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UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization (25 visite)
Signal Transduction And Targeted Therapy, 2017 Jun; N/D: N/D-N/D.
Tipo di articolo: Journal Article,
Impact factor: 0
Impact factor a 5 anni: 0
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Url: Non disponibile.
Methylation/demethylation of cytosine plays an important role in
epigenetic signaling, the reversibility of epigenetic modifications
offering important opportunities for targeted therapies. Actually,
methylated sites have been correlated with mutational hotspots detected
in skin cancers. The present brief review discusses the physicochemical
parameters underlying the specific ultraviolet-induced reactivity of
methylated cytosine. It focuses on dimerization reactions giving rise to
cyclobutane pyrimidine dimers and pyrimidine (6–4) pyrimidone adducts.
According to recent studies, four conformational and electronic factors
that are affected by cytosine methylation may control these reactions:
the red-shift of the absorption spectrum, the lengthening of the excited
state lifetime, changes in the sugar puckering modifying the stacking
between reactive pyrimidines and an increase in the rigidity of duplexes
favoring excitation energy transfer toward methylated pyrimidines.
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