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Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (73 views) (PDF public 20 views)

Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E

Aging Cell (ISSN: 1474-9726electronic, 1474-9718linking), 2017 Nov 01; N/D: N/D-N/D.

Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with synaptic dysfunction, pathological accumulation of beta-amyloid (Abeta), and neuronal loss. The self-association of Abeta monomers into soluble oligomers seems to be crucial for the development of neurotoxicity (J. Neurochem., 00, 2007 and 1172). Abeta oligomers have been suggested to compromise neuronal functions in AD by reducing the expression levels of the CREB target gene and brain-derived neurotrophic factor (BDNF) (J. Neurosci., 27, 2007 and 2628; Neurobiol. Aging, 36, 2015 and 20406 Mol. Neurodegener., 6, 2011 and 60). We previously reported a broad neuroprotective activity of physiological Abeta monomers, involving the activation of type-1 insulin-like growth factor receptors (IGF-IRs) (J. Neurosci., 29, 2009 and 10582, Front Cell Neurosci., 9, 2015 and 297). We now provide evidence that Abeta monomers, by activating the IGF-IR-stimulated PI3-K/AKT pathway, induce the activation of CREB in neurons and sustain BDNF transcription and release.

Affiliations ▼
*** IBB - CNR Affiliation

Institute of Biostructures and Bioimaging, National Council of Research (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, via Palermo 636, 95122, Catania, Italy., Department of Drug Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy., Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.,

Details ▼
Impact factor: 6.714, 5-year impact factor: 6.456

Paper type: Journal Article,

Keywords: Alzheimer Disease, Beta Monomers, Bdnf, Creb, Igf1-R,

Url: Not available.

References ▼
Not available.

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Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (public domain) (20 views)

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* Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology (2 views)
Galati C, Spinella N, Renna L, Milardi D, Attanasio F, Sciacca MFM, Bongiorno C
Beilstein J Nanotechnol (ISSN: 2190-4286print, 2190-4286linking), 2017 Nov 20; 8: 2446-2453.
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* The underexplored question of beta-amyloid monomers (23 views)
Copani A
Eur J Pharmacol (ISSN: 1879-0712electronic, 0014-2999linking), 2017 May 31; N/D: N/D-N/D.
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* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (105 views)
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
Frontiers In Cellular Neuroscience (ISSN: 1662-5102electronic, 1662-5102linking), 2015 Aug 7; 9(AUGUST): 297-297.
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* Different zinc(II) complex species and binding modes at Aβ N-terminus drive distinct long range cross-talks in the Aβ monomers (51 views)
Pietropaolo A, Satriano C, Strano G, La Mendola D, Rizzarelli E
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
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* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (86 views)
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
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* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (80 views)
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
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* Beta-Amyloid Monomers Are Neuroprotective (100 views)
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
The Journal Of Neuroscience (ISSN: 1529-2401), 2009 Sep 26; 29(34): 10582-10587.
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7 Records (7 excluding Abstracts and Conferences).
Total impact factor: 24.675 (24.675 excluding Abstracts and Conferences).
Total 5-year impact factor: 25.8 (25.8 excluding Abstracts and Conferences).



Your bibliography query: (([btitle, keywords, abstract] ALZHEIMER AND [btitle, keywords, abstract] DISEASE AND [btitle, keywords, abstract] BETA AND [btitle, keywords, abstract] MONOMERS)) AND NOT [id] = 53623



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