Benzoxaborole as a new chemotype for carbonic anhydrase inhibition
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Benzoxaborole as a new chemotype for carbonic anhydrase inhibition (53 visite)

Alterio V, Cadoni R, Esposito D, Vullo D, Fiore AD, Monti SM, Caporale A, Ruvo M, Sechi M, Dumy P, Supuran CT, De Simone G, Winum JY

Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2016 Sep 29; 52(80): 11983-11986.

Tipo di articolo: Journal Article,

Impact factor: 6.319

Impact factor a 5 anni: 6.238


Parole chiave: Non disponibili.

Url: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc06399c#!divRelatedContent

In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.
*** IBB - CNR ***

Istituto di Biostrutture e Bioimagini-CNR, Naples, Italy. 
  • Institut des Biomolécules Max Mousseron (IBMM) UMR5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
  • Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.
  • Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Sassari, Italy.
  • Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.
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    * Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (111 visite)
    De Simone G, Alterio V, Supuran CT
    Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (119 visite)
    Monti SM, Supuran CT, De Simone G
    Expert Opin Ther Pat Expert Opinion On Therapeutic Patents (ISSN: 1354-3776), 2013 Jun; 23(6): 737-749.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * X-ray structure of the first 'extremo-alpha-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 (98 visite)
    Di Fiore A, Capasso C, De Luca V, Monti SM, Carginale V, Supuran CT, Scozzafava A, Pedone C, Rossi M, De Simone G
    Acta Crystallogr Sect D Biol Crystallogr Acta Crystallographica Section D Biological Crystallography (ISSN: 0907-4449), 2013 Jun; 69(6): 1150-1159.
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    * Kinetic And Anion Inhibition Studies Of A Beta-Carbonic Anhydrase (fbica 1) From The C-4 Plant Flaveria Bidentis (102 visite)
    Monti SM, De Simone G, Dathan NA, Ludwig M, Vullo D, Scozzafava A, Capasso C, Supuran CT
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2013 Mar 15; 23(6): 1626-1630.
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    * Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (97 visite)
    Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
    J Proteome Res Journal Of Proteome Research (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
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    * Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (97 visite)
    Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
    Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
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    * Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (97 visite)
    Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
    Chemical Reviews (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
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    * (In)organic anions as carbonic anhydrase inhibitors (103 visite)
    De Simone G, Supuran CT
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (107 visite)
    Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM
    Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1232-1241.
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    * Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (75 visite)
    Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
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    * Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (76 visite)
    Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
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    * Carbonic anhydrase IX as a target for designing novel anticancer drugs (131 visite)
    Monti SM, Supuran CT, De Simone G
    Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata (87 visite)
    Monti SM, Maresca A, Viparelli F, Carta F, De Simone G, Muehlschlegel FA, Scozzafava A, Supuran CT
    Bioorg Med Chem Lett (ISSN: 0960-894x), 2012 Jan 15; 22(2): 859-862.
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    * Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (103 visite)
    D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783.
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    * Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (70 visite)
    Di Fiore A, Maresca A, Supuran CT, De Simone G
    Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
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    * Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (82 visite)
    Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
    Cell Death Dis (ISSN: 2041-4889), 2012; 3(12): N/D-N/D.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation (100 visite)
    Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
    Plos One (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): N/D-N/D.
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    * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (80 visite)
    Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G
    Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(42): 11636-11638.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Inhibition Of The R1 Fragment Of The Cadmium-Containing Zeta-Class Carbonic Anhydrase From The Diatom Thalassiosira Weissflogii With Anions (90 visite)
    Viparelli F, Monti SM, De Simone G, Innocenti A, Scozzafava A, Xu Y, Morel FMM, Supuran CT
    Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Sep 15; 20(16): 4745-4748.
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    * The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (98 visite)
    Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
    Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
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    * Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (79 visite)
    Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
    Bioorg Chem, 2010 Sep; 38(5): 196-201.
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    * In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (106 visite)
    Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A,  Palma G, Barbieri A, Quinto I, Scala G
    Blood (ISSN: 0006-4971, 0006-6497), 2010 Jul 15; 116(2): 226-238.
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    * Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (76 visite)
    Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
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    * Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (134 visite)
    De Simone G, Supuran CT
    Biochim Biophys Acta (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (179 visite)
    Guler OO, De Simone G, Supuran CT
    Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII (91 visite)
    Supuran CT, Di Fiore A, Alterio V, Monti SM, De Simone G
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2010; 16(29): 3246-3254.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors (59 visite)
    Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT
    Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2009 Oct 15; 19(20): 5825-5828.
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    * Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis- sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (125 visite)
    Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2009 Oct 8; 52(19): 5990-5998.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (156 visite)
    Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
    Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
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    * Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (81 visite)
    De Simone G, Scozzafava A, Supuran CT
    Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
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    * Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (78 visite)
    Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G
    Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Jan; 74(1): 164-175.
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    * Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV (84 visite)
    Hilvo M, De Simone G, Supuran CT, Parkkila S
    Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 273-283.
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    * Drug Design of Antiobesity Carbonic Anhydrase Inhibitors (97 visite)
    De Simone G, Supuran CT
    Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; 66(DECEMBERSPEC.I): 241-254.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (95 visite)
    Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
    Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 73-138.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (90 visite)
    Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
    J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Oct 10; 283(41): 27799-27809.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Designing trehalose-conjugated peptides for the inhibition of Alzheimer's A beta oligornerization and neurotoxicity (86 visite)
    De Bona P, Giuffrida ML, Attanasio F, Copani A, Pignataro B, Cataldo S, Rizzarelli E, Pappalardo G
    J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (105 visite)
    D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT
    J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2008 Jun 12; 51(11): 3230-3237.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (106 visite)
    Supuran CT, Di Fiore A, De Simone G
    Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors (83 visite)
    Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G
    Bioorg Med Chem Lett (ISSN: 1464-3405, 0960-894x, 1464-3405electronic), 2008 Apr 15; 18(8): 2669-2674.
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    * Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (58 visite)
    Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
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    * Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (96 visite)
    De Simone G, Di Fiore A, Supuran CT
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (131 visite)
    D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
    Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Inhibition of poly (ADP-Ribose) polymerase synergizes with the DNA-topoisomerase-1-inhibitor, topotecan, and radiation in human glioblastoma cell lines (61 visite)
    Sabbatino F, Pacelli R, Punzo G, Fusciello C, Vernieri C, Della Vittoria Scarpati G, Pepe S
    Cytometry Part A (ISSN: 1552-4922), 2008 Jan; 73A(1): N/D-N/D.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    Carbonic anhydrases--an overview (87 visite)
    Supuran CT, De Simone G
    Curr Pharm Des, 2008; 14(7): 603-614.
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    * Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (87 visite)
    Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
    Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (86 visite)
    Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
    Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
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    * Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (76 visite)
    Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
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    * Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (86 visite)
    Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
    Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (82 visite)
    Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
    Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
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    * Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (97 visite)
    Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
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    * Antiobesity carbonic anhydrase inhibitors (120 visite)
    De Simone G, Supuran CT
    Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (84 visite)
    Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
    Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (115 visite)
    De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (92 visite)
    Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
    J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Inhibition of NF-kappa B activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells (72 visite)
    Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
    Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2006 Apr; 47: N/D-N/D.
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    * Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (91 visite)
    Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (87 visite)
    Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
    Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
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    * Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (115 visite)
    Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
    J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
    Dettagli    Esporta in BibTeX    Esporta in EndNote

    * Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (88 visite)
    De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
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    * Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (111 visite)
    Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
    Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
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    * Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (101 visite)
    La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
    Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
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    * Ribosomal crystallography: Peptide bond formation and its inhibition (82 visite)
    Bashan A, Zarivach R, Schluenzen F, Agmon I, Harms J, Auerbach T, Baram D, Berisio R, Bartels H, Hansen HAS, Fucini P, Wilson D, Peretz M, Kessler M, Yonath A
    Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
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    * Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (99 visite)
    Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
    Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
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    Carbonic anhydrase I reduction in colonic mucosa of patients with active ulcerative colitis (55 visite)
    Fonti R, Latella G, Caprilli R, Frieri G, Marcheggiano A, Sambuy Y
    Digestive Diseases And Sciences (ISSN: 0163-2116), 1998; 43(9): 2086-2092.
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    INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (90 visite)
    Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
    J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
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    108 Records (101 escludendo Abstract e Conferenze).
    Impact factor totale: 471.196 (445.916 escludendo Abstract e Conferenze).
    Impact factor a 5 anni totale: 471.889 (446.297 escludendo Abstract e Conferenze).

    Interrogazione bibliografica effettuata: (([btitle] "Benzoxaborole" OR [btitle] "chemotype" OR [btitle] "carbonic" OR [btitle] "anhydrase" OR [btitle] "inhibition") AND NOT [id] = 53321)







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