Export to BibTeX Export to EndNoteMicrogel assisted Lab-on-Fiber Optrode (115 views) (PDF public 26 views)Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2017 Oct 31; 7(1): 14459-14459.Related activities ▼
Precision medicine is continuously demanding for novel point of care systems, potentially exploitable also for in-vivo analysis. Biosensing probes based on Lab-On-Fiber Technology have been recently developed to meet these challenges. However, devices exploiting standard label-free approaches (based on ligand/target molecule interaction) suffer from low sensitivity in all cases where the detection of small molecules at low concentrations is needed. Here we report on a platform developed through the combination of Lab-On-Fiber probes with microgels, which are directly integrated onto the resonant plasmonic nanostructure realized on the fiber tip. In response to binding events, the microgel network concentrates the target molecule and amplifies the optical response, leading to remarkable sensitivity enhancement. Moreover, by acting on the microgel degrees of freedom such as concentration and operating temperature, it is possible to control the limit of detection, tune the working range as well as the response time of the probe. These unique characteristics pave the way for advanced label-free biosensing platforms, suitably reconfigurable depending on the specific application.
|*** IBB - CNR Affiliation|
Optoelectronics Group, Department of Engineering, University of Sannio, I-82100, Benevento, Italy., ENEA, Portici Research Center, P.le E. Fermi 1, I-80055 Portici, Napoli, Italy., Institute of Biostructure and Bioimaging, National Research Council, I-80143, Napoli, Italy., Optoelectronics Group, Department of Engineering, University of Sannio, I-82100, Benevento, Italy. firstname.lastname@example.org.,
|Impact factor: 4.259, 5-year impact factor: 4.847|
Paper type: Journal Article,
Keywords: Optrode, Microgel Assisted, Lab On Fiber,
Url: Not available.
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Last modified by Marco Comerci on Tuesday 07 November 2017, 14:56:21
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