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Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation (80 views) (PDF restricted 41 views)

Squeglia F, Ruggiero A, Berisio R

Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2017 Sep 19; N/D: N/D-N/D.

The cell wall envelope of mycobacteria is structurally distinct from that of both Gram-positive and Gram-negative bacteria. In Mycobacterium tuberculosis, this cell wall has unique structural features and plays a crucial role in drug resistance and macrophage survival under stress conditions. Peptidoglycan is the major constituent of this cell wall, with an important structural role, giving structural strength, and counteracting the osmotic pressure of the cytoplasm. Synthesis of this complex polymer takes place in three stages that occur at three different locations in the cell, from the cytoplasm to the external side of the cell membrane, where polymerization occurs. A fine balance of peptidoglycan synthesis and degradation is responsible for a plethora of molecular mechanisms which are key to the pathogenicity of M. tuberculosis. Enlargement of mycobacterial cells can occur via synthesis of new peptidoglycan, autolysis of old peptidoglycan or a combination of both processes. Here, we discuss the chemical aspects of peptidoglycan synthesis and degradation, in relation to metabolic stages of M. tuberculosis. In a travel from inside the mycobacterial cytoplasm to outside its membrane, we describe the assembly line of peptidoglycan synthesis and polymerization, to continue with its depolymerization events and their consequences on mycobacterial life and resuscitation from dormancy.

Affiliations ▼
*** IBB - CNR Affiliation

Institute of Biostructures and Bioimaging, ITALY., Institute of Biostructures and Bioimaging, CNR, Napoli, ITALY., Consiglio Nazionale delle Ricerche, IBB, Via Mezzocannone 1, 80134, Napoli, ITALY.,

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Impact factor: 5.317, 5-year impact factor: 5.184

Paper type: Journal Article,

Keywords: Peptidoglycan, Cell Wall, Mycobacteria, Structure,

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Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation (restricted access) (41 views)

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* Exit from mycobacterial dormancy: a structural perspective (98 views)
Squeglia F, Ruggiero A, Berisio R
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 Feb 9; 22(14): 1698-1709.
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2 Records (2 excluding Abstracts and Conferences).
Total impact factor: 9.792 (9.792 excluding Abstracts and Conferences).
Total 5-year impact factor: 9.651 (9.651 excluding Abstracts and Conferences).

Your bibliography query: (([btitle, keywords, abstract] PEPTIDOGLYCAN AND [btitle, keywords, abstract] CELL AND [btitle, keywords, abstract] WALL AND [btitle, keywords, abstract] MYCOBACTERIA AND [btitle, keywords, abstract] STRUCTURE)) AND NOT [id] = 53594

Last modified by Rita Berisio on Thursday 21 September 2017, 11:18:05
80 views. Last viewed on Monday 19 February 2018, 14:11:03

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