Home Ricerca Sedi Chi siamo Organigramma Personale Contatti Didattica Login Documenti EN
Progetti in evidenza
INCIPIT
(Link esterno)

ISTAPCA
(1182 visite)

Fondo Europeo Pesca
(591 visite)

Euro-BioImaging
(Link esterno)

Fondazione Veronesi
(Link esterno)

LightDyNAmics
(1050 visite)

 INMiND
(1160 visite)

Instruct-IT
(Link esterno)

 PRIN
(1294 visite)

 eHealthNet
(1062 visite)

Ponrec
(1004 visite)

MFAG Grant
(1101 visite)

MERIT
(Link esterno)


Collegamenti



UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization (41 visite)

Martinez-fernandez L, Banyasz A, Esposito L, Markovitsi D, Improta R

Signal Transduction And Targeted Therapy, 2017 Jun; N/D: N/D-N/D.

Tipo di articolo: Journal Article,

Impact factor: 0

Impact factor a 5 anni: 0


Parole chiave: Non disponibili.

Url: Non disponibile.

Methylation/demethylation of cytosine plays an important role in
epigenetic signaling, the reversibility of epigenetic modifications
offering important opportunities for targeted therapies. Actually,
methylated sites have been correlated with mutational hotspots detected
in skin cancers. The present brief review discusses the physicochemical
parameters underlying the specific ultraviolet-induced reactivity of
methylated cytosine. It focuses on dimerization reactions giving rise to
cyclobutane pyrimidine dimers and pyrimidine (6–4) pyrimidone adducts.
According to recent studies, four conformational and electronic factors
that are affected by cytosine methylation may control these reactions:
the red-shift of the absorption spectrum, the lengthening of the excited
state lifetime, changes in the sugar puckering modifying the stacking
between reactive pyrimidines and an increase in the rigidity of duplexes
favoring excitation energy transfer toward methylated pyrimidines.
*** IBB - CNR ***
Non disponibile.
Nessun risultato.
Nessun risultato.

Contiene: [X]      Estesa         Autori: [X]      Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Conti I, Martinez-fernandez L, Esposito L, Hofinger S, Nenov A, Garavelli M, Improta R
* Multiple Electronic and Structural Factors Control Cyclobutane Pyrimidine Dimer and 6-4 Thymine-Thymine Photodimerization in a DNA Duplex (44 visite)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2017 Oct 26; 23(60): 15177-15188.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Martinez-fernandez L, Improta R
* Novel adenine/thymine photodimerization channels mapped by PCM/TD-DFT calculations on dApT and TpdA dinucleotides (46 visite)
Photochem Photobiol Sci (ISSN: 1474-9092electronic, 1474-905xlinking), 2017 Jun 22; N/D: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pepino AJ, Segarra-marti J, Nenov A, Improta R, Garavelli M
* Resolving Ultrafast Photoinduced Deactivations in Water-Solvated Pyrimidine Nucleosides (55 visite)
J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2017 Apr 20; 8(8): 1777-1783.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Cerezo J, Martinez-fernandez L, Improta R, Santoro F
* Vibronic approach to the calculation of the decay rate of the photoexcited charge-transfer state of Guanine-Cytosine stacked dimer in water solution (60 visite)
Theoretical Chemistry Accounts, 2016 Sep; N/D: N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Vullo D, Supuran CT, Scozzafava A, De Simone G, Monti SM, Alterio V, Carta F
* Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1, 6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors (66 visite)
Bioorg Med Chem (ISSN: 1464-3391electronic, 0968-0896linking), 2016 Aug 15; 24(16): 3643-3648.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Banyasz A, Esposito L, Douki T, Perron M, Lepori C, Improta R, Markovitsi D
* Effect of C5-Methylation of Cytosine on the UV-Induced Reactivity of Duplex DNA: Conformational and Electronic Factors (83 visite)
J Phys Chem B (ISSN: 1520-5207electronic, 1520-5207linking, 1520-6106), 2016 May 12; 120(18): 4232-4242.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Huix-Rotllant M, Brazard J, Improta R, Burghardt I, Markovitsi D
* Stabilization of mixed frenkel-charge transfer excitons extended across both strands of guanine-cytosine DNA duplexes (119 visite)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic), 2015; 6(12): 2247-2251.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Fahleson T, Kauczor J, Norman P, Santoro F, Improta R, Coriani S
* TD-DFT investigation of the magnetic circular dichroism spectra of some purine and pyrimidine bases of nucleic acids (127 visite)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic), 2015; 119(21): 5476-5489.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (101 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2014 Sep 6; 136(31): 10838-10841.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Hayafune M, Berisio R, Marchetti R, Silipo A, Kayama M, Desaki Y, Arima S, Squeglia F, Ruggiero A, Tokuyasu K, Molinaro A, Kaku H, Shibuya N
* Chitin-induced activation of immune signaling by the rice receptor CEBiP relies on a unique sandwich-type dimerization (153 visite)
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2014 Jan 21; 111(3): E404-E404.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Gustavsson T, Improta R, Banyasz A, Vaya I, Markovitsi D
* The effect of methylation on the excited state dynamics of aminouracils (99 visite)
J Photochem Photobiol A Chem (ISSN: 1010-6030), 2012 Apr 15; 234: 37-43.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
* Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination (114 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2012 Mar 23; 586(6): 659-667.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Biemann L, Kovalenko SA, Kleinermanns K, Mahrwald R, Markert M, Improta R
* Excited state proton transfer is not involved in the ultrafast deactivation of Guanine-cytosine pair in solution (75 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2011 Dec 14; 133(49): 19664-19667.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (106 visite)
Cell Mol Life Sci Cellular And Molecular Life Sciences (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (116 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Tornatore L, Montil SM, Marasco D, Dathan N, Vitale RM, Benedetti E, Pedone C, Papa S, Franzoso G, Ruvo M
* Gadd45beta dimerization does not affect MKK7 binding (103 visite)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 367-368.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (129 visite)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Pensato S, Saviano M, Renda M, Leccia F, Pedone P, Pedone C, Romanelli A
* PNA zipper: inducing dimerization of the basic region of a bZip protein by a PNA duplex (71 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Santoro F, Barone V, Improta R
* Can TD-DFT calculations accurately describe the excited states behavior of stacked nucleobases? The cytosine dimer as a test case (98 visite)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic, 0192-8651linking), 2008 Apr 30; 29(6): 957-964.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (112 visite)
Cancer Immunology Immunotherapy (ISSN: 0340-7004), 1993 Sep; 37(3): 150-156.
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraglia M, Correale P, Genua G, Pepe S, Del Vecchio S, Esposito G, Bianco AR, Tagliaferri P
EPIDERMAL GROWTH-FACTOR (EGFR) AND TRANSFERRIN (TRFR) RECEPTOR UP-REGULATION IS INDUCED BY ARABINOSIDE CYTOSINE (ARA-C) ON HUMAN TUMOR-CELLS (92 visite)
(ISSN: 0361-090x), 1993; 17(2): 337-338.
Dettagli    Esporta in BibTeX    Esporta in EndNote



21 Records (20 escludendo Abstract e Conferenze).
Impact factor totale: 95.337 (93.683 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 96.837 (95.055 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote

Ultima modifica di Gennaro Angrisano in data Monday 10 July 2017, 12:20:17
41 visite. Ultima visita in data Monday 22 October 2018, 11:35:23

Webmaster and developer: Marco Comerci
Per problemi e suggerimenti: adminibb.cnr.it
Ultimo aggiornamento: Thursday 15 November 2018, 17:18:12