Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease
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Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease (315 views)

Sarappa C, Salvatore E, Filla A, Cocozza S, Russo CV, Sacca F, Brunetti A, De Michele G, Quarantelli M

Brain Imaging Behav (ISSN: 1931-7557), 2017 Oct; 11(5): 1459-1469.

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Paper type: Journal Article,

Impact factor: 3.719, 5-year impact factor: 4.21

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041996376&doi=10.1007%2fs11682-016-9630-6&partnerID=40&md5=95ba20813da9b897d3c8c68e048d18f5

Keywords: Amplitude Of Low-Frequency Fluctuations, Huntington, S Disease, Local Functional Connectivity, Regional Homogeneity, Resting-State Fmri, Spontaneous Neuronal Activity, Adolescent , Adult , Aged , Brain Diagnostic Imaging Physiopathology , Brain Mapping , Cerebrovascular Circulation Physiology , Female , Functional Laterality , Heterozygote , Humans , Huntingtin Protein Genetics , Huntington Disease Diagnostic Imaging Genetics Physiopathology , Magnetic Resonance Imaging , Middle Aged , Oxygen Blood , Prodromal Symptoms , Severity Of Illness Index , Young Adult,

Affiliations:
*** IBB - CNR ***

Department of Advanced Biomedical Sciences, University "Federico II", Edificio 10, Via S. Pansini 5, 80131, Naples, Italy., Department of Neurosciences, Reproductive and Odontostomatological Sciences, University "Federico II", Edificio 17, Via S. Pansini 5, 80131, Naples, Italy., Biostructure and Bioimaging Institute, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy. quarante@unina.it.,


References:
Not available.
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease

The fractional Amplitude of Low Frequency Fluctuations (fALFF) and the degree of local synchronization (Regional Homogeneity - ReHo) of resting-state BOLD signal have been suggested to map spontaneous neuronal activity and local functional connectivity, respectively. We compared voxelwise, independent of atrophy, the fALFF and ReHo patterns of 11 presymptomatic (ps-HD) and 28 symptomatic (sHD) Huntington's disease mutation carriers, with those of 40 normal volunteers, and tested their possible correlations with the motor and cognitive subscores of the Unified Huntington's Disease Rating Scale. In sHD patients, fALFF was mainly reduced bilaterally in parietal lobes (right precuneus being already affected in psHD), and in superior frontal gyri, and increased bilaterally in cerebellar lobules VI, VIII and IX, as well as in the right inferior temporal gyrus. In sHD, and to a lesser extent in psHD, ReHo was bilaterally reduced in putamina, cerebellar lobules III to VI, and superior medial frontal gyri, and increased in both psHD and sHD in fronto-basal cortices, and in the right temporal lobe. fALFF correlated inversely with cognitive scores in lobule IX of the cerebellum (mainly with total Stroop score, p < 0.0001), and in the medial portions of both thalami. These results are consistent with a reduced neuronal activity in the cortical components of the executive networks, known to be affected in Huntington's Disease, and with reduced local functional integration in subcortical and cerebellar components of the sensori-motor network. Cerebellar clusters of significant correlation of fALFF with executive function scores may be related to compensatory mechanisms.
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease

▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease

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Last modified by Gennaro Angrisano on Sunday 12 July 2020, 13:14:43
315 views. Last view on Thursday 22 September 2022, 7:34:18