*** IBB - CNR *** a Department of Chemical Sciences , University of Naples Federico II , Naples , Italy., b Institute of Biostructures and Bioimaging, CNR , Naples , Italy., c Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Universita degli Studi di Firenze , Florence , Italy.,
Carbonic anhydrases (CAs) III and VII are two cytosolic isoforms of the alpha-CA family which catalyze the physiological reaction of carbon dioxide hydration to bicarbonate and proton. Despite these two enzymes share a 49% sequence identity and present a very similar three-dimensional structure, they show profound differences when comparing the specific activity for CO2 hydration reaction, with CA VII being much more active than CA III. Recently, CA III and CA VII have been proposed to play a new role as scavenger enzymes in cells where oxidative damage occurs. Here, we will examine functional and structural features of these two isoforms giving insights into their newly proposed protective role against oxidative stress.
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(232 visite) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote
394 Records (384 escludendo Abstract e Conferenze). Impact factor totale: 1501.972 (1466.187 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 1545.432 (1505.974 escludendo Abstract e Conferenze).