Molecular players in Tuberculosis drug development: another break in the cell wall
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Molecular players in Tuberculosis drug development: another break in the cell wall (113 visite)

Squeglia F, RomanoM, Ruggiero A, Berisio R

CURR MED CHEM (ISSN: 0929-8673), 2017 Feb 08; 24: 3954-3969.



Tipo di articolo: Review, Journal Article,

Impact factor: 3.469, Impact factor a 5 anni: 3.519

Url: Non disponibile.

Parole chiave: Drug, Protein Structure., Tuberculosis,

Affiliazioni:

*** IBB - CNR ***
Institute of Biostructures and Bioimaging - CNR Naples,Italy.,


Riferimenti:

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Tuberculosis is a leading killer, especially for people living with HIV. It is a real medical need to tackle this disease, which is made difficult to treat due to the increasing spread of multi-drug-resistant and extensively drug-resistant bacterial strains. Cases of tuberculosis that are resistant to virtually all drugs currently available are increasing at an alarming rate around the world. Here, we review the current knowledge in the field of drug development against tuberculosis with a focus on the mechanisms of action of drugs and the targeted bacterial cell processes involved. Particular emphasis is dedicated to the process of cell wall synthesis, which has proven to provide strong potentialities for drug development. It is hoped that a deeper understanding of key molecular machineries to tackle will provide us with a better outline of possible antibacterial mechanisms of action and offer hints for the design of more efficient strategies to treat resistant tuberculosis in the future.
▼    Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection

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De Maio F, Squeglia F, Goletti D, Delogu G
* The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis (15 visite)
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Ruggiero A, Squeglia F, RomanoM, Vitagliano L, De Simone A, Berisio R
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Ruggiero A, Squeglia F, Romanò MF, Vitagliano L, De Simone A, Berisio R
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Romanò MF, Squeglia F, Berisio R
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Squeglia F, Ruggiero A, Romanò MF, Vitagliano L, Berisio R
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Squeglia F, Romanò MF, Ruggiero A, Vitagliano L, De Simone A, Berisio R
* Carbohydrate recognition by RpfB from mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses (156 visite)
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Correale S, Ruggiero A, Pedone E, Berisio R
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Impact Factor: 0.568
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Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (129 visite)
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Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
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Impact Factor: 3.582
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Castellano I, Merlino A
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
* Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation (97 visite)
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Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (120 visite)
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (116 visite)
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Esposito C, Pethoukov MV, Svergun DI, Ruggiero A, Pedone C, Pedone E, Berisio R
* Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis (105 visite)
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (122 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
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27 Records (27 escludendo Abstract e Conferenze).
Impact factor totale: 104.588 (104.588 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 100.572 (100.572 escludendo Abstract e Conferenze).







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