Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation
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Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation (151 visite)

Oliveri V, Bellia F, Vecchio G

CHEMPLUSCHEM (ISSN: 2192-6506), 2015; 80(4): 762-770.



Tipo di articolo: Journal Article,

Impact factor: 2.836, Impact factor a 5 anni: 2.91

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969751459&doi=10.1002%2fcplu.201402450&partnerID=40&md5=656f14f5e4393ea293873428745a2d36

Parole chiave: Amyloid Beta-Peptides, Copper, Glycoconjugates, Metal Chelators, Zinc,

Affiliazioni:

*** IBB - CNR ***
Dipartimento di Chimica, Università di Catania, Viale A. Doria 6, Catania, Italy
Istituto di Biostrutture e Bioimmagini (IBB), CNR, via P. Gaifami 18, Catania, Italy


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Cyclodextrins are used increasingly in pharmacotherapy. Experimental and clinical data suggest that cyclodextrins can be used not only as excipients for marketed drugs, but also as active pharmaceutical ingredients to treat neurological diseases including Niemann-Pick typeC disease. Disruption of metal and cholesterol homeostasis, protein misfolding, and aggregation are recognized among the major pathological features in triggering neurodegenerative disorders, and therefore it is becoming more and more evident that the next generation of therapies should have multiple functions to combat the multifactorial nature of diseases. A novel class of compounds obtained by conjugating 8-hydroxyquinoline with cyclodextrin has been proposed to combine antioxidant activity, chelating, antiaggregant, and inclusion ability into one compound designed for metal-associated neurodegenerative diseases. Herein, the synthesis and characterization of the new compound 3A-deoxy-3A-[(8-hydroxyquinolyl)-2-methylamino]-2A(S),3A(R)-β-cyclodextrin is reported. Moreover, the interaction of copper-Aβ and zinc-Aβ amyloid with this class of cyclodextrin conjugates was investigated for the first time. New information about the effects of different modified chelating cyclodextrins may be important for further development of drugs against neurodegenerative disorders. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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30 Records (29 escludendo Abstract e Conferenze).
Impact factor totale: 118.631 (114.539 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 121.154 (116.617 escludendo Abstract e Conferenze).







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