Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. tamasi@unisi.it., Department of Chemical Sciences, University of Naples Federico II, Via Cintia, 80126, Napoli, Italy and Institute of Biostructure and Bioimaging, CNR, Via Mezzocannone 16, 80120, Napoli, Italy., Department of Chemistry, University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Florence, Italy., Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria and Research Platform "Translational Cancer Therapy Research", University of Vienna, Wahringer Strasse 42, 1090 Vienna, Austria., Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, 1090 Vienna, Austria. bernhard.keppler@univie.ac.at., Research Platform "Translational Cancer Therapy Research", University of Vienna, Wahringer Strasse 42, 1090 Vienna, Austria and Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, 1090 Vienna, Austria. bernhard.keppler@univie.ac.at.,
Department of Chemical Sciences, University of Naples Federico II, Via Cintia, 80126, Napoli, Italy and Institute of Biostructure and Bioimaging, CNR, Via Mezzocannone 16, 80120, Napoli, Italy.
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria and Research Platform "Translational Cancer Therapy Research", University of Vienna, Währinger Straße 42, 1090 Vienna, Austria.
Institute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090 Vienna, Austria. bernhard.keppler@univie.ac.at.
Research Platform "Translational Cancer Therapy Research", University of Vienna, Währinger Straße 42, 1090 Vienna, Austria and Institute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090 Vienna, Austria. bernhard.keppler@univie.ac.at.
References Riferimenti: Not available. Non disponibili.
{Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo
The reaction of [Ru(CO)(6)Cl(2)], 1, with N[combining low line](3)-methylbenzimidazole (MBI) and 5,6-dimethylbenzimidazole (DMBI) afforded two new complexes with the general formula fac-[Ru(II)(CO)(3)Cl(2)L], L = MBI (2) or DMBI (4). Crystals of cis,trans-[Ru(II)(CO)(2)Cl(2)(N[combining low line](3)-MBI)(2)], 3, were also obtained from the mother liquor that produced 2. In the presence of water, the dissociation of Ru-N, Ru-Cl and Ru-CO bonds occurred as a function of time, water content and pH. Density functional theory structure simulations/optimizations were carried out at the Becke3LYP level of theory for evaluating the relative stability of possible conformers. ESI-MS studies revealed the ability of the complexes to link model proteins, such as lysozyme, bovine pancreatic ribonuclease and cytochrome c, with the partial release of the heteroaromatic base, chlorido and carbonyl ligands. X-ray diffraction studies on crystals grown from a solution of HEWL and 2 showed the partial removal of chloride and CO. Cytotoxicity tests yielded two-digit micromolar IC(50) values in CH1/PA-1 and SW480 cancer cells. In contrast to CORM-3 and 2, a significantly reduced tumor growth was observed with 4 in the murine colon cancer CT-26 model in vivo.
{Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(211 visite) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 DettagliEsporta in BibTeXEsporta in EndNote
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