Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (322 views visite)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
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Paper type Tipo di articolo: Journal Article
Impact factor: 3.476, 5-year impact factor Impact factor a 5 anni: 3.792
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031779417&doi=10.3233%2fJAD-170389&partnerID=40&md5=607c9327d4eee76e9ce54e850679547b
Keywords Parole chiave: Apeh, Alzheimer, S Disease, Blood-Based Indicator System, Oxidized Peptide Hydrolase Activity, Proteasome, Protein Quality Control, Aged , Alzheimer Disease Blood Enzymology , Blotting, Western , Erythrocytes Enzymology , Female , Humans , Peptide Hydrolases Metabolism , Proteasome Endopeptidase Complex Metabolism , Proteostasis , Real-Time Polymerase Chain Reaction , Alzheimer’s Disease
Affiliations Affiliazioni:
*** IBB - CNR ***
Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), Napoli, Italy., Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy., Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.,
Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy.
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
References Riferimenti:
Not available. Non disponibili.
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article
Impact factor: 3.476, 5-year impact factor Impact factor a 5 anni: 3.792
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031779417&doi=10.3233%2fJAD-170389&partnerID=40&md5=607c9327d4eee76e9ce54e850679547b
Keywords Parole chiave: Apeh, Alzheimer, S Disease, Blood-Based Indicator System, Oxidized Peptide Hydrolase Activity, Proteasome, Protein Quality Control, Aged , Alzheimer Disease Blood Enzymology , Blotting, Western , Erythrocytes Enzymology , Female , Humans , Peptide Hydrolases Metabolism , Proteasome Endopeptidase Complex Metabolism , Proteostasis , Real-Time Polymerase Chain Reaction , Alzheimer’s Disease
Affiliations Affiliazioni:
*** IBB - CNR ***
Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), Napoli, Italy., Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy., Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.,
Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy.
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
References Riferimenti:
Not available. Non disponibili.
Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis?
Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder that is the main cause of dementia. To date, there are no definitive diagnostic tests that can predict or assess onset and progression of the disease. Blood biomarkers for AD are being sought for many years but their identification remains a challenging task. In this study, we investigated the potential relationship between AD and levels of acyl-peptide hydrolase (APEH) and proteasome in erythrocyte samples of 52 participants (26 AD and 26 cognitively healthy controls). A statistically significant decrease in proteasome and exopeptidase/endopeptidase APEH activities was found in AD samples compared to those of healthy controls. Moreover, in contrast to what was observed for proteasome transcripts, APEH activities reduction in AD patients was unrelated to its gene expression levels, suggesting the occurrence of posttranslational modifications or the expression of endogenous inhibitors that might impair enzyme activity. These preliminary data further support a relationship between the APEH-proteasome system and AD molecular players, providing the first evidence of its potential use as a novel blood-based indicator for the routine detection of AD.
Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder that is the main cause of dementia. To date, there are no definitive diagnostic tests that can predict or assess onset and progression of the disease. Blood biomarkers for AD are being sought for many years but their identification remains a challenging task. In this study, we investigated the potential relationship between AD and levels of acyl-peptide hydrolase (APEH) and proteasome in erythrocyte samples of 52 participants (26 AD and 26 cognitively healthy controls). A statistically significant decrease in proteasome and exopeptidase/endopeptidase APEH activities was found in AD samples compared to those of healthy controls. Moreover, in contrast to what was observed for proteasome transcripts, APEH activities reduction in AD patients was unrelated to its gene expression levels, suggesting the occurrence of posttranslational modifications or the expression of endogenous inhibitors that might impair enzyme activity. These preliminary data further support a relationship between the APEH-proteasome system and AD molecular players, providing the first evidence of its potential use as a novel blood-based indicator for the routine detection of AD.
Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis?
| ▼ Structural characterization of the porphyrins/proteasome interaction Caratterizzazione strutturale dell’interazione porfirine/proteosoma |
Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis?
Gogliettino M, Cocca E, Sandomenico A, Gratino L, Iaccarino E, Calvanese L, Rossi M, Palmieri G
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Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M
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* APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome (320 visite)
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Santoro AM, Monaco I, Attanasio F, Lanza V, Pappalardo G, Tomasello MF, Cunsolo A, Rizzarelli E, De Luigi A, Salmona M, Milardi D
* Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study (314 visite)
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Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (630 visite) (PDF 227 visite)
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Ciccarelli M, Rusciano MR, Sorriento D, Basilicata MF, Santulli G, Campiglia P, Bertamino A, De Luca N, Trimarco B, Iaccarino G, Illario M
* CaMKII protects MKP-1 from proteasome degradation in endothelial cells (238 visite)
Cell Signal (ISSN: 0898-6568), 2014; 26(10): 2167-2174.
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Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
* RedOx status, proteasome and APEH: Insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells (667 visite)
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Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (425 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (398 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (527 visite)
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* Copper-triggered aggregation of ubiquitin (510 visite)
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Impact Factor: 4.351
Dettagli Esporta in BibTeX Esporta in EndNote
Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM
* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (212 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
Impact Factor: 1.438
Dettagli Esporta in BibTeX Esporta in EndNote
16 Records (14 escludendo Abstract e Conferenze).
Impact factor totale: 78.134 (70.249 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 79.575 (71.177 escludendo Abstract e Conferenze).
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Gogliettino M, Cocca E, Sandomenico A, Gratino L, Iaccarino E, Calvanese L, Rossi M, Palmieri G
* Selective inhibition of acylpeptide hydrolase in SAOS-2 osteosarcoma cells: is this enzyme a viable anticancer target? (9 visite)
Mol Biol Rep (ISSN: 0301-4851linking), 2021 Feb; 48(2): 1505-1519.
Impact Factor: 2.316
Dettagli Esporta in BibTeX Esporta in EndNote
Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-dubouch MP, Marini S, Coletta M
* The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S (264 visite) (PDF 104 visite)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2018 Sep; 75(18): 3441-3456.
Impact Factor: 7.047
Dettagli Esporta in BibTeX Esporta in EndNote
Dato AD, Cunsolo A, Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M
* Electrostatic Map Of Proteasome alpha-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding (329 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Dec 6; 7(1): 17098-17098.
Impact Factor: 4.122
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (428 visite)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
Dettagli Esporta in BibTeX Esporta in EndNote
Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (355 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
Dettagli Esporta in BibTeX Esporta in EndNote
Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M
* Multiple functions of insulin-degrading enzyme: a metabolic crosslight? (234 visite)
Crit Rev Biochem Mol (ISSN: 1040-9238), 2017 Jun; N/D: 1-29.
Impact Factor: 5.279
Dettagli Esporta in BibTeX Esporta in EndNote
Palumbo R, Gogliettino M, Cocca E, Iannitti R, Sandomenico A, Ruvo M, Balestrieri M, Rossi M, Palmieri G
* APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome (320 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Sep 23; 17(10): N/D-N/D.
Impact Factor: 3.226
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro AM, Monaco I, Attanasio F, Lanza V, Pappalardo G, Tomasello MF, Cunsolo A, Rizzarelli E, De Luigi A, Salmona M, Milardi D
* Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study (314 visite)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2016 Sep 16; 6: 33444-33444.
Impact Factor: 4.259
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (630 visite) (PDF 227 visite)
Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.
Impact Factor: 8.668
Dettagli Esporta in BibTeX Esporta in EndNote
Ciccarelli M, Rusciano MR, Sorriento D, Basilicata MF, Santulli G, Campiglia P, Bertamino A, De Luca N, Trimarco B, Iaccarino G, Illario M
* CaMKII protects MKP-1 from proteasome degradation in endothelial cells (238 visite)
Cell Signal (ISSN: 0898-6568), 2014; 26(10): 2167-2174.
Impact Factor: 4.315
Dettagli Esporta in BibTeX Esporta in EndNote
Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
* RedOx status, proteasome and APEH: Insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells (667 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2013 Nov 19; 8(11): N/D-N/D.
Impact Factor: 3.534
Dettagli Esporta in BibTeX Esporta in EndNote
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (425 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
Dettagli Esporta in BibTeX Esporta in EndNote
Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (398 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (527 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (510 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
Dettagli Esporta in BibTeX Esporta in EndNote
Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM
* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (212 visite)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
Impact Factor: 1.438
Dettagli Esporta in BibTeX Esporta in EndNote
16 Records (14 escludendo Abstract e Conferenze).
Impact factor totale: 78.134 (70.249 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 79.575 (71.177 escludendo Abstract e Conferenze).
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