Prognostic role of FDG PET/CT in patients with differentiated thyroid cancer treated with 131-iodine empiric therapy(73 visite)(PDF pubblico56 visite) Salvatore B, Klain M, Nicolai E, D'Amico D, De Matteis G, Raddi M, Fonti R, Pellegrino T, Storto G, Cuocolo A, Pace L
Medicine (ISSN: 1536-5964electronic, 0025-7974linking), 2017 Oct; 96(42): e8344-e8344.
*** IBB - CNR *** aIstituto di Biostrutture e Bioimmagini, CNR bDipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli FedericoII cIRCCS - SDN, Napoli dMedicina Nucleare, IRCCS - CROB, Rionero in Vulture eDipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana," Universita degli Studi di Salerno, Salerno, Italy.,
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BACKGROUND: To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg). METHODS: Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a mean period of 7.9 +/- 5 years after empiric RAI therapy were retrospectively analyzed. RESULTS: FDG-PET/CT was negative in 15 (30.6%) patients and positive in 34 (69.4%), whereas postradioiodine therapy whole body scan (t-WBS) was negative in 16 (32.7%) and positive in 33 (67.3%) patients. FDG-PET/CT and t-WBS were in agreement in 32 patients (7 both negative and 25 both positive); on the contrary, in 17 patients there was disagreement between FDG-PET/CT and t-WBS (P =ns). At short-term follow-up, Tg normalized in 19 (38.8%) patients and was unchanged or increased in 30 (61.2%). Of the 15 patients with negative FDG-PET/CT, 11 (73.3%) showed Tg normalization, whereas of the 34 patients with positive FDG-PET/CT, only 8 (23.5%) had Tg normalization (chi =8.9, P < .005). At multivariate analysis, FDG-PET/CT and Tg normalization at short-term follow-up were independent predictors of disease-free survival (chi =26.3, P < .0001), while Tg normalization was the only variable associated with overall survival chi =7.2, P < .01). CONCLUSION: FDG-PET/CT in association with Tg normalization at short-term follow-up may be useful for long-term prognostic stratification in DTC patients.
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752 Records (712 escludendo Abstract e Conferenze). Impact factor totale: 2311.5 (2193.932 escludendo Abstract e Conferenze). Impact factor a 5 anni totale: 2529.974 (2379.635 escludendo Abstract e Conferenze).
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