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Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications (87 visite)

Calvanese L, Caporale A, Foca G, Iaccarino E, Sandomenico A, Doti N, Apicella I, Incisivo GM, De Falco S, Falcigno L, D'Auria G, Ruvo M

Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2017 Dec 2; N/D: N/D-N/D.

Tipo di articolo: Journal Article,

Impact factor: 4.106

Impact factor a 5 anni: 3.541


Parole chiave: Cancer Detection, Flow Cytometry, Receptor Binding, Retro-Inverso Peptide Sequence,

Url: Non disponibile.

Pharmacological strategies aimed at preventing cancer growth are in most cases paralleled by diagnostic investigations for monitoring and prognosticating therapeutic efficacy. A relevant approach in cancer is the suppression of pathological angiogenesis, which is principally driven by vascular endothelial growth factor (VEGF) or closely related factors and by activation of specific receptors, prevailingly VEGFR1 and VEGFR2, set on the surface of endothelial cells. Monitoring the presence of these receptors in vivo is henceforth a way to predict therapy outcome. We have designed small peptides able to bind and possibly antagonize VEGF ligands by targeting VEGF receptors. Peptide systems have been designed to be small, cyclic and to host triplets of residues known to be essential for VEGF receptors recognition and we named them 'mini-factors'. They have been structurally characterized by CD, NMR and molecular dynamics (MD) simulations. Mini-factors do bind with different specificity and affinity VEGF receptors but none blocks receptor activity. Following derivatization with suitable tracers they have been employed as molecular probes for sensing receptors on cell surface without affecting their activity as is usually observed with other binders having neutralizing activity.
*** IBB - CNR ***

Istituto di Biostrutture e Bioimmagini del CNR, CIRPeB, University of Naples Federico II, via Mezzocannone, 16, 80134, Naples, Italy., CNR-IBB, via Mezzocannone, 16, 80134, Naples, Italy., DISTABiF, Universita degli Studi della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100, Caserta, Italy., Angiogenesis Lab, Institute of Genetics and Biophysics-CNR, Via P. Castellino 111, 80131, Naples, Italy., Fresenius Kabi Anti Infectives srl, Via San Leonardo 23, 45010, Villadose, RO, Italy., Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80134, Naples, Italy., Istituto di Biostrutture e Bioimmagini del CNR, CIRPeB, University of Naples Federico II, via Mezzocannone, 16, 80134, Naples, Italy. menotti.ruvo@unina.it., CNR-IBB, via Mezzocannone, 16, 80134, Naples, Italy. menotti.ruvo@unina.it.,
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Contiene: [X]      Estesa         Autori: [X]      Tipo di lavoro: [X]
Data iniziale: Data finale: [X]      Sede: Affiliazione IBB     
    
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Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G
* Clinical proof of concept for a safe and effective NF-kappaB-targeting strategy in multiple myeloma (23 visite)
Br J Haematol (ISSN: 1365-2141electronic, 0007-1048linking), 2018 Sep 26; N/D: N/D-N/D.
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Sandomenico A, Ruvo M
* Targeting Nodal and Cripto-1: perspectives inside dual potential theranostic cancer biomarkers (28 visite)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Sep 11; N/D: N/D-N/D.
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Mcnitt DH, De Water LV, Marasco D, Berisio R, Lukomski S
* Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting (20 visite)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Aug 31; N/D: N/D-N/D.
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Iommelli F, De Rosa V, Terlizzi C, Monti M, Panico M, Fonti R, Del Vecchio S
* Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non-Small Cell Lung Cancer Detected by (18)F-fluorothymidine (260 visite)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jul 1; 24(13): 3126-3136.
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Ferrucci V, De Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M
* Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition (85 visite)
(ISSN: 1460-2156electronic, 0006-8950linking), 2018 Feb 27; N/D: N/D-N/D.
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Doti N, Ruvo M
* Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death (87 visite)
Neural Regen Res (ISSN: 1673-5374print, 1673-5374linking), 2017 Sep; 12(9): 1428-1429.
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Monaco I, Arena F, Biffi S, Locatelli E, Bortot B, La Cava F, Marini GM, Severini GM, Terreno E, Comes Franchini M
* Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging (52 visite)
Bioconjug Chem (ISSN: 1520-4812electronic, 1043-1802linking), 2017 May 17; 28(5): 1382-1390.
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Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
* Mitochondria Targeting with Luminescent Rhenium(I) Complexes (55 visite)
Molecules (ISSN: 1420-3049electronic, 1420-3049linking), 2017 May 15; 22(5): N/D-N/D.
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Majkowska-skrobek G, Latka A, Berisio R, Maciejewska B, Squeglia F, RomanoM, Lavigne R, Struve C, Drulis-kawa Z
* Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy (95 visite)
Viruses (ISSN: 1999-4915electronic, 1999-4915linking), 2016 Dec 1; 8(12): N/D-N/D.
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Mercurio FA, Marasco D, Di Natale C, Pirone L, Costantini S, Pedone EM, Leone M
* Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues (109 visite)
Chembiochem (ISSN: 1439-7633electronic, 1439-4227linking), 2016 Nov 17; 17(22): 2179-2188.
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Di Pietro P, Zaccaro L, Comegna D, Del Gatto A, Saviano M, Snyders R, Cossement D, Satriano C, Rizzarelli E
* Silver nanoparticles functionalized with a fluorescent cyclic RGD peptide: a versatile integrin targeting platform for cells and bacteria (45 visite) (PDF 45 visite)
The Royal Society Of Chemistry, 2016 Jan 01; 6: N/D-N/D.
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (121 visite)
Biochemia Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
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Valente G, Depalo N, De Paola I, Iacobazzi RM, Denora N, Laquintana V, Comparelli R, Altamura E, Latronico T, Altomare M, Fanizza E, Striccoli M, Agostiano A, Saviano M, Del Gatto A, Zaccaro L, Curri ML
* Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures (109 visite)
Nano Research (ISSN: 1998-0124), 2016; 9(3): 644-662.
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Calce E, Saviano M, De Luca S
* Development of Targeting Ligands for HER2 Receptor: Simplified Receptor Model Employed for Selecting Highly Specific Molecules (73 visite)
International Journal Of Peptide Research And Therapeutics, 2015 Dec; N/D: N/D-N/D.
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Bottini A, Wu B, Barile E, De SK, Leone  M, Pellecchia M
* High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH (98 visite)
Chemmedchem (ISSN: 1860-7187electronic, 1860-7179linking), 2015 Nov 23; 11(8): 919-927.
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
* Effects of a novel Nodal-targeting monoclonal antibody in melanoma (203 visite) (PDF 119 visite)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2015 Oct 27; 6(33): 34071-34086.
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (268 visite) (PDF 153 visite)
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2015 Sep 7; 16(9): 21342-21362.
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Cipolletta E, Rusciano MR, Maione AS, Santulli G, Sorriento D, Del Giudice C, Ciccarelli M, Franco A, Crola C, Campiglia P, Sala M, Gomez-Monterrey I, De Luca N, Trimarco B, Iaccarino G, Illario M
* Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy (99 visite)
Plos One (ISSN: 1932-6203electronic, 1932-6203linking), 2015 Jun 25; 10(6): e0130477-e0130477.
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (258 visite)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2015 May 20; 22(21): 2525-2538.
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Carotenuto M, de Antonellis P, Chiarolla CM, Attanasio C, Damiani V, Boffa I, Aiese N, Pedone E, Accordi B, Basso G, Navas L, Imbimbo C, Zollo M
* A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction (106 visite)
Naunyn Schmiedebergs Arch Pharmacol (ISSN: 0028-1298), 2015 Feb; 388(2): 257-269.
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Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (141 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 2; 21(1): 91-95.
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (135 visite)
Int J Mol Sc (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2015; 16(6): 12159-12173.
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (205 visite)
Cancer Cell (ISSN: 1878-3686, 1535-6108), 2014 Oct 13; 26(4): 495-508.
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (190 visite)
Int J Nanomedicine (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2014 Mar 27; 9(1): 1537-1557.
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Cigliano L, De Rosa L, Diana D, Di Stasi R, Spagnuolo MS, Maresca B, Fattorusso R, D'Andrea LD
* Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin (133 visite)
Rsc Advances (ISSN: 2046-2069), 2014; 4(93): 51353-51361.
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (168 visite)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
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Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
* Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates (173 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520.
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (113 visite)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
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Accardo A, Tesauro D, Morelli G
* Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (132 visite)
Polym J (ISSN: 0032-3896), 2013 May; 45(5): 481-493.
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (136 visite)
Chemical Reviews (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (122 visite)
Biochem Biophys Res Commun Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
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Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (129 visite)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
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Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (150 visite)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (139 visite)
Int J Nanomedicine (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
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Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (165 visite)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (166 visite)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (258 visite)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (141 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
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Finnema SJ, Varrone A, Farde L, Halldin C
* D-Amphetamine decreases [C-11]AZ10419369 receptor binding in the monkey brain (91 visite)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
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Finnema SJ, Nakao R, Haaparanta-solin M, Varrone A, Stepanov V, Solin O, Ingman K, Sallinen J, Scheinin M, Farde L, Halldin C
* Quantitative measurement of [C-11]ORM-13070 receptor binding in the monkey brain using a bolus-infusion protocol (91 visite)
Journal Of Labelled Compounds & Radiopharmaceuticals (ISSN: 0362-4803), 2011; 54: N/D-N/D.
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A,  Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (142 visite)
Haematologica (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
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Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
* PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans (122 visite)
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
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Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (99 visite)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (13877 visite)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
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Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (111 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
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Mcnab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T
* Changes in cortical dopamine D1 receptor binding associated with cognitive training (140 visite)
Science (ISSN: 0036-8075), 2009 Feb 6; 323(5915): 800-802.
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Bartolazzi A, D'Alessandria C, Parisella MG, Signore A, Del Prete F, Lavra L, Braesch-Andersen S, Massari R, Trotta C, Soluri A, Sciacchitano S, Scopinaro F
* Thyroid cancer imaging in vivo by targeting the anti-apoptotic molecule galectin-3 (133 visite)
Plos One (ISSN: 1932-6203, 1932-6203electronic), 2008 Nov 20; 3(11): e3768-e3768.
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (99 visite)
J Biol Chem Journal Of Biological Chemistry (ISSN: 0021-9258, 1083-351x), 2008 Sep 1; 283(31): 21769-21778.
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D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT
* Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (137 visite)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2008 Jun 12; 51(11): 3230-3237.
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (88 visite)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (88 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello  GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (86 visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (141 visite)
Proc Natl Acad Sci U S A (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (117 visite)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
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Musumeci D, Valente M, Capasso D, Palumbo R, Schmidtke M, Goerlach M, Zell R, Roviello  GN, Sapio R, Pedone C, Bucci EM
* Targeting of PNA to a cytoplasmic virus (104 visite)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (123 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (109 visite)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (121 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (118 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
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D’Andrea LD, Fattorusso R, Carannante C, Pedone C
* Targeting VEGF Receptors Using Designed Polypeptide (93 visite)
Peptides 2002, 2002; ConferenceBook: 454-455.
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Pani R, Scopinaro F, Pellegrini R, Soluri A, Weinberg IN, De Vincentis G
The role of compton background and breast compression on cancer detection in scintimammography (92 visite)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 1997 May; 17(3B): 1645-1649.
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (112 visite)
Cancer Immunology Immunotherapy (ISSN: 0340-7004), 1993 Sep; 37(3): 150-156.
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62 Records (57 escludendo Abstract e Conferenze).
Impact factor totale: 308.539 (302.147 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 313.95 (308.147 escludendo Abstract e Conferenze).







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