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Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (3 views)

Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K

J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.

The implication of guanine-rich DNA sequences in biologically important roles such as telomerase dysfunction and the regulation of gene expression has prompted the search for structure-specific G-quadruplex agents for targeted diagnostic and therapeutic applications. Herein, we report on a near-infrared (NIR) two-photon poly(cationic) anthracene-based macromolecule able to selectively target G-quadruplexes (G4s) over genomic double-stranded DNA. In particular, the striking changes in its linear and third-order nonlinear optical properties, combined with the emergence of a strong induced electronic circular dichroism (ECD) signal upon binding to canonical and noncanonical DNA secondary structures allowed for a highly specific detection of several different G4s. Furthermore, through a detailed computational analysis we bring compelling evidence that our probe intercalation within G4s is a thermodynamically favored event, and we fully rationalize the spectroscopic evolution resulting from this complexation event by providing a reasonable explanation regarding the origin of the peculiar ECD effect that accompanies it.

Affiliations ▼
*** IBB - CNR Affiliation

Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology , Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland., Universite Lyon, ENS de Lyon, CNRS UMR 5182, Universite Lyon 1 , Laboratoire de Chimie, F69342, Lyon, France., Consiglio Nazionale delle Ricerche, Istituto di Biostrutture e Bioimmagini , 80134 Naples, Italy., LIDYL, CEA, CNRS, Universite Paris-Saclay , F-91191 Gif-sur-Yvette, France., Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences , Rudolfa Weigla 12, 53-114 Wroclaw, Poland.,

Details ▼
Impact factor: 6.687, 5-year impact factor: 6.91

Paper type: Journal Article

Keywords: Not available.

Url: Not available.

References ▼
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* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (74 views)
Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
Biochim Biophys Acta (ISSN: 0006-3002print, 0006-3002linking, 0005-2728), 2014 Jun; 1840(6): 2050-2059.

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1 Records (1 excluding Abstracts and Conferences).
Total impact factor: 5.353 (5.353 excluding Abstracts and Conferences).
Total 5-year impact factor: 5.132 (5.132 excluding Abstracts and Conferences).

Your bibliography query: (([btitle, keywords, abstract] SPECIFIC AND [btitle, keywords, abstract] RECOGNITION AND [btitle, keywords, abstract] QUADRUPLEXES)) AND NOT [id] = 53638

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