Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics(56 visite) Tavarelli M, Malandrino P, Vigneri P, Richiusa P, Maniglia A, Violi MA, Sapuppo G, Vella V, Dardanoni G, Vigneri R, Pellegriti G
FRONT ENDOCRINOL (ISSN: 1664-2392), 2017 Oct 20; 8: 277-277.
Parole chiave: Thyroid Cancer Registry, Anaplastic Thyroid Cancer, Thyroid Cancer And Volcanic Environment, Thyroid Cancer Epidemiology,
*** IBB - CNR *** Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy., Medical Oncology, Department of Clinical Experimental Medicine, University of Catania, Policlinic Hospital, Catania, Italy., Endocrinology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy., Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Motor Sciences, School of Human and Social Sciences, "Kore" University, Enna, Italy., Osservatorio Epidemiologico Regionale, Assessorato Salute Regione Siciliana, Palermo, Italy., Institute of Biostructure and Bioimaging, CNR, Catania, Italy.,
Background: Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30-40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim, data regarding ATC incidences in urban/rural and industrial, iodine-deficient, and volcanic vs control areas were compared in Sicily as well as ATC data from Sicily and USA. Methods: Using the Sicilian Register of Thyroid Cancer (SRTC) database incidence, age, gender, tumor size and histotype, extrathyroidal extension, stage, and coexistence with pre-existing differentiated thyroid cancer (DTC) were evaluated in different areas of Sicily and also compared with Surveillance Epidemiology and End Results data in USA. Results: Forty-three ATCs were identified in Sicily in the period 2002-2009. In our series only age <70 years at diagnosis (p = 0.01), coexistence with DTC (p = 0.027) and tumor size
36 Records (33 escludendo Abstract e Conferenze). Impact factor totale: 146.216 (142.682 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 177.993 (173.978 escludendo Abstract e Conferenze).