Home Research Locations About us Organization Staff Contacts Education Login Documents IT
Projects highlights

INCIPIT

ISTAPCA (836 views)

Euro-BioImaging

Instruct-IT

Fondazione Veronesi

Fondo Europeo Pesca (248 views)

 INMiND (912 views)

 PRIN (1016 views)

 eHealthNet (839 views)

  Ponrec (794 views)

MFAG Grant (862 views)


Links

 |<  < >  >| 

    Export to BibTeX    Export to EndNote

Mode-specific vibrational relaxation of photoexcited guanosine 5'-monophosphate and its acid form: a femtosecond broadband mid-IR transient absorption and theoretical study (7 views)

Zhang Y, Improta R, Kohler B

Phys Chem Chem Phys (ISSN: 1463-9084electronic, 1463-9076linking), 2014 Jan 28; 16(4): 1487-1499.

Abstract
UV-pump/broadband-mid-IR-probe transient absorption (TA) experiments and ab initio quantum mechanical (QM) calculations were used to investigate the photophysics in heavy water of the neutral and acid forms of guanosine 5'-monophosphate (GMP and GMPD(+), respectively). Excited GMP undergoes ultrafast internal conversion (IC) and returns to the electronic ground state in less than one picosecond with a large amount of excess vibrational energy. The spectroscopic signals are dominated by vibrational cooling - a process in which the solute dissipates vibrational energy to the solvent. For neutral GMP, cooling proceeds with a time constant of 3 ps. Following IC, at least some medium-frequency modes such as the carbonyl stretch and an in-plane ring vibration are excited, suggesting that the vibrational energy distribution is non-statistical. This is consistent with predicted structural changes upon passage through the S1/S0 conical intersection. GMPD(+) differs from GMP by a single deuteron at the N7 position, but has a dramatically longer lifetime of 200 ps. Vibrational cooling of the S1 state of GMPD(+) was monitored via several medium-frequency modes that were assigned using QM calculations. These medium-frequency modes are also vibrationally excited in a non-statistical fashion. Excitation of these modes is in line with the change in geometry at the S1 minimum of GMPD(+) predicted by QM calculations. Furthermore, these modes relax at different rates, fully consistent with QM calculations, which predict that excited vibrational states of the carbonyl stretch couple strongly to the D2O solvent and thus deactivate via intermolecular energy transfer (IET). In contrast, the ring stretch couples strongly to other ring modes of the guanine chromophore and appears to decay via intramolecular vibrational energy redistribution (IVR).

Affiliations ▼
Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59715, USA. kohler@chemistry.montana.edu.,

Details ▼
Impact factor: 4.198, 5-year impact factor: 4.023

Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Non-P. H. S.,

Keywords: Acids, Chemistry, Guanosine Monophosphate, Photochemical Processes, Quantum Theory, Spectroscopy, Fourier Transform Infrared, Time Factors, Vibration,

Url: Not available.

References ▼
Not available.

Related activities ▼
Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Nucleic acid and protein binding studies (250 views)
Protein semi-synthesis for biophysical and chemical biology applications (177 views)
Peptide modulators of the VEGF-dependent angiogenesis (381 views)
Production and characterization of recombinant enzymes for biochemical and biotechnological applications (216 views)

Related papers ▼
Advances in molecular preclinical therapy mediated by imaging (public domain) (9 views)
An EPR and voltammetric study of simple and mixed copper(II) complexes with L- or D-glutamate and L-arginate in aqueous solution (restricted access) (20 views)
Antimicrobial activity of Lactobacillus plantarum strains isolated from different environments: a preliminary study (public domain) (9 views)
Cationic porphyrins are tunable gatekeepers of the 20S proteasome (restricted access) (86 views)
Chemistry of Lipid A: At the Heart of Innate Immunity (restricted access) (118 views)
Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (public domain) (10 views)
Design and engineering of artificial oxygen-activating metalloenzymes (public domain) (33 views)
Designing Covalently Linked Heterodimeric Four-Helix Bundles (public domain) (30 views)
Elucidating the role of the pLG72 R30K substitution in schizophreniasusceptibility (public domain) (9 views)
Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (public domain) (9 views)
Functional Characterization of Brain Tumors: An Overview of the Potential Clinical Value (restricted access) (74 views)
Inorganic Stressors of Ubiquitin (restricted access) (33 views)
Insights into the anticancer properties of the first antimicrobialpeptide from Archaea (public domain) (13 views)
Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen (restricted access) (41 views)
New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (public domain) (80 views)
Out of the active site binding pocket for carbonic anhydrase inhibitors (restricted access) (74 views)
Regulating levels of the neuromodulator D-serine in human brain: structural insight into pLG72 and D-amino acid oxidase interaction (public domain) (49 views)
Thermus thermophilus as source of thermozymes for biotechnologicalapplications: homologous expression and biochemical characterization of anα-galactosidase. (public domain) (9 views)
UV-Induced Proton Transfer between DNA Strands (restricted access) (50 views)

Related bibliography ▼

Content: [X]
Extended

Authors: [X]
AND Paper type: [X]

AND Start date: End date: [X]   AND Site:    AND  IBB affiliation

[Clear form]

<=2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017   ALL YEARS

Sort by: date    title    journal    authors      impact factor

* Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide (63 views)
Zhang Y, Dood J, Beckstead AA, Li X-B, Nguyen KV, Burrows CJ, Improta R, Kohler B
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Sep 12; 111(32): 11612-11617.

View    Export to BibTeX    Export to EndNote    Upload PDF


1 Records (1 excluding Abstracts and Conferences).
Total impact factor: 9.809 (9.809 excluding Abstracts and Conferences).
Total 5-year impact factor: 10.727 (10.727 excluding Abstracts and Conferences).



Your bibliography query: (([btitle, keywords, abstract] ACIDS AND [btitle, keywords, abstract] CHEMISTRY AND [btitle, keywords, abstract] GUANOSINE)) AND NOT [id] = 53476



Last modified by Gennaro Angrisano on Tuesday 16 May 2017, 16:30:55
7 views. Last viewed on Thursday 14 September 2017, 10:50:43


Webmaster and developer: Marco Comerci
For problems and suggestions: adminibb.cnr.it
Last updated: Wednesday 20 September 2017, 10:43:29