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Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis (99 visite)

Ruggiero A, Squeglia F, RomanoM, Vitagliano L, De Simone A, Berisio R

J Biomol Struct Dyn (ISSN: 1538-0254electronic, 0739-1102linking), 2017 May; 35(6): 1322-1330.

Tipo di articolo: Journal Article, , Impact factor: 3.123, Impact factor a 5 anni: 2.555, Url: Non disponibile.

Parole chiave: Dormancy, Molecular Dynamics, Resuscitation, Tuberculosis, Amino Acid Sequence, Bacterial Proteins, Chemistry, Catalytic Domain, Molecular Dynamics Simulation, Mycobacterium Tuberculosis, Metabolism, Protein Conformation, Protein Domains, Protein Interaction Domains And Motifs, Protein Stability, Recombinant Proteins,

Affiliazioni: *** IBB - CNR ***
a Institute of Biostructures and Bioimaging , CNR , Naples , Italy., b Division of Molecular Biosciences , Imperial College London , London , UK.,


Riferimenti: Non disponibile.

RpfB is multidomain protein that is crucial for Mycobacterium tuberculosis resuscitation from dormancy. This protein cleaves cell wall peptidoglycan, an essential bacterial cell wall polymer formed by glycan chains of beta-(1-4)-linked-N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) cross-linked by short peptide stems. RpfB is structurally complex being composed of five distinct domains, namely a catalytic, a G5 and three DUF348 domains. Here, we have undertaken a combined experimental and computation structural investigations on the entire protein to gain insights into its structure-function relationships. CD spectroscopy and light scattering experiments have provided insights into the protein fold stability and into its oligomeric state. Using the available structure information, we modeled the entire protein structure, which includes the two DUF348 domains whose structure is experimentally unknown, and we analyzed the dynamic behavior of RpfB using molecular dynamics simulations. Present results highlight an intricate mutual influence of the dynamics of the different protein domains. These data provide interesting clues on the functional role of non-catalytic domains of RpfB and on the mechanism of peptidoglycan degradation necessary to resuscitation of M. tuberculosis.

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De Maio F, Squeglia F, Goletti D, Delogu G
* The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis (5 visite)
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Squeglia F, Ruggiero A, Berisio R
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Impact Factor: 4.897
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Impact Factor: 6.721
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Squeglia F, Ruggiero A, Berisio R
* Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation (150 visite) (PDF 115 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018; 24: 2533-2546.
Impact Factor: 5.317
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Squeglia F, RomanoM, Ruggiero A, Berisio R
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Impact Factor: 3.249
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Barone D, Balasco N, Autiero I, Vitagliano L
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Maione V, Ruggiero A, Russo L, De Simone A, Pedone PV, Malgieri G, Berisio R, Isernia C
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Impact Factor: 3.057
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Ruggiero A, Squeglia F, Romanò MF, Vitagliano L, De Simone A, Berisio  R
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Impact Factor: 4.864
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Romanò MF, Squeglia F, Berisio R
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Impact Factor: 3.455
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Nikitushkin VD, Demina GR, Shleeva MO, Guryanova SV, Ruggiero A, Berisio R, Kaprelyants AS
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Impact Factor: 4.237
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Autiero I, Saviano M, Langella E
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Impact Factor: 3.902
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Squeglia F, Ruggiero A, Berisio R
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Balasco N, Barone D, Vitagliano L
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Squeglia F, Ruggiero A, Romanò MF, Vitagliano L, Berisio R
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Impact Factor: 14.1
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
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Autiero I, Saviano M, Langella E
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Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
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Squeglia F, Romanò MF, Ruggiero A, Vitagliano L, De Simone A, Berisio R
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Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
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Autiero I, Langella E, Saviano M
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Caruso P, Causà M, Cimino P, Crescenzi O, D'Amore M, Improta R, Pavone M, Rega N
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Theor Chem Acc (ISSN: 1432-881x), 2012 Apr; 131(4): 1211-1212.
Impact Factor: 2.233
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Impact Factor: 3.582
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Merlino A, Vitiello G, Grimaldi M, Sica F, Busi E, Basosi R, D’Ursi A, Fragneto G, Paduano L, D’Errico G
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Squeglia F, Marchetti R, Ruggiero A, Lanzetta R, Marasco D, Dworkin J, Petoukhov M, Molinaro A, Berisio R, Silipo A
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
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Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (109 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
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Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
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Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
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J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 May 27; 114(20): 7002-7008.
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Esposito C, Carullo C, Pedone E, Graziano G, Del Vecchio P, Berisio R
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
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Impact Factor: 1.849
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Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(8): 2266-2277.
Impact Factor: 3.042
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
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J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 192-199.
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
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J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Palmieri G, Catara G, Saviano M, Langella E, Gogliettino M, Rossi M
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J Proteome Res Journal Of Proteome Research (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Impact Factor: 5.132
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Vitagliano L, Esposito L, Pedone C, De Simone A
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Milardi D, Pappalardo M, Pannuzzo M, Grasso DM, Rosa CL
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Chemical Physics Letters (ISSN: 0009-2614), 2008 Oct 1; 463(4-6): 396-399.
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De Simone A, Esposito L, Pedone C, Vitagliano L
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Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 Sep 15; 95(4): 1965-1973.
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Esposito C, Pethoukov MV, Svergun DI, Ruggiero A, Pedone C, Pedone E, Berisio R
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Esposito L, Paladino A, Pedone C, Vitagliano L
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
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Impact Factor: 2.823
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (91 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
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Pietropaolo A, Raiola L, Muccioli L, Tiberio G, Zannoni C, Fattorusso R, Isernia C, La Mendola D, Pappalardo G, Rizzarelli E
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
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Pappalardo M, Milardi D, Grasso D, La Rosa C
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New Journal Of Chemistry (ISSN: 1144-0546), 2007; 31(6): 901-905.
Impact Factor: 2.651
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Esposito L, Pedone C, Vitagliano L
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Langella E, Improta R, Crescenzi O, Barone V
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Impact Factor: 3.73
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Merlino A, Esposito L, Vitagliano L
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
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Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
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Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (108 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (141 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (129 visite)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Pappalardo M, Milardi D, La Rosa C, Zannoni C, Rizzarelli E, Grasso D
* A molecular dynamics study on the conformational stability of PrP 180-193 helix II prion fragment (113 visite)
Chemical Physics Letters (ISSN: 0009-2614), 2004 Jun 1; 390(4-6): 511-516.
Impact Factor: 2.438
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Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Free energy perturbation and molecular dynamics calculations of copper binding to azurin (118 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2003 Apr 30; 24(6): 779-785.
Impact Factor: 3.186
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Merlino A, Vitagliano L, Ceruso M, Di Nola A, Mazzarella L
* Global and local motions in ribonuclease A: A molecular dynamics study (114 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002 Nov 15; 65(4): 274-283.
Impact Factor: 2.372
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Saviano M, Rossi F, Pavone V, Di Blasio B, Pedone C
Molecular dynamics simulation in vacuo and in solution of [Aib5, 6-D- Ala8] Cyclolinopeptide A: A conformational and comparative study (117 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 1992 Jun; 9(6): 1045-1060.
Impact Factor: 1.283
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63 Records (63 escludendo Abstract e Conferenze).
Impact factor totale: 239.309 (239.309 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 229.314 (229.314 escludendo Abstract e Conferenze).







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