Hierarchical Analysis of Self-Assembled PEGylated Hexaphenylalanine Photoluminescent Nanostructures(280 visite) Diaferia C, Sibillano T, Balasco N, Giannini C, Roviello V, Vitagliano L, Morelli G, Accardo A
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Oct 5; N/D: N/D-N/D.
Tipo di articolo: Journal Article,
Impact factor: 5.317, Impact factor a 5 anni: 5.184
Url: Non disponibile.
Parole chiave: Diphenylalanine, Molecular Dynamics, Nanostructures, Peptide Materials, Photoluminescence,
*** IBB - CNR *** Department of Pharmacy, Research Centre on Bioactive Peptides (CIRPeB), University of Naples "Federico II" and DFM Scarl, Via Mezzocannone 16, 80134, Naples, Italy., Institute of Crystallography (IC), CNR, Via Amendola 122, 70126, Bari, Italy., Institute of Biostructures and Bioimaging (IBB), CNR, Via Mezzocannone 16, 80134, Naples, Italy., Regional Center of Competence Technologies Scarl, Via Nuova Agnano, 11, 80125, Naples, Italy., Department of Pharmacy, Research Centre on Bioactive Peptides (CIRPeB), University of Naples "Federico II" and DFM Scarl, Via Mezzocannone 16, 80134, Naples, Italy. Antonella.firstname.lastname@example.org.,
Despite the growing literature about diphenylalanine-based peptide materials, it still remains a challenge to delineate the theoretical insight into peptide nanostructure formation and the structural features that could permit materials with enhanced properties to be engineered. Herein, we report the synthesis of a novel peptide building block composed of six phenylalanine residues and eight PEG units, PEG8 -F6. This aromatic peptide self-assembles in water in stable and well-ordered nanostructures with optoelectronic properties. A variety of techniques, such as fluorescence, FTIR, CD, DLS, SEM, SAXS, and WAXS allowed us to correlate the photoluminescence properties of the self-assembled nanostructures with the structural organization of the peptide building block at the micro- and nanoscale. Finally, a model of hexaphenylalanine in aqueous solution by molecular dynamics simulations is presented to suggest structural and energetic factors controlling the formation of nanostructures.
191 Records (186 escludendo Abstract e Conferenze). Impact factor totale: 745.976 (723.893 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 786.395 (764.159 escludendo Abstract e Conferenze).