Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease(286 views visite) Sarappa C, Salvatore E, Filla A, Cocozza S, Russo CV, Sacca F, Brunetti A, De Michele G, Quarantelli M
Keywords Parole chiave: Amplitude Of Low-Frequency Fluctuations, Huntington, S Disease, Local Functional Connectivity, Regional Homogeneity, Resting-State Fmri, Spontaneous Neuronal Activity, Adolescent
, Adult
, Aged
, Brain Diagnostic Imaging Physiopathology
, Brain Mapping
, Cerebrovascular Circulation Physiology
, Female
, Functional Laterality
, Heterozygote
, Humans
, Huntingtin Protein Genetics
, Huntington Disease Diagnostic Imaging Genetics Physiopathology
, Magnetic Resonance Imaging
, Middle Aged
, Oxygen Blood
, Prodromal Symptoms
, Severity Of Illness Index
, Young Adult,
Affiliations Affiliazioni: *** IBB - CNR ***
Department of Advanced Biomedical Sciences, University "Federico II", Edificio 10, Via S. Pansini 5, 80131, Naples, Italy., Department of Neurosciences, Reproductive and Odontostomatological Sciences, University "Federico II", Edificio 17, Via S. Pansini 5, 80131, Naples, Italy., Biostructure and Bioimaging Institute, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy. quarante@unina.it.,
References Riferimenti: Not available. Non disponibili.
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease
The fractional Amplitude of Low Frequency Fluctuations (fALFF) and the degree of local synchronization (Regional Homogeneity - ReHo) of resting-state BOLD signal have been suggested to map spontaneous neuronal activity and local functional connectivity, respectively. We compared voxelwise, independent of atrophy, the fALFF and ReHo patterns of 11 presymptomatic (ps-HD) and 28 symptomatic (sHD) Huntington's disease mutation carriers, with those of 40 normal volunteers, and tested their possible correlations with the motor and cognitive subscores of the Unified Huntington's Disease Rating Scale. In sHD patients, fALFF was mainly reduced bilaterally in parietal lobes (right precuneus being already affected in psHD), and in superior frontal gyri, and increased bilaterally in cerebellar lobules VI, VIII and IX, as well as in the right inferior temporal gyrus. In sHD, and to a lesser extent in psHD, ReHo was bilaterally reduced in putamina, cerebellar lobules III to VI, and superior medial frontal gyri, and increased in both psHD and sHD in fronto-basal cortices, and in the right temporal lobe. fALFF correlated inversely with cognitive scores in lobule IX of the cerebellum (mainly with total Stroop score, p < 0.0001), and in the medial portions of both thalami. These results are consistent with a reduced neuronal activity in the cortical components of the executive networks, known to be affected in Huntington's Disease, and with reduced local functional integration in subcortical and cerebellar components of the sensori-motor network. Cerebellar clusters of significant correlation of fALFF with executive function scores may be related to compensatory mechanisms.
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(217 visite) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
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