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (122 visite)
    Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
    Impact Factor: 2.689
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    Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
    * The mode of action of anticancer gold-based drugs: a structural perspective (108 visite)
    Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
    Impact Factor: 6.718
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    Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
    * Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (133 visite)
    Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
    Impact Factor: 5.831
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    Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
    * Metal ions affect insulin-degrading enzyme activity (110 visite)
    J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
    Impact Factor: 3.197
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    Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
    * Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (156 visite)
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    Impact Factor: 2.768
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    Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
    * Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (173 visite)
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    Impact Factor: 3.024
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    Berisio R
    * Editorial: cell processes in bacterial diseases (133 visite)
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    Impact Factor: 1.994
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    Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
    * Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (145 visite)
    Chemical Reviews (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
    Impact Factor: 41.298
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    Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
    * Cationic porphyrins are reversible proteasome inhibitors (153 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
    Impact Factor: 10.677
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    De Simone G, Supuran CT
    * (In)organic anions as carbonic anhydrase inhibitors (133 visite)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129.
    Impact Factor: 3.197
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    Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
    * Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (127 visite)
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    Impact Factor: 3.73
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    Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM
    * Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (151 visite)
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    Impact Factor: 3.142
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    Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
    * Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (120 visite)
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    Impact Factor: 5.614
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    Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
    * Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (102 visite)
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    Impact Factor: 2.338
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    Monti SM, Supuran CT, De Simone G
    * Carbonic anhydrase IX as a target for designing novel anticancer drugs (184 visite)
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    Impact Factor: 4.07
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    De Simone G
    * Editorial: Zinc Metallo-Enzymes As Target For Drug Design (116 visite)
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    Impact Factor: 4.07
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    Monti SM, Maresca A, Viparelli F, Carta F, De Simone G, Muehlschlegel FA, Scozzafava A, Supuran CT
    * Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata (121 visite)
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    Impact Factor: 2.338
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    D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
    * Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (134 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783.
    Impact Factor: 5.614
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    Di Fiore A, Maresca A, Supuran CT, De Simone G
    * Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (101 visite)
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    Impact Factor: 6.378
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    Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
    * Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (131 visite)
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    Impact Factor: 6.044
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    Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
    * Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (146 visite)
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    Impact Factor: 3.463
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    Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
    * Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation (159 visite)
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    Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
    * Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (107 visite)
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    Roviello GN, Di Gaetano S, Capasso D, Franco S, Crescenzo C, Bucci EM, Pedone C
    * RNA-binding and viral reverse transcriptase inhibitory activity of a novel cationic diamino acid-based peptide (118 visite)
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    Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
    * Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (134 visite)
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    Impact Factor: 5.248
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    Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
    * Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (168 visite)
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    Impact Factor: 5.925
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    Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (109 visite)
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    Impact Factor: 6.169
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    Viparelli F, Monti SM, De Simone G, Innocenti A, Scozzafava A, Xu Y, Morel FMM, Supuran CT
    * Inhibition Of The R1 Fragment Of The Cadmium-Containing Zeta-Class Carbonic Anhydrase From The Diatom Thalassiosira Weissflogii With Anions (134 visite)
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    Impact Factor: 2.661
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    Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
    * The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (126 visite)
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    Impact Factor: 3.451
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    Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R
    * Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (148 visite)
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    Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G
    * Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide (98 visite)
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    Impact Factor: 2.661
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    Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
    * Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (123 visite)
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    Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (100 visite)
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    Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
    * Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (129 visite)
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    Impact Factor: 4.106
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    Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
    * Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (108 visite)
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    De Simone G, Supuran CT
    * Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (161 visite)
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    Impact Factor: 2.773
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    Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
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    Guler OO, De Simone G, Supuran CT
    * Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (201 visite)
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    Supuran CT, Di Fiore A, Alterio V, Monti SM, De Simone G
    * Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII (120 visite)
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    Impact Factor: 4.774
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    Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
    * The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (107 visite)
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    Impact Factor: 7.135
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    Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT
    * The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors (84 visite)
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    Impact Factor: 2.65
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    Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis- sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (165 visite)
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    Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
    * Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (202 visite)
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    Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
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    De Simone G, Scozzafava A, Supuran CT
    * Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (113 visite)
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    Impact Factor: 2.473
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    Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G
    * Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (105 visite)
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    Impact Factor: 3.085
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    Palmieri G, Catara G, Saviano M, Langella E, Gogliettino M, Rossi M
    * First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop (108 visite)
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    Impact Factor: 5.132
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    Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
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    Impact Factor: 4.16
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    Hilvo M, De Simone G, Supuran CT, Parkkila S
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    De Simone G, Supuran CT
    * Drug Design of Antiobesity Carbonic Anhydrase Inhibitors (126 visite)
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    Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
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    Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
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    Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
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    Marasco D, Perretta G, Sabatella M, Ruvo M
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    De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
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    D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT
    * Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (145 visite)
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    Supuran CT, Di Fiore A, De Simone G
    * Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (132 visite)
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    Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
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    Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors (108 visite)
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    Impact Factor: 2.531
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    Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
    * Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (82 visite)
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    Impact Factor: 2.531
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    Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
    * Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (115 visite)
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    Impact Factor: 2.276
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    Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
    * The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (95 visite)
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    Impact Factor: 4.898
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    De Simone G, Di Fiore A, Supuran CT
    * Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (122 visite)
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    Impact Factor: 4.399
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    D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (155 visite)
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    Impact Factor: 3.15
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    Sabbatino F, Pacelli R, Punzo G, Fusciello C, Vernieri C, Della Vittoria Scarpati G, Pepe S
    * Inhibition of poly (ADP-Ribose) polymerase synergizes with the DNA-topoisomerase-1-inhibitor, topotecan, and radiation in human glioblastoma cell lines (99 visite)
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    Impact Factor: 3.259
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    Supuran CT, De Simone G
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    Impact Factor: 0
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    * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (113 visite)
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    Impact Factor: 4.399
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    Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
    * TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (132 visite)
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    Impact Factor: 4.533
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    Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
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    Impact Factor: 9.38
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    Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
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    Impact Factor: 6.44
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    * Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (117 visite)
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    Impact Factor: 2.604
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    Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
    * Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (116 visite)
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    Impact Factor: 5.581
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    Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
    * Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (121 visite)
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    Impact Factor: 2.662
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    Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
    * Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (124 visite)
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    Impact Factor: 3.446
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    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (99 visite)
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    Impact Factor: 3.664
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    * The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (124 visite)
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    Impact Factor: 3.078
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    Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
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    Impact Factor: 2.749
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    Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
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    Impact Factor: 4.895
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    Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (126 visite)
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    Impact Factor: 2.604
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    Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
    * Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (143 visite)
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    Impact Factor: 3.259
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    De Simone G, Supuran CT
    * Antiobesity carbonic anhydrase inhibitors (158 visite)
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    Impact Factor: 4.325
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    Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
    * Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (145 visite)
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    Impact Factor: 0.723
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    Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
    * 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (307 visite)
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    Impact Factor: 5.115
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    * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (109 visite)
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    Impact Factor: 2.538
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    Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
    * The chemical synthesis of the GstI protein by NCL on a X-Met site (122 visite)
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    Impact Factor: 2.48
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    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
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    Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
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    Impact Factor: 5.115
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    * Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (142 visite)
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    Impact Factor: 5.115
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    * Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (120 visite)
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    Impact Factor: 7.696
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    Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
    * Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (151 visite)
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    Impact Factor: 3.11
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    Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
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    Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (115 visite)
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    Impact Factor: 2.538
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    Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
    * Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (138 visite)
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    Impact Factor: 3.617
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    * Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (141 visite)
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    Impact Factor: 4.926
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    Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
    * Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (86 visite)
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    Impact Factor: 3.415
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    De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
    * Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (117 visite)
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    Impact Factor: 2.478
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    * Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (146 visite)
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    Impact Factor: 2.478
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    Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
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    Impact Factor: 5.108
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    La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
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    Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
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    Impact Factor: 5.854
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    Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
    * Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (132 visite)
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    Sica F, Di Fiore A, Merlino A, Mazzarella L
    * Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (116 visite)
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    Impact Factor: 6.355
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    De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
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    Impact Factor: 6.355
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    Impact Factor: 2.733
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    Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
    * Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (143 visite)
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    Impact Factor: 3.324
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    Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
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    Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
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    Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
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    Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
    * Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (122 visite)
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    Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
    From natural to synthetic multisite thrombin inhibitors (99 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
    Impact Factor: 2.331
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    Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
    Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (118 visite)
    Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
    Impact Factor: 2.189
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    Fonti R, Latella G, Caprilli R, Frieri G, Marcheggiano A, Sambuy Y
    Carbonic anhydrase I reduction in colonic mucosa of patients with active ulcerative colitis (80 visite)
    Digestive Diseases And Sciences (ISSN: 0163-2116), 1998; 43(9): 2086-2092.
    Impact Factor: 1.972
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    Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
    INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (133 visite)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
    Impact Factor: 1.342
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    209 Records (198 escludendo Abstract e Conferenze).
    Impact factor totale: 934.532 (896.238 escludendo Abstract e Conferenze).
    Impact factor a 5 anni totale: 911.933 (872.003 escludendo Abstract e Conferenze).







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