Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (141 visite)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Tipo di articolo: Journal Article,
Impact factor: 2.507, Impact factor a 5 anni: 2.381
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d
Parole chiave: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,
Affiliazioni:
*** IBB - CNR ***
[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy
Riferimenti:
Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-58
Clarke, M.J., Zhu, F., Frasca, D.R., (1999) Chem. Rev., 99, pp. 2511-2533
Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, pp. 219-235
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., (2012) Mini-Rev. Med. Chem., 12, pp. 1216-1229
Messori, L., Casini, A., (2011) Curr. Top. Med. Chem., 11, pp. 2647-2660
Ott, I., (2009) Coord. Chem. Rev., 253, pp. 1670-1681
Roder, C., Thomson, M.J., (2015) Drugs R&D, 15, pp. 13-20
https://clinicaltrials.gov/ct2/show/NCT01747798
Mirabelli, C.K., Johnson, R.K., Hill, D.T., Faucette, L.F., Girard, G.R., Kuo, G.Y., Sung, C.M., Crooket, S.T., (1986) J. Med. Chem., 29, pp. 218-223
Gutiérrez, A., Gracia-Fleta, L., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2014) Dalton Trans., 43, pp. 17054-17066
Goitia, H., Nieto, Y., Villacampa, M.D., Kasper, C., Laguna, A., Gimeno, M.C., (2013) Organometallics, 32, pp. 6069-6078
Gutiérrez, A., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2015) Chem. Eur. J., 21, pp. 11088-11095
Baker, M.V., Barnard, P.J., Berners-Price, S.J., Brayshaw, S.K., Hickey, J.L., Skelton, B.W., White, A.H., (2005) J. Organomet. Chem., 690, pp. 5625-5635
Liu, W., Gust, R., (2013) Chem. Soc. Rev., 42, pp. 755-773
Raubenheimer, H.G., Cronje, S., (2008) Chem. Soc. Rev., 37, pp. 1998-2011
Messori, L., Gabbiani, C., (2005) Metal Compounds in Cancer Chemotherapy, pp. 355-375. , “Recent Trends in Antitumor gold(III) Complexes Innovative Cytotoxic Metallodrugs for Cancer Treatment” in, in, (Eds., J. M. Pérez, M. A. Fuertes C. Alonso, Research Signpost, Keral
Tessier, C.A., Cannon, C.L., Youngs, W.J., (2009) Chem. Rev., 109, pp. 3859-3884
Rubbiani, R., Can, S., Kitanovic, I., Alborzinia, H., Stefanopoulou, M., Kokoschka, M., Mönchgesang, S., Ott, I., (2011) J. Med. Chem., 54, pp. 8646-8657
Cisnetti, F., Gautier, A., (2013) Angew. Chem. Int. Ed., 52, pp. 11976-11978
(2013) Angew. Chem., 125, p. 12194
Hu, C., Li, X., Wang, W., Zhang, R., Deng, L., (2014) Curr. Med. Chem., 21, pp. 1220-1230
Gutiérrez, A., Gimeno, M.C., Marzo, I., Metzler-Nolte, N., (2014) Eur. J. Inorg. Chem., pp. 2512-2519
Visbal, R., Fernández-Moreira, V., Marzo, I., Laguna, A., Gimeno, M.C., (2016) Dalton Trans., 45, pp. 15026-15033
Weaver, J., Gaillard, S., Toye, C., Macpherson, S., Nolan, S.P., Riches, A., (2011) Chem. Eur. J., 17, pp. 6620-6624. , For representative examples, see a
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., (2014) Inorg. Chem., 53, pp. 2396-2403
Cheng, X., Holenya, P., Can, S., Alborzinia, H., Rubbiani, R., Ott, I., Wölfl, S., (2014) Mol. Cancer, 13, p. 221
Tacke, M., (2015) J. Organomet. Chem., 782, pp. 17-21
García-Moreno, E., Gascón, S., García de Jalón, J.A., Romanos, E., Rodriguez-Yoldi, M.J., Laguna, M., (2015) Anti-Cancer Agents Med. Chem., 15, pp. 773-782
Bertrand, B., Casini, A., (2014) Dalton Trans., 43, pp. 4209-4219
Hickey, J.L., Ruhayel, R.A., Barnard, P.J., Baker, M.V., Berners-Price, S.J., Filipovska, A.J., (2008) J. Am. Chem. Soc., 130, pp. 12570-12571
Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L., (2009) Coord. Chem. Rev., 253, pp. 1692-1707
Pratesi, A., Gabbiani, C., Michelucci, E., Ginanneschi, M., Papini, A.M., Rubbiani, R., Ott, I., Messori, L., (2014) J. Inorg. Biochem., 136, pp. 161-169
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, pp. 2099-2111
Krishnamurthy, D., Karver, M.R., Fiorillo, E., Orru, V., Stanford, S.M., Bottini, N., Barrios, A.M., (2008) J. Med. Chem., 51, pp. 4790-4795
Gabbiani, C., Scaletti, F., Massai, L., Michelucci, E., Cinellu, M., Messori, L., (2012) Chem. Commun., 48, pp. 11623-11625
Ferraro, G., Gabbiani, C., Merlino, A., (2016) Bioconjugate Chem., 27, pp. 1584-1587
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., (2014) Inorg. Chem., 53, pp. 2296-2303
Maftei, C.V., Fodor, E., Jones, P.G., Freytag, M., Franz, M.H., Kelter, G., Fiebig, H.H., Neda, I., (2015) Eur. J. Med. Chem., 101, pp. 431-445
Niu, W., Chen, X., Tan, W., Veige, A.S., (2016) Angew. Chem. Int. Ed., 55, pp. 8889-8893
(2016) Angew. Chem., 128, p. 9035
Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., (2009) Science, 324, pp. 1029-1033
Warburg, O., (1956) Science, 123, pp. 309-314
Wang, Q., Huang, Z., Ma, J., Lu, X., Zhang, L., Wang, X., Wang, P.G., (2016) Dalton Trans., 45, pp. 10366-10374
Storr, T., (2014) Ligand Design in Medicinal Inorganic Chemistry, , in, John Wiley & Sons, Chicheste
Benessere, V., Lega, M., Ruffo, F., (2014) J. Organomet. Chem., 771, pp. 105-116. , and references cited therein
Nishioka, T., Shibata, T., Kinoshita, I., (2007) Organometallics, 26, pp. 1126-1128
Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A., (2015) J. Organomet. Chem., 775, pp. 124-129
de Fremont, P., Scott, N.M., Stevens, E.D., Nolan, S.P., (2005) Organometallics, 24, pp. 2411-2418
Benessere, V., Ruffo, F., (2010) Tetrahedron: Asymmetry, 21, pp. 171-176
Liu, W., Bensdorf, K., Proetto, M., Abram, U., Hagenbach, A., Gust, R., (2011) J. Med. Chem., 54, pp. 8605-8615
Lin, I.J.B., Vasam, C.S., (2005) Can. J. Chem., 83, pp. 812-825
The inertness of [bis(magi)Au][BF,] was confirmed with several cancer cell lines (data not show)
Weinlich, R., Oberst, A., Beere, H.M., Green, D.R., (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 127-136
Uson, R., Laguna, A., Laguna, M., (1989) Inorg. Synth., 26, pp. 85-91
Szarek, W.A., Achmatowicz, O., Plenkiewicz, J., Radatus, B.K., (1978) Tetrahedron, 34, pp. 1427-1433
(2002) SADABS, , Bruker-Nonius, Delf
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G.L., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Spagna, R., (1999) J. Appl. Crystallogr., 32, pp. 115-119
Sheldrick, G.M., (2015) Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 71, pp. 3-8
Farrugia, L.J., (1997) J. Appl. Crystallogr., 30, pp. 565-566
Macrae, C.F., Edgington, P.R., McCabe, P., Pidcock, E., Shields, G.P., Taylor, R., Towler, M., van der Streek, J., (2006) J. Appl. Crystallogr., 39, pp. 453-457
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Tipo di articolo: Journal Article,
Impact factor: 2.507, Impact factor a 5 anni: 2.381
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d
Parole chiave: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,
Affiliazioni:
*** IBB - CNR ***
[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy
Riferimenti:
Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-58
Clarke, M.J., Zhu, F., Frasca, D.R., (1999) Chem. Rev., 99, pp. 2511-2533
Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, pp. 219-235
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., (2012) Mini-Rev. Med. Chem., 12, pp. 1216-1229
Messori, L., Casini, A., (2011) Curr. Top. Med. Chem., 11, pp. 2647-2660
Ott, I., (2009) Coord. Chem. Rev., 253, pp. 1670-1681
Roder, C., Thomson, M.J., (2015) Drugs R&D, 15, pp. 13-20
https://clinicaltrials.gov/ct2/show/NCT01747798
Mirabelli, C.K., Johnson, R.K., Hill, D.T., Faucette, L.F., Girard, G.R., Kuo, G.Y., Sung, C.M., Crooket, S.T., (1986) J. Med. Chem., 29, pp. 218-223
Gutiérrez, A., Gracia-Fleta, L., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2014) Dalton Trans., 43, pp. 17054-17066
Goitia, H., Nieto, Y., Villacampa, M.D., Kasper, C., Laguna, A., Gimeno, M.C., (2013) Organometallics, 32, pp. 6069-6078
Gutiérrez, A., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2015) Chem. Eur. J., 21, pp. 11088-11095
Baker, M.V., Barnard, P.J., Berners-Price, S.J., Brayshaw, S.K., Hickey, J.L., Skelton, B.W., White, A.H., (2005) J. Organomet. Chem., 690, pp. 5625-5635
Liu, W., Gust, R., (2013) Chem. Soc. Rev., 42, pp. 755-773
Raubenheimer, H.G., Cronje, S., (2008) Chem. Soc. Rev., 37, pp. 1998-2011
Messori, L., Gabbiani, C., (2005) Metal Compounds in Cancer Chemotherapy, pp. 355-375. , “Recent Trends in Antitumor gold(III) Complexes Innovative Cytotoxic Metallodrugs for Cancer Treatment” in, in, (Eds., J. M. Pérez, M. A. Fuertes C. Alonso, Research Signpost, Keral
Tessier, C.A., Cannon, C.L., Youngs, W.J., (2009) Chem. Rev., 109, pp. 3859-3884
Rubbiani, R., Can, S., Kitanovic, I., Alborzinia, H., Stefanopoulou, M., Kokoschka, M., Mönchgesang, S., Ott, I., (2011) J. Med. Chem., 54, pp. 8646-8657
Cisnetti, F., Gautier, A., (2013) Angew. Chem. Int. Ed., 52, pp. 11976-11978
(2013) Angew. Chem., 125, p. 12194
Hu, C., Li, X., Wang, W., Zhang, R., Deng, L., (2014) Curr. Med. Chem., 21, pp. 1220-1230
Gutiérrez, A., Gimeno, M.C., Marzo, I., Metzler-Nolte, N., (2014) Eur. J. Inorg. Chem., pp. 2512-2519
Visbal, R., Fernández-Moreira, V., Marzo, I., Laguna, A., Gimeno, M.C., (2016) Dalton Trans., 45, pp. 15026-15033
Weaver, J., Gaillard, S., Toye, C., Macpherson, S., Nolan, S.P., Riches, A., (2011) Chem. Eur. J., 17, pp. 6620-6624. , For representative examples, see a
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., (2014) Inorg. Chem., 53, pp. 2396-2403
Cheng, X., Holenya, P., Can, S., Alborzinia, H., Rubbiani, R., Ott, I., Wölfl, S., (2014) Mol. Cancer, 13, p. 221
Tacke, M., (2015) J. Organomet. Chem., 782, pp. 17-21
García-Moreno, E., Gascón, S., García de Jalón, J.A., Romanos, E., Rodriguez-Yoldi, M.J., Laguna, M., (2015) Anti-Cancer Agents Med. Chem., 15, pp. 773-782
Bertrand, B., Casini, A., (2014) Dalton Trans., 43, pp. 4209-4219
Hickey, J.L., Ruhayel, R.A., Barnard, P.J., Baker, M.V., Berners-Price, S.J., Filipovska, A.J., (2008) J. Am. Chem. Soc., 130, pp. 12570-12571
Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L., (2009) Coord. Chem. Rev., 253, pp. 1692-1707
Pratesi, A., Gabbiani, C., Michelucci, E., Ginanneschi, M., Papini, A.M., Rubbiani, R., Ott, I., Messori, L., (2014) J. Inorg. Biochem., 136, pp. 161-169
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, pp. 2099-2111
Krishnamurthy, D., Karver, M.R., Fiorillo, E., Orru, V., Stanford, S.M., Bottini, N., Barrios, A.M., (2008) J. Med. Chem., 51, pp. 4790-4795
Gabbiani, C., Scaletti, F., Massai, L., Michelucci, E., Cinellu, M., Messori, L., (2012) Chem. Commun., 48, pp. 11623-11625
Ferraro, G., Gabbiani, C., Merlino, A., (2016) Bioconjugate Chem., 27, pp. 1584-1587
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., (2014) Inorg. Chem., 53, pp. 2296-2303
Maftei, C.V., Fodor, E., Jones, P.G., Freytag, M., Franz, M.H., Kelter, G., Fiebig, H.H., Neda, I., (2015) Eur. J. Med. Chem., 101, pp. 431-445
Niu, W., Chen, X., Tan, W., Veige, A.S., (2016) Angew. Chem. Int. Ed., 55, pp. 8889-8893
(2016) Angew. Chem., 128, p. 9035
Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., (2009) Science, 324, pp. 1029-1033
Warburg, O., (1956) Science, 123, pp. 309-314
Wang, Q., Huang, Z., Ma, J., Lu, X., Zhang, L., Wang, X., Wang, P.G., (2016) Dalton Trans., 45, pp. 10366-10374
Storr, T., (2014) Ligand Design in Medicinal Inorganic Chemistry, , in, John Wiley & Sons, Chicheste
Benessere, V., Lega, M., Ruffo, F., (2014) J. Organomet. Chem., 771, pp. 105-116. , and references cited therein
Nishioka, T., Shibata, T., Kinoshita, I., (2007) Organometallics, 26, pp. 1126-1128
Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A., (2015) J. Organomet. Chem., 775, pp. 124-129
de Fremont, P., Scott, N.M., Stevens, E.D., Nolan, S.P., (2005) Organometallics, 24, pp. 2411-2418
Benessere, V., Ruffo, F., (2010) Tetrahedron: Asymmetry, 21, pp. 171-176
Liu, W., Bensdorf, K., Proetto, M., Abram, U., Hagenbach, A., Gust, R., (2011) J. Med. Chem., 54, pp. 8605-8615
Lin, I.J.B., Vasam, C.S., (2005) Can. J. Chem., 83, pp. 812-825
The inertness of [bis(magi)Au][BF,] was confirmed with several cancer cell lines (data not show)
Weinlich, R., Oberst, A., Beere, H.M., Green, D.R., (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 127-136
Uson, R., Laguna, A., Laguna, M., (1989) Inorg. Synth., 26, pp. 85-91
Szarek, W.A., Achmatowicz, O., Plenkiewicz, J., Radatus, B.K., (1978) Tetrahedron, 34, pp. 1427-1433
(2002) SADABS, , Bruker-Nonius, Delf
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G.L., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Spagna, R., (1999) J. Appl. Crystallogr., 32, pp. 115-119
Sheldrick, G.M., (2015) Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 71, pp. 3-8
Farrugia, L.J., (1997) J. Appl. Crystallogr., 30, pp. 565-566
Macrae, C.F., Edgington, P.R., McCabe, P., Pidcock, E., Shields, G.P., Taylor, R., Towler, M., van der Streek, J., (2006) J. Appl. Crystallogr., 39, pp. 453-457
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside-incorporated N-heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC-3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Nessun risultato. |
Nessun risultato. |
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (17 visite)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor:
Dettagli Esporta in BibTeX Esporta in EndNote
Russi S, Verma HK, Laurino S, Mazzone P, Storto G, Nardelli A, Zoppoli P, Calice G, La Rocca F, Sgambato A, Lucci V, Falco G, Ruggieri V
* Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells (44 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2019 Jul 31; 20(15): N/D-N/D.
Impact Factor: 4.183
Dettagli Esporta in BibTeX Esporta in EndNote
D'Amora A, Cucciolito M, E , Iannitti R, Morelli G, Palumbo R, Ruffo F, Tesauro D
* Pyridine Ruthenium(III) complexes entrapped in liposomes with enhanced cytotoxic properties in PC-3 prostate cancer cells (36 visite)
Ournal Of Drug Delivery Science And Technology, 2019; N/D: N/D-N/D.
Impact Factor: 2.606
Dettagli Esporta in BibTeX Esporta in EndNote
Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (92 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
Dettagli Esporta in BibTeX Esporta in EndNote
Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (246 visite)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
Dettagli Esporta in BibTeX Esporta in EndNote
Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
* Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells (116 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2016 Jun 9; 11(6): e0155970-e0155970.
Impact Factor: 2.806
Dettagli Esporta in BibTeX Esporta in EndNote
Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (167 visite)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
Dettagli Esporta in BibTeX Esporta in EndNote
Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (252 visite)
Biotechnol J (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
Impact Factor: 3.781
Dettagli Esporta in BibTeX Esporta in EndNote
Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (255 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
Dettagli Esporta in BibTeX Esporta in EndNote
Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (191 visite)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
Dettagli Esporta in BibTeX Esporta in EndNote
Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
* Branched porphyrins as functional scaffolds for multisite bioconjugation (153 visite)
Biotechnol Appl Bioc (ISSN: 0885-4513), 2014 Sep 21; N/D: N/D-N/D.
Impact Factor: 1.362
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (198 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
Dettagli Esporta in BibTeX Esporta in EndNote
Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (153 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
Dettagli Esporta in BibTeX Esporta in EndNote
Langlois C, Del Gatto A, Arseneault G, Lafrance-vanasse J, De Simone M, Morse T, De Paola I, Lussier-price M, Legault P, Pedone C, Zaccaro L, Omichinski JG
* Structure-based design of a potent artificial transactivation domain based on p53 (191 visite)
J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), 2012 Jan 25; 134(3): 1715-1723.
Impact Factor: 5.65
Dettagli Esporta in BibTeX Esporta in EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (200 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
Dettagli Esporta in BibTeX Esporta in EndNote
De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (159 visite)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
Dettagli Esporta in BibTeX Esporta in EndNote
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (184 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
Dettagli Esporta in BibTeX Esporta in EndNote
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (268 visite)
J Biol Chem (ISSN: 1083-351x, 0021-9258), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (208 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (150 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
Dettagli Esporta in BibTeX Esporta in EndNote
Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (173 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (162 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
Dettagli Esporta in BibTeX Esporta in EndNote
Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (203 visite)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
Dettagli Esporta in BibTeX Esporta in EndNote
Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (156 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
Dettagli Esporta in BibTeX Esporta in EndNote
Arpaia P, Clemente F, Manna C, Montenero G
* Automatic modeling based on cultural programming for osseointegration diagnosis (128 visite)
Vols 1 3i2mtc (ISSN: 1091-5281), 2009; N/D: 1278-1283.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (133 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
Dettagli Esporta in BibTeX Esporta in EndNote
Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (182 visite)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
Dettagli Esporta in BibTeX Esporta in EndNote
Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (178 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
Dettagli Esporta in BibTeX Esporta in EndNote
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (381 visite)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (263 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (209 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (206 visite)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (200 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (180 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (127 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
Dettagli Esporta in BibTeX Esporta in EndNote
Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (120 visite)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
Dettagli Esporta in BibTeX Esporta in EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (155 visite)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
Dettagli Esporta in BibTeX Esporta in EndNote
37 Records (31 escludendo Abstract e Conferenze).
Impact factor totale: 137.177 (112.204 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 145.999 (117.37 escludendo Abstract e Conferenze).
Impact factor totale: 137.177 (112.204 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 145.999 (117.37 escludendo Abstract e Conferenze).
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Marco Comerci in data Thursday 20 December 2018, 17:03:05
141 visite. Ultima visita in data Sunday 08 December 2019, 12:44:49
ibb.cnr.it