Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (253 views visite)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.507, 5-year impact factor Impact factor a 5 anni: 2.381
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d
Keywords Parole chiave: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,
Affiliations Affiliazioni:
*** IBB - CNR ***
[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy
References Riferimenti:
Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-58
Clarke, M.J., Zhu, F., Frasca, D.R., (1999) Chem. Rev., 99, pp. 2511-2533
Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, pp. 219-235
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., (2012) Mini-Rev. Med. Chem., 12, pp. 1216-1229
Messori, L., Casini, A., (2011) Curr. Top. Med. Chem., 11, pp. 2647-2660
Ott, I., (2009) Coord. Chem. Rev., 253, pp. 1670-1681
Roder, C., Thomson, M.J., (2015) Drugs R&D, 15, pp. 13-20
https://clinicaltrials.gov/ct2/show/NCT01747798
Mirabelli, C.K., Johnson, R.K., Hill, D.T., Faucette, L.F., Girard, G.R., Kuo, G.Y., Sung, C.M., Crooket, S.T., (1986) J. Med. Chem., 29, pp. 218-223
Gutiérrez, A., Gracia-Fleta, L., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2014) Dalton Trans., 43, pp. 17054-17066
Goitia, H., Nieto, Y., Villacampa, M.D., Kasper, C., Laguna, A., Gimeno, M.C., (2013) Organometallics, 32, pp. 6069-6078
Gutiérrez, A., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2015) Chem. Eur. J., 21, pp. 11088-11095
Baker, M.V., Barnard, P.J., Berners-Price, S.J., Brayshaw, S.K., Hickey, J.L., Skelton, B.W., White, A.H., (2005) J. Organomet. Chem., 690, pp. 5625-5635
Liu, W., Gust, R., (2013) Chem. Soc. Rev., 42, pp. 755-773
Raubenheimer, H.G., Cronje, S., (2008) Chem. Soc. Rev., 37, pp. 1998-2011
Messori, L., Gabbiani, C., (2005) Metal Compounds in Cancer Chemotherapy, pp. 355-375. , “Recent Trends in Antitumor gold(III) Complexes Innovative Cytotoxic Metallodrugs for Cancer Treatment” in, in, (Eds., J. M. Pérez, M. A. Fuertes C. Alonso, Research Signpost, Keral
Tessier, C.A., Cannon, C.L., Youngs, W.J., (2009) Chem. Rev., 109, pp. 3859-3884
Rubbiani, R., Can, S., Kitanovic, I., Alborzinia, H., Stefanopoulou, M., Kokoschka, M., Mönchgesang, S., Ott, I., (2011) J. Med. Chem., 54, pp. 8646-8657
Cisnetti, F., Gautier, A., (2013) Angew. Chem. Int. Ed., 52, pp. 11976-11978
(2013) Angew. Chem., 125, p. 12194
Hu, C., Li, X., Wang, W., Zhang, R., Deng, L., (2014) Curr. Med. Chem., 21, pp. 1220-1230
Gutiérrez, A., Gimeno, M.C., Marzo, I., Metzler-Nolte, N., (2014) Eur. J. Inorg. Chem., pp. 2512-2519
Visbal, R., Fernández-Moreira, V., Marzo, I., Laguna, A., Gimeno, M.C., (2016) Dalton Trans., 45, pp. 15026-15033
Weaver, J., Gaillard, S., Toye, C., Macpherson, S., Nolan, S.P., Riches, A., (2011) Chem. Eur. J., 17, pp. 6620-6624. , For representative examples, see a
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., (2014) Inorg. Chem., 53, pp. 2396-2403
Cheng, X., Holenya, P., Can, S., Alborzinia, H., Rubbiani, R., Ott, I., Wölfl, S., (2014) Mol. Cancer, 13, p. 221
Tacke, M., (2015) J. Organomet. Chem., 782, pp. 17-21
García-Moreno, E., Gascón, S., García de Jalón, J.A., Romanos, E., Rodriguez-Yoldi, M.J., Laguna, M., (2015) Anti-Cancer Agents Med. Chem., 15, pp. 773-782
Bertrand, B., Casini, A., (2014) Dalton Trans., 43, pp. 4209-4219
Hickey, J.L., Ruhayel, R.A., Barnard, P.J., Baker, M.V., Berners-Price, S.J., Filipovska, A.J., (2008) J. Am. Chem. Soc., 130, pp. 12570-12571
Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L., (2009) Coord. Chem. Rev., 253, pp. 1692-1707
Pratesi, A., Gabbiani, C., Michelucci, E., Ginanneschi, M., Papini, A.M., Rubbiani, R., Ott, I., Messori, L., (2014) J. Inorg. Biochem., 136, pp. 161-169
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, pp. 2099-2111
Krishnamurthy, D., Karver, M.R., Fiorillo, E., Orru, V., Stanford, S.M., Bottini, N., Barrios, A.M., (2008) J. Med. Chem., 51, pp. 4790-4795
Gabbiani, C., Scaletti, F., Massai, L., Michelucci, E., Cinellu, M., Messori, L., (2012) Chem. Commun., 48, pp. 11623-11625
Ferraro, G., Gabbiani, C., Merlino, A., (2016) Bioconjugate Chem., 27, pp. 1584-1587
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., (2014) Inorg. Chem., 53, pp. 2296-2303
Maftei, C.V., Fodor, E., Jones, P.G., Freytag, M., Franz, M.H., Kelter, G., Fiebig, H.H., Neda, I., (2015) Eur. J. Med. Chem., 101, pp. 431-445
Niu, W., Chen, X., Tan, W., Veige, A.S., (2016) Angew. Chem. Int. Ed., 55, pp. 8889-8893
(2016) Angew. Chem., 128, p. 9035
Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., (2009) Science, 324, pp. 1029-1033
Warburg, O., (1956) Science, 123, pp. 309-314
Wang, Q., Huang, Z., Ma, J., Lu, X., Zhang, L., Wang, X., Wang, P.G., (2016) Dalton Trans., 45, pp. 10366-10374
Storr, T., (2014) Ligand Design in Medicinal Inorganic Chemistry, , in, John Wiley & Sons, Chicheste
Benessere, V., Lega, M., Ruffo, F., (2014) J. Organomet. Chem., 771, pp. 105-116. , and references cited therein
Nishioka, T., Shibata, T., Kinoshita, I., (2007) Organometallics, 26, pp. 1126-1128
Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A., (2015) J. Organomet. Chem., 775, pp. 124-129
de Fremont, P., Scott, N.M., Stevens, E.D., Nolan, S.P., (2005) Organometallics, 24, pp. 2411-2418
Benessere, V., Ruffo, F., (2010) Tetrahedron: Asymmetry, 21, pp. 171-176
Liu, W., Bensdorf, K., Proetto, M., Abram, U., Hagenbach, A., Gust, R., (2011) J. Med. Chem., 54, pp. 8605-8615
Lin, I.J.B., Vasam, C.S., (2005) Can. J. Chem., 83, pp. 812-825
The inertness of [bis(magi)Au][BF,] was confirmed with several cancer cell lines (data not show)
Weinlich, R., Oberst, A., Beere, H.M., Green, D.R., (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 127-136
Uson, R., Laguna, A., Laguna, M., (1989) Inorg. Synth., 26, pp. 85-91
Szarek, W.A., Achmatowicz, O., Plenkiewicz, J., Radatus, B.K., (1978) Tetrahedron, 34, pp. 1427-1433
(2002) SADABS, , Bruker-Nonius, Delf
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G.L., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Spagna, R., (1999) J. Appl. Crystallogr., 32, pp. 115-119
Sheldrick, G.M., (2015) Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 71, pp. 3-8
Farrugia, L.J., (1997) J. Appl. Crystallogr., 30, pp. 565-566
Macrae, C.F., Edgington, P.R., McCabe, P., Pidcock, E., Shields, G.P., Taylor, R., Towler, M., van der Streek, J., (2006) J. Appl. Crystallogr., 39, pp. 453-457
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.507, 5-year impact factor Impact factor a 5 anni: 2.381
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d
Keywords Parole chiave: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,
Affiliations Affiliazioni:
*** IBB - CNR ***
[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy
References Riferimenti:
Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-58
Clarke, M.J., Zhu, F., Frasca, D.R., (1999) Chem. Rev., 99, pp. 2511-2533
Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, pp. 219-235
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., (2012) Mini-Rev. Med. Chem., 12, pp. 1216-1229
Messori, L., Casini, A., (2011) Curr. Top. Med. Chem., 11, pp. 2647-2660
Ott, I., (2009) Coord. Chem. Rev., 253, pp. 1670-1681
Roder, C., Thomson, M.J., (2015) Drugs R&D, 15, pp. 13-20
https://clinicaltrials.gov/ct2/show/NCT01747798
Mirabelli, C.K., Johnson, R.K., Hill, D.T., Faucette, L.F., Girard, G.R., Kuo, G.Y., Sung, C.M., Crooket, S.T., (1986) J. Med. Chem., 29, pp. 218-223
Gutiérrez, A., Gracia-Fleta, L., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2014) Dalton Trans., 43, pp. 17054-17066
Goitia, H., Nieto, Y., Villacampa, M.D., Kasper, C., Laguna, A., Gimeno, M.C., (2013) Organometallics, 32, pp. 6069-6078
Gutiérrez, A., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2015) Chem. Eur. J., 21, pp. 11088-11095
Baker, M.V., Barnard, P.J., Berners-Price, S.J., Brayshaw, S.K., Hickey, J.L., Skelton, B.W., White, A.H., (2005) J. Organomet. Chem., 690, pp. 5625-5635
Liu, W., Gust, R., (2013) Chem. Soc. Rev., 42, pp. 755-773
Raubenheimer, H.G., Cronje, S., (2008) Chem. Soc. Rev., 37, pp. 1998-2011
Messori, L., Gabbiani, C., (2005) Metal Compounds in Cancer Chemotherapy, pp. 355-375. , “Recent Trends in Antitumor gold(III) Complexes Innovative Cytotoxic Metallodrugs for Cancer Treatment” in, in, (Eds., J. M. Pérez, M. A. Fuertes C. Alonso, Research Signpost, Keral
Tessier, C.A., Cannon, C.L., Youngs, W.J., (2009) Chem. Rev., 109, pp. 3859-3884
Rubbiani, R., Can, S., Kitanovic, I., Alborzinia, H., Stefanopoulou, M., Kokoschka, M., Mönchgesang, S., Ott, I., (2011) J. Med. Chem., 54, pp. 8646-8657
Cisnetti, F., Gautier, A., (2013) Angew. Chem. Int. Ed., 52, pp. 11976-11978
(2013) Angew. Chem., 125, p. 12194
Hu, C., Li, X., Wang, W., Zhang, R., Deng, L., (2014) Curr. Med. Chem., 21, pp. 1220-1230
Gutiérrez, A., Gimeno, M.C., Marzo, I., Metzler-Nolte, N., (2014) Eur. J. Inorg. Chem., pp. 2512-2519
Visbal, R., Fernández-Moreira, V., Marzo, I., Laguna, A., Gimeno, M.C., (2016) Dalton Trans., 45, pp. 15026-15033
Weaver, J., Gaillard, S., Toye, C., Macpherson, S., Nolan, S.P., Riches, A., (2011) Chem. Eur. J., 17, pp. 6620-6624. , For representative examples, see a
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., (2014) Inorg. Chem., 53, pp. 2396-2403
Cheng, X., Holenya, P., Can, S., Alborzinia, H., Rubbiani, R., Ott, I., Wölfl, S., (2014) Mol. Cancer, 13, p. 221
Tacke, M., (2015) J. Organomet. Chem., 782, pp. 17-21
García-Moreno, E., Gascón, S., García de Jalón, J.A., Romanos, E., Rodriguez-Yoldi, M.J., Laguna, M., (2015) Anti-Cancer Agents Med. Chem., 15, pp. 773-782
Bertrand, B., Casini, A., (2014) Dalton Trans., 43, pp. 4209-4219
Hickey, J.L., Ruhayel, R.A., Barnard, P.J., Baker, M.V., Berners-Price, S.J., Filipovska, A.J., (2008) J. Am. Chem. Soc., 130, pp. 12570-12571
Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L., (2009) Coord. Chem. Rev., 253, pp. 1692-1707
Pratesi, A., Gabbiani, C., Michelucci, E., Ginanneschi, M., Papini, A.M., Rubbiani, R., Ott, I., Messori, L., (2014) J. Inorg. Biochem., 136, pp. 161-169
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, pp. 2099-2111
Krishnamurthy, D., Karver, M.R., Fiorillo, E., Orru, V., Stanford, S.M., Bottini, N., Barrios, A.M., (2008) J. Med. Chem., 51, pp. 4790-4795
Gabbiani, C., Scaletti, F., Massai, L., Michelucci, E., Cinellu, M., Messori, L., (2012) Chem. Commun., 48, pp. 11623-11625
Ferraro, G., Gabbiani, C., Merlino, A., (2016) Bioconjugate Chem., 27, pp. 1584-1587
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., (2014) Inorg. Chem., 53, pp. 2296-2303
Maftei, C.V., Fodor, E., Jones, P.G., Freytag, M., Franz, M.H., Kelter, G., Fiebig, H.H., Neda, I., (2015) Eur. J. Med. Chem., 101, pp. 431-445
Niu, W., Chen, X., Tan, W., Veige, A.S., (2016) Angew. Chem. Int. Ed., 55, pp. 8889-8893
(2016) Angew. Chem., 128, p. 9035
Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., (2009) Science, 324, pp. 1029-1033
Warburg, O., (1956) Science, 123, pp. 309-314
Wang, Q., Huang, Z., Ma, J., Lu, X., Zhang, L., Wang, X., Wang, P.G., (2016) Dalton Trans., 45, pp. 10366-10374
Storr, T., (2014) Ligand Design in Medicinal Inorganic Chemistry, , in, John Wiley & Sons, Chicheste
Benessere, V., Lega, M., Ruffo, F., (2014) J. Organomet. Chem., 771, pp. 105-116. , and references cited therein
Nishioka, T., Shibata, T., Kinoshita, I., (2007) Organometallics, 26, pp. 1126-1128
Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A., (2015) J. Organomet. Chem., 775, pp. 124-129
de Fremont, P., Scott, N.M., Stevens, E.D., Nolan, S.P., (2005) Organometallics, 24, pp. 2411-2418
Benessere, V., Ruffo, F., (2010) Tetrahedron: Asymmetry, 21, pp. 171-176
Liu, W., Bensdorf, K., Proetto, M., Abram, U., Hagenbach, A., Gust, R., (2011) J. Med. Chem., 54, pp. 8605-8615
Lin, I.J.B., Vasam, C.S., (2005) Can. J. Chem., 83, pp. 812-825
The inertness of [bis(magi)Au][BF,] was confirmed with several cancer cell lines (data not show)
Weinlich, R., Oberst, A., Beere, H.M., Green, D.R., (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 127-136
Uson, R., Laguna, A., Laguna, M., (1989) Inorg. Synth., 26, pp. 85-91
Szarek, W.A., Achmatowicz, O., Plenkiewicz, J., Radatus, B.K., (1978) Tetrahedron, 34, pp. 1427-1433
(2002) SADABS, , Bruker-Nonius, Delf
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G.L., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Spagna, R., (1999) J. Appl. Crystallogr., 32, pp. 115-119
Sheldrick, G.M., (2015) Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 71, pp. 3-8
Farrugia, L.J., (1997) J. Appl. Crystallogr., 30, pp. 565-566
Macrae, C.F., Edgington, P.R., McCabe, P., Pidcock, E., Shields, G.P., Taylor, R., Towler, M., van der Streek, J., (2006) J. Appl. Crystallogr., 39, pp. 453-457
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside-incorporated N-heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC-3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside-incorporated N-heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC-3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
Susana F, Fagoonee S, Alessandro S, Valentina G, Chiara R, Marco P, Fiorella A, Danilo D
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (85 visite)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
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Caporale A, Monti A, Selis F, Sandomenico A, Tonon G, Ruvo M, Doti N
* A comparative analysis of catalytic activity and stability of microbial transglutaminase in controlled denaturing conditions (80 visite)
J Biotechnol (ISSN: 0168-1656linking), 2019 Aug 20; 302: 48-57.
Impact Factor: 3.163
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Russi S, Verma HK, Laurino S, Mazzone P, Storto G, Nardelli A, Zoppoli P, Calice G, La Rocca F, Sgambato A, Lucci V, Falco G, Ruggieri V
* Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells (144 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2019 Jul 31; 20(15): N/D-N/D.
Impact Factor: 4.183
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D'Amora A, Cucciolito M, E , Iannitti R, Morelli G, Palumbo R, Ruffo F, Tesauro D
* Pyridine Ruthenium(III) complexes entrapped in liposomes with enhanced cytotoxic properties in PC-3 prostate cancer cells (100 visite)
Journal Of Drug Delivery Science And Technology, 2019; 51: 552-558.
Impact Factor: 2.606
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (143 visite)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (227 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (401 visite)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (305 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
* Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells (180 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2016 Jun 9; 11(6): e0155970-e0155970.
Impact Factor: 2.806
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Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (278 visite)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
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Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (377 visite)
Biotechnol J (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
Impact Factor: 3.781
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (441 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (334 visite)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
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Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
* Branched porphyrins as functional scaffolds for multisite bioconjugation (271 visite)
Biotechnol Appl Bioc (ISSN: 0885-4513), 2014 Sep 21; N/D: N/D-N/D.
Impact Factor: 1.362
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (323 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (318 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Langlois C, Del Gatto A, Arseneault G, Lafrance-vanasse J, De Simone M, Morse T, De Paola I, Lussier-price M, Legault P, Pedone C, Zaccaro L, Omichinski JG
* Structure-based design of a potent artificial transactivation domain based on p53 (326 visite)
J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), 2012 Jan 25; 134(3): 1715-1723.
Impact Factor: 5.65
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (350 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (299 visite)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (308 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (469 visite)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (377 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
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Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (304 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (413 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (259 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (322 visite)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (284 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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Arpaia P, Clemente F, Manna C, Montenero G
* Automatic modeling based on cultural programming for osseointegration diagnosis (241 visite)
Vols 1 3i2mtc (ISSN: 1091-5281), 2009; N/D: 1278-1283.
Impact Factor: 0
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (237 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (323 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (330 visite)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (344 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
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Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (699 visite)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (415 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (310 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (327 visite)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
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Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (295 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (282 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (204 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (259 visite)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (260 visite)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Susana F, Fagoonee S, Alessandro S, Valentina G, Chiara R, Marco P, Fiorella A, Danilo D
* Impedance-based drug-resistance characterization of colon cancer cells through real-time cell culture monitoring (11 visite)
Talanta (ISSN: 0039-9140linking), 2021 Jan 15; 222: 121441-121441.
Impact Factor: 5.339
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Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
* Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives (5 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2020 Oct 21; 21(20): N/D-N/D.
Impact Factor: 4.556
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Siciliano G, Corricelli M, Iacobazzi RM, Canepa F, Comegna D, Fanizza E, Del Gatto A, Saviano M, Laquintana V, Comparelli R, Mascolo G, Murgolo S, Striccoli M, Agostiano A, Denora N, Zaccaro L, Curri ML, Depalo N
* Gold-Speckled SPION@SiO(2) Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications (5 visite)
Chemistry (ISSN: 0947-6539linking), 2020 Aug 26; 26(48): 11048-11059.
Impact Factor: 4.857
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Capasso D, Borbone N, Terracciano M, Di Gaetano S, Piccialli V
* Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells (5 visite)
Mar Drugs (ISSN: 1660-3397linking), 2020 Jul 29; 18(8): N/D-N/D.
Impact Factor: 4.379
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Cavallari E, Carrera C, Di Matteo G, Bondar O, Aime S, Reineri F
* In-vitro NMR Studies of Prostate Tumor Cell Metabolism by Means of Hyperpolarized [1-(13)C]Pyruvate Obtained Using the PHIP-SAH Method (5 visite)
Front Oncol (ISSN: 2234-943xlinking), 2020 Apr 17; 10: 497-497.
Impact Factor: 4.25
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Doti N, Caporale A, Monti A, Sandomenico A, Selis F, Ruvo M
* A recent update on the use of microbial transglutaminase for the generation of biotherapeutics (14 visite)
World J Microbiol Biotechnol (ISSN: 0959-3993linking), 2020 Mar 14; 36(4): 53-53.
Impact Factor: 2.477
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (63 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (85 visite)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
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Caporale A, Monti A, Selis F, Sandomenico A, Tonon G, Ruvo M, Doti N
* A comparative analysis of catalytic activity and stability of microbial transglutaminase in controlled denaturing conditions (80 visite)
J Biotechnol (ISSN: 0168-1656linking), 2019 Aug 20; 302: 48-57.
Impact Factor: 3.163
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Russi S, Verma HK, Laurino S, Mazzone P, Storto G, Nardelli A, Zoppoli P, Calice G, La Rocca F, Sgambato A, Lucci V, Falco G, Ruggieri V
* Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells (144 visite)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2019 Jul 31; 20(15): N/D-N/D.
Impact Factor: 4.183
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D'Amora A, Cucciolito M, E , Iannitti R, Morelli G, Palumbo R, Ruffo F, Tesauro D
* Pyridine Ruthenium(III) complexes entrapped in liposomes with enhanced cytotoxic properties in PC-3 prostate cancer cells (100 visite)
Journal Of Drug Delivery Science And Technology, 2019; 51: 552-558.
Impact Factor: 2.606
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (143 visite)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (227 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (401 visite)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (305 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
* Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells (180 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2016 Jun 9; 11(6): e0155970-e0155970.
Impact Factor: 2.806
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Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (278 visite)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
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Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (377 visite)
Biotechnol J (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
Impact Factor: 3.781
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (441 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (334 visite)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
Dettagli Esporta in BibTeX Esporta in EndNote
Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
* Branched porphyrins as functional scaffolds for multisite bioconjugation (271 visite)
Biotechnol Appl Bioc (ISSN: 0885-4513), 2014 Sep 21; N/D: N/D-N/D.
Impact Factor: 1.362
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (323 visite)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (318 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Langlois C, Del Gatto A, Arseneault G, Lafrance-vanasse J, De Simone M, Morse T, De Paola I, Lussier-price M, Legault P, Pedone C, Zaccaro L, Omichinski JG
* Structure-based design of a potent artificial transactivation domain based on p53 (326 visite)
J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), 2012 Jan 25; 134(3): 1715-1723.
Impact Factor: 5.65
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (350 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (299 visite)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (308 visite)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (469 visite)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (377 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (304 visite)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
Dettagli Esporta in BibTeX Esporta in EndNote
Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (413 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (259 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
Dettagli Esporta in BibTeX Esporta in EndNote
Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (322 visite)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
Dettagli Esporta in BibTeX Esporta in EndNote
Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (284 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
Dettagli Esporta in BibTeX Esporta in EndNote
Arpaia P, Clemente F, Manna C, Montenero G
* Automatic modeling based on cultural programming for osseointegration diagnosis (241 visite)
Vols 1 3i2mtc (ISSN: 1091-5281), 2009; N/D: 1278-1283.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (237 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (323 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
Dettagli Esporta in BibTeX Esporta in EndNote
Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (330 visite)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
Dettagli Esporta in BibTeX Esporta in EndNote
Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (344 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
Dettagli Esporta in BibTeX Esporta in EndNote
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (699 visite)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (415 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (310 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
Dettagli Esporta in BibTeX Esporta in EndNote
Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (327 visite)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (295 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (282 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
Dettagli Esporta in BibTeX Esporta in EndNote
Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (204 visite)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
Dettagli Esporta in BibTeX Esporta in EndNote
Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (259 visite)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
Dettagli Esporta in BibTeX Esporta in EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (260 visite)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
Dettagli Esporta in BibTeX Esporta in EndNote
48 Records (42 escludendo Abstract e Conferenze).
Impact factor totale: 181.855 (156.882 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 177.764 (149.135 escludendo Abstract e Conferenze).
Impact factor totale: 181.855 (156.882 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 177.764 (149.135 escludendo Abstract e Conferenze).
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