Molecular players in Tuberculosis drug development: another break in the cell wall
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Molecular players in Tuberculosis drug development: another break in the cell wall (189 visite)

Squeglia F, Romano M, Ruggiero A, Berisio R

Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Feb 08; 24: 3954-3969.



Tipo di articolo: Review, Journal Article

Impact factor: 3.469, Impact factor a 5 anni: 3.519

Url: Non disponibile.

Parole chiave: Drug, Protein Structure., Tuberculosis

Affiliazioni:

*** IBB - CNR ***
Institute of Biostructures and Bioimaging - CNR Naples,Italy.,


Riferimenti:

Non disponibile.

Tuberculosis is a leading killer, especially for people living with HIV. It is a real medical need to tackle this disease, which is made difficult to treat due to the increasing spread of multi-drug-resistant and extensively drug-resistant bacterial strains. Cases of tuberculosis that are resistant to virtually all drugs currently available are increasing at an alarming rate around the world. Here, we review the current knowledge in the field of drug development against tuberculosis with a focus on the mechanisms of action of drugs and the targeted bacterial cell processes involved. Particular emphasis is dedicated to the process of cell wall synthesis, which has proven to provide strong potentialities for drug development. It is hoped that a deeper understanding of key molecular machineries to tackle will provide us with a better outline of possible antibacterial mechanisms of action and offer hints for the design of more efficient strategies to treat resistant tuberculosis in the future.
▼    Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection

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Impact Factor: 2.385
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* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (283 visite)
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Impact Factor: 7.232
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Correale S, Ruggiero A, Pedone E, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis (278 visite)
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Ruggiero A, Marchant J, Squeglia F, Makarov V, De Simone A, Berisio R
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* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (278 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
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Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
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* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (270 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
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28 Records (28 escludendo Abstract e Conferenze).
Impact factor totale: 107.698 (107.698 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 103.682 (103.682 escludendo Abstract e Conferenze).







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