Benzoxaborole as a new chemotype for carbonic anhydrase inhibition
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Benzoxaborole as a new chemotype for carbonic anhydrase inhibition (102 visite)

Alterio V, Cadoni R, Esposito D, Vullo D, Fiore AD, Monti SM, Caporale A, Ruvo M, Sechi M, Dumy P, Supuran CT, De Simone G, Winum JY

CHEM COMMUN (ISSN: 1359-7345), 2016 Sep 29; 52(80): 11983-11986.



Tipo di articolo: Journal Article,

Impact factor: 6.319, Impact factor a 5 anni: 6.238

Url: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc06399c#!divRelatedContent

Parole chiave: Non disponibili.

Affiliazioni:

*** IBB - CNR ***
Istituto di Biostrutture e Bioimagini-CNR, Naples, Italy. 
  • Institut des Biomolécules Max Mousseron (IBMM) UMR5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
  • Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.
  • Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Sassari, Italy.
  • Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.



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    In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.
    ▼    CA IX as target for the development of new anti-tumour drugs
    ▼    Carbonic Anhydrase family as target for rational drug design
    
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    Mollica A, Locatelli M, Macedonio G, Carradori S, Sobolev AP, De Salvador RF, Monti SM, Buonanno M, Zengin G, Angeli A, Supuran CT
    * Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars (101 visite)
    J Enzyme Inhib Med Chem, 2016; 31(sup4): N/D-N/D.
    Impact Factor: 3.428
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    Palladino P, Aura AM, Spoto G
    * Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (161 visite)
    ANAL BIOANAL CHEM (ISSN: 1618-2642), 2016; 408(3): 849-854.
    Impact Factor: 3.431
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    De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
    * Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (328 visite)
    CLIN CANCER RES (ISSN: 1078-0432), 2015 Nov 15; 21(22): 5110-5120.
    Impact Factor: 8.738
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    La Regina G, Coluccia A, Famiglini V, Pelliccia S, Monti L, Vullo D, Nuti E, Alterio V, De Simone G, Monti SM, Pan P, Parkkila S, Supuran CT, Rossello A, Silvestri R
    * Discovery of 1, 1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors (131 visite)
    J MED CHEM (ISSN: 0022-2623), 2015 Nov 12; 58(21): 8564-8572.
    Impact Factor: 5.589
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    Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
    * A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (576 visite) (PDF 171 visite)
    CANCER LETT (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
    Impact Factor: 5.992
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    Di Fiore A, Vergara A, Caterino M, Alterio V, Monti SM, Ombouma J, Dumy P, Vullo D, Supuran CT, Winum JY, De Simone G
    * Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors (147 visite) (PDF 134 visite)
    CHEM COMMUN (ISSN: 1359-7345), 2015 Jul 2; 51(57): 11519-11522.
    Impact Factor: 6.567
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    De Simone G, Monti SM, Alterio V, Buonanno M, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C, Di Fiore A
    * Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense (109 visite)
    BIOORG MED CHEM LETT (ISSN: 0960-894X), 2015 May 1; 25(9): 2002-2006.
    Impact Factor: 2.486
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    Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT
    * X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor (149 visite)
    ORG BIOMOL CHEM (ISSN: 1477-0520), 2015 Apr 7; 13(13): 4064-4069.
    Impact Factor: 3.559
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    De Simone G, Di Fiore A, Capasso C, Supuran CT
    * The zinc coordination pattern in the eta-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families (233 visite)
    BIOORG MED CHEM LETT (ISSN: 0960-894X), 2015 Apr 1; 25(7): 1385-1389.
    Impact Factor: 2.486
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    Alterio V, Langella E, De Simone G, Monti SM
    * Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (161 visite)
    MAR DRUGS (ISSN: 1660-3397), 2015 Apr; 13(4): 1688-1697.
    Impact Factor: 3.345
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    Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
    * In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (211 visite) (PDF 150 visite)
    NUCL MED BIOL (ISSN: 0969-8051), 2015 Mar; 42(3): 309-316.
    Impact Factor: 2.429
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    Monti SM, Supuran CT,  De Simone G
    * DPP-4 inhibitors: a patent review (2012 - 2014) (108 visite)
    EXPERT OPIN THER PAT (ISSN: 1354-3776), 2015 Feb; 25(2): 209-236.
    Impact Factor: 4.626
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    Supuran CT, Capasso C, De Simone G
    * Carbonic Anhydrase II as Target for Drug Design (105 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 51-90.
    Impact Factor: 0
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    Monti SM, Supuran CT, De Simone G, Di Fiore A
    * Carbonic Anhydrase VII (81 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 151-168.
    Impact Factor: 0
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    Supuran CT, De Simone G
    Carbonic Anhydrases: An Overview (90 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 3-13.
    Impact Factor: 0
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    D'Ambrosio K, De Simone G, Supuran CT
    * Human Carbonic Anhydrases: Catalytic Properties, Structural Features, and Tissue Distribution (95 visite)
    Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 17-30.
    Impact Factor: 0
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    D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G
    * Out of the active site binding pocket for carbonic anhydrase inhibitors (158 visite) (PDF 134 visite)
    CHEM COMMUN (ISSN: 1359-7345), 2015 Jan 7; 51(2): 302-305.
    Impact Factor: 6.567
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    Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
    * New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (117 visite)
    BRIT J CANCER (ISSN: 0007-0920), 2015 Jan 6; 112(1): 77-85.
    Impact Factor: 5.569
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    Galdiero S, Falanga A, Morelli G, Galdiero M
    * gH625: A milestone in understanding the many roles of membranotropic peptides (171 visite)
    BBA-MOL BASIS DIS (ISSN: 0925-4439), 2015 Jan; 1848(PA): 16-25.
    Impact Factor: 5.158
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    Yousif AM, Minopoli M, Bifulco K, Ingangi V, Di Carluccio G, Merlino F, Motti ML, Grieco P, Carriero MV
    * Cyclization of the urokinase receptor-derived Ser-Arg-Ser-Arg-Tyr peptide generates a potent inhibitor of trans-endothelial migration of monocytes (146 visite)
    PLOS ONE (ISSN: 1932-6203), 2015; 10(5): N/D-N/D.
    Impact Factor: 3.057
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    Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
    * Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (3 visite)
    J NAT PROD (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
    Impact Factor: 3.662
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    Ceruso M, Carta F, Osman SM, Alothman Z, Monti SM, Supuran CT
    * Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties (134 visite)
    BIOORGAN MED CHEM (ISSN: 0968-0896), 2015; 23(15): 4181-4187.
    Impact Factor: 2.923
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    Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
    * Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (128 visite)
    ONCOTARGET (ISSN: 1949-2553), 2015; 6(12): 10563-10576.
    Impact Factor: 5.008
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    Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
    * Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (152 visite)
    HEAD NECK-J SCI SPEC (ISSN: 1043-3074), 2015; 37(5): 763-770.
    Impact Factor: 2.76
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    Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
    * Recent developments of carbonic anhydrase inhibitors as potential drugs (124 visite)
    BIOMED RES INT (ISSN: 2314-6133), 2015; 2015: 174178-174178.
    Impact Factor: 2.134
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M
    * Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (104 visite)
    RSC ADV (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
    Impact Factor: 3.289
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
    * Thermostable carbonic anhydrases in biotechnological applications (139 visite)
    INT J MOL SCI (ISSN: 1422-0067), 2015; 16(7): 15456-15480.
    Impact Factor: 3.257
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    Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
    * Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor (158 visite)
    J MED CHEM (ISSN: 0022-2623), 2014 Jul 24; 57(14): 5965-5974.
    Impact Factor: 5.447
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    Musumeci D, Roviello GN, Montesarchio D
    * An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (174 visite)
    PHARMACOL THERAPEUT (ISSN: 0163-7258), 2014 Mar; 141(3): 347-357.
    Impact Factor: 9.723
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    Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
    * Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (149 visite)
    BIOORGAN MED CHEM (ISSN: 0968-0896), 2014 Feb 1; 22(3): 960-966.
    Impact Factor: 2.793
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    Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
    * Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (146 visite)
    CELL DEATH DIS (ISSN: 2041-4889), 2014 Jan 16; 5(1): e993-e993.
    Impact Factor: 5.014
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
    * Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (132 visite)
    J ENZYM INHIB MED CH (ISSN: 1475-6366), 2014; 29(4): 500-504.
    Impact Factor: 2.332
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    Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
    * Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (142 visite)
    Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
    Impact Factor: 0.635
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    De Simone G, Pizika G, Monti SM, Di Fiore A, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT, Alterio V
    * Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors (118 visite)
    BIOMED RES INT (ISSN: 2314-6133), 2014; 2014: 523210-523210.
    Impact Factor: 1.579
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
    * The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (134 visite)
    BIOPOLYMERS (ISSN: 0006-3525), 2014; 101(7): 769-778.
    Impact Factor: 2.385
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    Alterio V, Monti SM, De Simone G
    * Thermal-stable carbonic anhydrases: a structural overview (157 visite)
    Subcell Biochem (ISSN: 0306-0225), 2014; 75: 387-404.
    Impact Factor: 33.116
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    Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
    * Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates (181 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520.
    Impact Factor: 5.48
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    De Rosa V, Iommelli F, Votta G, Monti M, Ortosecco G, Fonti R, Mainolfi C, Stoppelli M, Del Vecchio S
    * Changes of Glycolytic Pathway in Response to Efficient Inhibition of EGFR Signaling in Non-small Cell Lung Cancer (NSCLC) (96 visite)
    Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
    Impact Factor: 5.217
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    Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
    * Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (128 visite)
    Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013 Sep 13; 8(9): N/D-N/D.
    Impact Factor: 3.534
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Alterio V, Supuran CT
    * Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (160 visite)
    Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
    Impact Factor: 3.467
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    Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
    * Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (153 visite)
    Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
    Impact Factor: 4.906
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    Monti SM, Supuran CT, De Simone G
    * Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (147 visite)
    Expert Opinion On Therapeutic Patents (ISSN: 1354-3776, 1744-7674electronic), 2013 Jun; 23(6): 737-749.
    Impact Factor: 3.441
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    Doti N, Raimondo D, Sabatella M, Ruvo M
    * Identification of Protease Inhibitors by a Fast Fluorimetric Assay (100 visite)
    Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2013 Jun; 54(2): 283-291.
    Impact Factor: 2.275
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    Di Fiore A, Capasso C, De Luca V, Monti SM, Carginale V, Supuran CT, Scozzafava A, Pedone C, Rossi M, De Simone G
    * X-ray structure of the first 'extremo-alpha-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 (124 visite)
    Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jun; 69(6): 1150-1159.
    Impact Factor: 7.232
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    Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
    * A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (153 visite)
    Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2013 Apr 2; 52(14): 3926-3930.
    Impact Factor: 11.336
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Monti SM, De Simone G, Dathan NA, Ludwig M, Vullo D, Scozzafava A, Capasso C, Supuran CT
    * Kinetic And Anion Inhibition Studies Of A Beta-Carbonic Anhydrase (fbica 1) From The C-4 Plant Flaveria Bidentis (144 visite)
    Bioorg Med Chem Lett (ISSN: 0960-894x), 2013 Mar 15; 23(6): 1626-1630.
    Impact Factor: 2.331
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    Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
    * Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (145 visite)
    Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
    Impact Factor: 8.193
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    Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
    * Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (123 visite)
    J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
    Impact Factor: 5.001
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    Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
    * Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (133 visite)
    Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
    Impact Factor: 2.61
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    Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
    * Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (130 visite)
    Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
    Impact Factor: 3.432
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    Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
    * Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (122 visite)
    Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
    Impact Factor: 2.689
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    Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
    * The mode of action of anticancer gold-based drugs: a structural perspective (108 visite)
    Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
    Impact Factor: 6.718
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    Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
    * Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (134 visite)
    Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
    Impact Factor: 5.831
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    Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
    * Metal ions affect insulin-degrading enzyme activity (110 visite)
    J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
    Impact Factor: 3.197
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    Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
    * Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (157 visite)
    Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
    Impact Factor: 2.768
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    Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
    * Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (173 visite)
    Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723), 2012 Nov; 31(11): 3047-3055.
    Impact Factor: 3.024
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    Berisio R
    * Editorial: cell processes in bacterial diseases (133 visite)
    Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
    Impact Factor: 1.994
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    Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
    * Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (145 visite)
    Chemical Reviews (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
    Impact Factor: 41.298
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    Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
    * Cationic porphyrins are reversible proteasome inhibitors (154 visite)
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    Impact Factor: 3.197
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    Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
    * Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (127 visite)
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    Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM
    * Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (152 visite)
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    Impact Factor: 3.142
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    Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
    * Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (135 visite)
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    Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
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    Monti SM, Supuran CT, De Simone G
    * Carbonic anhydrase IX as a target for designing novel anticancer drugs (185 visite)
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    De Simone G
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    Monti SM, Maresca A, Viparelli F, Carta F, De Simone G, Muehlschlegel FA, Scozzafava A, Supuran CT
    * Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata (121 visite)
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    Impact Factor: 2.338
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    D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
    * Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (134 visite)
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    Impact Factor: 5.614
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    Di Fiore A, Maresca A, Supuran CT, De Simone G
    * Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (106 visite)
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    Impact Factor: 6.378
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    Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
    * Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (131 visite)
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    Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
    * Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (146 visite)
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    Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
    * Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation (160 visite)
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    Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
    * Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (123 visite)
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    Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
    * Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (168 visite)
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    * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (109 visite)
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    Impact Factor: 6.169
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    Viparelli F, Monti SM, De Simone G, Innocenti A, Scozzafava A, Xu Y, Morel FMM, Supuran CT
    * Inhibition Of The R1 Fragment Of The Cadmium-Containing Zeta-Class Carbonic Anhydrase From The Diatom Thalassiosira Weissflogii With Anions (134 visite)
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    Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
    * The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (126 visite)
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    Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R
    * Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (149 visite)
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    Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G
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    * Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (100 visite)
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    Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
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    Impact Factor: 4.106
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    Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
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    De Simone G, Supuran CT
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    Impact Factor: 2.773
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    * The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors (84 visite)
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    Marasco D, Perretta G, Sabatella M, Ruvo M
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    Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
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    Impact Factor: 3.322
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    Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
    * Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (132 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
    Impact Factor: 4.898
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Di Fiore A, Supuran CT
    * Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (122 visite)
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
    Impact Factor: 4.399
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (155 visite)
    Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
    Impact Factor: 3.15
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Sabbatino F, Pacelli R, Punzo G, Fusciello C, Vernieri C, Della Vittoria Scarpati G, Pepe S
    * Inhibition of poly (ADP-Ribose) polymerase synergizes with the DNA-topoisomerase-1-inhibitor, topotecan, and radiation in human glioblastoma cell lines (99 visite)
    Cytometry Part A (ISSN: 1552-4922), 2008 Jan; 73A(1): N/D-N/D.
    Impact Factor: 3.259
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Supuran CT, De Simone G
    Carbonic anhydrases--an overview (114 visite)
    Curr Pharm Des, 2008; 14(7): 603-614.
    Impact Factor: 0
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
    * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (113 visite)
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
    Impact Factor: 4.399
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
    * TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (133 visite)
    Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
    Impact Factor: 4.533
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
    * The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (97 visite)
    Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
    Impact Factor: 9.38
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
    * Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (98 visite)
    Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
    Impact Factor: 6.44
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
    * Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (117 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
    Impact Factor: 2.604
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
    * Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (116 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2007 Jun 29; 282(26): 19029-19041.
    Impact Factor: 5.581
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
    * Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (122 visite)
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
    Impact Factor: 2.662
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
    * Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (124 visite)
    Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
    Impact Factor: 3.446
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (100 visite)
    Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
    Impact Factor: 3.664
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
    * The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (124 visite)
    Biochim Biophys Acta (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
    Impact Factor: 3.078
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
    * Trehalose effects on alpha-crystallin aggregates (163 visite)
    Biochem Biophys Res Commun (ISSN: 0006-291x, 0006-291xlinking), 2007 Mar 23; 354(4): 899-905.
    Impact Factor: 2.749
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
    * Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (151 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
    Impact Factor: 4.895
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
    * Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (126 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
    Impact Factor: 2.604
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
    * Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (144 visite)
    Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 83-90.
    Impact Factor: 3.259
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Supuran CT
    * Antiobesity carbonic anhydrase inhibitors (158 visite)
    Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
    Impact Factor: 4.325
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
    * Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (145 visite)
    Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
    Impact Factor: 0.723
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
    * 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (308 visite)
    J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
    Impact Factor: 5.115
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
    * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (109 visite)
    Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
    Impact Factor: 2.538
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
    * The chemical synthesis of the GstI protein by NCL on a X-Met site (122 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Dec 5; 83(5): 508-518.
    Impact Factor: 2.48
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
    * In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (127 visite)
    J Mass Spectrom Journal Of Mass Spectrometry (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
    Impact Factor: 2.945
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
    * Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (100 visite)
    J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
    Impact Factor: 1.801
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
    * Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (122 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
    Impact Factor: 5.115
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
    * Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (142 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
    Impact Factor: 5.115
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (120 visite)
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
    Impact Factor: 7.696
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
    * Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (151 visite)
    Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
    Impact Factor: 3.11
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
    * Inhibition of NF-kappa B activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells (119 visite)
    Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2006 Apr; 47: N/D-N/D.
    Impact Factor: 0
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello  GN, Sapio R, Pedone C, Bucci EM
    * A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (94 visite)
    J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
    Impact Factor: 1.801
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
    * Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (115 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
    Impact Factor: 2.538
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
    * Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (138 visite)
    Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
    Impact Factor: 3.617
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
    * Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (141 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
    Impact Factor: 4.926
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
    * Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (87 visite)
    Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
    Impact Factor: 3.415
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
    * Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (117 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
    Impact Factor: 2.478
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
    * Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (146 visite)
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
    Impact Factor: 2.478
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
    * Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (166 visite)
    Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
    Impact Factor: 5.108
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    La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
    * Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (160 visite)
    Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
    Impact Factor: 3.152
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    Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
    * Assignment of the binding site for haptoglobin on apolipoprotein A-I (98 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2005 Jan 14; 280(2): 1193-1198.
    Impact Factor: 5.854
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
    * Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (132 visite)
    Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
    Impact Factor: 4.104
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Sica F, Di Fiore A, Merlino A, Mazzarella L
    * Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (116 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2004 Sep 27; 279(35): 36753-36760.
    Impact Factor: 6.355
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
    * A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (111 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2004 Feb 20; 279(8): 6815-6823.
    Impact Factor: 6.355
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT
    * Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: Molecular and X-ray crystallographic studies (114 visite)
    Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2003 Sep 5; 42(30): 9013-9021.
    Impact Factor: 3.922
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Bashan A, Zarivach R, Schluenzen F, Agmon I, Harms J, Auerbach T, Baram D, Berisio R, Bartels H, Hansen HAS, Fucini P, Wilson D, Peretz M, Kessler M, Yonath A
    * Ribosomal crystallography: Peptide bond formation and its inhibition (133 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
    Impact Factor: 2.733
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
    * Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (143 visite)
    Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
    Impact Factor: 3.324
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
    * The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (107 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2002 Dec 27; 277(52): 50348-50354.
    Impact Factor: 6.696
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
    * Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (131 visite)
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
    Impact Factor: 4.566
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
    * Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (128 visite)
    Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
    Impact Factor: 3.568
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    De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
    * Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (142 visite)
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2001 Sep 28; 276(39): 36613-36623.
    Impact Factor: 7.258
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
    * Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (122 visite)
    Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001 Mar 16; 7(6): 1176-1183.
    Impact Factor: 4.614
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
    From natural to synthetic multisite thrombin inhibitors (99 visite)
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
    Impact Factor: 2.331
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
    Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (119 visite)
    Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
    Impact Factor: 2.189
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    Fonti R, Latella G, Caprilli R, Frieri G, Marcheggiano A, Sambuy Y
    Carbonic anhydrase I reduction in colonic mucosa of patients with active ulcerative colitis (80 visite)
    Digestive Diseases And Sciences (ISSN: 0163-2116), 1998; 43(9): 2086-2092.
    Impact Factor: 1.972
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    Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
    INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (134 visite)
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
    Impact Factor: 1.342
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    209 Records (198 escludendo Abstract e Conferenze).
    Impact factor totale: 935.06 (896.766 escludendo Abstract e Conferenze).
    Impact factor a 5 anni totale: 918.088 (878.158 escludendo Abstract e Conferenze).







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