Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
CNR Ibb | back to homepage
▲NavBar
Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]


Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (94 visite)

Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A

Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.



Tipo di articolo: Journal Article,

Impact factor: 2.507, Impact factor a 5 anni: 2.381

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d

Parole chiave: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,

Affiliazioni:

*** IBB - CNR ***
[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy


Riferimenti:

Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-58

Clarke, M.J., Zhu, F., Frasca, D.R., (1999) Chem. Rev., 99, pp. 2511-2533

Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, pp. 219-235

Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., (2012) Mini-Rev. Med. Chem., 12, pp. 1216-1229

Messori, L., Casini, A., (2011) Curr. Top. Med. Chem., 11, pp. 2647-2660

Ott, I., (2009) Coord. Chem. Rev., 253, pp. 1670-1681

Roder, C., Thomson, M.J., (2015) Drugs R&D, 15, pp. 13-20

https://clinicaltrials.gov/ct2/show/NCT01747798

Mirabelli, C.K., Johnson, R.K., Hill, D.T., Faucette, L.F., Girard, G.R., Kuo, G.Y., Sung, C.M., Crooket, S.T., (1986) J. Med. Chem., 29, pp. 218-223

Gutiérrez, A., Gracia-Fleta, L., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2014) Dalton Trans., 43, pp. 17054-17066

Goitia, H., Nieto, Y., Villacampa, M.D., Kasper, C., Laguna, A., Gimeno, M.C., (2013) Organometallics, 32, pp. 6069-6078

Gutiérrez, A., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2015) Chem. Eur. J., 21, pp. 11088-11095

Baker, M.V., Barnard, P.J., Berners-Price, S.J., Brayshaw, S.K., Hickey, J.L., Skelton, B.W., White, A.H., (2005) J. Organomet. Chem., 690, pp. 5625-5635

Liu, W., Gust, R., (2013) Chem. Soc. Rev., 42, pp. 755-773

Raubenheimer, H.G., Cronje, S., (2008) Chem. Soc. Rev., 37, pp. 1998-2011

Messori, L., Gabbiani, C., (2005) Metal Compounds in Cancer Chemotherapy, pp. 355-375. , “Recent Trends in Antitumor gold(III) Complexes Innovative Cytotoxic Metallodrugs for Cancer Treatment” in, in, (Eds., J. M. Pérez, M. A. Fuertes C. Alonso, Research Signpost, Keral

Tessier, C.A., Cannon, C.L., Youngs, W.J., (2009) Chem. Rev., 109, pp. 3859-3884

Rubbiani, R., Can, S., Kitanovic, I., Alborzinia, H., Stefanopoulou, M., Kokoschka, M., Mönchgesang, S., Ott, I., (2011) J. Med. Chem., 54, pp. 8646-8657

Cisnetti, F., Gautier, A., (2013) Angew. Chem. Int. Ed., 52, pp. 11976-11978

(2013) Angew. Chem., 125, p. 12194

Hu, C., Li, X., Wang, W., Zhang, R., Deng, L., (2014) Curr. Med. Chem., 21, pp. 1220-1230

Gutiérrez, A., Gimeno, M.C., Marzo, I., Metzler-Nolte, N., (2014) Eur. J. Inorg. Chem., pp. 2512-2519

Visbal, R., Fernández-Moreira, V., Marzo, I., Laguna, A., Gimeno, M.C., (2016) Dalton Trans., 45, pp. 15026-15033

Weaver, J., Gaillard, S., Toye, C., Macpherson, S., Nolan, S.P., Riches, A., (2011) Chem. Eur. J., 17, pp. 6620-6624. , For representative examples, see a

Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., (2014) Inorg. Chem., 53, pp. 2396-2403

Cheng, X., Holenya, P., Can, S., Alborzinia, H., Rubbiani, R., Ott, I., Wölfl, S., (2014) Mol. Cancer, 13, p. 221

Tacke, M., (2015) J. Organomet. Chem., 782, pp. 17-21

García-Moreno, E., Gascón, S., García de Jalón, J.A., Romanos, E., Rodriguez-Yoldi, M.J., Laguna, M., (2015) Anti-Cancer Agents Med. Chem., 15, pp. 773-782

Bertrand, B., Casini, A., (2014) Dalton Trans., 43, pp. 4209-4219

Hickey, J.L., Ruhayel, R.A., Barnard, P.J., Baker, M.V., Berners-Price, S.J., Filipovska, A.J., (2008) J. Am. Chem. Soc., 130, pp. 12570-12571

Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L., (2009) Coord. Chem. Rev., 253, pp. 1692-1707

Pratesi, A., Gabbiani, C., Michelucci, E., Ginanneschi, M., Papini, A.M., Rubbiani, R., Ott, I., Messori, L., (2014) J. Inorg. Biochem., 136, pp. 161-169

Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, pp. 2099-2111

Krishnamurthy, D., Karver, M.R., Fiorillo, E., Orru, V., Stanford, S.M., Bottini, N., Barrios, A.M., (2008) J. Med. Chem., 51, pp. 4790-4795

Gabbiani, C., Scaletti, F., Massai, L., Michelucci, E., Cinellu, M., Messori, L., (2012) Chem. Commun., 48, pp. 11623-11625

Ferraro, G., Gabbiani, C., Merlino, A., (2016) Bioconjugate Chem., 27, pp. 1584-1587

Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., (2014) Inorg. Chem., 53, pp. 2296-2303

Maftei, C.V., Fodor, E., Jones, P.G., Freytag, M., Franz, M.H., Kelter, G., Fiebig, H.H., Neda, I., (2015) Eur. J. Med. Chem., 101, pp. 431-445

Niu, W., Chen, X., Tan, W., Veige, A.S., (2016) Angew. Chem. Int. Ed., 55, pp. 8889-8893

(2016) Angew. Chem., 128, p. 9035

Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., (2009) Science, 324, pp. 1029-1033

Warburg, O., (1956) Science, 123, pp. 309-314

Wang, Q., Huang, Z., Ma, J., Lu, X., Zhang, L., Wang, X., Wang, P.G., (2016) Dalton Trans., 45, pp. 10366-10374

Storr, T., (2014) Ligand Design in Medicinal Inorganic Chemistry, , in, John Wiley & Sons, Chicheste

Benessere, V., Lega, M., Ruffo, F., (2014) J. Organomet. Chem., 771, pp. 105-116. , and references cited therein

Nishioka, T., Shibata, T., Kinoshita, I., (2007) Organometallics, 26, pp. 1126-1128

Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A., (2015) J. Organomet. Chem., 775, pp. 124-129

de Fremont, P., Scott, N.M., Stevens, E.D., Nolan, S.P., (2005) Organometallics, 24, pp. 2411-2418

Benessere, V., Ruffo, F., (2010) Tetrahedron: Asymmetry, 21, pp. 171-176

Liu, W., Bensdorf, K., Proetto, M., Abram, U., Hagenbach, A., Gust, R., (2011) J. Med. Chem., 54, pp. 8605-8615

Lin, I.J.B., Vasam, C.S., (2005) Can. J. Chem., 83, pp. 812-825

The inertness of [bis(magi)Au][BF,] was confirmed with several cancer cell lines (data not show)

Weinlich, R., Oberst, A., Beere, H.M., Green, D.R., (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 127-136

Uson, R., Laguna, A., Laguna, M., (1989) Inorg. Synth., 26, pp. 85-91

Szarek, W.A., Achmatowicz, O., Plenkiewicz, J., Radatus, B.K., (1978) Tetrahedron, 34, pp. 1427-1433

(2002) SADABS, , Bruker-Nonius, Delf

Altomare, A., Burla, M.C., Camalli, M., Cascarano, G.L., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Spagna, R., (1999) J. Appl. Crystallogr., 32, pp. 115-119

Sheldrick, G.M., (2015) Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 71, pp. 3-8

Farrugia, L.J., (1997) J. Appl. Crystallogr., 30, pp. 565-566

Macrae, C.F., Edgington, P.R., McCabe, P., Pidcock, E., Shields, G.P., Taylor, R., Towler, M., van der Streek, J., (2006) J. Appl. Crystallogr., 39, pp. 453-457



A series of neutral and cationic gold(I) complexes bearing a glucopyranoside-incorporated N-heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC-3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Nessun risultato.
Nessun risultato.

Ricerca avanzata▼
Contiene: [X]      Estesa     Autori: [X]  Tipo di lavoro: [X]   Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
[Pulisci modulo]
Vai a fine pagina   Versione per copia e incolla facile   Esporta tutto in BibTeX   Esporta tutto in EndNote


Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (7 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
Dettagli    Esporta in BibTeX    Esporta in EndNote

Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (136 visite)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
Dettagli    Esporta in BibTeX    Esporta in EndNote

Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
* Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells (96 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2016 Jun 9; 11(6): e0155970-e0155970.
Impact Factor: 2.806
Dettagli    Esporta in BibTeX    Esporta in EndNote

Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (136 visite)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (181 visite)
Biotechnol J (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
Impact Factor: 3.781
Dettagli    Esporta in BibTeX    Esporta in EndNote

Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (157 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
Dettagli    Esporta in BibTeX    Esporta in EndNote

Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (146 visite)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
Dettagli    Esporta in BibTeX    Esporta in EndNote

Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
* Branched porphyrins as functional scaffolds for multisite bioconjugation (100 visite)
Biotechnol Appl Bioc (ISSN: 0885-4513), 2014 Sep 21; N/D: N/D-N/D.
Impact Factor: 1.362
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (161 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
Dettagli    Esporta in BibTeX    Esporta in EndNote

Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M,  Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (131 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
Dettagli    Esporta in BibTeX    Esporta in EndNote

Langlois C, Del Gatto A, Arseneault G, Lafrance-vanasse J, De Simone M, Morse T, De Paola I, Lussier-price M, Legault P, Pedone C, Zaccaro L, Omichinski JG
* Structure-based design of a potent artificial transactivation domain based on p53 (140 visite)
J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), 2012 Jan 25; 134(3): 1715-1723.
Impact Factor: 5.65
Dettagli    Esporta in BibTeX    Esporta in EndNote

Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (135 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
Dettagli    Esporta in BibTeX    Esporta in EndNote

De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (108 visite)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
Dettagli    Esporta in BibTeX    Esporta in EndNote

Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (149 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
Dettagli    Esporta in BibTeX    Esporta in EndNote

Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (177 visite)
J Biol Chem (ISSN: 1083-351x, 0021-9258), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
Dettagli    Esporta in BibTeX    Esporta in EndNote

Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (155 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
Dettagli    Esporta in BibTeX    Esporta in EndNote

Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (129 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
Dettagli    Esporta in BibTeX    Esporta in EndNote

Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (116 visite)
J Biol Chem (ISSN: 0021-9258, 1083-351x), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
Dettagli    Esporta in BibTeX    Esporta in EndNote

Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (129 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
Dettagli    Esporta in BibTeX    Esporta in EndNote

Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (119 visite)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
Dettagli    Esporta in BibTeX    Esporta in EndNote

Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (96 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
Dettagli    Esporta in BibTeX    Esporta in EndNote

Arpaia P, Clemente F, Manna C, Montenero G
* Automatic modeling based on cultural programming for osseointegration diagnosis (101 visite)
Vols 1 3i2mtc (ISSN: 1091-5281), 2009; N/D: 1278-1283.
Impact Factor: 0
Dettagli    Esporta in BibTeX    Esporta in EndNote

Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (94 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
Dettagli    Esporta in BibTeX    Esporta in EndNote

Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (137 visite)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
Dettagli    Esporta in BibTeX    Esporta in EndNote

Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (133 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
Dettagli    Esporta in BibTeX    Esporta in EndNote

Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (318 visite)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (160 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
Dettagli    Esporta in BibTeX    Esporta in EndNote

Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (116 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
Dettagli    Esporta in BibTeX    Esporta in EndNote

Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (102 visite)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (112 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli    Esporta in BibTeX    Esporta in EndNote

Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (103 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli    Esporta in BibTeX    Esporta in EndNote

Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (105 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
Dettagli    Esporta in BibTeX    Esporta in EndNote

Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (76 visite)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
Dettagli    Esporta in BibTeX    Esporta in EndNote

Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (121 visite)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
Dettagli    Esporta in BibTeX    Esporta in EndNote



34 Records (28 escludendo Abstract e Conferenze).
Impact factor totale: 130.388 (105.415 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 143.382 (114.753 escludendo Abstract e Conferenze).







    Esporta in BibTeX    Esporta in EndNote