Progetti in evidenza
Fondo Europeo Pesca(587 visite)
Fondazione Veronesi(Link esterno)
MFAG Grant(1095 visite)
Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications (87 visite)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2017 Dec 2; N/D: N/D-N/D.
Tipo di articolo: Journal Article,
Impact factor: 4.106
Impact factor a 5 anni: 3.541
Parole chiave: Cancer Detection, Flow Cytometry, Receptor Binding, Retro-Inverso Peptide Sequence,
Url: Non disponibile.
Pharmacological strategies aimed at preventing cancer growth are in most cases paralleled by diagnostic investigations for monitoring and prognosticating therapeutic efficacy. A relevant approach in cancer is the suppression of pathological angiogenesis, which is principally driven by vascular endothelial growth factor (VEGF) or closely related factors and by activation of specific receptors, prevailingly VEGFR1 and VEGFR2, set on the surface of endothelial cells. Monitoring the presence of these receptors in vivo is henceforth a way to predict therapy outcome. We have designed small peptides able to bind and possibly antagonize VEGF ligands by targeting VEGF receptors. Peptide systems have been designed to be small, cyclic and to host triplets of residues known to be essential for VEGF receptors recognition and we named them 'mini-factors'. They have been structurally characterized by CD, NMR and molecular dynamics (MD) simulations. Mini-factors do bind with different specificity and affinity VEGF receptors but none blocks receptor activity. Following derivatization with suitable tracers they have been employed as molecular probes for sensing receptors on cell surface without affecting their activity as is usually observed with other binders having neutralizing activity.
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini del CNR, CIRPeB, University of Naples Federico II, via Mezzocannone, 16, 80134, Naples, Italy., CNR-IBB, via Mezzocannone, 16, 80134, Naples, Italy., DISTABiF, Universita degli Studi della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100, Caserta, Italy., Angiogenesis Lab, Institute of Genetics and Biophysics-CNR, Via P. Castellino 111, 80131, Naples, Italy., Fresenius Kabi Anti Infectives srl, Via San Leonardo 23, 45010, Villadose, RO, Italy., Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80134, Naples, Italy., Istituto di Biostrutture e Bioimmagini del CNR, CIRPeB, University of Naples Federico II, via Mezzocannone, 16, 80134, Naples, Italy. firstname.lastname@example.org., CNR-IBB, via Mezzocannone, 16, 80134, Naples, Italy. email@example.com.,
Esporta in BibTeX Esporta in EndNote
Ultima modifica di Gennaro Angrisano in data Friday 05 January 2018, 8:52:21
87 visite. Ultima visita in data Saturday 27 October 2018, 14:13:27
Nessun bando in corso.
Archivio Concorsi>>> (954 visite)
Nessun evento in programma.
Archivio Eventi>>> (884 visite)