The RNA-binding protein ESRP1 promotes human colorectal cancer progression (169 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Feb 07; 8(6): 10007-10024.
Tipo di articolo: Journal Article,
Impact factor: 5.168, Impact factor a 5 anni: 5.312
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011982159&doi=10.18632%2foncotarget.14318&partnerID=40&md5=19abe33cfe3dbb5c707d47263ae4d09e
Parole chiave: Esrp1, Rna Binding Protein, Human Colorectal Cancer, Proto-Oncogene, Animals , Caco-2 Cells , Cell Proliferation , Colorectal Neoplasms Genetics Metabolism Pathology , Disease Progression , Gene Expression Regulation, Neoplastic , Liver Neoplasms Genetics Metabolism Secondary , Mice, Inbred Nod , Scid , Neoplasm Micrometastasis , Phosphatidylinositol 3-Kinase Metabolism , Proto-Oncogene Proteins C-Akt Metabolism , Rna Interference , Rna-Binding Proteins Genetics Metabolism , Receptor, Fibroblast Growth Factor, Type 1 Metabolism , Type 2 Metabolism , Signal Transduction , Snail Family Transcription Factors Metabolism , Time Factors , Transfection , Tumor Burden,
Affiliazioni:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNR, Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy., Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy., Candiolo Cancer Institute-IRCCS, University of Turin, Italy., present address: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., S.C. Gastroenterologia U, Endoscopia San Giovanni A.S., Azienda Citta' della Salute e della Scienza di Torino, Turin, Italy., EuroClone S.p.A Research Laboratory, Molecular Biotechnology Centre, University of Turin, Italy., Center for Experimental Research and Medical Studies, University of Turin, Italy., Department of Medical Sciences, University of Turin, Italy., Cancer Research Institute, BIDMC, Harvard Medical School, Boston, USA.,
Riferimenti:
Non disponibile.
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Feb 07; 8(6): 10007-10024.
Tipo di articolo: Journal Article,
Impact factor: 5.168, Impact factor a 5 anni: 5.312
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011982159&doi=10.18632%2foncotarget.14318&partnerID=40&md5=19abe33cfe3dbb5c707d47263ae4d09e
Parole chiave: Esrp1, Rna Binding Protein, Human Colorectal Cancer, Proto-Oncogene, Animals , Caco-2 Cells , Cell Proliferation , Colorectal Neoplasms Genetics Metabolism Pathology , Disease Progression , Gene Expression Regulation, Neoplastic , Liver Neoplasms Genetics Metabolism Secondary , Mice, Inbred Nod , Scid , Neoplasm Micrometastasis , Phosphatidylinositol 3-Kinase Metabolism , Proto-Oncogene Proteins C-Akt Metabolism , Rna Interference , Rna-Binding Proteins Genetics Metabolism , Receptor, Fibroblast Growth Factor, Type 1 Metabolism , Type 2 Metabolism , Signal Transduction , Snail Family Transcription Factors Metabolism , Time Factors , Transfection , Tumor Burden,
Affiliazioni:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNR, Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy., Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Italy., Candiolo Cancer Institute-IRCCS, University of Turin, Italy., present address: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., S.C. Gastroenterologia U, Endoscopia San Giovanni A.S., Azienda Citta' della Salute e della Scienza di Torino, Turin, Italy., EuroClone S.p.A Research Laboratory, Molecular Biotechnology Centre, University of Turin, Italy., Center for Experimental Research and Medical Studies, University of Turin, Italy., Department of Medical Sciences, University of Turin, Italy., Cancer Research Institute, BIDMC, Harvard Medical School, Boston, USA.,
Riferimenti:
Non disponibile.
Epithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific RNA binding protein that controls several key cellular processes, like alternative splicing and translation. Previous studies have demonstrated a tumor suppressor role for this protein. Recently, however, a pro-metastatic function of ESRP1 has been reported. We thus aimed at clarifying the role of ESRP1 in Colorectal Cancer (CRC) by performing loss- and gain-of-function studies, and evaluating tumorigenesis and malignancy with in vitro and in vivo approaches. We found that ESRP1 plays a role in anchorage-independent growth of CRC cells. ESRP1-overexpressing cells grown in suspension showed enhanced fibroblast growth factor receptor (FGFR1/2) signalling, Akt activation, and Snail upregulation. Moreover, ESRP1 promoted the ability of CRC cells to generate macrometastases in mice livers. High ESRP1 expression may thus stimulate growth of cancer epithelial cells and promote colorectal cancer progression. Our findings provide mechanistic insights into a previously unreported, pro-oncogenic role for ESRP1 in CRC, and suggest that fine-tuning the level of this RNA-binding protein could be relevant in modulating tumor growth in a subset of CRC patients.
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Impact factor a 5 anni totale: 175.978 (169.934 escludendo Abstract e Conferenze).
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