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Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (227 visite) (PDF pubblico 78 visite)

Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E

Aging Cell (ISSN: 1474-9726electronic, 1474-9718linking), 2017 Nov 01; N/D: N/D-N/D.

Tipo di articolo: Journal Article

Impact factor: 6.714

Impact factor a 5 anni: 6.456


Parole chiave: Alzheimer Disease, Beta Monomers, Bdnf, Creb, Igf1-R

Url: Non disponibile.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with synaptic dysfunction, pathological accumulation of beta-amyloid (Abeta), and neuronal loss. The self-association of Abeta monomers into soluble oligomers seems to be crucial for the development of neurotoxicity (J. Neurochem., 00, 2007 and 1172). Abeta oligomers have been suggested to compromise neuronal functions in AD by reducing the expression levels of the CREB target gene and brain-derived neurotrophic factor (BDNF) (J. Neurosci., 27, 2007 and 2628; Neurobiol. Aging, 36, 2015 and 20406 Mol. Neurodegener., 6, 2011 and 60). We previously reported a broad neuroprotective activity of physiological Abeta monomers, involving the activation of type-1 insulin-like growth factor receptors (IGF-IRs) (J. Neurosci., 29, 2009 and 10582, Front Cell Neurosci., 9, 2015 and 297). We now provide evidence that Abeta monomers, by activating the IGF-IR-stimulated PI3-K/AKT pathway, induce the activation of CREB in neurons and sustain BDNF transcription and release.
*** IBB - CNR ***

Institute of Biostructures and Bioimaging, National Council of Research (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, via Palermo 636, 95122, Catania, Italy., Department of Drug Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy., Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.,
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* Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity (38 visite)
Marchitelli R, Aiello M, Cachia A, Quarantelli M, Cavaliere C, Postiglione A, Tedeschi G, Montella P, Milan G, Salvatore M, Salvatore E, Baron JC, Pappata S
Neuroimage (ISSN: 1053-8119linking), 2018 Aug 1; 176: 246-258.
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* The underexplored question of beta-amyloid monomers (48 visite)
Copani A
Eur J Pharmacol (ISSN: 1879-0712electronic, 0014-2999linking), 2017 May 31; N/D: N/D-N/D.
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* A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms (220 visite)
Antonini D, Sirico A, Aberdam E, Ambrosio R, Campanile C, Fagoonee S, Altruda F, Aberdam D, Brissette JL, Missero C
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2015 Jan; 43(2): 862-874.
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* Different zinc(II) complex species and binding modes at Aβ N-terminus drive distinct long range cross-talks in the Aβ monomers (89 visite)
Pietropaolo A, Satriano C, Strano G, La Mendola D, Rizzarelli E
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
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* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (117 visite)
Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
Molecular Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
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* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (146 visite)
Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
Molecular Biology Of The Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
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* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (104 visite)
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
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* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (99 visite) (PDF 114 visite)
Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano MF
Cell Death Dis (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
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* Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (195 visite)
Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
Sci Rep (ISSN: 2045-2322, 2045-2322electronic), 2013 Mar 1; 3: 1351-1351.
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* A joint experimental/theoretical study of the ultrafast excited state deactivation of deoxyadenosine and 9-methyladenine in water and acetonitrile (87 visite)
Gustavsson T, Sarkar S, Vaya I, Jimenez MC, Markovitsi D, Improta R
Photochem Photobiol Sci (ISSN: 1474-905x), 2013; 12(8): 1375-1386.
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* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (95 visite)
Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
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* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (89 visite)
Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
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* A new function for beta-amyloid monomers (94 visite)
Giuffrida M-, Tomasello F, Caraci F, Pandini G, Chiechio S, Battaglia G, De Bona P, Pappalardo G, Vigneri R, Nicoletti F, Rizzarelli E, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2011; 41: N/D-N/D.
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* Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (97 visite)
Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
Nucleic Acids Res (ISSN: 1362-4962, 0305-1048, 1362-4962electronic), 2010 Dec; 38(22): 8239-8256.
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* Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (95 visite)
Roviello GN, Gröschel S, Pedone C, Diederichsen U
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
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* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (112 visite)
Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
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* Basic understanding of the activities of beta-amyloid (A beta) monomers (90 visite)
Giuffrida M, Tomasello F, Caraci F, Pappalardo G, Rizzarelli E, Nicoletti F, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2010; 40: N/D-N/D.
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* Erratum: Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (Amino Acids DOI: 10. 1007/s00726-009-0324-x) (98 visite)
Roviello GN, Gröschel S, Pedone C, Diederichsen U
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010; 38(5): 1311-1312.
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* Beta-Amyloid Monomers Are Neuroprotective (138 visite)
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
The Journal Of Neuroscience (ISSN: 1529-2401), 2009 Sep 26; 29(34): 10582-10587.
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* Imaging of Bcl-2/Bcl-x(L) dysregulated apoptotic program in NSCLC cells resistant to EGFR tyrosine kinase inhibitors (83 visite)
Zannetti A, Iommelli F, Fonti R, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
Eur J Nucl Med Mol Imaging (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
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* Regulated BMP-4 Expression for Bone Regeneration by Thymidine Kinase and Ganciclovir Treatments (77 visite)
Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Brunetti A, Montanaro D, Troncone G, Salvatore F, Pastore L
Molecular Therapy (ISSN: 1525-0016, 1525-0024), 2009 May; 17: N/D-N/D.
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* Monomers of beta-amyloid protein are endowed with neuroprotective activity (96 visite)
Giuffrida M, Caraci F, Molinaro G, Cataldo S, Pignataro B, Bruno V, De Bona P, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani AG
Society For Neuroscience Abstract Viewer And Itinerary Planner, 2009; 39: N/D-N/D.
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* New synthetic route to gamma-mercaptomethyl PNA monomers (113 visite)
Pensato S, D'Andrea LD, Pedone C, Romanelli A
Synth Commun Synthetic Communications (ISSN: 0039-7911), 2008; 38(15): 2499-2506.
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* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (76 visite)
Musumeci D, Roviello  GN, Valente M, Sapio R, Pedone C, Bucci EM
Biopolymers, 2004; 76(6): 535-542.
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Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2 ', 5 ')adenosine (87 visite)
Vitagliano L, Adinolfi S, Riccio A, Sica F, Zagari A, Mazzarella L
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Sep; 7(8): 1691-1699.
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Adenosine coronary vasodilation in coronary artery disease: Technetium- 99m tetrofosmin myocardial tomography versus echocardiography (86 visite)
Cuocolo A, Sullo P, Pace L, Nappi A, Gisonni P, Nicolai E, Trimarco B, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Jul; 38(7): 1089-1094.
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Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (90 visite)
Cucinotta V, Grasso D, Grasso G, Milardi D
Nucleosides Nucleotides (ISSN: 0732-8311), 1997; 16(10-11): 1847-1854.
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Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease (80 visite)
Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N
Radiology (ISSN: 0033-8419, 1527-1315), 1996 Nov; 201: N/D-N/D.
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EFFECT OF ADENOSINE ON CEREBRAL BLOOD-FLOW AS EVALUATED BY SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY IN NORMAL SUBJECTS AND IN PATIENTS WITH OCCLUSIVE CAROTID DISEASE - A COMPARISON WITH ACETAZOLAMIDE (70 visite)
Soricelli A, Postiglione A, Cuocolo A, De Chiara S, Ruocco A, Brunetti A, Salvatore M, Ell PJ
Stroke (ISSN: 0039-2499), 1995 Sep; 26(9): 1572-1576.
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ADENOSINE TECHNETIUM-99M-METHOXY ISOBUTYL ISONITRILE MYOCARDIAL TOMOGRAPHY IN PATIENTS WITH CORONARY-ARTERY DISEASE - COMPARISON WITH EXERCISE (72 visite)
Cuocolo A, Soricelli A, Pace L, Nicolai E, Castelli L, Nappi A, Imbriaco M, Morisco C, Ell PJ, Salvatore M
Journal Of Nuclear Medicine (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Jul; 35(7): 1110-1115.
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Enzyme deficiency and tumor suppressor genes: absence of 5'-deoxy-5'-methylthioadenosine phosphorylase in human tumors (49 visite)
Della Ragione F, Oliva A, Palumbo R, Russo GL, Zappia V
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1993; 348: 31-43.
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Deficiency of 5'-deoxy-5'-methylthioadenosine phosphorylase activity in malignancy. Absence of the protein in human enzyme-deficient cell lines (61 visite)
Della Ragione F, Oliva A, Palumbo R, Russo GL, Gragnaniello V, Zappia V
Biochem J (ISSN: 0264-6021print, 0264-6021linking, 1470-8728electronic), 1992 Jan 15; 281(Pt2): 533-538.
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Physico-chemical and immunological properties of bovine liver 5'-deoxy-5'-methylthioadenosine phosphorylase (95 visite)
Della Ragione F, Oliva A, Fioretti M, Russo GL, Palumbo R, Zappia V
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1988; 250: 187-197.
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33 Records (24 escludendo Abstract e Conferenze).
Impact factor totale: 145.753 (110.381 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 142.851 (107.454 escludendo Abstract e Conferenze).

Interrogazione bibliografica effettuata: (([btitle] "Alzheimer Disease" OR [btitle] "Beta Monomers" OR [btitle] "monomers" OR [btitle] "regulate" OR [btitle] "adenosine") AND NOT [id] = 53623)







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