fac-[Re(H2O)3(CO)3]+ Complexed with Histidine and Imidazole in aqueous solution: Speciation, Affinity and Binding Features(74 visite) De Tommaso G, Celentano V, Malgieri G, Fattorusso R, Romanelli A, D'Andrea LD, Iuliano M, Isernia C
The use of isotopes of transition metal has opened many perspectives in <br>the development of novel compounds utilizable for therapeutic or <br>diagnostic purposes. In order to be exploited, though, they must be <br>stabilized by chelating systems in coordination complexes. The <br>tricarbonyl complexes of Technetium(I) and Rhenium(I) have assumed <br>important roles in these fields as they are readily conjugated to <br>biomolecules to form stable probe useful in the targeting approach. In <br>this context the amino acid histidine represents a valuable ligand for <br>bioconjugation. Since little is reported on the chemistry and speciation<br> of Re(I) and Tc(I) in aqueous solution, here, we analyze the <br>interaction of fac-[Re(H<sub>2</sub>O)<sub>3</sub>(CO)<sub>3</sub>]<sup>+</sup><br> with histidine or with the simple imidazole ring by means of <br>potentiometric and spectroscopic techniques. We describe in details the <br>equilibria that arise in solution, calculate the constants of each <br>equilibrium reaction and report coordination properties and atomic <br>details of the formed complexes. Our data represent a valuable <br>contribute towards the exploitation in nuclear medicine of histidine <br>containing biomolecules complexing Tc (I) and Re(I).
Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F * Results of clinical trials with SPEM(107 visite) Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50. Impact Factor:3.221 DettagliEsporta in BibTeXEsporta in EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(111 visite) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 DettagliEsporta in BibTeXEsporta in EndNote
393 Records (372 escludendo Abstract e Conferenze). Impact factor totale: 1419.948 (1359.054 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 1543.081 (1480.626 escludendo Abstract e Conferenze).
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