Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a
Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a(96 visite) Lanzillo R, Carbone F, Quarantelli M, Bruzzese D, Carotenuto A, De RosaV, Colamatteo A, Micillo T, De Luca Picione C, Saccà F, De Rosa A, Moccia M, Brescia Morra V, Matarese G
Parole chiave: Adjuvants, Immunologic Therapeutic Use
, Biomarkers Blood
, Humans
, Interferon Beta-1a Therapeutic Use
, Multiple Sclerosis, Relapsing-Remitting Blood Drug Therapy
, Predictive Value Of Tests
, Transcriptome Immunology
, Autoimmunity
, Ifn-Beta-1a
, Il-6
, Leptin, Beta1a Interferon, Biological Marker, Cd40 Ligand, Interleukin 6, Monocyte Chemotactic Protein 1, Tumor Necrosis Factor Receptor, Immunological Adjuvant, Adult, Article, Body Mass, Clinical Article, Clinical Feature, Clinical Outcome, Clinical Practice, Corticosteroid Therapy, Disease Activity, Disease Association, Disease Course, Disease Duration, Disease Severity, Drug Formulation, Female, Follow Up, Immunoassay, Nuclear Magnetic Resonance Imaging, Priority Journal, Recurrence Risk, Risk Factor,
Affiliazioni:
*** IBB - CNR *** Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, Universita degli Studi di Napoli "Federico II", Napoli, Italy. Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy. Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Napoli, Italy. Dipartimento di Sanita Pubblica, Universita degli Studi di Napoli "Federico II", Napoli, Italy. Dipartimento di Biologia, Universita degli Studi di Napoli "Federico II", Napoli, Italy. Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli "Federico II", Napoli, Italy. Electronic address: giuseppe.matarese@unina.it.
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Reliable immunologic biomarkers able to monitor disease course during <br>multiple sclerosis (MS) are still missing. We aimed at identifying <br>possible immunometabolic biomarkers able to predict the clinical outcome<br> in MS patients during treatment with interferon (IFN)-beta-1a. We <br>measured in 45 relapsing-remitting (RR) MS patients, blood circulating <br>levels of several immunometabolic markers, at enrolment, and correlated <br>their levels to disease activity and progression over time. Higher <br>levels of interleukin (IL)-6, soluble-CD40-ligand (sCD40L) and leptin at<br> baseline associated with a higher relapse rate and a greater risk of <br>experiencing at least one relapse in the following year. Higher values <br>of soluble tumor necrosis factor receptor (sTNF-R) and leptin at <br>baseline were predictive of a higher number of lesions in the following <br>one-year of follow up. In conclusion, our data suggest that an <br>immunometabolic profiling measuring IL-6, sCD40L, leptin and sTNF-R at <br>baseline, could represent a useful tool to predict disease course in <br>RRMS patients during treatment with IFN-beta-1a.
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